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Protein

Olfactory receptor 1L1

Gene

OR1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173679-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L1
Alternative name(s):
Olfactory receptor 1L2
Olfactory receptor 9-C
Short name:
OR9-C
Olfactory receptor OR9-27
Gene namesi
Name:OR1L1
Synonyms:OR1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8213. OR1L1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75ExtracellularSequence analysisAdd BLAST75
Transmembranei76 – 99Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini100 – 107CytoplasmicSequence analysis8
Transmembranei108 – 129Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini130 – 150ExtracellularSequence analysisAdd BLAST21
Transmembranei151 – 170Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini171 – 189CytoplasmicSequence analysisAdd BLAST19
Transmembranei190 – 208Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini209 – 246ExtracellularSequence analysisAdd BLAST38
Transmembranei247 – 269Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini270 – 286CytoplasmicSequence analysisAdd BLAST17
Transmembranei287 – 309Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini310 – 321ExtracellularSequence analysisAdd BLAST12
Transmembranei322 – 341Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini342 – 360CytoplasmicSequence analysisAdd BLAST19

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173679.
PharmGKBiPA32084.

Polymorphism and mutation databases

DMDMi229462947.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504421 – 360Olfactory receptor 1L1Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi147 ↔ 239PROSITE-ProRule annotation
Glycosylationi315N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH94.
PeptideAtlasiQ8NH94.
PRIDEiQ8NH94.

PTM databases

iPTMnetiQ8NH94.
PhosphoSitePlusiQ8NH94.

Expressioni

Gene expression databases

CleanExiHS_OR1L1.

Organism-specific databases

HPAiCAB025429.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310773.

Structurei

3D structure databases

ProteinModelPortaliQ8NH94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFXJ. Eukaryota.
ENOG41114P7. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH94.
KOiK04257.
OMAiITVMTEG.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NH94.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNHNPDNC NVLNFFFADK KNKRRNFGQI VSDVGRICYS VSLSLGEPTT
60 70 80 90 100
MGRNNLTRPS EFILLGLSSR PEDQKPLFAV FLPIYLITVI GNLLIILAIR
110 120 130 140 150
SDTRLQTPMY FFLSILSFVD ICYVTVIIPK MLVNFLSETK TISYSECLTQ
160 170 180 190 200
MYFFLAFGNT DSYLLAAMAI DRYVAICNPF HYITIMSHRC CVLLLVLSFC
210 220 230 240 250
IPHFHSLLHI LLTNQLIFCA SNVIHHFFCD DQPVLKLSCS SHFVKEITVM
260 270 280 290 300
TEGLAVIMTP FSCIIISYLR ILITVLKIPS AAGKRKAFST CGSHLTVVTL
310 320 330 340 350
FYGSISYLYF QPLSNYTVKD QIATIIYTVL TPMLNPFIYS LRNKDMKQGL
360
AKLMHRMKCQ
Length:360
Mass (Da):41,046
Last modified:May 5, 2009 - v3
Checksum:i0C4C894477361176
GO

Sequence cautioni

The sequence BAC05743 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW87540 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047141145S → G.2 PublicationsCorresponds to variant rs70157dbSNPEnsembl.1
Natural variantiVAR_047142149T → A.Corresponds to variant rs16912055dbSNPEnsembl.1
Natural variantiVAR_047143308L → V.2 PublicationsCorresponds to variant rs237620dbSNPEnsembl.1
Natural variantiVAR_047144349G → R.Corresponds to variant rs16912062dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065491 Genomic DNA. Translation: BAC05743.1. Different initiation.
AL162254 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87540.1. Different initiation.
BK004230 Genomic DNA. Translation: DAA04628.1.
RefSeqiNP_001005236.3. NM_001005236.3.
UniGeneiHs.567736.

Genome annotation databases

EnsembliENST00000373686; ENSP00000362790; ENSG00000173679.
GeneIDi26737.
KEGGihsa:26737.
UCSCiuc064vng.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065491 Genomic DNA. Translation: BAC05743.1. Different initiation.
AL162254 Genomic DNA. No translation available.
CH471090 Genomic DNA. Translation: EAW87540.1. Different initiation.
BK004230 Genomic DNA. Translation: DAA04628.1.
RefSeqiNP_001005236.3. NM_001005236.3.
UniGeneiHs.567736.

3D structure databases

ProteinModelPortaliQ8NH94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000310773.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH94.
PhosphoSitePlusiQ8NH94.

Polymorphism and mutation databases

DMDMi229462947.

Proteomic databases

PaxDbiQ8NH94.
PeptideAtlasiQ8NH94.
PRIDEiQ8NH94.

Protocols and materials databases

DNASUi26737.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373686; ENSP00000362790; ENSG00000173679.
GeneIDi26737.
KEGGihsa:26737.
UCSCiuc064vng.1. human.

Organism-specific databases

CTDi26737.
GeneCardsiOR1L1.
HGNCiHGNC:8213. OR1L1.
HPAiCAB025429.
neXtProtiNX_Q8NH94.
OpenTargetsiENSG00000173679.
PharmGKBiPA32084.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFXJ. Eukaryota.
ENOG41114P7. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH94.
KOiK04257.
OMAiITVMTEG.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NH94.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173679-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1L1.
GenomeRNAii26737.
PROiQ8NH94.

Gene expression databases

CleanExiHS_OR1L1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH94
Secondary accession number(s): Q5T7Z3, Q6IFN2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: November 30, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-51 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.