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Protein

Olfactory receptor 9G1

Gene

OR9G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9G1
Alternative name(s):
Olfactory receptor 9G5
Olfactory receptor OR11-114
Gene namesi
Name:OR9G1
Synonyms:OR9G5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15319. OR9G1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini46 – 538CytoplasmicSequence Analysis
Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini75 – 9824ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
BLAST
Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 30514CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32788.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Olfactory receptor 9G1PRO_0000150678Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH87.
PRIDEiQ8NH87.

PTM databases

PhosphoSiteiQ8NH87.

Expressioni

Gene expression databases

CleanExiHS_OR9G1.
GenevestigatoriQ8NH87.

Structurei

3D structure databases

ProteinModelPortaliQ8NH87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46352.
GeneTreeiENSGT00780000121966.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH87.
KOiK04257.
OMAiCNDNIID.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH87.
TreeFamiTF352735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH87-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRSNHTVTE FILLGFTTDP GMQLGLFVVF LGVYSLTVVG NSTLIVLICN
60 70 80 90 100
DSCLHTPMYF FTGNLSFLDL WYSSVYTPKI LVTCISEDKS ISFAGCLCQF
110 120 130 140 150
FFSAGLAYSE CYLLAAVAYD RYVAISKPLL YAQAMSIKLC ALLVAVSYCG
160 170 180 190 200
GFINSSIITK KTFSFNFCRE NIIDDFFCDL LPLVELACGE KGGYKIMMYF
210 220 230 240 250
LLASNVICPA VLILASYLFI ITSVLRISSS KGYLKAFSTC SSHLTSVTLY
260 270 280 290 300
YGSILYIYAL PRSSYSFDMD KIVSTFYTVV FPMLNLMIYS LRNKDVKEAL

KKLLP
Length:305
Mass (Da):34,071
Last modified:October 1, 2002 - v1
Checksum:iB6452BB0DAAF5523
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti53 – 531C → H in DAA04911. 1 PublicationCurated
Sequence conflicti53 – 531C → H in BAC05960. 1 PublicationCurated
Sequence conflicti62 – 621T → V in DAA04911. 1 PublicationCurated
Sequence conflicti62 – 621T → V in BAC05960. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti53 – 531C → R.
Corresponds to variant rs532637 [ dbSNP | Ensembl ].
VAR_032777
Natural varianti53 – 531C → Y.
Corresponds to variant rs532635 [ dbSNP | Ensembl ].
VAR_060017
Natural varianti61 – 611F → V.
Corresponds to variant rs3975155 [ dbSNP | Ensembl ].
VAR_032778
Natural varianti62 – 621T → I.
Corresponds to variant rs2865520 [ dbSNP | Ensembl ].
VAR_060018
Natural varianti83 – 831T → I.
Corresponds to variant rs602224 [ dbSNP | Ensembl ].
VAR_032779
Natural varianti98 – 981C → G.
Corresponds to variant rs11228732 [ dbSNP | Ensembl ].
VAR_060019
Natural varianti112 – 1121Y → C.
Corresponds to variant rs4990194 [ dbSNP | Ensembl ].
VAR_032780
Natural varianti117 – 1171V → M.
Corresponds to variant rs591369 [ dbSNP | Ensembl ].
VAR_032781
Natural varianti169 – 1691R → C.
Corresponds to variant rs11228733 [ dbSNP | Ensembl ].
VAR_053254
Natural varianti185 – 1851E → K.
Corresponds to variant rs11228735 [ dbSNP | Ensembl ].
VAR_053255
Natural varianti231 – 2311K → Q.
Corresponds to variant rs12420076 [ dbSNP | Ensembl ].
VAR_053256
Natural varianti233 – 2331Y → C.
Corresponds to variant rs10896517 [ dbSNP | Ensembl ].
VAR_060020
Natural varianti233 – 2331Y → H.
Corresponds to variant rs10896516 [ dbSNP | Ensembl ].
VAR_060021
Natural varianti259 – 2591A → S.
Corresponds to variant rs7121276 [ dbSNP | Ensembl ].
VAR_034276

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065500 Genomic DNA. Translation: BAC05750.1.
AB065739 Genomic DNA. Translation: BAC05960.1.
BK004513 Genomic DNA. Translation: DAA04911.1.
CCDSiCCDS31536.1.
RefSeqiNP_001005213.1. NM_001005213.1.
UniGeneiHs.553752.

Genome annotation databases

EnsembliENST00000312153; ENSP00000309012; ENSG00000174914.
GeneIDi390174.
KEGGihsa:390174.

Polymorphism databases

DMDMi38372827.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065500 Genomic DNA. Translation: BAC05750.1.
AB065739 Genomic DNA. Translation: BAC05960.1.
BK004513 Genomic DNA. Translation: DAA04911.1.
CCDSiCCDS31536.1.
RefSeqiNP_001005213.1. NM_001005213.1.
UniGeneiHs.553752.

3D structure databases

ProteinModelPortaliQ8NH87.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NH87.

Polymorphism databases

DMDMi38372827.

Proteomic databases

PaxDbiQ8NH87.
PRIDEiQ8NH87.

Protocols and materials databases

DNASUi390174.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312153; ENSP00000309012; ENSG00000174914.
GeneIDi390174.
KEGGihsa:390174.

Organism-specific databases

CTDi390174.
GeneCardsiGC11P056469.
HGNCiHGNC:15319. OR9G1.
neXtProtiNX_Q8NH87.
PharmGKBiPA32788.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46352.
GeneTreeiENSGT00780000121966.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH87.
KOiK04257.
OMAiCNDNIID.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH87.
TreeFamiTF352735.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR9G1.
GenomeRNAii390174.
NextBioi103482.
PROiQ8NH87.

Gene expression databases

CleanExiHS_OR9G1.
GenevestigatoriQ8NH87.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR9G1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH87
Secondary accession number(s): Q6IEU9, Q8NGQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.