Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NH90 (O5AK2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5AK2
Gene names
Name:OR5AK2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Olfactory receptor 5AK2
PRO_0000150575

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13313Cytoplasmic Potential
Transmembrane134 – 15421Helical; Name=4; Potential
Topological domain155 – 19642Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 30917Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation1551N-linked (GlcNAc...) Potential
Glycosylation2651N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant41G → V.
Corresponds to variant rs10896563 [ dbSNP | Ensembl ].
VAR_034215
Natural variant431S → T.
Corresponds to variant rs12420424 [ dbSNP | Ensembl ].
VAR_060007
Natural variant921M → I. Ref.2
Corresponds to variant rs2853083 [ dbSNP | Ensembl ].
VAR_034216

Sequences

Sequence LengthMass (Da)Tools
Q8NH90 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 6022418115A44AC4

FASTA30934,627
        10         20         30         40         50         60 
MTLGNSTEVT EFYLLGFGAQ HEFWCILFIV FLLIYVTSIM GNSGIILLIN TDSRFQTLTY 

        70         80         90        100        110        120 
FFLQHLAFVD ICYTSAITPK MLQSFTEEKN LMLFQGCVIQ FLVYATFATS DCYLLAMMAV 

       130        140        150        160        170        180 
DPYVAICKPL HYTVIMSRTV CIRLVAGSYI MGSINASVQT GFTCSLSFCK SNSINHFFCD 

       190        200        210        220        230        240 
VPPILALSCS NVDINIMLLV VFVGSNLIFT GLVVIFSYIY IMATILKMSS SAGRKKSFST 

       250        260        270        280        290        300 
CASHLTAVTI FYGTLSYMYL QSHSNNSQEN MKVAFIFYGT VIPMLNPLIY SLRNKEVKEA 


LKVIGKKLF 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-92.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065496 Genomic DNA. Translation: BAC05747.1.
BC137198 mRNA. Translation: AAI37199.1.
RefSeqNP_001005323.1. NM_001005323.1.
UniGeneHs.554520.

3D structure databases

ProteinModelPortalQ8NH90.
SMRQ8NH90. Positions 109-140, 278-306.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372829.

Proteomic databases

PaxDbQ8NH90.
PRIDEQ8NH90.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000326855; ENSP00000322784; ENSG00000181273.
GeneID390181.
KEGGhsa:390181.
UCSCuc010rjp.2. human.

Organism-specific databases

CTD390181.
GeneCardsGC11P056756.
HGNCHGNC:15251. OR5AK2.
neXtProtNX_Q8NH90.
PharmGKBPA32460.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45497.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NH90.
KOK04257.
OMANVDINIM.
OrthoDBEOG71K63J.
PhylomeDBQ8NH90.
TreeFamTF352756.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NH90.
CleanExHS_OR5AK2.
GenevestigatorQ8NH90.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5AK2.
GenomeRNAi390181.
NextBio103486.
PROQ8NH90.

Entry information

Entry nameO5AK2_HUMAN
AccessionPrimary (citable) accession number: Q8NH90
Secondary accession number(s): B2RNZ9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries