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Q8NHA4

- O2AE1_HUMAN

UniProt

Q8NHA4 - O2AE1_HUMAN

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Protein

Olfactory receptor 2AE1

Gene

OR2AE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2AE1
Alternative name(s):
Olfactory receptor 2AE2
Gene namesi
Name:OR2AE1
Synonyms:OR2AE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:15087. OR2AE1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32123.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 323323Olfactory receptor 2AE1PRO_0000150471Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NHA4.
PRIDEiQ8NHA4.

Expressioni

Gene expression databases

CleanExiHS_OR2AE1.
GenevestigatoriQ8NHA4.

Organism-specific databases

HPAiHPA042957.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000313936.

Structurei

3D structure databases

ProteinModelPortaliQ8NHA4.
SMRiQ8NHA4. Positions 25-174.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence AnalysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Topological domaini292 – 32332CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei196 – 21823Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG151201.
GeneTreeiENSGT00760000118850.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NHA4.
KOiK04257.
OMAiQLWLPRV.
OrthoDBiEOG7WDN31.
PhylomeDBiQ8NHA4.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NHA4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWQKNQTSLA DFILEGLFDD SLTHLFLFSL TMVVFLIAVS GNTLTILLIC
60 70 80 90 100
IDPQLHTPMY FLLSQLSLMD LMHVSTIILK MATNYLSGKK SISFVGCATQ
110 120 130 140 150
HFLYLCLGGA ECFLLAVMSY DRYVAICHPL RYAVLMNKKV GLMMAVMSWL
160 170 180 190 200
GASVNSLIHM AILMHFPFCG PRKVYHFYCE FPAVVKLVCG DITVYETTVY
210 220 230 240 250
ISSILLLLPI FLISTSYVFI LQSVIQMRSS GSKRNAFATC GSHLTVVSLW
260 270 280 290 300
FGACIFSYMR PRSQCTLLQN KVGSVFYSII TPTLNSLIYT LRNKDVAKAL
310 320
RRVLRRDVIT QCIQRLQLWL PRV
Length:323
Mass (Da):36,588
Last modified:October 1, 2002 - v1
Checksum:iA74B4E9D9F41C434
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771I → T.
Corresponds to variant rs2572023 [ dbSNP | Ensembl ].
VAR_053138
Natural varianti217 – 2171Y → C.
Corresponds to variant rs60737583 [ dbSNP | Ensembl ].
VAR_062019
Natural varianti267 – 2671L → V.
Corresponds to variant rs17161997 [ dbSNP | Ensembl ].
VAR_053139

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065478 Genomic DNA. Translation: BAC05732.1.
BC137375 mRNA. Translation: AAI37376.1.
BC137376 mRNA. Translation: AAI37377.1.
CCDSiCCDS34696.1.
RefSeqiNP_001005276.1. NM_001005276.1.
UniGeneiHs.647523.

Genome annotation databases

EnsembliENST00000316368; ENSP00000313936; ENSG00000244623.
GeneIDi81392.
KEGGihsa:81392.
UCSCiuc003usc.1. human.

Polymorphism databases

DMDMi38372832.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065478 Genomic DNA. Translation: BAC05732.1 .
BC137375 mRNA. Translation: AAI37376.1 .
BC137376 mRNA. Translation: AAI37377.1 .
CCDSi CCDS34696.1.
RefSeqi NP_001005276.1. NM_001005276.1.
UniGenei Hs.647523.

3D structure databases

ProteinModelPortali Q8NHA4.
SMRi Q8NHA4. Positions 25-174.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000313936.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372832.

Proteomic databases

PaxDbi Q8NHA4.
PRIDEi Q8NHA4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316368 ; ENSP00000313936 ; ENSG00000244623 .
GeneIDi 81392.
KEGGi hsa:81392.
UCSCi uc003usc.1. human.

Organism-specific databases

CTDi 81392.
GeneCardsi GC07M099473.
HGNCi HGNC:15087. OR2AE1.
HPAi HPA042957.
neXtProti NX_Q8NHA4.
PharmGKBi PA32123.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG151201.
GeneTreei ENSGT00760000118850.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NHA4.
KOi K04257.
OMAi QLWLPRV.
OrthoDBi EOG7WDN31.
PhylomeDBi Q8NHA4.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2AE1.
GenomeRNAii 81392.
NextBioi 71644.
PROi Q8NHA4.

Gene expression databases

CleanExi HS_OR2AE1.
Genevestigatori Q8NHA4.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiO2AE1_HUMAN
AccessioniPrimary (citable) accession number: Q8NHA4
Secondary accession number(s): B2RPD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3