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Protein

Olfactory receptor 1L3

Gene

OR1L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1L3
Alternative name(s):
Olfactory receptor 9-D
Short name:
OR9-D
Olfactory receptor OR9-28
Gene namesi
Name:OR1L3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:8215. OR1L3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence Analysis
Transmembranei58 – 7922Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence AnalysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini159 – 19638ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21923Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23617CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25923Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27112ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 32433CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32085.

Polymorphism and mutation databases

BioMutaiOR1L3.
DMDMi38372830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Olfactory receptor 1L3PRO_0000150443Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH93.
PRIDEiQ8NH93.

Expressioni

Gene expression databases

CleanExiHS_OR1L3.

Organism-specific databases

HPAiHPA058878.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000302863.

Structurei

3D structure databases

ProteinModelPortaliQ8NH93.
SMRiQ8NH93. Positions 27-304.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG44632.
GeneTreeiENSGT00800000124028.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH93.
KOiK04257.
OMAiYVTVMNH.
OrthoDBiEOG7D85WJ.
PhylomeDBiQ8NH93.
TreeFamiTF341149.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH93-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSNLTRLS EFILLGLSSR SEDQRPLFAL FLIIYLVTLM GNLLIILAIH
60 70 80 90 100
SDPRLQNPMY FFLSILSFAD ICYTTVIVPK MLVNFLSEKK TISYAECLAQ
110 120 130 140 150
MYFFLVFGNI DSYLLAAMAI NRCVAICNPF HYVTVMNRRC CVLLLAFPIT
160 170 180 190 200
FSYFHSLLHV LLVNRLTFCT SNVIHHFFCD VNPVLKLSCS STFVNEIVAM
210 220 230 240 250
TEGLASVMAP FVCIIISYLR ILIAVLKIPS AAGKHKAFST CSSHLTVVIL
260 270 280 290 300
FYGSISYVYL QPLSSYTVKD RIATINYTVL TSVLNPFIYS LRNKDMKRGL
310 320
QKLINKIKSQ MSRFSTKTNK ICGP
Length:324
Mass (Da):36,633
Last modified:October 1, 2002 - v1
Checksum:i088889EBE28353F8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti54 – 541R → G.
Corresponds to variant rs12379744 [ dbSNP | Ensembl ].
VAR_059979
Natural varianti106 – 1061V → A.
Corresponds to variant rs16912096 [ dbSNP | Ensembl ].
VAR_034169
Natural varianti121 – 1211N → D.
Corresponds to variant rs16912099 [ dbSNP | Ensembl ].
VAR_034170

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065492 Genomic DNA. Translation: BAC05744.1.
AL162254 Genomic DNA. Translation: CAI16291.1.
CH471090 Genomic DNA. Translation: EAW87541.1.
BC136857 mRNA. Translation: AAI36858.1.
BC136859 mRNA. Translation: AAI36860.1.
BK004231 Genomic DNA. Translation: DAA04629.1.
CCDSiCCDS35128.1.
RefSeqiNP_001005234.1. NM_001005234.1.
UniGeneiHs.626839.

Genome annotation databases

EnsembliENST00000304820; ENSP00000302863; ENSG00000171481.
GeneIDi26735.
KEGGihsa:26735.
UCSCiuc011lzb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065492 Genomic DNA. Translation: BAC05744.1.
AL162254 Genomic DNA. Translation: CAI16291.1.
CH471090 Genomic DNA. Translation: EAW87541.1.
BC136857 mRNA. Translation: AAI36858.1.
BC136859 mRNA. Translation: AAI36860.1.
BK004231 Genomic DNA. Translation: DAA04629.1.
CCDSiCCDS35128.1.
RefSeqiNP_001005234.1. NM_001005234.1.
UniGeneiHs.626839.

3D structure databases

ProteinModelPortaliQ8NH93.
SMRiQ8NH93. Positions 27-304.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302863.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR1L3.
DMDMi38372830.

Proteomic databases

PaxDbiQ8NH93.
PRIDEiQ8NH93.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304820; ENSP00000302863; ENSG00000171481.
GeneIDi26735.
KEGGihsa:26735.
UCSCiuc011lzb.2. human.

Organism-specific databases

CTDi26735.
GeneCardsiGC09P125438.
HGNCiHGNC:8215. OR1L3.
HPAiHPA058878.
neXtProtiNX_Q8NH93.
PharmGKBiPA32085.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG44632.
GeneTreeiENSGT00800000124028.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH93.
KOiK04257.
OMAiYVTVMNH.
OrthoDBiEOG7D85WJ.
PhylomeDBiQ8NH93.
TreeFamiTF341149.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1L3.
GenomeRNAii26735.
NextBioi49089.
PROiQ8NH93.

Gene expression databases

CleanExiHS_OR1L3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR1L3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH93
Secondary accession number(s): B2RNF4, Q6IFN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.