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Q8NHC8

- OR2T6_HUMAN

UniProt

Q8NHC8 - OR2T6_HUMAN

Protein

Olfactory receptor 2T6

Gene

OR2T6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2T6
    Alternative name(s):
    OST703
    Olfactory receptor 2T9
    Gene namesi
    Name:OR2T6
    Synonyms:OR2T6P, OR2T9
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:15018. OR2T6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32206.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Olfactory receptor 2T6PRO_0000150501Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NHC8.
    PRIDEiQ8NHC8.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2T6.
    GenevestigatoriQ8NHC8.

    Interactioni

    Protein-protein interaction databases

    BioGridi129055. 1 interaction.
    IntActiQ8NHC8. 1 interaction.
    STRINGi9606.ENSP00000347965.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NHC8.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini79 – 9820ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 14526CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini167 – 20337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 23612CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27114ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 30816CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG81984.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NHC8.
    KOiK04257.
    OMAiCASHQIN.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NHC8.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NHC8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNENNETLTR GFTLMGLFTH NKCSGFFFGV ICAVFFMAMI ANGVMIFLIN    50
    IDPHLHTPMY FLLSHLSVID TLYISTIVPK MLVDYLMGEG TISFIACTAQ 100
    CFLYMGFMGA EFFLLGLMAY DRYVAICNPL RYPVLISWRV CWMILASSWF 150
    GGALDSFLLT PITMSLPFCA SHQINHFFCE APTMLRLACG DKTTYETVMY 200
    VCCVAMLLIP FSVVTASYTR ILITVHQMTS AEGRKKAFAT CSSHMMVVTL 250
    FYGAALYTYT LPQSYHTPIK DKVFSAFYTI LTPLLNPLIY SLRNRDVMGA 300
    LKRVVARC 308
    Length:308
    Mass (Da):34,765
    Last modified:January 15, 2008 - v2
    Checksum:i687529A6037E88B5
    GO

    Sequence cautioni

    The sequence BAC05705.1 differs from that shown. Reason: Hybrid of two separate genomic loci.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti21 – 211N → D.
    Corresponds to variant rs7417616 [ dbSNP | Ensembl ].
    VAR_060001
    Natural varianti23 – 231C → G.
    Corresponds to variant rs6587467 [ dbSNP | Ensembl ].
    VAR_060002
    Natural varianti57 – 571T → N.
    Corresponds to variant rs6693032 [ dbSNP | Ensembl ].
    VAR_053152
    Natural varianti159 – 1591L → P.
    Corresponds to variant rs6701129 [ dbSNP | Ensembl ].
    VAR_053153
    Natural varianti243 – 2431S → A.
    Corresponds to variant rs954475 [ dbSNP | Ensembl ].
    VAR_053154

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065438 Genomic DNA. Translation: BAC05705.1. Sequence problems.
    AC138089 Genomic DNA. No translation available.
    CCDSiCCDS31114.1.
    RefSeqiNP_001005471.1. NM_001005471.1.
    UniGeneiHs.626884.

    Genome annotation databases

    EnsembliENST00000355728; ENSP00000347965; ENSG00000198104.
    GeneIDi254879.
    KEGGihsa:254879.
    UCSCiuc001iei.1. human.

    Polymorphism databases

    DMDMi166214964.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065438 Genomic DNA. Translation: BAC05705.1 . Sequence problems.
    AC138089 Genomic DNA. No translation available.
    CCDSi CCDS31114.1.
    RefSeqi NP_001005471.1. NM_001005471.1.
    UniGenei Hs.626884.

    3D structure databases

    ProteinModelPortali Q8NHC8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129055. 1 interaction.
    IntActi Q8NHC8. 1 interaction.
    STRINGi 9606.ENSP00000347965.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 166214964.

    Proteomic databases

    PaxDbi Q8NHC8.
    PRIDEi Q8NHC8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000355728 ; ENSP00000347965 ; ENSG00000198104 .
    GeneIDi 254879.
    KEGGi hsa:254879.
    UCSCi uc001iei.1. human.

    Organism-specific databases

    CTDi 254879.
    GeneCardsi GC01P248550.
    HGNCi HGNC:15018. OR2T6.
    neXtProti NX_Q8NHC8.
    PharmGKBi PA32206.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG81984.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NHC8.
    KOi K04257.
    OMAi CASHQIN.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NHC8.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2T6.
    GenomeRNAii 254879.
    NextBioi 92407.
    PROi Q8NHC8.

    Gene expression databases

    CleanExi HS_OR2T6.
    Genevestigatori Q8NHC8.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiOR2T6_HUMAN
    AccessioniPrimary (citable) accession number: Q8NHC8
    Secondary accession number(s): A6NE36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 20, 2005
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3