ID   OR2T6_HUMAN             Reviewed;         308 AA.
AC   Q8NHC8; A6NE36;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   24-JAN-2024, entry version 143.
DE   RecName: Full=Olfactory receptor 2T6;
DE   AltName: Full=OST703;
DE   AltName: Full=Olfactory receptor 2T9;
GN   Name=OR2T6; Synonyms=OR2T6P, OR2T9;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC05705.1; Type=Miscellaneous discrepancy; Note=Hybrid of two separate genomic loci.; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR2T6";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB065438; BAC05705.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AC138089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS31114.1; -.
DR   RefSeq; NP_001005471.1; NM_001005471.1.
DR   AlphaFoldDB; Q8NHC8; -.
DR   SMR; Q8NHC8; -.
DR   BioGRID; 129055; 1.
DR   IntAct; Q8NHC8; 1.
DR   STRING; 9606.ENSP00000493366; -.
DR   GlyCosmos; Q8NHC8; 1 site, No reported glycans.
DR   GlyGen; Q8NHC8; 1 site.
DR   iPTMnet; Q8NHC8; -.
DR   PhosphoSitePlus; Q8NHC8; -.
DR   BioMuta; OR2T6; -.
DR   DMDM; 166214964; -.
DR   MassIVE; Q8NHC8; -.
DR   PaxDb; 9606-ENSP00000347965; -.
DR   Antibodypedia; 68598; 69 antibodies from 18 providers.
DR   DNASU; 254879; -.
DR   Ensembl; ENST00000612137.1; ENSP00000478358.1; ENSG00000278659.1.
DR   Ensembl; ENST00000621336.1; ENSP00000481800.1; ENSG00000278689.1.
DR   Ensembl; ENST00000641644.1; ENSP00000493366.1; ENSG00000198104.4.
DR   Ensembl; ENST00000709575.1; ENSP00000517769.1; ENSG00000292016.1.
DR   GeneID; 254879; -.
DR   KEGG; hsa:254879; -.
DR   MANE-Select; ENST00000641644.1; ENSP00000493366.1; NM_001005471.2; NP_001005471.1.
DR   UCSC; uc001iei.1; human.
DR   AGR; HGNC:15018; -.
DR   CTD; 254879; -.
DR   DisGeNET; 254879; -.
DR   GeneCards; OR2T6; -.
DR   HGNC; HGNC:15018; OR2T6.
DR   HPA; ENSG00000198104; Not detected.
DR   neXtProt; NX_Q8NHC8; -.
DR   PharmGKB; PA32206; -.
DR   VEuPathDB; HostDB:ENSG00000198104; -.
DR   eggNOG; ENOG502RTYZ; Eukaryota.
DR   GeneTree; ENSGT01090000260018; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q8NHC8; -.
DR   OMA; MSLPFCS; -.
DR   OrthoDB; 3784606at2759; -.
DR   PhylomeDB; Q8NHC8; -.
DR   TreeFam; TF337295; -.
DR   PathwayCommons; Q8NHC8; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q8NHC8; -.
DR   BioGRID-ORCS; 254879; 7 hits in 749 CRISPR screens.
DR   ChiTaRS; OR2T6; human.
DR   GeneWiki; OR2T6; -.
DR   GenomeRNAi; 254879; -.
DR   Pharos; Q8NHC8; Tdark.
DR   PRO; PR:Q8NHC8; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NHC8; Protein.
DR   Bgee; ENSG00000198104; Expressed in primordial germ cell in gonad and 2 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15421; 7tmA_OR2T-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF57; OLFACTORY RECEPTOR 2T6; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..308
FT                   /note="Olfactory receptor 2T6"
FT                   /id="PRO_0000150501"
FT   TOPO_DOM        1..28
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        29..49
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        50..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        120..145
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        146..166
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        167..203
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        204..224
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        225..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..308
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..179
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         21
FT                   /note="N -> D (in dbSNP:rs7417616)"
FT                   /id="VAR_060001"
FT   VARIANT         23
FT                   /note="C -> G (in dbSNP:rs6587467)"
FT                   /id="VAR_060002"
FT   VARIANT         57
FT                   /note="T -> N (in dbSNP:rs6693032)"
FT                   /id="VAR_053152"
FT   VARIANT         159
FT                   /note="L -> P (in dbSNP:rs6701129)"
FT                   /id="VAR_053153"
FT   VARIANT         243
FT                   /note="S -> A (in dbSNP:rs954475)"
FT                   /id="VAR_053154"
SQ   SEQUENCE   308 AA;  34765 MW;  687529A6037E88B5 CRC64;
     MNENNETLTR GFTLMGLFTH NKCSGFFFGV ICAVFFMAMI ANGVMIFLIN IDPHLHTPMY
     FLLSHLSVID TLYISTIVPK MLVDYLMGEG TISFIACTAQ CFLYMGFMGA EFFLLGLMAY
     DRYVAICNPL RYPVLISWRV CWMILASSWF GGALDSFLLT PITMSLPFCA SHQINHFFCE
     APTMLRLACG DKTTYETVMY VCCVAMLLIP FSVVTASYTR ILITVHQMTS AEGRKKAFAT
     CSSHMMVVTL FYGAALYTYT LPQSYHTPIK DKVFSAFYTI LTPLLNPLIY SLRNRDVMGA
     LKRVVARC
//