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Protein

Olfactory receptor 10J5

Gene

OR10J5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-31467-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10J5
Alternative name(s):
Olfactory receptor OR1-28
Gene namesi
Name:OR10J5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:14993. OR10J5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 309CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi127385.
OpenTargetsiENSG00000184155.
PharmGKBiPA31986.

Polymorphism and mutation databases

BioMutaiOR10J5.
DMDMi38372836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507091 – 309Olfactory receptor 10J5Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHC4.
PeptideAtlasiQ8NHC4.
PRIDEiQ8NHC4.

Expressioni

Gene expression databases

CleanExiHS_OR10J5.
ExpressionAtlasiQ8NHC4. baseline.

Organism-specific databases

HPAiCAB034045.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000334441.

Structurei

3D structure databases

ProteinModelPortaliQ8NHC4.
SMRiQ8NHC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBT. Eukaryota.
ENOG4111C5X. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC4.
KOiK04257.
OMAiTVIMSKG.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NHC4.
TreeFamiTF337624.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKNFTEVS EFIFLGFSSF GKHQITLFVV FLTVYILTLV ANIIIVTIIC
60 70 80 90 100
IDHHLHTPMY FFLSMLASSE TVYTLVIVPR MLLSLIFHNQ PISLAGCATQ
110 120 130 140 150
MFFFVILATN NCFLLTAMGY DRYVAICRPL RYTVIMSKGL CAQLVCGSFG
160 170 180 190 200
IGLTMAVLHV TAMFNLPFCG TVVDHFFCDI YPVMKLSCID TTINEIINYG
210 220 230 240 250
VSSFVIFVPI GLIFISYVLV ISSILQIASA EGRKKTFATC VSHLTVVIVH
260 270 280 290 300
CGCASIAYLK PKSESSIEKD LVLSVTYTII TPLLNPVVYS LRNKEVKDAL

CRVVGRNIS
Length:309
Mass (Da):34,401
Last modified:October 1, 2002 - v1
Checksum:iEB1770EBC32074EB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062064233R → W.Corresponds to variant rs35393723dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065443 Genomic DNA. Translation: BAC05709.1.
AL606752 Genomic DNA. Translation: CAI16580.1.
CH471121 Genomic DNA. Translation: EAW52783.1.
BC137025 mRNA. Translation: AAI37026.1.
BC137026 mRNA. Translation: AAI37027.1.
BK004290 Genomic DNA. Translation: DAA04688.1.
CCDSiCCDS30910.1.
RefSeqiNP_001004469.1. NM_001004469.1.
UniGeneiHs.553587.

Genome annotation databases

EnsembliENST00000334857; ENSP00000334441; ENSG00000184155.
GeneIDi127385.
KEGGihsa:127385.
UCSCiuc010piw.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065443 Genomic DNA. Translation: BAC05709.1.
AL606752 Genomic DNA. Translation: CAI16580.1.
CH471121 Genomic DNA. Translation: EAW52783.1.
BC137025 mRNA. Translation: AAI37026.1.
BC137026 mRNA. Translation: AAI37027.1.
BK004290 Genomic DNA. Translation: DAA04688.1.
CCDSiCCDS30910.1.
RefSeqiNP_001004469.1. NM_001004469.1.
UniGeneiHs.553587.

3D structure databases

ProteinModelPortaliQ8NHC4.
SMRiQ8NHC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000334441.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10J5.
DMDMi38372836.

Proteomic databases

PaxDbiQ8NHC4.
PeptideAtlasiQ8NHC4.
PRIDEiQ8NHC4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000334857; ENSP00000334441; ENSG00000184155.
GeneIDi127385.
KEGGihsa:127385.
UCSCiuc010piw.2. human.

Organism-specific databases

CTDi127385.
DisGeNETi127385.
GeneCardsiOR10J5.
HGNCiHGNC:14993. OR10J5.
HPAiCAB034045.
neXtProtiNX_Q8NHC4.
OpenTargetsiENSG00000184155.
PharmGKBiPA31986.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFBT. Eukaryota.
ENOG4111C5X. LUCA.
GeneTreeiENSGT00760000119043.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHC4.
KOiK04257.
OMAiTVIMSKG.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NHC4.
TreeFamiTF337624.

Enzyme and pathway databases

BioCyciZFISH:G66-31467-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10J5.
GenomeRNAii127385.
PROiQ8NHC4.

Gene expression databases

CleanExiHS_OR10J5.
ExpressionAtlasiQ8NHC4. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10J5_HUMAN
AccessioniPrimary (citable) accession number: Q8NHC4
Secondary accession number(s): B9EH35, Q6IFH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.