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Protein

Olfactory receptor 2T6

Gene

OR2T6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2T6
Alternative name(s):
OST703
Olfactory receptor 2T9
Gene namesi
Name:OR2T6
Synonyms:OR2T6P, OR2T9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15018. OR2T6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei29 – 4921Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9820ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 14526CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini167 – 20337ExtracellularSequence AnalysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 23612CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27114ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 30816CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32206.

Polymorphism and mutation databases

BioMutaiOR2T6.
DMDMi166214964.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Olfactory receptor 2T6PRO_0000150501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHC8.
PRIDEiQ8NHC8.

Expressioni

Gene expression databases

CleanExiHS_OR2T6.

Interactioni

Protein-protein interaction databases

BioGridi129055. 1 interaction.
IntActiQ8NHC8. 1 interaction.
STRINGi9606.ENSP00000347965.

Structurei

3D structure databases

ProteinModelPortaliQ8NHC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG81984.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC8.
KOiK04257.
OMAiCASHQIN.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NHC8.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNENNETLTR GFTLMGLFTH NKCSGFFFGV ICAVFFMAMI ANGVMIFLIN
60 70 80 90 100
IDPHLHTPMY FLLSHLSVID TLYISTIVPK MLVDYLMGEG TISFIACTAQ
110 120 130 140 150
CFLYMGFMGA EFFLLGLMAY DRYVAICNPL RYPVLISWRV CWMILASSWF
160 170 180 190 200
GGALDSFLLT PITMSLPFCA SHQINHFFCE APTMLRLACG DKTTYETVMY
210 220 230 240 250
VCCVAMLLIP FSVVTASYTR ILITVHQMTS AEGRKKAFAT CSSHMMVVTL
260 270 280 290 300
FYGAALYTYT LPQSYHTPIK DKVFSAFYTI LTPLLNPLIY SLRNRDVMGA

LKRVVARC
Length:308
Mass (Da):34,765
Last modified:January 15, 2008 - v2
Checksum:i687529A6037E88B5
GO

Sequence cautioni

The sequence BAC05705.1 differs from that shown.Hybrid of two separate genomic loci.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211N → D.
Corresponds to variant rs7417616 [ dbSNP | Ensembl ].
VAR_060001
Natural varianti23 – 231C → G.
Corresponds to variant rs6587467 [ dbSNP | Ensembl ].
VAR_060002
Natural varianti57 – 571T → N.
Corresponds to variant rs6693032 [ dbSNP | Ensembl ].
VAR_053152
Natural varianti159 – 1591L → P.
Corresponds to variant rs6701129 [ dbSNP | Ensembl ].
VAR_053153
Natural varianti243 – 2431S → A.
Corresponds to variant rs954475 [ dbSNP | Ensembl ].
VAR_053154

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065438 Genomic DNA. Translation: BAC05705.1. Sequence problems.
AC138089 Genomic DNA. No translation available.
CCDSiCCDS31114.1.
RefSeqiNP_001005471.1. NM_001005471.1.
UniGeneiHs.626884.

Genome annotation databases

EnsembliENST00000355728; ENSP00000347965; ENSG00000198104.
ENST00000612137; ENSP00000478358; ENSG00000278659.
ENST00000621336; ENSP00000481800; ENSG00000278689.
GeneIDi254879.
KEGGihsa:254879.
UCSCiuc001iei.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065438 Genomic DNA. Translation: BAC05705.1. Sequence problems.
AC138089 Genomic DNA. No translation available.
CCDSiCCDS31114.1.
RefSeqiNP_001005471.1. NM_001005471.1.
UniGeneiHs.626884.

3D structure databases

ProteinModelPortaliQ8NHC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi129055. 1 interaction.
IntActiQ8NHC8. 1 interaction.
STRINGi9606.ENSP00000347965.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2T6.
DMDMi166214964.

Proteomic databases

PaxDbiQ8NHC8.
PRIDEiQ8NHC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355728; ENSP00000347965; ENSG00000198104.
ENST00000612137; ENSP00000478358; ENSG00000278659.
ENST00000621336; ENSP00000481800; ENSG00000278689.
GeneIDi254879.
KEGGihsa:254879.
UCSCiuc001iei.1. human.

Organism-specific databases

CTDi254879.
GeneCardsiGC01P248550.
HGNCiHGNC:15018. OR2T6.
neXtProtiNX_Q8NHC8.
PharmGKBiPA32206.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG81984.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC8.
KOiK04257.
OMAiCASHQIN.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NHC8.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2T6.
GenomeRNAii254879.
NextBioi92407.
PROiQ8NHC8.

Gene expression databases

CleanExiHS_OR2T6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOR2T6_HUMAN
AccessioniPrimary (citable) accession number: Q8NHC8
Secondary accession number(s): A6NE36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: July 22, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.