Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 2V1

Gene

OR2V1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2V1
Gene namesi
Name:OR2V1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8280. OR2V1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 586CytoplasmicSequence Analysis
Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 9920ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 14929CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini171 – 19828ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 2V1PRO_0000312488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHB1.
PRIDEiQ8NHB1.

PTM databases

PhosphoSiteiQ8NHB1.

Expressioni

Gene expression databases

GenevestigatoriQ8NHB1.

Organism-specific databases

HPAiHPA049953.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000404102.

Structurei

3D structure databases

ProteinModelPortaliQ8NHB1.
SMRiQ8NHB1. Positions 27-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39955.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHB1.
KOiK04257.
OMAiIIQMVAA.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NHB1.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRWVNQSYT DGFFLLGIFS HSQTDLVLFS AVMVVFTVAL CGNVLLIFLI
60 70 80 90 100
YLDAGLHTPM YFFLSQLSLM DLMLVCNIVP KMAANFLSGR KSISFVGCGI
110 120 130 140 150
QIGFFVSLVG SEGLLLGLMA YDRYVAVSHP LHYPILMNQR VCLQITGSSW
160 170 180 190 200
AFGIIDGVIQ MVAAMGLPYC GSRSVDHFFC EVQALLKLAC ADTSLFDTLL
210 220 230 240 250
FACCVFMLLL PFSIIMASYA CILGAVLRIR SAQAWKKALA TCSSHLTAVT
260 270 280 290 300
LFYGAAMFMY LRPRRYRAPS HDKVASIFYT VLTPMLNPLI YSLRNGEVMG
310
ALRKGLDRCR IGSQH
Length:315
Mass (Da):34,857
Last modified:December 4, 2007 - v2
Checksum:iDA8CDA246020E9E1
GO

Sequence cautioni

The sequence BAC05724.1 differs from that shown. Reason: Frameshift at position 223. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065465 Genomic DNA. Translation: BAC05724.1. Frameshift.
AC008620 Genomic DNA. No translation available.
CCDSiCCDS58992.1.
RefSeqiNP_001245212.1. NM_001258283.1.
UniGeneiHs.742585.

Genome annotation databases

EnsembliENST00000329365; ENSP00000404102; ENSG00000185372.
GeneIDi26693.
KEGGihsa:26693.
UCSCiuc031smg.1. human.

Polymorphism databases

DMDMi162416234.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065465 Genomic DNA. Translation: BAC05724.1. Frameshift.
AC008620 Genomic DNA. No translation available.
CCDSiCCDS58992.1.
RefSeqiNP_001245212.1. NM_001258283.1.
UniGeneiHs.742585.

3D structure databases

ProteinModelPortaliQ8NHB1.
SMRiQ8NHB1. Positions 27-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000404102.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NHB1.

Polymorphism databases

DMDMi162416234.

Proteomic databases

PaxDbiQ8NHB1.
PRIDEiQ8NHB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329365; ENSP00000404102; ENSG00000185372.
GeneIDi26693.
KEGGihsa:26693.
UCSCiuc031smg.1. human.

Organism-specific databases

CTDi26693.
GeneCardsiGC05M180552.
HGNCiHGNC:8280. OR2V1.
HPAiHPA049953.
neXtProtiNX_Q8NHB1.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG39955.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHB1.
KOiK04257.
OMAiIIQMVAA.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NHB1.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii26693.
NextBioi49063.
PROiQ8NHB1.

Gene expression databases

GenevestigatoriQ8NHB1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOR2V1_HUMAN
AccessioniPrimary (citable) accession number: Q8NHB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: January 7, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.