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Protein

Putative olfactory receptor 2W6

Gene

OR2W6P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 2W6
Alternative name(s):
Olfactory receptor OR6-3
Putative olfactory receptor 2W7
Gene namesi
Name:OR2W6P
Synonyms:OR2W7P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:15072. OR2W6P.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence analysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini53 – 6311CytoplasmicSequence analysisAdd
BLAST
Transmembranei64 – 8421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini85 – 10319ExtracellularSequence analysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini125 – 14521CytoplasmicSequence analysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini167 – 20236ExtracellularSequence analysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini224 – 24522CytoplasmicSequence analysisAdd
BLAST
Transmembranei246 – 26621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini267 – 27711ExtracellularSequence analysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini299 – 31820CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74760337.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Putative olfactory receptor 2W6PRO_0000342512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi103 ↔ 185PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ8NHA6.

Structurei

3D structure databases

ProteinModelPortaliQ8NHA6.
SMRiQ8NHA6. Positions 32-307.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ8NHA6.
PhylomeDBiQ8NHA6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFYHVGQAA FELLTSSFIL VGFSDRPHLE LIVFVVVLIF YLLTLLGNMT
60 70 80 90 100
IVLLSALDSR LHTPMYFFLA NLSFLDMCFT TGSIPQMLYN LWGPDKTISY
110 120 130 140 150
VGCAIQLYFV LALGGVECVL LAVMAYDRYA AVCKPLHYTI IMHPRLCGQL
160 170 180 190 200
ASVAWLSGFG NSLIMAPQTL MLPRCGHRRV DHFLCEMPAL IGMACVDTMM
210 220 230 240 250
LEALAFALAI FIILAPLILI LISYGYVGGT VLRIKSAAGR KKAFNTCSSH
260 270 280 290 300
LIVVSLFYGT IIYMYLQPAN TYSQDQGKFL TLFYTIVTPS VNPLIYTLRN
310
KDVKEAMKKV LGKGSAEI
Length:318
Mass (Da):35,283
Last modified:October 1, 2002 - v1
Checksum:iE70ED182920CF4AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065475 Genomic DNA. Translation: BAC05729.1.
CH471081 Genomic DNA. Translation: EAX03126.1.
BK004697 Genomic DNA. No translation available.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065475 Genomic DNA. Translation: BAC05729.1.
CH471081 Genomic DNA. Translation: EAX03126.1.
BK004697 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliQ8NHA6.
SMRiQ8NHA6. Positions 32-307.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi74760337.

Proteomic databases

PRIDEiQ8NHA6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR2W6P.
HGNCiHGNC:15072. OR2W6P.
neXtProtiNX_Q8NHA6.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ8NHA6.
PhylomeDBiQ8NHA6.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR2W6_HUMAN
AccessioniPrimary (citable) accession number: Q8NHA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.