Q8NHB1 (OR2V1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2V1

Gene names

Name:

OR2V1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	315 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence BAC05724.1 differs from that shown. Reason: Frameshift at position 223.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 315	315	Olfactory receptor 2V1		PRO_0000312488
Regions
	Topological domain	1 – 31	31	Extracellular Potential
	Transmembrane	32 – 52	21	Helical; Name=1; Potential
	Topological domain	53 – 58	6	Cytoplasmic Potential
	Transmembrane	59 – 79	21	Helical; Name=2; Potential
	Topological domain	80 – 99	20	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 149	29	Cytoplasmic Potential
	Transmembrane	150 – 170	21	Helical; Name=4; Potential
	Topological domain	171 – 198	28	Extracellular Potential
	Transmembrane	199 – 219	21	Helical; Name=5; Potential
	Topological domain	220 – 238	19	Cytoplasmic Potential
	Transmembrane	239 – 259	21	Helical; Name=6; Potential
	Topological domain	260 – 272	13	Extracellular Potential
	Transmembrane	273 – 293	21	Helical; Name=7; Potential
	Topological domain	294 – 315	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	6	1	N-linked (GlcNAc...) Potential
	Disulfide bond	98 ↔ 180		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NHB1 [UniParc]. Last modified December 4, 2007. Version 2. Checksum: DA8CDA246020E9E1	FASTA	315	34,857
	10 20 30 40 50 60 MGRWVNQSYT DGFFLLGIFS HSQTDLVLFS AVMVVFTVAL CGNVLLIFLI YLDAGLHTPM 70 80 90 100 110 120 YFFLSQLSLM DLMLVCNIVP KMAANFLSGR KSISFVGCGI QIGFFVSLVG SEGLLLGLMA 130 140 150 160 170 180 YDRYVAVSHP LHYPILMNQR VCLQITGSSW AFGIIDGVIQ MVAAMGLPYC GSRSVDHFFC 190 200 210 220 230 240 EVQALLKLAC ADTSLFDTLL FACCVFMLLL PFSIIMASYA CILGAVLRIR SAQAWKKALA 250 260 270 280 290 300 TCSSHLTAVT LFYGAAMFMY LRPRRYRAPS HDKVASIFYT VLTPMLNPLI YSLRNGEVMG 310 ALRKGLDRCR IGSQH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065465 Genomic DNA. Translation: BAC05724.1. Frameshift. AC008620 Genomic DNA. No translation available.
IPI	IPI00169241.
RefSeq	NP_001245212.1. NM_001258283.1.
UniGene	Hs.742585.
3D structure databases
ProteinModelPortal	Q8NHB1.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000404102.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NHB1.
Polymorphism databases
DMDM	162416234.
Proteomic databases
PaxDb	Q8NHB1.
PRIDE	Q8NHB1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000329365; ENSP00000404102; ENSG00000185372.
GeneID	26693.
KEGG	hsa:26693.
Organism-specific databases
CTD	26693.
GeneCards	GC05M180552.
HGNC	HGNC:8280. OR2V1.
HPA	HPA049953.
neXtProt	NX_Q8NHB1.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG39955.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
KO	K04257.
OMA	IIQMVAA.
OrthoDB	EOG4K3KWM.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Genevestigator	Q8NHB1.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	49063.

Entry information

Entry name

OR2V1_HUMAN

Accession

Primary (citable) accession number: Q8NHB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
Last sequence update:	December 4, 2007
Last modified:	May 1, 2013
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.