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Protein

Olfactory receptor 1L1

Gene

OR1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L1
Alternative name(s):
Olfactory receptor 1L2
Olfactory receptor 9-C
Short name:
OR9-C
Olfactory receptor OR9-27
Gene namesi
Name:OR1L1
Synonyms:OR1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000173679.2.
HGNCiHGNC:8213. OR1L1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75ExtracellularSequence analysisAdd BLAST75
Transmembranei76 – 99Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini100 – 107CytoplasmicSequence analysis8
Transmembranei108 – 129Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini130 – 150ExtracellularSequence analysisAdd BLAST21
Transmembranei151 – 170Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini171 – 189CytoplasmicSequence analysisAdd BLAST19
Transmembranei190 – 208Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini209 – 246ExtracellularSequence analysisAdd BLAST38
Transmembranei247 – 269Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini270 – 286CytoplasmicSequence analysisAdd BLAST17
Transmembranei287 – 309Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini310 – 321ExtracellularSequence analysisAdd BLAST12
Transmembranei322 – 341Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini342 – 360CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32084.

Polymorphism and mutation databases

DMDMi229462947.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504421 – 360Olfactory receptor 1L1Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi147 ↔ 239PROSITE-ProRule annotation
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH94.
PeptideAtlasiQ8NH94.
PRIDEiQ8NH94.

PTM databases

iPTMnetiQ8NH94.
PhosphoSitePlusiQ8NH94.

Expressioni

Gene expression databases

BgeeiENSG00000173679.
CleanExiHS_OR1L1.
ExpressionAtlasiQ8NH94. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310773.

Structurei

3D structure databases

ProteinModelPortaliQ8NH94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFXJ. Eukaryota.
ENOG41114P7. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH94.
KOiK04257.
OMAiITVMTEG.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NH94.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NH94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNHNPDNC NVLNFFFADK KNKRRNFGQI VSDVGRICYS VSLSLGEPTT
60 70 80 90 100
MGRNNLTRPS EFILLGLSSR PEDQKPLFAV FLPIYLITVI GNLLIILAIR
110 120 130 140 150
SDTRLQTPMY FFLSILSFVD ICYVTVIIPK MLVNFLSETK TISYSECLTQ
160 170 180 190 200
MYFFLAFGNT DSYLLAAMAI DRYVAICNPF HYITIMSHRC CVLLLVLSFC
210 220 230 240 250
IPHFHSLLHI LLTNQLIFCA SNVIHHFFCD DQPVLKLSCS SHFVKEITVM
260 270 280 290 300
TEGLAVIMTP FSCIIISYLR ILITVLKIPS AAGKRKAFST CGSHLTVVTL
310 320 330 340 350
FYGSISYLYF QPLSNYTVKD QIATIIYTVL TPMLNPFIYS LRNKDMKQGL
360
AKLMHRMKCQ
Length:360
Mass (Da):41,046
Last modified:May 5, 2009 - v3
Checksum:i0C4C894477361176
GO

Sequence cautioni

The sequence BAC05743 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW87540 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047141145S → G2 PublicationsCorresponds to variant dbSNP:rs70157Ensembl.1
Natural variantiVAR_047142149T → A. Corresponds to variant dbSNP:rs16912055Ensembl.1
Natural variantiVAR_047143308L → V2 PublicationsCorresponds to variant dbSNP:rs237620Ensembl.1
Natural variantiVAR_047144349G → R. Corresponds to variant dbSNP:rs16912062Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065491 Genomic DNA. Translation: BAC05743.1. Different initiation.
AL162254 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87540.1. Different initiation.
BK004230 Genomic DNA. Translation: DAA04628.1.
RefSeqiNP_001005236.3. NM_001005236.3.
UniGeneiHs.567736.

Genome annotation databases

EnsembliENST00000373686; ENSP00000362790; ENSG00000173679.
GeneIDi26737.
KEGGihsa:26737.
UCSCiuc064vng.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH94
Secondary accession number(s): Q5T7Z3, Q6IFN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: September 27, 2017
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-51 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families