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Q8NHB1 (OR2V1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2V1
Gene names
Name:OR2V1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05724.1 differs from that shown. Reason: Frameshift at position 223.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Olfactory receptor 2V1
PRO_0000312488

Regions

Topological domain1 – 3131Extracellular Potential
Transmembrane32 – 5221Helical; Name=1; Potential
Topological domain53 – 586Cytoplasmic Potential
Transmembrane59 – 7921Helical; Name=2; Potential
Topological domain80 – 9920Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 14929Cytoplasmic Potential
Transmembrane150 – 17021Helical; Name=4; Potential
Topological domain171 – 19828Extracellular Potential
Transmembrane199 – 21921Helical; Name=5; Potential
Topological domain220 – 23819Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29321Helical; Name=7; Potential
Topological domain294 – 31522Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond98 ↔ 180 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NHB1 [UniParc].

Last modified December 4, 2007. Version 2.
Checksum: DA8CDA246020E9E1

FASTA31534,857
        10         20         30         40         50         60 
MGRWVNQSYT DGFFLLGIFS HSQTDLVLFS AVMVVFTVAL CGNVLLIFLI YLDAGLHTPM 

        70         80         90        100        110        120 
YFFLSQLSLM DLMLVCNIVP KMAANFLSGR KSISFVGCGI QIGFFVSLVG SEGLLLGLMA 

       130        140        150        160        170        180 
YDRYVAVSHP LHYPILMNQR VCLQITGSSW AFGIIDGVIQ MVAAMGLPYC GSRSVDHFFC 

       190        200        210        220        230        240 
EVQALLKLAC ADTSLFDTLL FACCVFMLLL PFSIIMASYA CILGAVLRIR SAQAWKKALA 

       250        260        270        280        290        300 
TCSSHLTAVT LFYGAAMFMY LRPRRYRAPS HDKVASIFYT VLTPMLNPLI YSLRNGEVMG 

       310 
ALRKGLDRCR IGSQH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065465 Genomic DNA. Translation: BAC05724.1. Frameshift.
AC008620 Genomic DNA. No translation available.
CCDSCCDS58992.1.
RefSeqNP_001245212.1. NM_001258283.1.
UniGeneHs.742585.

3D structure databases

ProteinModelPortalQ8NHB1.
SMRQ8NHB1. Positions 27-304.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000404102.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NHB1.

Polymorphism databases

DMDM162416234.

Proteomic databases

PaxDbQ8NHB1.
PRIDEQ8NHB1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329365; ENSP00000404102; ENSG00000185372.
GeneID26693.
KEGGhsa:26693.
UCSCuc031smg.1. human.

Organism-specific databases

CTD26693.
GeneCardsGC05M180552.
HGNCHGNC:8280. OR2V1.
HPAHPA049953.
neXtProtNX_Q8NHB1.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39955.
HOGENOMHOG000041365.
HOVERGENHBG017625.
KOK04257.
OMAIIQMVAA.
OrthoDBEOG71K63J.
PhylomeDBQ8NHB1.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

GenevestigatorQ8NHB1.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio49063.
PROQ8NHB1.

Entry information

Entry nameOR2V1_HUMAN
AccessionPrimary (citable) accession number: Q8NHB1
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: July 9, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries