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Protein

Olfactory receptor 2AE1

Gene

OR2AE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-30932-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AE1
Alternative name(s):
Olfactory receptor 2AE2
Gene namesi
Name:OR2AE1
Synonyms:OR2AE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:15087. OR2AE1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 218Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 323CytoplasmicSequence analysisAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000244623.
PharmGKBiPA32123.

Polymorphism and mutation databases

BioMutaiOR2AE1.
DMDMi38372832.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504711 – 323Olfactory receptor 2AE1Add BLAST323

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHA4.
PRIDEiQ8NHA4.

Expressioni

Gene expression databases

CleanExiHS_OR2AE1.

Organism-specific databases

HPAiHPA042957.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000313936.

Structurei

3D structure databases

ProteinModelPortaliQ8NHA4.
SMRiQ8NHA4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKFP. Eukaryota.
ENOG4111DW8. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHA4.
KOiK04257.
OMAiIVVSFWF.
OrthoDBiEOG091G0AUV.
PhylomeDBiQ8NHA4.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHA4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWQKNQTSLA DFILEGLFDD SLTHLFLFSL TMVVFLIAVS GNTLTILLIC
60 70 80 90 100
IDPQLHTPMY FLLSQLSLMD LMHVSTIILK MATNYLSGKK SISFVGCATQ
110 120 130 140 150
HFLYLCLGGA ECFLLAVMSY DRYVAICHPL RYAVLMNKKV GLMMAVMSWL
160 170 180 190 200
GASVNSLIHM AILMHFPFCG PRKVYHFYCE FPAVVKLVCG DITVYETTVY
210 220 230 240 250
ISSILLLLPI FLISTSYVFI LQSVIQMRSS GSKRNAFATC GSHLTVVSLW
260 270 280 290 300
FGACIFSYMR PRSQCTLLQN KVGSVFYSII TPTLNSLIYT LRNKDVAKAL
310 320
RRVLRRDVIT QCIQRLQLWL PRV
Length:323
Mass (Da):36,588
Last modified:October 1, 2002 - v1
Checksum:iA74B4E9D9F41C434
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05313877I → T.Corresponds to variant rs2572023dbSNPEnsembl.1
Natural variantiVAR_062019217Y → C.Corresponds to variant rs60737583dbSNPEnsembl.1
Natural variantiVAR_053139267L → V.Corresponds to variant rs17161997dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065478 Genomic DNA. Translation: BAC05732.1.
BC137375 mRNA. Translation: AAI37376.1.
BC137376 mRNA. Translation: AAI37377.1.
CCDSiCCDS34696.1.
RefSeqiNP_001005276.1. NM_001005276.1.
UniGeneiHs.647523.

Genome annotation databases

EnsembliENST00000316368; ENSP00000313936; ENSG00000244623.
GeneIDi81392.
KEGGihsa:81392.
UCSCiuc003usc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065478 Genomic DNA. Translation: BAC05732.1.
BC137375 mRNA. Translation: AAI37376.1.
BC137376 mRNA. Translation: AAI37377.1.
CCDSiCCDS34696.1.
RefSeqiNP_001005276.1. NM_001005276.1.
UniGeneiHs.647523.

3D structure databases

ProteinModelPortaliQ8NHA4.
SMRiQ8NHA4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000313936.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR2AE1.
DMDMi38372832.

Proteomic databases

PaxDbiQ8NHA4.
PRIDEiQ8NHA4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000316368; ENSP00000313936; ENSG00000244623.
GeneIDi81392.
KEGGihsa:81392.
UCSCiuc003usc.2. human.

Organism-specific databases

CTDi81392.
GeneCardsiOR2AE1.
HGNCiHGNC:15087. OR2AE1.
HPAiHPA042957.
neXtProtiNX_Q8NHA4.
OpenTargetsiENSG00000244623.
PharmGKBiPA32123.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKFP. Eukaryota.
ENOG4111DW8. LUCA.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHA4.
KOiK04257.
OMAiIVVSFWF.
OrthoDBiEOG091G0AUV.
PhylomeDBiQ8NHA4.
TreeFamiTF337295.

Enzyme and pathway databases

BioCyciZFISH:G66-30932-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2AE1.
GenomeRNAii81392.
PROiQ8NHA4.

Gene expression databases

CleanExiHS_OR2AE1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO2AE1_HUMAN
AccessioniPrimary (citable) accession number: Q8NHA4
Secondary accession number(s): B2RPD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.