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Protein

Olfactory receptor 5K2

Gene

OR5K2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5K2
Alternative name(s):
Olfactory receptor OR3-9
Gene namesi
Name:OR5K2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:14774. OR5K2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19636ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31624CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32543.

Polymorphism and mutation databases

BioMutaiOR5K2.
DMDMi134047867.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 316316Olfactory receptor 5K2PRO_0000150601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHB8.
PRIDEiQ8NHB8.

PTM databases

iPTMnetiQ8NHB8.
PhosphoSiteiQ8NHB8.

Expressioni

Gene expression databases

BgeeiQ8NHB8.
CleanExiHS_OR5K2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000393889.

Structurei

3D structure databases

ProteinModelPortaliQ8NHB8.
SMRiQ8NHB8. Positions 20-184.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9MS. Eukaryota.
ENOG41116R8. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NHB8.
KOiK04257.
OMAiCACAIIP.
OrthoDBiEOG7DFXCK.
PhylomeDBiQ8NHB8.
TreeFamiTF352737.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHB8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEENHTMKN EFILTGFTDH PELKTLLFVV FFAIYLITVV GNISLVALIF
60 70 80 90 100
THCRLHTPMY IFLGNLALVD SCCACAITPK MLENFFSEGK RISLYECAVQ
110 120 130 140 150
FYFLCTVETA DCFLLAAVAY DRYVAICNPL QYHIMMSKKL CIQMTTGAFI
160 170 180 190 200
AGNLHSMIHV GLVFRLVFCG LNHINHFYCD TLPLYRLSCV DPFINELVLF
210 220 230 240 250
IFSGSVQVFT IGSVLISYLY ILLTIFRMKS KEGRAKAFST CASHFSSVSL
260 270 280 290 300
FYGSIFFLYI RPNLLEEGGN DIPAAILFTI VVPLLNPFIY SLRNKEVISV
310
LRKILLKIKS QGSVNK
Length:316
Mass (Da):35,763
Last modified:March 20, 2007 - v3
Checksum:i3FB40EFC6C9DA2A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531C → R in AC074274 (PubMed:16641997).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065457 Genomic DNA. Translation: BAC05717.1.
AC074274 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79861.1.
BC136724 mRNA. Translation: AAI36725.1.
BC136725 mRNA. Translation: AAI36726.1.
BK004415 Genomic DNA. Translation: DAA04813.1.
CCDSiCCDS33804.1.
RefSeqiNP_001004737.1. NM_001004737.1.
UniGeneiHs.632558.

Genome annotation databases

EnsembliENST00000427338; ENSP00000393889; ENSG00000231861.
GeneIDi402135.
KEGGihsa:402135.
UCSCiuc011bgx.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065457 Genomic DNA. Translation: BAC05717.1.
AC074274 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79861.1.
BC136724 mRNA. Translation: AAI36725.1.
BC136725 mRNA. Translation: AAI36726.1.
BK004415 Genomic DNA. Translation: DAA04813.1.
CCDSiCCDS33804.1.
RefSeqiNP_001004737.1. NM_001004737.1.
UniGeneiHs.632558.

3D structure databases

ProteinModelPortaliQ8NHB8.
SMRiQ8NHB8. Positions 20-184.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000393889.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NHB8.
PhosphoSiteiQ8NHB8.

Polymorphism and mutation databases

BioMutaiOR5K2.
DMDMi134047867.

Proteomic databases

PaxDbiQ8NHB8.
PRIDEiQ8NHB8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000427338; ENSP00000393889; ENSG00000231861.
GeneIDi402135.
KEGGihsa:402135.
UCSCiuc011bgx.3. human.

Organism-specific databases

CTDi402135.
GeneCardsiOR5K2.
HGNCiHGNC:14774. OR5K2.
neXtProtiNX_Q8NHB8.
PharmGKBiPA32543.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9MS. Eukaryota.
ENOG41116R8. LUCA.
GeneTreeiENSGT00550000074564.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NHB8.
KOiK04257.
OMAiCACAIIP.
OrthoDBiEOG7DFXCK.
PhylomeDBiQ8NHB8.
TreeFamiTF352737.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5K2.
GenomeRNAii402135.
PROiQ8NHB8.

Gene expression databases

BgeeiQ8NHB8.
CleanExiHS_OR5K2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5K2_HUMAN
AccessioniPrimary (citable) accession number: Q8NHB8
Secondary accession number(s): B2RN70, Q6IF47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 20, 2007
Last modified: June 8, 2016
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.