ID   O10J5_HUMAN             Reviewed;         309 AA.
AC   Q8NHC4; B9EH35; Q6IFH2;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 155.
DE   RecName: Full=Olfactory receptor 10J5 {ECO:0000305};
DE   AltName: Full=Olfactory receptor OR1-28;
GN   Name=OR10J5 {ECO:0000312|HGNC:HGNC:14993};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [6]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
RN   [7]
RP   TISSUE SPECIFICITY, AND FUNCTION.
RX   PubMed=25791473; DOI=10.1016/j.bbrc.2015.03.046;
RA   Kim S.H., Yoon Y.C., Lee A.S., Kang N., Koo J., Rhyu M.R., Park J.H.;
RT   "Expression of human olfactory receptor 10J5 in heart aorta, coronary
RT   artery, and endothelial cells and its functional role in angiogenesis.";
RL   Biochem. Biophys. Res. Commun. 460:404-408(2015).
RN   [8]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=28842679; DOI=10.1038/s41598-017-10379-x;
RA   Tong T., Ryu S.E., Min Y., de March C.A., Bushdid C., Golebiowski J.,
RA   Moon C., Park T.;
RT   "Olfactory receptor 10J5 responding to alpha-cedrene regulates hepatic
RT   steatosis via the cAMP-PKA pathway.";
RL   Sci. Rep. 7:9471-9471(2017).
CC   -!- FUNCTION: Olfactory receptor. Activated by the synthetic floral
CC       odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of
CC       cedarwood oil. Its activation increases intracellular Ca(2+)
CC       (PubMed:25791473, PubMed:28842679). Acts as a key regulator of
CC       myogenesis through its actions on cell migration and adhesion by
CC       activating the Ca(2+)-dependent AKT signal transduction pathway (By
CC       similarity). Acts also as a regulator of angiogenesis
CC       (PubMed:25791473). Moreover, plays a role in the regulation of lipid
CC       accumulation in hepatocytes via the cAMP-PKA pathway (PubMed:28842679).
CC       May be involved in sperm chemotaxis and motility (By similarity).
CC       {ECO:0000250|UniProtKB:Q62007, ECO:0000269|PubMed:25791473,
CC       ECO:0000269|PubMed:28842679}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28842679};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in both the aorta, the coronary artery
CC       and umbilical vein endothelial cells (HUVECs) (at protein level).
CC       {ECO:0000269|PubMed:25791473}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10J5";
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DR   EMBL; AB065443; BAC05709.1; -; Genomic_DNA.
DR   EMBL; AL606752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471121; EAW52783.1; -; Genomic_DNA.
DR   EMBL; BC137025; AAI37026.1; -; mRNA.
DR   EMBL; BC137026; AAI37027.1; -; mRNA.
DR   EMBL; BK004290; DAA04688.1; -; Genomic_DNA.
DR   CCDS; CCDS30910.1; -.
DR   RefSeq; NP_001004469.1; NM_001004469.1.
DR   AlphaFoldDB; Q8NHC4; -.
DR   SMR; Q8NHC4; -.
DR   BioGRID; 126054; 3.
DR   STRING; 9606.ENSP00000334441; -.
DR   GlyCosmos; Q8NHC4; 1 site, No reported glycans.
DR   GlyGen; Q8NHC4; 1 site.
DR   BioMuta; OR10J5; -.
DR   DMDM; 38372836; -.
DR   PaxDb; 9606-ENSP00000334441; -.
DR   Antibodypedia; 20471; 150 antibodies from 24 providers.
DR   DNASU; 127385; -.
DR   Ensembl; ENST00000334857.3; ENSP00000334441.2; ENSG00000184155.8.
DR   GeneID; 127385; -.
DR   KEGG; hsa:127385; -.
DR   MANE-Select; ENST00000334857.3; ENSP00000334441.2; NM_001004469.1; NP_001004469.1.
DR   UCSC; uc010piw.2; human.
DR   AGR; HGNC:14993; -.
DR   CTD; 127385; -.
DR   DisGeNET; 127385; -.
DR   GeneCards; OR10J5; -.
DR   HGNC; HGNC:14993; OR10J5.
DR   HPA; ENSG00000184155; Not detected.
DR   MIM; 619546; gene.
DR   neXtProt; NX_Q8NHC4; -.
DR   OpenTargets; ENSG00000184155; -.
DR   PharmGKB; PA31986; -.
DR   VEuPathDB; HostDB:ENSG00000184155; -.
DR   eggNOG; ENOG502RU27; Eukaryota.
DR   GeneTree; ENSGT00940000159272; -.
DR   HOGENOM; CLU_012526_1_2_1; -.
DR   InParanoid; Q8NHC4; -.
DR   OMA; SIFGKHQ; -.
DR   OrthoDB; 4018856at2759; -.
DR   PhylomeDB; Q8NHC4; -.
DR   TreeFam; TF337624; -.
DR   PathwayCommons; Q8NHC4; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 127385; 10 hits in 740 CRISPR screens.
DR   GeneWiki; OR10J5; -.
DR   GenomeRNAi; 127385; -.
DR   Pharos; Q8NHC4; Tdark.
DR   PRO; PR:Q8NHC4; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q8NHC4; Protein.
DR   Bgee; ENSG00000184155; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 2 other cell types or tissues.
DR   ExpressionAtlas; Q8NHC4; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IDA:UniProtKB.
DR   GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR   GO; GO:0006935; P:chemotaxis; ISS:UniProtKB.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   GO; GO:0007187; P:G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; IDA:UniProtKB.
DR   GO; GO:0055088; P:lipid homeostasis; IMP:UniProtKB.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:0045765; P:regulation of angiogenesis; IMP:UniProtKB.
DR   GO; GO:0051147; P:regulation of muscle cell differentiation; ISS:UniProtKB.
DR   GO; GO:0007608; P:sensory perception of smell; IDA:UniProtKB.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF700; OLFACTORY RECEPTOR 10J5; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   Angiogenesis; Cell membrane; Disulfide bond; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Myogenesis; Olfaction; Receptor;
KW   Reference proteome; Sensory transduction; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Olfactory receptor 10J5"
FT                   /id="PRO_0000150709"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..196
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        197..216
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        217..236
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..270
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        271..291
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        292..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..188
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         233
FT                   /note="R -> W (in dbSNP:rs35393723)"
FT                   /id="VAR_062064"
SQ   SEQUENCE   309 AA;  34401 MW;  EB1770EBC32074EB CRC64;
     MKRKNFTEVS EFIFLGFSSF GKHQITLFVV FLTVYILTLV ANIIIVTIIC IDHHLHTPMY
     FFLSMLASSE TVYTLVIVPR MLLSLIFHNQ PISLAGCATQ MFFFVILATN NCFLLTAMGY
     DRYVAICRPL RYTVIMSKGL CAQLVCGSFG IGLTMAVLHV TAMFNLPFCG TVVDHFFCDI
     YPVMKLSCID TTINEIINYG VSSFVIFVPI GLIFISYVLV ISSILQIASA EGRKKTFATC
     VSHLTVVIVH CGCASIAYLK PKSESSIEKD LVLSVTYTII TPLLNPVVYS LRNKEVKDAL
     CRVVGRNIS
//