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Q8NHB1

- OR2V1_HUMAN

UniProt

Q8NHB1 - OR2V1_HUMAN

Protein

Olfactory receptor 2V1

Gene

OR2V1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (04 Dec 2007)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2V1
    Gene namesi
    Name:OR2V1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:8280. OR2V1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Olfactory receptor 2V1PRO_0000312488Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi98 ↔ 180PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NHB1.
    PRIDEiQ8NHB1.

    PTM databases

    PhosphoSiteiQ8NHB1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8NHB1.

    Organism-specific databases

    HPAiHPA049953.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000404102.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NHB1.
    SMRiQ8NHB1. Positions 27-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 586CytoplasmicSequence Analysis
    Topological domaini80 – 9920ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 14929CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 19828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 31522CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG39955.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    KOiK04257.
    OMAiIIQMVAA.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NHB1.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NHB1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRWVNQSYT DGFFLLGIFS HSQTDLVLFS AVMVVFTVAL CGNVLLIFLI    50
    YLDAGLHTPM YFFLSQLSLM DLMLVCNIVP KMAANFLSGR KSISFVGCGI 100
    QIGFFVSLVG SEGLLLGLMA YDRYVAVSHP LHYPILMNQR VCLQITGSSW 150
    AFGIIDGVIQ MVAAMGLPYC GSRSVDHFFC EVQALLKLAC ADTSLFDTLL 200
    FACCVFMLLL PFSIIMASYA CILGAVLRIR SAQAWKKALA TCSSHLTAVT 250
    LFYGAAMFMY LRPRRYRAPS HDKVASIFYT VLTPMLNPLI YSLRNGEVMG 300
    ALRKGLDRCR IGSQH 315
    Length:315
    Mass (Da):34,857
    Last modified:December 4, 2007 - v2
    Checksum:iDA8CDA246020E9E1
    GO

    Sequence cautioni

    The sequence BAC05724.1 differs from that shown. Reason: Frameshift at position 223.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065465 Genomic DNA. Translation: BAC05724.1. Frameshift.
    AC008620 Genomic DNA. No translation available.
    CCDSiCCDS58992.1.
    RefSeqiNP_001245212.1. NM_001258283.1.
    UniGeneiHs.742585.

    Genome annotation databases

    EnsembliENST00000329365; ENSP00000404102; ENSG00000185372.
    GeneIDi26693.
    KEGGihsa:26693.
    UCSCiuc031smg.1. human.

    Polymorphism databases

    DMDMi162416234.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065465 Genomic DNA. Translation: BAC05724.1 . Frameshift.
    AC008620 Genomic DNA. No translation available.
    CCDSi CCDS58992.1.
    RefSeqi NP_001245212.1. NM_001258283.1.
    UniGenei Hs.742585.

    3D structure databases

    ProteinModelPortali Q8NHB1.
    SMRi Q8NHB1. Positions 27-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000404102.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NHB1.

    Polymorphism databases

    DMDMi 162416234.

    Proteomic databases

    PaxDbi Q8NHB1.
    PRIDEi Q8NHB1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329365 ; ENSP00000404102 ; ENSG00000185372 .
    GeneIDi 26693.
    KEGGi hsa:26693.
    UCSCi uc031smg.1. human.

    Organism-specific databases

    CTDi 26693.
    GeneCardsi GC05M180552.
    HGNCi HGNC:8280. OR2V1.
    HPAi HPA049953.
    neXtProti NX_Q8NHB1.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39955.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    KOi K04257.
    OMAi IIQMVAA.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NHB1.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    NextBioi 49063.
    PROi Q8NHB1.

    Gene expression databases

    Genevestigatori Q8NHB1.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiOR2V1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NHB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: December 4, 2007
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3