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Q8NHC8 (OR2T6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2T6
Alternative name(s):
OST703
Olfactory receptor 2T9
Gene names
Name:OR2T6
Synonyms:OR2T6P, OR2T9
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05705.1 differs from that shown. Reason: Hybrid of two separate genomic loci.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Olfactory receptor 2T6
PRO_0000150501

Regions

Topological domain1 – 2828Extracellular Potential
Transmembrane29 – 4921Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7821Helical; Name=2; Potential
Topological domain79 – 9820Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 14526Cytoplasmic Potential
Transmembrane146 – 16621Helical; Name=4; Potential
Topological domain167 – 20337Extracellular Potential
Transmembrane204 – 22421Helical; Name=5; Potential
Topological domain225 – 23612Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 27114Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 30816Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 179 By similarity

Natural variations

Natural variant211N → D.
Corresponds to variant rs7417616 [ dbSNP | Ensembl ].
VAR_060001
Natural variant231C → G.
Corresponds to variant rs6587467 [ dbSNP | Ensembl ].
VAR_060002
Natural variant571T → N.
Corresponds to variant rs6693032 [ dbSNP | Ensembl ].
VAR_053152
Natural variant1591L → P.
Corresponds to variant rs6701129 [ dbSNP | Ensembl ].
VAR_053153
Natural variant2431S → A.
Corresponds to variant rs954475 [ dbSNP | Ensembl ].
VAR_053154

Sequences

Sequence LengthMass (Da)Tools
Q8NHC8 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 687529A6037E88B5

FASTA30834,765
        10         20         30         40         50         60 
MNENNETLTR GFTLMGLFTH NKCSGFFFGV ICAVFFMAMI ANGVMIFLIN IDPHLHTPMY 

        70         80         90        100        110        120 
FLLSHLSVID TLYISTIVPK MLVDYLMGEG TISFIACTAQ CFLYMGFMGA EFFLLGLMAY 

       130        140        150        160        170        180 
DRYVAICNPL RYPVLISWRV CWMILASSWF GGALDSFLLT PITMSLPFCA SHQINHFFCE 

       190        200        210        220        230        240 
APTMLRLACG DKTTYETVMY VCCVAMLLIP FSVVTASYTR ILITVHQMTS AEGRKKAFAT 

       250        260        270        280        290        300 
CSSHMMVVTL FYGAALYTYT LPQSYHTPIK DKVFSAFYTI LTPLLNPLIY SLRNRDVMGA 


LKRVVARC 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065438 Genomic DNA. Translation: BAC05705.1. Sequence problems.
AC138089 Genomic DNA. No translation available.
CCDSCCDS31114.1.
RefSeqNP_001005471.1. NM_001005471.1.
UniGeneHs.626884.

3D structure databases

ProteinModelPortalQ8NHC8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129055. 1 interaction.
IntActQ8NHC8. 1 interaction.
STRING9606.ENSP00000347965.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM166214964.

Proteomic databases

PaxDbQ8NHC8.
PRIDEQ8NHC8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355728; ENSP00000347965; ENSG00000198104.
GeneID254879.
KEGGhsa:254879.
UCSCuc001iei.1. human.

Organism-specific databases

CTD254879.
GeneCardsGC01P248550.
HGNCHGNC:15018. OR2T6.
neXtProtNX_Q8NHC8.
PharmGKBPA32206.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG81984.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NHC8.
KOK04257.
OMACASHQIN.
OrthoDBEOG71K63J.
PhylomeDBQ8NHC8.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2T6.
GenevestigatorQ8NHC8.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2T6.
GenomeRNAi254879.
NextBio92407.
PROQ8NHC8.

Entry information

Entry nameOR2T6_HUMAN
AccessionPrimary (citable) accession number: Q8NHC8
Secondary accession number(s): A6NE36
Entry history
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: January 15, 2008
Last modified: July 9, 2014
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries