Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NH87 (OR9G1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 9G1
Alternative name(s):
Olfactory receptor 9G5
Olfactory receptor OR11-114
Gene names
Name:OR9G1
Synonyms:OR9G5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Olfactory receptor 9G1
PRO_0000150678

Regions

Topological domain1 – 2424Extracellular Potential
Transmembrane25 – 4521Helical; Name=1; Potential
Topological domain46 – 538Cytoplasmic Potential
Transmembrane54 – 7421Helical; Name=2; Potential
Topological domain75 – 9824Extracellular Potential
Transmembrane99 – 11921Helical; Name=3; Potential
Topological domain120 – 13819Cytoplasmic Potential
Transmembrane139 – 15921Helical; Name=4; Potential
Topological domain160 – 19637Extracellular Potential
Transmembrane197 – 21620Helical; Name=5; Potential
Topological domain217 – 23620Cytoplasmic Potential
Transmembrane237 – 25721Helical; Name=6; Potential
Topological domain258 – 27013Extracellular Potential
Transmembrane271 – 29121Helical; Name=7; Potential
Topological domain292 – 30514Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond96 ↔ 188 By similarity

Natural variations

Natural variant531C → R.
Corresponds to variant rs532637 [ dbSNP | Ensembl ].
VAR_032777
Natural variant531C → Y.
Corresponds to variant rs532635 [ dbSNP | Ensembl ].
VAR_060017
Natural variant611F → V.
Corresponds to variant rs3975155 [ dbSNP | Ensembl ].
VAR_032778
Natural variant621T → I.
Corresponds to variant rs2865520 [ dbSNP | Ensembl ].
VAR_060018
Natural variant831T → I.
Corresponds to variant rs602224 [ dbSNP | Ensembl ].
VAR_032779
Natural variant981C → G.
Corresponds to variant rs11228732 [ dbSNP | Ensembl ].
VAR_060019
Natural variant1121Y → C.
Corresponds to variant rs4990194 [ dbSNP | Ensembl ].
VAR_032780
Natural variant1171V → M.
Corresponds to variant rs591369 [ dbSNP | Ensembl ].
VAR_032781
Natural variant1691R → C.
Corresponds to variant rs11228733 [ dbSNP | Ensembl ].
VAR_053254
Natural variant1851E → K.
Corresponds to variant rs11228735 [ dbSNP | Ensembl ].
VAR_053255
Natural variant2311K → Q.
Corresponds to variant rs12420076 [ dbSNP | Ensembl ].
VAR_053256
Natural variant2331Y → C.
Corresponds to variant rs10896517 [ dbSNP | Ensembl ].
VAR_060020
Natural variant2331Y → H.
Corresponds to variant rs10896516 [ dbSNP | Ensembl ].
VAR_060021
Natural variant2591A → S.
Corresponds to variant rs7121276 [ dbSNP | Ensembl ].
VAR_034276

Experimental info

Sequence conflict531C → H in DAA04911. Ref.1
Sequence conflict531C → H in BAC05960. Ref.1
Sequence conflict621T → V in DAA04911. Ref.1
Sequence conflict621T → V in BAC05960. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8NH87 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: B6452BB0DAAF5523

FASTA30534,071
        10         20         30         40         50         60 
MQRSNHTVTE FILLGFTTDP GMQLGLFVVF LGVYSLTVVG NSTLIVLICN DSCLHTPMYF 

        70         80         90        100        110        120 
FTGNLSFLDL WYSSVYTPKI LVTCISEDKS ISFAGCLCQF FFSAGLAYSE CYLLAAVAYD 

       130        140        150        160        170        180 
RYVAISKPLL YAQAMSIKLC ALLVAVSYCG GFINSSIITK KTFSFNFCRE NIIDDFFCDL 

       190        200        210        220        230        240 
LPLVELACGE KGGYKIMMYF LLASNVICPA VLILASYLFI ITSVLRISSS KGYLKAFSTC 

       250        260        270        280        290        300 
SSHLTSVTLY YGSILYIYAL PRSSYSFDMD KIVSTFYTVV FPMLNLMIYS LRNKDVKEAL 


KKLLP 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065500 Genomic DNA. Translation: BAC05750.1.
AB065739 Genomic DNA. Translation: BAC05960.1.
BK004513 Genomic DNA. Translation: DAA04911.1.
CCDSCCDS31536.1.
RefSeqNP_001005213.1. NM_001005213.1.
UniGeneHs.553752.

3D structure databases

ProteinModelPortalQ8NH87.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NH87.

Polymorphism databases

DMDM38372827.

Proteomic databases

PaxDbQ8NH87.
PRIDEQ8NH87.

Protocols and materials databases

DNASU390174.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312153; ENSP00000309012; ENSG00000174914.
GeneID390174.
KEGGhsa:390174.

Organism-specific databases

CTD390174.
GeneCardsGC11P056469.
HGNCHGNC:15319. OR9G1.
neXtProtNX_Q8NH87.
PharmGKBPA32788.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG46352.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NH87.
KOK04257.
OMACNDNIID.
OrthoDBEOG71K63J.
PhylomeDBQ8NH87.
TreeFamTF352735.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR9G1.
GenevestigatorQ8NH87.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR9G1.
NextBio103482.
PROQ8NH87.

Entry information

Entry nameOR9G1_HUMAN
AccessionPrimary (citable) accession number: Q8NH87
Secondary accession number(s): Q6IEU9, Q8NGQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries