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Q8NHA4

- O2AE1_HUMAN

UniProt

Q8NHA4 - O2AE1_HUMAN

Protein

Olfactory receptor 2AE1

Gene

OR2AE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2AE1
    Alternative name(s):
    Olfactory receptor 2AE2
    Gene namesi
    Name:OR2AE1
    Synonyms:OR2AE2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:15087. OR2AE1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32123.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 323323Olfactory receptor 2AE1PRO_0000150471Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NHA4.
    PRIDEiQ8NHA4.

    Expressioni

    Gene expression databases

    CleanExiHS_OR2AE1.
    GenevestigatoriQ8NHA4.

    Organism-specific databases

    HPAiHPA042957.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000313936.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NHA4.
    SMRiQ8NHA4. Positions 25-174.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 32332CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21823Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG151201.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NHA4.
    KOiK04257.
    OMAiQLWLPRV.
    OrthoDBiEOG7WDN31.
    PhylomeDBiQ8NHA4.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NHA4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWQKNQTSLA DFILEGLFDD SLTHLFLFSL TMVVFLIAVS GNTLTILLIC    50
    IDPQLHTPMY FLLSQLSLMD LMHVSTIILK MATNYLSGKK SISFVGCATQ 100
    HFLYLCLGGA ECFLLAVMSY DRYVAICHPL RYAVLMNKKV GLMMAVMSWL 150
    GASVNSLIHM AILMHFPFCG PRKVYHFYCE FPAVVKLVCG DITVYETTVY 200
    ISSILLLLPI FLISTSYVFI LQSVIQMRSS GSKRNAFATC GSHLTVVSLW 250
    FGACIFSYMR PRSQCTLLQN KVGSVFYSII TPTLNSLIYT LRNKDVAKAL 300
    RRVLRRDVIT QCIQRLQLWL PRV 323
    Length:323
    Mass (Da):36,588
    Last modified:October 1, 2002 - v1
    Checksum:iA74B4E9D9F41C434
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771I → T.
    Corresponds to variant rs2572023 [ dbSNP | Ensembl ].
    VAR_053138
    Natural varianti217 – 2171Y → C.
    Corresponds to variant rs60737583 [ dbSNP | Ensembl ].
    VAR_062019
    Natural varianti267 – 2671L → V.
    Corresponds to variant rs17161997 [ dbSNP | Ensembl ].
    VAR_053139

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065478 Genomic DNA. Translation: BAC05732.1.
    BC137375 mRNA. Translation: AAI37376.1.
    BC137376 mRNA. Translation: AAI37377.1.
    CCDSiCCDS34696.1.
    RefSeqiNP_001005276.1. NM_001005276.1.
    UniGeneiHs.647523.

    Genome annotation databases

    EnsembliENST00000316368; ENSP00000313936; ENSG00000244623.
    GeneIDi81392.
    KEGGihsa:81392.
    UCSCiuc003usc.1. human.

    Polymorphism databases

    DMDMi38372832.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065478 Genomic DNA. Translation: BAC05732.1 .
    BC137375 mRNA. Translation: AAI37376.1 .
    BC137376 mRNA. Translation: AAI37377.1 .
    CCDSi CCDS34696.1.
    RefSeqi NP_001005276.1. NM_001005276.1.
    UniGenei Hs.647523.

    3D structure databases

    ProteinModelPortali Q8NHA4.
    SMRi Q8NHA4. Positions 25-174.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000313936.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372832.

    Proteomic databases

    PaxDbi Q8NHA4.
    PRIDEi Q8NHA4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316368 ; ENSP00000313936 ; ENSG00000244623 .
    GeneIDi 81392.
    KEGGi hsa:81392.
    UCSCi uc003usc.1. human.

    Organism-specific databases

    CTDi 81392.
    GeneCardsi GC07M099473.
    HGNCi HGNC:15087. OR2AE1.
    HPAi HPA042957.
    neXtProti NX_Q8NHA4.
    PharmGKBi PA32123.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG151201.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NHA4.
    KOi K04257.
    OMAi QLWLPRV.
    OrthoDBi EOG7WDN31.
    PhylomeDBi Q8NHA4.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2AE1.
    GenomeRNAii 81392.
    NextBioi 71644.
    PROi Q8NHA4.

    Gene expression databases

    CleanExi HS_OR2AE1.
    Genevestigatori Q8NHA4.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiO2AE1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NHA4
    Secondary accession number(s): B2RPD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3