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Q8NHB1

- OR2V1_HUMAN

UniProt

Q8NHB1 - OR2V1_HUMAN

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Protein

Olfactory receptor 2V1

Gene

OR2V1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2V1
Gene namesi
Name:OR2V1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:8280. OR2V1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 2V1PRO_0000312488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi98 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHB1.
PRIDEiQ8NHB1.

PTM databases

PhosphoSiteiQ8NHB1.

Expressioni

Gene expression databases

GenevestigatoriQ8NHB1.

Organism-specific databases

HPAiHPA049953.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000404102.

Structurei

3D structure databases

ProteinModelPortaliQ8NHB1.
SMRiQ8NHB1. Positions 27-304.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Topological domaini53 – 586CytoplasmicSequence Analysis
Topological domaini80 – 9920ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 14929CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini171 – 19828ExtracellularSequence AnalysisAdd
BLAST
Topological domaini220 – 23819CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39955.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHB1.
KOiK04257.
OMAiIIQMVAA.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NHB1.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHB1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRWVNQSYT DGFFLLGIFS HSQTDLVLFS AVMVVFTVAL CGNVLLIFLI
60 70 80 90 100
YLDAGLHTPM YFFLSQLSLM DLMLVCNIVP KMAANFLSGR KSISFVGCGI
110 120 130 140 150
QIGFFVSLVG SEGLLLGLMA YDRYVAVSHP LHYPILMNQR VCLQITGSSW
160 170 180 190 200
AFGIIDGVIQ MVAAMGLPYC GSRSVDHFFC EVQALLKLAC ADTSLFDTLL
210 220 230 240 250
FACCVFMLLL PFSIIMASYA CILGAVLRIR SAQAWKKALA TCSSHLTAVT
260 270 280 290 300
LFYGAAMFMY LRPRRYRAPS HDKVASIFYT VLTPMLNPLI YSLRNGEVMG
310
ALRKGLDRCR IGSQH
Length:315
Mass (Da):34,857
Last modified:December 4, 2007 - v2
Checksum:iDA8CDA246020E9E1
GO

Sequence cautioni

The sequence BAC05724.1 differs from that shown. Reason: Frameshift at position 223.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065465 Genomic DNA. Translation: BAC05724.1. Frameshift.
AC008620 Genomic DNA. No translation available.
CCDSiCCDS58992.1.
RefSeqiNP_001245212.1. NM_001258283.1.
UniGeneiHs.742585.

Genome annotation databases

EnsembliENST00000329365; ENSP00000404102; ENSG00000185372.
GeneIDi26693.
KEGGihsa:26693.
UCSCiuc031smg.1. human.

Polymorphism databases

DMDMi162416234.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065465 Genomic DNA. Translation: BAC05724.1 . Frameshift.
AC008620 Genomic DNA. No translation available.
CCDSi CCDS58992.1.
RefSeqi NP_001245212.1. NM_001258283.1.
UniGenei Hs.742585.

3D structure databases

ProteinModelPortali Q8NHB1.
SMRi Q8NHB1. Positions 27-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000404102.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NHB1.

Polymorphism databases

DMDMi 162416234.

Proteomic databases

PaxDbi Q8NHB1.
PRIDEi Q8NHB1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329365 ; ENSP00000404102 ; ENSG00000185372 .
GeneIDi 26693.
KEGGi hsa:26693.
UCSCi uc031smg.1. human.

Organism-specific databases

CTDi 26693.
GeneCardsi GC05M180552.
HGNCi HGNC:8280. OR2V1.
HPAi HPA049953.
neXtProti NX_Q8NHB1.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39955.
GeneTreei ENSGT00760000118850.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NHB1.
KOi K04257.
OMAi IIQMVAA.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NHB1.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii 26693.
NextBioi 49063.
PROi Q8NHB1.

Gene expression databases

Genevestigatori Q8NHB1.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOR2V1_HUMAN
AccessioniPrimary (citable) accession number: Q8NHB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3