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Protein

Olfactory receptor 10J5

Gene

OR10J5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10J5
Alternative name(s):
Olfactory receptor OR1-28
Gene namesi
Name:OR10J5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000184155.8
HGNCiHGNC:14993 OR10J5
neXtProtiNX_Q8NHC4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 309CytoplasmicSequence analysisAdd BLAST18

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184155
PharmGKBiPA31986

Polymorphism and mutation databases

BioMutaiOR10J5
DMDMi38372836

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507091 – 309Olfactory receptor 10J5Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHC4
PeptideAtlasiQ8NHC4
PRIDEiQ8NHC4

Expressioni

Gene expression databases

BgeeiENSG00000184155
CleanExiHS_OR10J5
ExpressionAtlasiQ8NHC4 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi1260541 interactor.
STRINGi9606.ENSP00000334441

Structurei

3D structure databases

ProteinModelPortaliQ8NHC4
SMRiQ8NHC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBT Eukaryota
ENOG4111C5X LUCA
GeneTreeiENSGT00760000119043
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NHC4
KOiK04257
OMAiTVIMSKG
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NHC4
TreeFamiTF337624

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NHC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRKNFTEVS EFIFLGFSSF GKHQITLFVV FLTVYILTLV ANIIIVTIIC
60 70 80 90 100
IDHHLHTPMY FFLSMLASSE TVYTLVIVPR MLLSLIFHNQ PISLAGCATQ
110 120 130 140 150
MFFFVILATN NCFLLTAMGY DRYVAICRPL RYTVIMSKGL CAQLVCGSFG
160 170 180 190 200
IGLTMAVLHV TAMFNLPFCG TVVDHFFCDI YPVMKLSCID TTINEIINYG
210 220 230 240 250
VSSFVIFVPI GLIFISYVLV ISSILQIASA EGRKKTFATC VSHLTVVIVH
260 270 280 290 300
CGCASIAYLK PKSESSIEKD LVLSVTYTII TPLLNPVVYS LRNKEVKDAL

CRVVGRNIS
Length:309
Mass (Da):34,401
Last modified:October 1, 2002 - v1
Checksum:iEB1770EBC32074EB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062064233R → W. Corresponds to variant dbSNP:rs35393723Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065443 Genomic DNA Translation: BAC05709.1
AL606752 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52783.1
BC137025 mRNA Translation: AAI37026.1
BC137026 mRNA Translation: AAI37027.1
BK004290 Genomic DNA Translation: DAA04688.1
CCDSiCCDS30910.1
RefSeqiNP_001004469.1, NM_001004469.1
UniGeneiHs.553587

Genome annotation databases

EnsembliENST00000334857; ENSP00000334441; ENSG00000184155
GeneIDi127385
KEGGihsa:127385
UCSCiuc010piw.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO10J5_HUMAN
AccessioniPrimary (citable) accession number: Q8NHC4
Secondary accession number(s): B9EH35, Q6IFH2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome