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Protein

Olfactory receptor 1L1

Gene

OR1L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-51 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L1
Alternative name(s):
Olfactory receptor 1L2
Olfactory receptor 9-C
Short name:
OR9-C
Olfactory receptor OR9-27
Gene namesi
Name:OR1L1
Synonyms:OR1L2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000173679.2
HGNCiHGNC:8213 OR1L1
neXtProtiNX_Q8NH94

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75ExtracellularSequence analysisAdd BLAST75
Transmembranei76 – 99Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini100 – 107CytoplasmicSequence analysis8
Transmembranei108 – 129Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini130 – 150ExtracellularSequence analysisAdd BLAST21
Transmembranei151 – 170Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini171 – 189CytoplasmicSequence analysisAdd BLAST19
Transmembranei190 – 208Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini209 – 246ExtracellularSequence analysisAdd BLAST38
Transmembranei247 – 269Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini270 – 286CytoplasmicSequence analysisAdd BLAST17
Transmembranei287 – 309Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini310 – 321ExtracellularSequence analysisAdd BLAST12
Transmembranei322 – 341Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini342 – 360CytoplasmicSequence analysisAdd BLAST19

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32084

Polymorphism and mutation databases

DMDMi229462947

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504421 – 360Olfactory receptor 1L1Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi55N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi147 ↔ 239PROSITE-ProRule annotation
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH94
PeptideAtlasiQ8NH94
PRIDEiQ8NH94
ProteomicsDBi73690

PTM databases

iPTMnetiQ8NH94
PhosphoSitePlusiQ8NH94

Expressioni

Gene expression databases

BgeeiENSG00000173679
CleanExiHS_OR1L1
ExpressionAtlasiQ8NH94 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310773

Structurei

3D structure databases

ProteinModelPortaliQ8NH94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFXJ Eukaryota
ENOG41114P7 LUCA
GeneTreeiENSGT00910000144098
HOGENOMiHOG000041364
HOVERGENiHBG017625
InParanoidiQ8NH94
KOiK04257
OMAiITVMTEG
OrthoDBiEOG091G0B53
PhylomeDBiQ8NH94

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERNHNPDNC NVLNFFFADK KNKRRNFGQI VSDVGRICYS VSLSLGEPTT
60 70 80 90 100
MGRNNLTRPS EFILLGLSSR PEDQKPLFAV FLPIYLITVI GNLLIILAIR
110 120 130 140 150
SDTRLQTPMY FFLSILSFVD ICYVTVIIPK MLVNFLSETK TISYSECLTQ
160 170 180 190 200
MYFFLAFGNT DSYLLAAMAI DRYVAICNPF HYITIMSHRC CVLLLVLSFC
210 220 230 240 250
IPHFHSLLHI LLTNQLIFCA SNVIHHFFCD DQPVLKLSCS SHFVKEITVM
260 270 280 290 300
TEGLAVIMTP FSCIIISYLR ILITVLKIPS AAGKRKAFST CGSHLTVVTL
310 320 330 340 350
FYGSISYLYF QPLSNYTVKD QIATIIYTVL TPMLNPFIYS LRNKDMKQGL
360
AKLMHRMKCQ
Length:360
Mass (Da):41,046
Last modified:May 5, 2009 - v3
Checksum:i0C4C894477361176
GO

Sequence cautioni

The sequence BAC05743 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence EAW87540 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047141145S → G2 PublicationsCorresponds to variant dbSNP:rs70157Ensembl.1
Natural variantiVAR_047142149T → A. Corresponds to variant dbSNP:rs16912055Ensembl.1
Natural variantiVAR_047143308L → V2 PublicationsCorresponds to variant dbSNP:rs237620Ensembl.1
Natural variantiVAR_047144349G → R. Corresponds to variant dbSNP:rs16912062Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065491 Genomic DNA Translation: BAC05743.1 Different initiation.
AL162254 Genomic DNA No translation available.
CH471090 Genomic DNA Translation: EAW87540.1 Different initiation.
BK004230 Genomic DNA Translation: DAA04628.1
RefSeqiNP_001005236.3, NM_001005236.3
UniGeneiHs.567736

Genome annotation databases

EnsembliENST00000373686; ENSP00000362790; ENSG00000173679
GeneIDi26737
KEGGihsa:26737
UCSCiuc064vng.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR1L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH94
Secondary accession number(s): Q5T7Z3, Q6IFN2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: June 20, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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