SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8NH93

- OR1L3_HUMAN

UniProt

Q8NH93 - OR1L3_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Olfactory receptor 1L3
Gene
OR1L3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L3
Alternative name(s):
Olfactory receptor 9-D
Short name:
OR9-D
Olfactory receptor OR9-28
Gene namesi
Name:OR1L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:8215. OR1L3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed prediction
Add
BLAST
Transmembranei26 – 4924Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini50 – 578Cytoplasmic Reviewed prediction
Transmembranei58 – 7922Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini80 – 10021Extracellular Reviewed prediction
Add
BLAST
Transmembranei101 – 12020Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei140 – 15819Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini159 – 19638Extracellular Reviewed prediction
Add
BLAST
Transmembranei197 – 21923Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini220 – 23617Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei237 – 25923Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini260 – 27112Extracellular Reviewed prediction
Add
BLAST
Transmembranei272 – 29120Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini292 – 32433Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Olfactory receptor 1L3
PRO_0000150443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi97 ↔ 189 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH93.
PRIDEiQ8NH93.

Expressioni

Gene expression databases

CleanExiHS_OR1L3.
GenevestigatoriQ8NH93.

Organism-specific databases

HPAiHPA058878.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302863.

Structurei

3D structure databases

ProteinModelPortaliQ8NH93.
SMRiQ8NH93. Positions 30-304.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44632.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH93.
KOiK04257.
OMAiGMSNLTR.
OrthoDBiEOG7D85WJ.
PhylomeDBiQ8NH93.
TreeFamiTF341149.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH93-1 [UniParc]FASTAAdd to Basket

« Hide

MGMSNLTRLS EFILLGLSSR SEDQRPLFAL FLIIYLVTLM GNLLIILAIH    50
SDPRLQNPMY FFLSILSFAD ICYTTVIVPK MLVNFLSEKK TISYAECLAQ 100
MYFFLVFGNI DSYLLAAMAI NRCVAICNPF HYVTVMNRRC CVLLLAFPIT 150
FSYFHSLLHV LLVNRLTFCT SNVIHHFFCD VNPVLKLSCS STFVNEIVAM 200
TEGLASVMAP FVCIIISYLR ILIAVLKIPS AAGKHKAFST CSSHLTVVIL 250
FYGSISYVYL QPLSSYTVKD RIATINYTVL TSVLNPFIYS LRNKDMKRGL 300
QKLINKIKSQ MSRFSTKTNK ICGP 324
Length:324
Mass (Da):36,633
Last modified:October 1, 2002 - v1
Checksum:i088889EBE28353F8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541R → G.
Corresponds to variant rs12379744 [ dbSNP | Ensembl ].
VAR_059979
Natural varianti106 – 1061V → A.
Corresponds to variant rs16912096 [ dbSNP | Ensembl ].
VAR_034169
Natural varianti121 – 1211N → D.
Corresponds to variant rs16912099 [ dbSNP | Ensembl ].
VAR_034170

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065492 Genomic DNA. Translation: BAC05744.1.
AL162254 Genomic DNA. Translation: CAI16291.1.
CH471090 Genomic DNA. Translation: EAW87541.1.
BC136857 mRNA. Translation: AAI36858.1.
BC136859 mRNA. Translation: AAI36860.1.
BK004231 Genomic DNA. Translation: DAA04629.1.
CCDSiCCDS35128.1.
RefSeqiNP_001005234.1. NM_001005234.1.
UniGeneiHs.626839.

Genome annotation databases

EnsembliENST00000304820; ENSP00000302863; ENSG00000171481.
GeneIDi26735.
KEGGihsa:26735.
UCSCiuc011lzb.2. human.

Polymorphism databases

DMDMi38372830.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065492 Genomic DNA. Translation: BAC05744.1 .
AL162254 Genomic DNA. Translation: CAI16291.1 .
CH471090 Genomic DNA. Translation: EAW87541.1 .
BC136857 mRNA. Translation: AAI36858.1 .
BC136859 mRNA. Translation: AAI36860.1 .
BK004231 Genomic DNA. Translation: DAA04629.1 .
CCDSi CCDS35128.1.
RefSeqi NP_001005234.1. NM_001005234.1.
UniGenei Hs.626839.

3D structure databases

ProteinModelPortali Q8NH93.
SMRi Q8NH93. Positions 30-304.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000302863.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372830.

Proteomic databases

PaxDbi Q8NH93.
PRIDEi Q8NH93.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000304820 ; ENSP00000302863 ; ENSG00000171481 .
GeneIDi 26735.
KEGGi hsa:26735.
UCSCi uc011lzb.2. human.

Organism-specific databases

CTDi 26735.
GeneCardsi GC09P125438.
HGNCi HGNC:8215. OR1L3.
HPAi HPA058878.
neXtProti NX_Q8NH93.
PharmGKBi PA32085.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG44632.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NH93.
KOi K04257.
OMAi GMSNLTR.
OrthoDBi EOG7D85WJ.
PhylomeDBi Q8NH93.
TreeFami TF341149.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR1L3.
GenomeRNAii 26735.
NextBioi 49089.
PROi Q8NH93.

Gene expression databases

CleanExi HS_OR1L3.
Genevestigatori Q8NH93.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1L3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH93
Secondary accession number(s): B2RNF4, Q6IFN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi