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Protein

Olfactory receptor 1S1

Gene

OR1S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1S1
Alternative name(s):
Olfactory receptor OR11-232
Gene namesi
Name:OR1S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8227. OR1S1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3838ExtracellularSequence analysisAdd
BLAST
Transmembranei39 – 6224Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini63 – 708CytoplasmicSequence analysis
Transmembranei71 – 9222Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini93 – 11321ExtracellularSequence analysisAdd
BLAST
Transmembranei114 – 13320Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini134 – 15219CytoplasmicSequence analysisAdd
BLAST
Transmembranei153 – 17119Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini172 – 20837ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 23224Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini233 – 24917CytoplasmicSequence analysisAdd
BLAST
Transmembranei250 – 27223Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini273 – 28513ExtracellularSequence analysisAdd
BLAST
Transmembranei286 – 30520Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini306 – 32520CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32098.

Polymorphism and mutation databases

BioMutaiOR1S1.
DMDMi218511728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Olfactory receptor 1S1PRO_0000150451Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi110 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH92.
PeptideAtlasiQ8NH92.
PRIDEiQ8NH92.

PTM databases

iPTMnetiQ8NH92.
PhosphoSiteiQ8NH92.

Expressioni

Gene expression databases

CleanExiHS_OR1S1.

Organism-specific databases

HPAiHPA049304.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311688.

Structurei

3D structure databases

ProteinModelPortaliQ8NH92.
SMRiQ8NH92. Positions 35-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKEE. Eukaryota.
ENOG411157D. LUCA.
GeneTreeiENSGT00810000125354.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH92.
KOiK04257.
OMAiGRNMHQG.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NH92.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFSSFLQI GRNMHQGNQT TITEFILLGF FKQDEHQNLL FVLFLGMYLV
60 70 80 90 100
TVIGNGLIIV AISLDTYLHT PMYLFLANLS FADISSISNS VPKMLVNIQT
110 120 130 140 150
KSQSISYESC ITQMYFSIVF VVIDNLLLGT MAYDHFVAIC HPLNYTILMR
160 170 180 190 200
PRFGILLTVI SWFLSNIIAL THTLLLIQLL FCNHNTLPHF FCDLAPLLKL
210 220 230 240 250
SCSDTLINEL VLFIVGLSVI IFPFTLSFFS YVCIIRAVLR VSSTQGKWKA
260 270 280 290 300
FSTCGSHLTV VLLFYGTIVG VYFFPSSTHP EDTDKIGAVL FTVVTPMINP
310 320
FIYSLRNKDM KGALRKLINR KISSL
Length:325
Mass (Da):36,707
Last modified:December 16, 2008 - v2
Checksum:iCDA11EA9E0CD4588
GO

Sequence cautioni

The sequence BAC05745 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti5 – 51S → G.
Corresponds to variant rs1966836 [ dbSNP | Ensembl ].
VAR_048039
Natural varianti123 – 1231I → T.
Corresponds to variant rs1966835 [ dbSNP | Ensembl ].
VAR_048040
Natural varianti135 – 1351H → R.
Corresponds to variant rs1966834 [ dbSNP | Ensembl ].
VAR_048041
Natural varianti183 – 1831N → D.
Corresponds to variant rs1993088 [ dbSNP | Ensembl ].
VAR_048042
Natural varianti206 – 2061L → M.
Corresponds to variant rs2867400 [ dbSNP | Ensembl ].
VAR_048043
Natural varianti227 – 2271S → I.
Corresponds to variant rs2903566 [ dbSNP | Ensembl ].
VAR_048044

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065493 Genomic DNA. Translation: BAC05745.1. Different initiation.
CH471076 Genomic DNA. Translation: EAW73800.1.
BK004299 Genomic DNA. Translation: DAA04697.1.
CCDSiCCDS31546.1.
RefSeqiNP_001004458.1. NM_001004458.1.
UniGeneiHs.553645.

Genome annotation databases

EnsembliENST00000309433; ENSP00000311688; ENSG00000172774.
ENST00000624470; ENSP00000485156; ENSG00000280204.
ENST00000624482; ENSP00000485365; ENSG00000280204.
GeneIDi219959.
KEGGihsa:219959.
UCSCiuc010rkc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065493 Genomic DNA. Translation: BAC05745.1. Different initiation.
CH471076 Genomic DNA. Translation: EAW73800.1.
BK004299 Genomic DNA. Translation: DAA04697.1.
CCDSiCCDS31546.1.
RefSeqiNP_001004458.1. NM_001004458.1.
UniGeneiHs.553645.

3D structure databases

ProteinModelPortaliQ8NH92.
SMRiQ8NH92. Positions 35-176.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311688.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH92.
PhosphoSiteiQ8NH92.

Polymorphism and mutation databases

BioMutaiOR1S1.
DMDMi218511728.

Proteomic databases

PaxDbiQ8NH92.
PeptideAtlasiQ8NH92.
PRIDEiQ8NH92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309433; ENSP00000311688; ENSG00000172774.
ENST00000624470; ENSP00000485156; ENSG00000280204.
ENST00000624482; ENSP00000485365; ENSG00000280204.
GeneIDi219959.
KEGGihsa:219959.
UCSCiuc010rkc.2. human.

Organism-specific databases

CTDi219959.
GeneCardsiOR1S1.
HGNCiHGNC:8227. OR1S1.
HPAiHPA049304.
neXtProtiNX_Q8NH92.
PharmGKBiPA32098.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKEE. Eukaryota.
ENOG411157D. LUCA.
GeneTreeiENSGT00810000125354.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH92.
KOiK04257.
OMAiGRNMHQG.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NH92.
TreeFamiTF337210.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1S1.
GenomeRNAii219959.
PROiQ8NH92.

Gene expression databases

CleanExiHS_OR1S1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1S1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH92
Secondary accession number(s): Q6IFG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 16, 2008
Last modified: September 7, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.