SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NHC8

- OR2T6_HUMAN

UniProt

Q8NHC8 - OR2T6_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Olfactory receptor 2T6

Gene
OR2T6, OR2T6P, OR2T9
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T6
Alternative name(s):
OST703
Olfactory receptor 2T9
Gene namesi
Name:OR2T6
Synonyms:OR2T6P, OR2T9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:15018. OR2T6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Extracellular Reviewed predictionAdd
BLAST
Transmembranei29 – 4921Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini50 – 578Cytoplasmic Reviewed prediction
Transmembranei58 – 7821Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini79 – 9820Extracellular Reviewed predictionAdd
BLAST
Transmembranei99 – 11921Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini120 – 14526Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei146 – 16621Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini167 – 20337Extracellular Reviewed predictionAdd
BLAST
Transmembranei204 – 22421Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini225 – 23612Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei237 – 25721Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini258 – 27114Extracellular Reviewed predictionAdd
BLAST
Transmembranei272 – 29221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini293 – 30816Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Olfactory receptor 2T6PRO_0000150501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 179 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHC8.
PRIDEiQ8NHC8.

Expressioni

Gene expression databases

CleanExiHS_OR2T6.
GenevestigatoriQ8NHC8.

Interactioni

Protein-protein interaction databases

BioGridi129055. 1 interaction.
IntActiQ8NHC8. 1 interaction.
STRINGi9606.ENSP00000347965.

Structurei

3D structure databases

ProteinModelPortaliQ8NHC8.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG81984.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC8.
KOiK04257.
OMAiCASHQIN.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NHC8.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHC8-1 [UniParc]FASTAAdd to Basket

« Hide

MNENNETLTR GFTLMGLFTH NKCSGFFFGV ICAVFFMAMI ANGVMIFLIN    50
IDPHLHTPMY FLLSHLSVID TLYISTIVPK MLVDYLMGEG TISFIACTAQ 100
CFLYMGFMGA EFFLLGLMAY DRYVAICNPL RYPVLISWRV CWMILASSWF 150
GGALDSFLLT PITMSLPFCA SHQINHFFCE APTMLRLACG DKTTYETVMY 200
VCCVAMLLIP FSVVTASYTR ILITVHQMTS AEGRKKAFAT CSSHMMVVTL 250
FYGAALYTYT LPQSYHTPIK DKVFSAFYTI LTPLLNPLIY SLRNRDVMGA 300
LKRVVARC 308
Length:308
Mass (Da):34,765
Last modified:January 15, 2008 - v2
Checksum:i687529A6037E88B5
GO

Sequence cautioni

The sequence BAC05705.1 differs from that shown. Reason: Hybrid of two separate genomic loci.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211N → D.
Corresponds to variant rs7417616 [ dbSNP | Ensembl ].
VAR_060001
Natural varianti23 – 231C → G.
Corresponds to variant rs6587467 [ dbSNP | Ensembl ].
VAR_060002
Natural varianti57 – 571T → N.
Corresponds to variant rs6693032 [ dbSNP | Ensembl ].
VAR_053152
Natural varianti159 – 1591L → P.
Corresponds to variant rs6701129 [ dbSNP | Ensembl ].
VAR_053153
Natural varianti243 – 2431S → A.
Corresponds to variant rs954475 [ dbSNP | Ensembl ].
VAR_053154

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065438 Genomic DNA. Translation: BAC05705.1. Sequence problems.
AC138089 Genomic DNA. No translation available.
CCDSiCCDS31114.1.
RefSeqiNP_001005471.1. NM_001005471.1.
UniGeneiHs.626884.

Genome annotation databases

EnsembliENST00000355728; ENSP00000347965; ENSG00000198104.
GeneIDi254879.
KEGGihsa:254879.
UCSCiuc001iei.1. human.

Polymorphism databases

DMDMi166214964.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065438 Genomic DNA. Translation: BAC05705.1 . Sequence problems.
AC138089 Genomic DNA. No translation available.
CCDSi CCDS31114.1.
RefSeqi NP_001005471.1. NM_001005471.1.
UniGenei Hs.626884.

3D structure databases

ProteinModelPortali Q8NHC8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129055. 1 interaction.
IntActi Q8NHC8. 1 interaction.
STRINGi 9606.ENSP00000347965.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 166214964.

Proteomic databases

PaxDbi Q8NHC8.
PRIDEi Q8NHC8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000355728 ; ENSP00000347965 ; ENSG00000198104 .
GeneIDi 254879.
KEGGi hsa:254879.
UCSCi uc001iei.1. human.

Organism-specific databases

CTDi 254879.
GeneCardsi GC01P248550.
HGNCi HGNC:15018. OR2T6.
neXtProti NX_Q8NHC8.
PharmGKBi PA32206.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG81984.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NHC8.
KOi K04257.
OMAi CASHQIN.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NHC8.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2T6.
GenomeRNAii 254879.
NextBioi 92407.
PROi Q8NHC8.

Gene expression databases

CleanExi HS_OR2T6.
Genevestigatori Q8NHC8.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOR2T6_HUMAN
AccessioniPrimary (citable) accession number: Q8NHC8
Secondary accession number(s): A6NE36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: September 3, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi