Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NH93

- OR1L3_HUMAN

UniProt

Q8NH93 - OR1L3_HUMAN

Protein

Olfactory receptor 1L3

Gene

OR1L3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 1L3
    Alternative name(s):
    Olfactory receptor 9-D
    Short name:
    OR9-D
    Olfactory receptor OR9-28
    Gene namesi
    Name:OR1L3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:8215. OR1L3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32085.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Olfactory receptor 1L3PRO_0000150443Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH93.
    PRIDEiQ8NH93.

    Expressioni

    Gene expression databases

    CleanExiHS_OR1L3.
    GenevestigatoriQ8NH93.

    Organism-specific databases

    HPAiHPA058878.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000302863.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH93.
    SMRiQ8NH93. Positions 30-304.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 578CytoplasmicSequence Analysis
    Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27112ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 32433CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21923Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44632.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NH93.
    KOiK04257.
    OMAiGMSNLTR.
    OrthoDBiEOG7D85WJ.
    PhylomeDBiQ8NH93.
    TreeFamiTF341149.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMSNLTRLS EFILLGLSSR SEDQRPLFAL FLIIYLVTLM GNLLIILAIH    50
    SDPRLQNPMY FFLSILSFAD ICYTTVIVPK MLVNFLSEKK TISYAECLAQ 100
    MYFFLVFGNI DSYLLAAMAI NRCVAICNPF HYVTVMNRRC CVLLLAFPIT 150
    FSYFHSLLHV LLVNRLTFCT SNVIHHFFCD VNPVLKLSCS STFVNEIVAM 200
    TEGLASVMAP FVCIIISYLR ILIAVLKIPS AAGKHKAFST CSSHLTVVIL 250
    FYGSISYVYL QPLSSYTVKD RIATINYTVL TSVLNPFIYS LRNKDMKRGL 300
    QKLINKIKSQ MSRFSTKTNK ICGP 324
    Length:324
    Mass (Da):36,633
    Last modified:October 1, 2002 - v1
    Checksum:i088889EBE28353F8
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti54 – 541R → G.
    Corresponds to variant rs12379744 [ dbSNP | Ensembl ].
    VAR_059979
    Natural varianti106 – 1061V → A.
    Corresponds to variant rs16912096 [ dbSNP | Ensembl ].
    VAR_034169
    Natural varianti121 – 1211N → D.
    Corresponds to variant rs16912099 [ dbSNP | Ensembl ].
    VAR_034170

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065492 Genomic DNA. Translation: BAC05744.1.
    AL162254 Genomic DNA. Translation: CAI16291.1.
    CH471090 Genomic DNA. Translation: EAW87541.1.
    BC136857 mRNA. Translation: AAI36858.1.
    BC136859 mRNA. Translation: AAI36860.1.
    BK004231 Genomic DNA. Translation: DAA04629.1.
    CCDSiCCDS35128.1.
    RefSeqiNP_001005234.1. NM_001005234.1.
    UniGeneiHs.626839.

    Genome annotation databases

    EnsembliENST00000304820; ENSP00000302863; ENSG00000171481.
    GeneIDi26735.
    KEGGihsa:26735.
    UCSCiuc011lzb.2. human.

    Polymorphism databases

    DMDMi38372830.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065492 Genomic DNA. Translation: BAC05744.1 .
    AL162254 Genomic DNA. Translation: CAI16291.1 .
    CH471090 Genomic DNA. Translation: EAW87541.1 .
    BC136857 mRNA. Translation: AAI36858.1 .
    BC136859 mRNA. Translation: AAI36860.1 .
    BK004231 Genomic DNA. Translation: DAA04629.1 .
    CCDSi CCDS35128.1.
    RefSeqi NP_001005234.1. NM_001005234.1.
    UniGenei Hs.626839.

    3D structure databases

    ProteinModelPortali Q8NH93.
    SMRi Q8NH93. Positions 30-304.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000302863.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372830.

    Proteomic databases

    PaxDbi Q8NH93.
    PRIDEi Q8NH93.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000304820 ; ENSP00000302863 ; ENSG00000171481 .
    GeneIDi 26735.
    KEGGi hsa:26735.
    UCSCi uc011lzb.2. human.

    Organism-specific databases

    CTDi 26735.
    GeneCardsi GC09P125438.
    HGNCi HGNC:8215. OR1L3.
    HPAi HPA058878.
    neXtProti NX_Q8NH93.
    PharmGKBi PA32085.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG44632.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NH93.
    KOi K04257.
    OMAi GMSNLTR.
    OrthoDBi EOG7D85WJ.
    PhylomeDBi Q8NH93.
    TreeFami TF341149.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR1L3.
    GenomeRNAii 26735.
    NextBioi 49089.
    PROi Q8NH93.

    Gene expression databases

    CleanExi HS_OR1L3.
    Genevestigatori Q8NH93.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR1L3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH93
    Secondary accession number(s): B2RNF4, Q6IFN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3