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Protein

Olfactory receptor 14A16

Gene

OR14A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 14A16
Alternative name(s):
Olfactory receptor 5AT1
Olfactory receptor OR1-45
Gene namesi
Name:OR14A16
Synonyms:OR5AT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:15022. OR14A16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence analysis
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13113CytoplasmicSequence analysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini153 – 19442ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 23520CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25520Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini256 – 26813ExtracellularSequence analysisAdd
BLAST
Transmembranei269 – 28921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 30920CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162398441.

Polymorphism and mutation databases

BioMutaiOR14A16.
DMDMi38372837.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 14A16PRO_0000150581Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHC5.
PRIDEiQ8NHC5.

Expressioni

Gene expression databases

CleanExiHS_OR14A16.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000350248.

Structurei

3D structure databases

ProteinModelPortaliQ8NHC5.
SMRiQ8NHC5. Positions 23-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEM2. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC5.
KOiK04257.
OMAiFCCFIVI.
OrthoDBiEOG7M98H6.
PhylomeDBiQ8NHC5.
TreeFamiTF352740.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLTIVTEF ILMGFSTNKN MCILHSILFL LIYLCALMGN VLIIMITTLD
60 70 80 90 100
HHLHTPVYFF LKNLSFLDLC LISVTAPKSI ANSLIHNNSI SFLGCVSQVF
110 120 130 140 150
LLLSSASAEL LLLTVMSFDR YTAICHPLHY DVIMDRSTCV QRATVSWLYG
160 170 180 190 200
GLIAVMHTAG TFSLSYCGSN MVHQFFCDIP QLLAISCSEN LIREIALILI
210 220 230 240 250
NVVLDFCCFI VIIITYVHVF STVKKIPSTE GQSKAYSICL PHLLVVLFLS
260 270 280 290 300
TGFIAYLKPA SESPSILDAV ISVFYTMLPP TFNPIIYSLR NKAIKVALGM

LIKGKLTKK
Length:309
Mass (Da):34,307
Last modified:October 1, 2002 - v1
Checksum:iC5A4E2C8E8A06A76
GO

Sequence cautioni

The sequence DAA04764.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti238 – 2381I → T.
Corresponds to variant rs6695283 [ dbSNP | Ensembl ].
VAR_043796

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065441 Genomic DNA. Translation: BAC05708.1.
BK004366 Genomic DNA. Translation: DAA04764.1. Different initiation.
CCDSiCCDS31097.1.
RefSeqiNP_001001966.1. NM_001001966.1.
XP_006711827.1. XM_006711764.2.
UniGeneiHs.626620.

Genome annotation databases

EnsembliENST00000357627; ENSP00000350248; ENSG00000196772.
GeneIDi284532.
KEGGihsa:284532.
UCSCiuc001idm.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065441 Genomic DNA. Translation: BAC05708.1.
BK004366 Genomic DNA. Translation: DAA04764.1. Different initiation.
CCDSiCCDS31097.1.
RefSeqiNP_001001966.1. NM_001001966.1.
XP_006711827.1. XM_006711764.2.
UniGeneiHs.626620.

3D structure databases

ProteinModelPortaliQ8NHC5.
SMRiQ8NHC5. Positions 23-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000350248.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR14A16.
DMDMi38372837.

Proteomic databases

PaxDbiQ8NHC5.
PRIDEiQ8NHC5.

Protocols and materials databases

DNASUi284532.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357627; ENSP00000350248; ENSG00000196772.
GeneIDi284532.
KEGGihsa:284532.
UCSCiuc001idm.1. human.

Organism-specific databases

CTDi284532.
GeneCardsiOR14A16.
HGNCiHGNC:15022. OR14A16.
neXtProtiNX_Q8NHC5.
PharmGKBiPA162398441.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEM2. Eukaryota.
ENOG410YBQN. LUCA.
GeneTreeiENSGT00760000118849.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC5.
KOiK04257.
OMAiFCCFIVI.
OrthoDBiEOG7M98H6.
PhylomeDBiQ8NHC5.
TreeFamiTF352740.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5AT1.
GenomeRNAii284532.
NextBioi94946.
PROiQ8NHC5.

Gene expression databases

CleanExiHS_OR14A16.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO14AG_HUMAN
AccessioniPrimary (citable) accession number: Q8NHC5
Secondary accession number(s): Q6IF96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: February 17, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.