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Q8NH90

- O5AK2_HUMAN

UniProt

Q8NH90 - O5AK2_HUMAN

Protein

Olfactory receptor 5AK2

Gene

OR5AK2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5AK2
    Gene namesi
    Name:OR5AK2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15251. OR5AK2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32460.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Olfactory receptor 5AK2PRO_0000150575Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
    Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH90.
    PRIDEiQ8NH90.

    Expressioni

    Gene expression databases

    BgeeiQ8NH90.
    CleanExiHS_OR5AK2.
    GenevestigatoriQ8NH90.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH90.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini155 – 19642ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 30917CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei134 – 15421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45497.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NH90.
    KOiK04257.
    OMAiNVDINIM.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NH90.
    TreeFamiTF352756.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH90-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLGNSTEVT EFYLLGFGAQ HEFWCILFIV FLLIYVTSIM GNSGIILLIN    50
    TDSRFQTLTY FFLQHLAFVD ICYTSAITPK MLQSFTEEKN LMLFQGCVIQ 100
    FLVYATFATS DCYLLAMMAV DPYVAICKPL HYTVIMSRTV CIRLVAGSYI 150
    MGSINASVQT GFTCSLSFCK SNSINHFFCD VPPILALSCS NVDINIMLLV 200
    VFVGSNLIFT GLVVIFSYIY IMATILKMSS SAGRKKSFST CASHLTAVTI 250
    FYGTLSYMYL QSHSNNSQEN MKVAFIFYGT VIPMLNPLIY SLRNKEVKEA 300
    LKVIGKKLF 309
    Length:309
    Mass (Da):34,627
    Last modified:October 1, 2002 - v1
    Checksum:i6022418115A44AC4
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41G → V.
    Corresponds to variant rs10896563 [ dbSNP | Ensembl ].
    VAR_034215
    Natural varianti43 – 431S → T.
    Corresponds to variant rs12420424 [ dbSNP | Ensembl ].
    VAR_060007
    Natural varianti92 – 921M → I.1 Publication
    Corresponds to variant rs2853083 [ dbSNP | Ensembl ].
    VAR_034216

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065496 Genomic DNA. Translation: BAC05747.1.
    BC137198 mRNA. Translation: AAI37199.1.
    CCDSiCCDS31538.1.
    RefSeqiNP_001005323.1. NM_001005323.1.
    UniGeneiHs.554520.

    Genome annotation databases

    EnsembliENST00000326855; ENSP00000322784; ENSG00000181273.
    GeneIDi390181.
    KEGGihsa:390181.
    UCSCiuc010rjp.2. human.

    Polymorphism databases

    DMDMi38372829.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065496 Genomic DNA. Translation: BAC05747.1 .
    BC137198 mRNA. Translation: AAI37199.1 .
    CCDSi CCDS31538.1.
    RefSeqi NP_001005323.1. NM_001005323.1.
    UniGenei Hs.554520.

    3D structure databases

    ProteinModelPortali Q8NH90.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372829.

    Proteomic databases

    PaxDbi Q8NH90.
    PRIDEi Q8NH90.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000326855 ; ENSP00000322784 ; ENSG00000181273 .
    GeneIDi 390181.
    KEGGi hsa:390181.
    UCSCi uc010rjp.2. human.

    Organism-specific databases

    CTDi 390181.
    GeneCardsi GC11P056756.
    HGNCi HGNC:15251. OR5AK2.
    neXtProti NX_Q8NH90.
    PharmGKBi PA32460.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45497.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NH90.
    KOi K04257.
    OMAi NVDINIM.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NH90.
    TreeFami TF352756.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5AK2.
    GenomeRNAii 390181.
    NextBioi 103486.
    PROi Q8NH90.

    Gene expression databases

    Bgeei Q8NH90.
    CleanExi HS_OR5AK2.
    Genevestigatori Q8NH90.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-92.

    Entry informationi

    Entry nameiO5AK2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH90
    Secondary accession number(s): B2RNZ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3