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Protein

Olfactory receptor 14C36

Gene

OR14C36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177174-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 14C36
Alternative name(s):
Olfactory receptor 5BF1
Olfactory receptor OR1-59
Gene namesi
Name:OR14C36
Synonyms:OR5BF1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15026. OR14C36.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 194ExtracellularSequence analysisAdd BLAST36
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 312CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000177174.
PharmGKBiPA162398442.

Polymorphism and mutation databases

BioMutaiOR14C36.
DMDMi38503051.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505891 – 312Olfactory receptor 14C36Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8NHC7.
PaxDbiQ8NHC7.
PRIDEiQ8NHC7.

PTM databases

iPTMnetiQ8NHC7.
PhosphoSitePlusiQ8NHC7.

Expressioni

Gene expression databases

CleanExiHS_OR14C36.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324534.

Structurei

3D structure databases

ProteinModelPortaliQ8NHC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJCG. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NHC7.
KOiK04257.
OMAiRIFYSEN.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NHC7.
TreeFamiTF337248.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHC7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNSTTVMEF LLMRFSDVWT LQILHSASFF MLYLVTLMGN ILIVTVTTCD
60 70 80 90 100
SSLHMPMYFF LRNLSILDAC YISVTVPTSC VNSLLDSTTI SKAGCVAQVF
110 120 130 140 150
LVVFFVYVEL LFLTIMAHDR YVAVCQPLHY PVIVNSRICI QMTLASLLSG
160 170 180 190 200
LVYAGMHTGS TFQLPFCRSN VIHQFFCDIP SLLKLSCSDT FSNEVMIVVS
210 220 230 240 250
ALGVGGGCFI FIIRSYIHIF STVLGFPRGA DRTKAFSTCI PHILVVSVFL
260 270 280 290 300
SSCSSVYLRP PAIPAATQDL ILSGFYSIMP PLFNPIIYSL RNKQIKVAIK
310
KIMKRIFYSE NV
Length:312
Mass (Da):34,815
Last modified:October 1, 2002 - v1
Checksum:i652D51698C971521
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062070141Q → R.Corresponds to variant rs28448343dbSNPEnsembl.1
Natural variantiVAR_062071225G → R.Corresponds to variant rs28377739dbSNPEnsembl.1
Natural variantiVAR_062072231D → Y.Corresponds to variant rs28545014dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065439 Genomic DNA. Translation: BAC05706.1.
AL450303 Genomic DNA. Translation: CAH71667.1.
BK004466 Genomic DNA. Translation: DAA04864.1.
CCDSiCCDS31112.1.
RefSeqiNP_001001918.1. NM_001001918.1.
UniGeneiHs.553583.

Genome annotation databases

EnsembliENST00000317861; ENSP00000324534; ENSG00000177174.
GeneIDi127066.
KEGGihsa:127066.
UCSCiuc010pzl.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065439 Genomic DNA. Translation: BAC05706.1.
AL450303 Genomic DNA. Translation: CAH71667.1.
BK004466 Genomic DNA. Translation: DAA04864.1.
CCDSiCCDS31112.1.
RefSeqiNP_001001918.1. NM_001001918.1.
UniGeneiHs.553583.

3D structure databases

ProteinModelPortaliQ8NHC7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000324534.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NHC7.
PhosphoSitePlusiQ8NHC7.

Polymorphism and mutation databases

BioMutaiOR14C36.
DMDMi38503051.

Proteomic databases

MaxQBiQ8NHC7.
PaxDbiQ8NHC7.
PRIDEiQ8NHC7.

Protocols and materials databases

DNASUi127066.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317861; ENSP00000324534; ENSG00000177174.
GeneIDi127066.
KEGGihsa:127066.
UCSCiuc010pzl.2. human.

Organism-specific databases

CTDi127066.
GeneCardsiOR14C36.
HGNCiHGNC:15026. OR14C36.
neXtProtiNX_Q8NHC7.
OpenTargetsiENSG00000177174.
PharmGKBiPA162398442.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJCG. Eukaryota.
ENOG41120HT. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NHC7.
KOiK04257.
OMAiRIFYSEN.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NHC7.
TreeFamiTF337248.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000177174-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5BF1.
GenomeRNAii127066.
PROiQ8NHC7.

Gene expression databases

CleanExiHS_OR14C36.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO14CZ_HUMAN
AccessioniPrimary (citable) accession number: Q8NHC7
Secondary accession number(s): Q6IEZ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.