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Protein

Olfactory receptor 14A16

Gene

OR14A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-32697-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 14A16
Alternative name(s):
Olfactory receptor 5AT1
Olfactory receptor OR1-45
Gene namesi
Name:OR14A16
Synonyms:OR5AT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15022. OR14A16.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 131CytoplasmicSequence analysisAdd BLAST13
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 194ExtracellularSequence analysisAdd BLAST42
Transmembranei195 – 215Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 255Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini256 – 268ExtracellularSequence analysisAdd BLAST13
Transmembranei269 – 289Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini290 – 309CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196772.
PharmGKBiPA162398441.

Polymorphism and mutation databases

BioMutaiOR14A16.
DMDMi38372837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505811 – 309Olfactory receptor 14A16Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi87N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ8NHC5.
PaxDbiQ8NHC5.
PeptideAtlasiQ8NHC5.
PRIDEiQ8NHC5.

PTM databases

iPTMnetiQ8NHC5.
PhosphoSitePlusiQ8NHC5.

Expressioni

Gene expression databases

CleanExiHS_OR14A16.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000350248.

Structurei

3D structure databases

ProteinModelPortaliQ8NHC5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEM2. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC5.
KOiK04257.
OMAiFCCFIVI.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NHC5.
TreeFamiTF352740.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLTIVTEF ILMGFSTNKN MCILHSILFL LIYLCALMGN VLIIMITTLD
60 70 80 90 100
HHLHTPVYFF LKNLSFLDLC LISVTAPKSI ANSLIHNNSI SFLGCVSQVF
110 120 130 140 150
LLLSSASAEL LLLTVMSFDR YTAICHPLHY DVIMDRSTCV QRATVSWLYG
160 170 180 190 200
GLIAVMHTAG TFSLSYCGSN MVHQFFCDIP QLLAISCSEN LIREIALILI
210 220 230 240 250
NVVLDFCCFI VIIITYVHVF STVKKIPSTE GQSKAYSICL PHLLVVLFLS
260 270 280 290 300
TGFIAYLKPA SESPSILDAV ISVFYTMLPP TFNPIIYSLR NKAIKVALGM

LIKGKLTKK
Length:309
Mass (Da):34,307
Last modified:October 1, 2002 - v1
Checksum:iC5A4E2C8E8A06A76
GO

Sequence cautioni

The sequence DAA04764 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_043796238I → T.Corresponds to variant rs6695283dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065441 Genomic DNA. Translation: BAC05708.1.
BK004366 Genomic DNA. Translation: DAA04764.1. Different initiation.
CCDSiCCDS31097.1.
RefSeqiNP_001001966.1. NM_001001966.1.
UniGeneiHs.626620.

Genome annotation databases

EnsembliENST00000357627; ENSP00000350248; ENSG00000196772.
GeneIDi284532.
KEGGihsa:284532.
UCSCiuc001idm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065441 Genomic DNA. Translation: BAC05708.1.
BK004366 Genomic DNA. Translation: DAA04764.1. Different initiation.
CCDSiCCDS31097.1.
RefSeqiNP_001001966.1. NM_001001966.1.
UniGeneiHs.626620.

3D structure databases

ProteinModelPortaliQ8NHC5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000350248.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NHC5.
PhosphoSitePlusiQ8NHC5.

Polymorphism and mutation databases

BioMutaiOR14A16.
DMDMi38372837.

Proteomic databases

EPDiQ8NHC5.
PaxDbiQ8NHC5.
PeptideAtlasiQ8NHC5.
PRIDEiQ8NHC5.

Protocols and materials databases

DNASUi284532.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357627; ENSP00000350248; ENSG00000196772.
GeneIDi284532.
KEGGihsa:284532.
UCSCiuc001idm.1. human.

Organism-specific databases

CTDi284532.
GeneCardsiOR14A16.
HGNCiHGNC:15022. OR14A16.
neXtProtiNX_Q8NHC5.
OpenTargetsiENSG00000196772.
PharmGKBiPA162398441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEM2. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC5.
KOiK04257.
OMAiFCCFIVI.
OrthoDBiEOG091G0CU6.
PhylomeDBiQ8NHC5.
TreeFamiTF352740.

Enzyme and pathway databases

BioCyciZFISH:G66-32697-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5AT1.
GenomeRNAii284532.
PROiQ8NHC5.

Gene expression databases

CleanExiHS_OR14A16.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO14AG_HUMAN
AccessioniPrimary (citable) accession number: Q8NHC5
Secondary accession number(s): Q6IF96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.