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Protein

Olfactory receptor 2T6

Gene

OR2T6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177151-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T6
Alternative name(s):
OST703
Olfactory receptor 2T9
Gene namesi
Name:OR2T6
Synonyms:OR2T6P, OR2T9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15018. OR2T6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 98ExtracellularSequence analysisAdd BLAST20
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 145CytoplasmicSequence analysisAdd BLAST26
Transmembranei146 – 166Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini167 – 203ExtracellularSequence analysisAdd BLAST37
Transmembranei204 – 224Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini225 – 236CytoplasmicSequence analysisAdd BLAST12
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 271ExtracellularSequence analysisAdd BLAST14
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 308CytoplasmicSequence analysisAdd BLAST16

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000198104.
ENSG00000278659.
ENSG00000278689.
PharmGKBiPA32206.

Polymorphism and mutation databases

BioMutaiOR2T6.
DMDMi166214964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505011 – 308Olfactory receptor 2T6Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHC8.
PeptideAtlasiQ8NHC8.
PRIDEiQ8NHC8.

PTM databases

iPTMnetiQ8NHC8.
PhosphoSitePlusiQ8NHC8.

Expressioni

Gene expression databases

CleanExiHS_OR2T6.

Interactioni

Protein-protein interaction databases

BioGridi129055. 1 interactor.
IntActiQ8NHC8. 1 interactor.
STRINGi9606.ENSP00000347965.

Structurei

3D structure databases

ProteinModelPortaliQ8NHC8.
SMRiQ8NHC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGYV. Eukaryota.
ENOG411199U. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC8.
KOiK04257.
OMAiCASHQIN.
OrthoDBiEOG091G0ECW.
PhylomeDBiQ8NHC8.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENNETLTR GFTLMGLFTH NKCSGFFFGV ICAVFFMAMI ANGVMIFLIN
60 70 80 90 100
IDPHLHTPMY FLLSHLSVID TLYISTIVPK MLVDYLMGEG TISFIACTAQ
110 120 130 140 150
CFLYMGFMGA EFFLLGLMAY DRYVAICNPL RYPVLISWRV CWMILASSWF
160 170 180 190 200
GGALDSFLLT PITMSLPFCA SHQINHFFCE APTMLRLACG DKTTYETVMY
210 220 230 240 250
VCCVAMLLIP FSVVTASYTR ILITVHQMTS AEGRKKAFAT CSSHMMVVTL
260 270 280 290 300
FYGAALYTYT LPQSYHTPIK DKVFSAFYTI LTPLLNPLIY SLRNRDVMGA

LKRVVARC
Length:308
Mass (Da):34,765
Last modified:January 15, 2008 - v2
Checksum:i687529A6037E88B5
GO

Sequence cautioni

The sequence BAC05705 differs from that shown. Hybrid of two separate genomic loci.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06000121N → D.Corresponds to variant rs7417616dbSNPEnsembl.1
Natural variantiVAR_06000223C → G.Corresponds to variant rs6587467dbSNPEnsembl.1
Natural variantiVAR_05315257T → N.Corresponds to variant rs6693032dbSNPEnsembl.1
Natural variantiVAR_053153159L → P.Corresponds to variant rs6701129dbSNPEnsembl.1
Natural variantiVAR_053154243S → A.Corresponds to variant rs954475dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065438 Genomic DNA. Translation: BAC05705.1. Sequence problems.
AC138089 Genomic DNA. No translation available.
CCDSiCCDS31114.1.
RefSeqiNP_001005471.1. NM_001005471.1.
UniGeneiHs.626884.

Genome annotation databases

EnsembliENST00000355728; ENSP00000347965; ENSG00000198104.
ENST00000612137; ENSP00000478358; ENSG00000278659.
ENST00000621336; ENSP00000481800; ENSG00000278689.
GeneIDi254879.
KEGGihsa:254879.
UCSCiuc001iei.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065438 Genomic DNA. Translation: BAC05705.1. Sequence problems.
AC138089 Genomic DNA. No translation available.
CCDSiCCDS31114.1.
RefSeqiNP_001005471.1. NM_001005471.1.
UniGeneiHs.626884.

3D structure databases

ProteinModelPortaliQ8NHC8.
SMRiQ8NHC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129055. 1 interactor.
IntActiQ8NHC8. 1 interactor.
STRINGi9606.ENSP00000347965.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NHC8.
PhosphoSitePlusiQ8NHC8.

Polymorphism and mutation databases

BioMutaiOR2T6.
DMDMi166214964.

Proteomic databases

PaxDbiQ8NHC8.
PeptideAtlasiQ8NHC8.
PRIDEiQ8NHC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355728; ENSP00000347965; ENSG00000198104.
ENST00000612137; ENSP00000478358; ENSG00000278659.
ENST00000621336; ENSP00000481800; ENSG00000278689.
GeneIDi254879.
KEGGihsa:254879.
UCSCiuc001iei.1. human.

Organism-specific databases

CTDi254879.
GeneCardsiOR2T6.
HGNCiHGNC:15018. OR2T6.
neXtProtiNX_Q8NHC8.
OpenTargetsiENSG00000198104.
ENSG00000278659.
ENSG00000278689.
PharmGKBiPA32206.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGYV. Eukaryota.
ENOG411199U. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC8.
KOiK04257.
OMAiCASHQIN.
OrthoDBiEOG091G0ECW.
PhylomeDBiQ8NHC8.
TreeFamiTF337295.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177151-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2T6.
GenomeRNAii254879.
PROiQ8NHC8.

Gene expression databases

CleanExiHS_OR2T6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2T6_HUMAN
AccessioniPrimary (citable) accession number: Q8NHC8
Secondary accession number(s): A6NE36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.