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Protein

Olfactory receptor 1S1

Gene

OR1S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172774-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1S1
Alternative name(s):
Olfactory receptor OR11-232
Gene namesi
Name:OR1S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8227. OR1S1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 38ExtracellularSequence analysisAdd BLAST38
Transmembranei39 – 62Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini63 – 70CytoplasmicSequence analysis8
Transmembranei71 – 92Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini93 – 113ExtracellularSequence analysisAdd BLAST21
Transmembranei114 – 133Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini134 – 152CytoplasmicSequence analysisAdd BLAST19
Transmembranei153 – 171Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini172 – 208ExtracellularSequence analysisAdd BLAST37
Transmembranei209 – 232Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini233 – 249CytoplasmicSequence analysisAdd BLAST17
Transmembranei250 – 272Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini273 – 285ExtracellularSequence analysisAdd BLAST13
Transmembranei286 – 305Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini306 – 325CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000280204.
PharmGKBiPA32098.

Polymorphism and mutation databases

BioMutaiOR1S1.
DMDMi218511728.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504511 – 325Olfactory receptor 1S1Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi110 ↔ 202PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH92.
PeptideAtlasiQ8NH92.
PRIDEiQ8NH92.

PTM databases

iPTMnetiQ8NH92.
PhosphoSitePlusiQ8NH92.

Expressioni

Gene expression databases

CleanExiHS_OR1S1.

Organism-specific databases

HPAiHPA049304.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311688.

Structurei

3D structure databases

ProteinModelPortaliQ8NH92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKEE. Eukaryota.
ENOG411157D. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH92.
KOiK04257.
OMAiGRNMHQG.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NH92.
TreeFamiTF337210.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTFSSFLQI GRNMHQGNQT TITEFILLGF FKQDEHQNLL FVLFLGMYLV
60 70 80 90 100
TVIGNGLIIV AISLDTYLHT PMYLFLANLS FADISSISNS VPKMLVNIQT
110 120 130 140 150
KSQSISYESC ITQMYFSIVF VVIDNLLLGT MAYDHFVAIC HPLNYTILMR
160 170 180 190 200
PRFGILLTVI SWFLSNIIAL THTLLLIQLL FCNHNTLPHF FCDLAPLLKL
210 220 230 240 250
SCSDTLINEL VLFIVGLSVI IFPFTLSFFS YVCIIRAVLR VSSTQGKWKA
260 270 280 290 300
FSTCGSHLTV VLLFYGTIVG VYFFPSSTHP EDTDKIGAVL FTVVTPMINP
310 320
FIYSLRNKDM KGALRKLINR KISSL
Length:325
Mass (Da):36,707
Last modified:December 16, 2008 - v2
Checksum:iCDA11EA9E0CD4588
GO

Sequence cautioni

The sequence BAC05745 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0480395S → G.Corresponds to variant rs1966836dbSNPEnsembl.1
Natural variantiVAR_048040123I → T.Corresponds to variant rs1966835dbSNPEnsembl.1
Natural variantiVAR_048041135H → R.Corresponds to variant rs1966834dbSNPEnsembl.1
Natural variantiVAR_048042183N → D.Corresponds to variant rs1993088dbSNPEnsembl.1
Natural variantiVAR_048043206L → M.Corresponds to variant rs2867400dbSNPEnsembl.1
Natural variantiVAR_048044227S → I.Corresponds to variant rs2903566dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065493 Genomic DNA. Translation: BAC05745.1. Different initiation.
CH471076 Genomic DNA. Translation: EAW73800.1.
BK004299 Genomic DNA. Translation: DAA04697.1.
RefSeqiNP_001004458.1. NM_001004458.1.
UniGeneiHs.553645.

Genome annotation databases

EnsembliENST00000624470; ENSP00000485156; ENSG00000280204.
GeneIDi219959.
KEGGihsa:219959.
UCSCiuc010rkc.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065493 Genomic DNA. Translation: BAC05745.1. Different initiation.
CH471076 Genomic DNA. Translation: EAW73800.1.
BK004299 Genomic DNA. Translation: DAA04697.1.
RefSeqiNP_001004458.1. NM_001004458.1.
UniGeneiHs.553645.

3D structure databases

ProteinModelPortaliQ8NH92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311688.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH92.
PhosphoSitePlusiQ8NH92.

Polymorphism and mutation databases

BioMutaiOR1S1.
DMDMi218511728.

Proteomic databases

PaxDbiQ8NH92.
PeptideAtlasiQ8NH92.
PRIDEiQ8NH92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000624470; ENSP00000485156; ENSG00000280204.
GeneIDi219959.
KEGGihsa:219959.
UCSCiuc010rkc.2. human.

Organism-specific databases

CTDi219959.
GeneCardsiOR1S1.
HGNCiHGNC:8227. OR1S1.
HPAiHPA049304.
neXtProtiNX_Q8NH92.
OpenTargetsiENSG00000280204.
PharmGKBiPA32098.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKEE. Eukaryota.
ENOG411157D. LUCA.
GeneTreeiENSGT00860000133676.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH92.
KOiK04257.
OMAiGRNMHQG.
OrthoDBiEOG091G0B53.
PhylomeDBiQ8NH92.
TreeFamiTF337210.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172774-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR1S1.
GenomeRNAii219959.
PROiQ8NH92.

Gene expression databases

CleanExiHS_OR1S1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1S1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH92
Secondary accession number(s): Q6IFG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: December 16, 2008
Last modified: November 30, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-14 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.