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Protein

Olfactory receptor 5AK2

Gene

OR5AK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5AK2
Gene namesi
Name:OR5AK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15251. OR5AK2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei134 – 15421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini155 – 19642ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 30917CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32460.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 5AK2PRO_0000150575Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence Analysis
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH90.
PRIDEiQ8NH90.

Expressioni

Gene expression databases

BgeeiQ8NH90.
CleanExiHS_OR5AK2.
GenevestigatoriQ8NH90.

Structurei

3D structure databases

ProteinModelPortaliQ8NH90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45497.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH90.
KOiK04257.
OMAiNVDINIM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH90.
TreeFamiTF352756.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH90-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLGNSTEVT EFYLLGFGAQ HEFWCILFIV FLLIYVTSIM GNSGIILLIN
60 70 80 90 100
TDSRFQTLTY FFLQHLAFVD ICYTSAITPK MLQSFTEEKN LMLFQGCVIQ
110 120 130 140 150
FLVYATFATS DCYLLAMMAV DPYVAICKPL HYTVIMSRTV CIRLVAGSYI
160 170 180 190 200
MGSINASVQT GFTCSLSFCK SNSINHFFCD VPPILALSCS NVDINIMLLV
210 220 230 240 250
VFVGSNLIFT GLVVIFSYIY IMATILKMSS SAGRKKSFST CASHLTAVTI
260 270 280 290 300
FYGTLSYMYL QSHSNNSQEN MKVAFIFYGT VIPMLNPLIY SLRNKEVKEA

LKVIGKKLF
Length:309
Mass (Da):34,627
Last modified:October 1, 2002 - v1
Checksum:i6022418115A44AC4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41G → V.
Corresponds to variant rs10896563 [ dbSNP | Ensembl ].
VAR_034215
Natural varianti43 – 431S → T.
Corresponds to variant rs12420424 [ dbSNP | Ensembl ].
VAR_060007
Natural varianti92 – 921M → I.1 Publication
Corresponds to variant rs2853083 [ dbSNP | Ensembl ].
VAR_034216

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065496 Genomic DNA. Translation: BAC05747.1.
BC137198 mRNA. Translation: AAI37199.1.
CCDSiCCDS31538.1.
RefSeqiNP_001005323.1. NM_001005323.1.
UniGeneiHs.554520.

Genome annotation databases

EnsembliENST00000326855; ENSP00000322784; ENSG00000181273.
GeneIDi390181.
KEGGihsa:390181.
UCSCiuc010rjp.2. human.

Polymorphism databases

DMDMi38372829.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065496 Genomic DNA. Translation: BAC05747.1.
BC137198 mRNA. Translation: AAI37199.1.
CCDSiCCDS31538.1.
RefSeqiNP_001005323.1. NM_001005323.1.
UniGeneiHs.554520.

3D structure databases

ProteinModelPortaliQ8NH90.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi38372829.

Proteomic databases

PaxDbiQ8NH90.
PRIDEiQ8NH90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326855; ENSP00000322784; ENSG00000181273.
GeneIDi390181.
KEGGihsa:390181.
UCSCiuc010rjp.2. human.

Organism-specific databases

CTDi390181.
GeneCardsiGC11P056756.
HGNCiHGNC:15251. OR5AK2.
neXtProtiNX_Q8NH90.
PharmGKBiPA32460.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG45497.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH90.
KOiK04257.
OMAiNVDINIM.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH90.
TreeFamiTF352756.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5AK2.
GenomeRNAii390181.
NextBioi103486.
PROiQ8NH90.

Gene expression databases

BgeeiQ8NH90.
CleanExiHS_OR5AK2.
GenevestigatoriQ8NH90.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ILE-92.

Entry informationi

Entry nameiO5AK2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH90
Secondary accession number(s): B2RNZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.