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Q8NH93 (OR1L3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 1L3
Alternative name(s):
Olfactory receptor 9-D
Short name=OR9-D
Olfactory receptor OR9-28
Gene names
Name:OR1L3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Olfactory receptor 1L3
PRO_0000150443

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4924Helical; Name=1; Potential
Topological domain50 – 578Cytoplasmic Potential
Transmembrane58 – 7922Helical; Name=2; Potential
Topological domain80 – 10021Extracellular Potential
Transmembrane101 – 12020Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 15819Helical; Name=4; Potential
Topological domain159 – 19638Extracellular Potential
Transmembrane197 – 21923Helical; Name=5; Potential
Topological domain220 – 23617Cytoplasmic Potential
Transmembrane237 – 25923Helical; Name=6; Potential
Topological domain260 – 27112Extracellular Potential
Transmembrane272 – 29120Helical; Name=7; Potential
Topological domain292 – 32433Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant541R → G.
Corresponds to variant rs12379744 [ dbSNP | Ensembl ].
VAR_059979
Natural variant1061V → A.
Corresponds to variant rs16912096 [ dbSNP | Ensembl ].
VAR_034169
Natural variant1211N → D.
Corresponds to variant rs16912099 [ dbSNP | Ensembl ].
VAR_034170

Sequences

Sequence LengthMass (Da)Tools
Q8NH93 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 088889EBE28353F8

FASTA32436,633
        10         20         30         40         50         60 
MGMSNLTRLS EFILLGLSSR SEDQRPLFAL FLIIYLVTLM GNLLIILAIH SDPRLQNPMY 

        70         80         90        100        110        120 
FFLSILSFAD ICYTTVIVPK MLVNFLSEKK TISYAECLAQ MYFFLVFGNI DSYLLAAMAI 

       130        140        150        160        170        180 
NRCVAICNPF HYVTVMNRRC CVLLLAFPIT FSYFHSLLHV LLVNRLTFCT SNVIHHFFCD 

       190        200        210        220        230        240 
VNPVLKLSCS STFVNEIVAM TEGLASVMAP FVCIIISYLR ILIAVLKIPS AAGKHKAFST 

       250        260        270        280        290        300 
CSSHLTVVIL FYGSISYVYL QPLSSYTVKD RIATINYTVL TSVLNPFIYS LRNKDMKRGL 

       310        320 
QKLINKIKSQ MSRFSTKTNK ICGP 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065492 Genomic DNA. Translation: BAC05744.1.
AL162254 Genomic DNA. Translation: CAI16291.1.
CH471090 Genomic DNA. Translation: EAW87541.1.
BC136857 mRNA. Translation: AAI36858.1.
BC136859 mRNA. Translation: AAI36860.1.
BK004231 Genomic DNA. Translation: DAA04629.1.
RefSeqNP_001005234.1. NM_001005234.1.
UniGeneHs.626839.

3D structure databases

ProteinModelPortalQ8NH93.
SMRQ8NH93. Positions 30-306.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000302863.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372830.

Proteomic databases

PaxDbQ8NH93.
PRIDEQ8NH93.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000304820; ENSP00000302863; ENSG00000171481.
GeneID26735.
KEGGhsa:26735.
UCSCuc011lzb.2. human.

Organism-specific databases

CTD26735.
GeneCardsGC09P125438.
HGNCHGNC:8215. OR1L3.
HPAHPA058878.
neXtProtNX_Q8NH93.
PharmGKBPA32085.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG44632.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NH93.
KOK04257.
OMAGMSNLTR.
OrthoDBEOG7D85WJ.
PhylomeDBQ8NH93.
TreeFamTF341149.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR1L3.
GenevestigatorQ8NH93.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR1L3.
GenomeRNAi26735.
NextBio49089.
PROQ8NH93.

Entry information

Entry nameOR1L3_HUMAN
AccessionPrimary (citable) accession number: Q8NH93
Secondary accession number(s): B2RNF4, Q6IFN1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries