Q8NHA4 (O2AE1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 2AE1

Alternative name(s):
Olfactory receptor 2AE2

Gene names

Name:	OR2AE1
Synonyms:	OR2AE2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Olfactory receptor 2AE1		PRO_0000150471
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 49	24	Helical; Name=1; Potential
	Topological domain	50 – 57	8	Cytoplasmic Potential
	Transmembrane	58 – 79	22	Helical; Name=2; Potential
	Topological domain	80 – 100	21	Extracellular Potential
	Transmembrane	101 – 120	20	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 158	19	Helical; Name=4; Potential
	Topological domain	159 – 195	37	Extracellular Potential
	Transmembrane	196 – 218	23	Helical; Name=5; Potential
	Topological domain	219 – 235	17	Cytoplasmic Potential
	Transmembrane	236 – 258	23	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 291	20	Helical; Name=7; Potential
	Topological domain	292 – 323	32	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	77	1	I → T. Corresponds to variant rs2572023 [ dbSNP | Ensembl ].		VAR_053138
	Natural variant	217	1	Y → C. Corresponds to variant rs60737583 [ dbSNP | Ensembl ].		VAR_062019
	Natural variant	267	1	L → V. Corresponds to variant rs17161997 [ dbSNP | Ensembl ].		VAR_053139

Sequences

	Sequence		Length	Mass (Da)
	Q8NHA4 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: A74B4E9D9F41C434	FASTA	323	36,588
	10 20 30 40 50 60 MWQKNQTSLA DFILEGLFDD SLTHLFLFSL TMVVFLIAVS GNTLTILLIC IDPQLHTPMY 70 80 90 100 110 120 FLLSQLSLMD LMHVSTIILK MATNYLSGKK SISFVGCATQ HFLYLCLGGA ECFLLAVMSY 130 140 150 160 170 180 DRYVAICHPL RYAVLMNKKV GLMMAVMSWL GASVNSLIHM AILMHFPFCG PRKVYHFYCE 190 200 210 220 230 240 FPAVVKLVCG DITVYETTVY ISSILLLLPI FLISTSYVFI LQSVIQMRSS GSKRNAFATC 250 260 270 280 290 300 GSHLTVVSLW FGACIFSYMR PRSQCTLLQN KVGSVFYSII TPTLNSLIYT LRNKDVAKAL 310 320 RRVLRRDVIT QCIQRLQLWL PRV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065478 Genomic DNA. Translation: BAC05732.1. BC137375 mRNA. Translation: AAI37376.1. BC137376 mRNA. Translation: AAI37377.1.
IPI	IPI00375225.
RefSeq	NP_001005276.1. NM_001005276.1.
UniGene	Hs.647523.
3D structure databases
ProteinModelPortal	Q8NHA4.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000313936.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	38372832.
Proteomic databases
PaxDb	Q8NHA4.
PRIDE	Q8NHA4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000316368; ENSP00000313936; ENSG00000244623.
GeneID	81392.
KEGG	hsa:81392.
UCSC	uc003usc.1. human.
Organism-specific databases
CTD	81392.
GeneCards	GC07M099473.
HGNC	HGNC:15087. OR2AE1.
HPA	HPA042957.
neXtProt	NX_Q8NHA4.
PharmGKB	PA32123.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG151201.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q8NHA4.
KO	K04257.
OMA	LICIDPQ.
OrthoDB	EOG44J2JM.
PhylomeDB	Q8NHA4.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR2AE1.
Genevestigator	Q8NHA4.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	81392.
NextBio	71644.

Entry information

Entry name

O2AE1_HUMAN

Accession

Primary (citable) accession number: Q8NHA4
Secondary accession number(s): B2RPD2

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.