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Q8NHA4 (O2AE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 2AE1
Alternative name(s):
Olfactory receptor 2AE2
Gene names
Name:OR2AE1
Synonyms:OR2AE2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length323 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 323323Olfactory receptor 2AE1
PRO_0000150471

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19537Extracellular Potential
Transmembrane196 – 21823Helical; Name=5; Potential
Topological domain219 – 23517Cytoplasmic Potential
Transmembrane236 – 25823Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29120Helical; Name=7; Potential
Topological domain292 – 32332Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant771I → T.
Corresponds to variant rs2572023 [ dbSNP | Ensembl ].
VAR_053138
Natural variant2171Y → C.
Corresponds to variant rs60737583 [ dbSNP | Ensembl ].
VAR_062019
Natural variant2671L → V.
Corresponds to variant rs17161997 [ dbSNP | Ensembl ].
VAR_053139

Sequences

Sequence LengthMass (Da)Tools
Q8NHA4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: A74B4E9D9F41C434

FASTA32336,588
        10         20         30         40         50         60 
MWQKNQTSLA DFILEGLFDD SLTHLFLFSL TMVVFLIAVS GNTLTILLIC IDPQLHTPMY 

        70         80         90        100        110        120 
FLLSQLSLMD LMHVSTIILK MATNYLSGKK SISFVGCATQ HFLYLCLGGA ECFLLAVMSY 

       130        140        150        160        170        180 
DRYVAICHPL RYAVLMNKKV GLMMAVMSWL GASVNSLIHM AILMHFPFCG PRKVYHFYCE 

       190        200        210        220        230        240 
FPAVVKLVCG DITVYETTVY ISSILLLLPI FLISTSYVFI LQSVIQMRSS GSKRNAFATC 

       250        260        270        280        290        300 
GSHLTVVSLW FGACIFSYMR PRSQCTLLQN KVGSVFYSII TPTLNSLIYT LRNKDVAKAL 

       310        320 
RRVLRRDVIT QCIQRLQLWL PRV 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065478 Genomic DNA. Translation: BAC05732.1.
BC137375 mRNA. Translation: AAI37376.1.
BC137376 mRNA. Translation: AAI37377.1.
CCDSCCDS34696.1.
RefSeqNP_001005276.1. NM_001005276.1.
UniGeneHs.647523.

3D structure databases

ProteinModelPortalQ8NHA4.
SMRQ8NHA4. Positions 25-174.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000313936.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372832.

Proteomic databases

PaxDbQ8NHA4.
PRIDEQ8NHA4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316368; ENSP00000313936; ENSG00000244623.
GeneID81392.
KEGGhsa:81392.
UCSCuc003usc.1. human.

Organism-specific databases

CTD81392.
GeneCardsGC07M099473.
HGNCHGNC:15087. OR2AE1.
HPAHPA042957.
neXtProtNX_Q8NHA4.
PharmGKBPA32123.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG151201.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NHA4.
KOK04257.
OMAQLWLPRV.
OrthoDBEOG7WDN31.
PhylomeDBQ8NHA4.
TreeFamTF337295.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR2AE1.
GenevestigatorQ8NHA4.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR2AE1.
GenomeRNAi81392.
NextBio71644.
PROQ8NHA4.

Entry information

Entry nameO2AE1_HUMAN
AccessionPrimary (citable) accession number: Q8NHA4
Secondary accession number(s): B2RPD2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries