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Q8NH87

- OR9G1_HUMAN

UniProt

Q8NH87 - OR9G1_HUMAN

Protein

Olfactory receptor 9G1

Gene

OR9G1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 9G1
    Alternative name(s):
    Olfactory receptor 9G5
    Olfactory receptor OR11-114
    Gene namesi
    Name:OR9G1
    Synonyms:OR9G5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15319. OR9G1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32788.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 305305Olfactory receptor 9G1PRO_0000150678Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH87.
    PRIDEiQ8NH87.

    PTM databases

    PhosphoSiteiQ8NH87.

    Expressioni

    Gene expression databases

    CleanExiHS_OR9G1.
    GenevestigatoriQ8NH87.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH87.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini46 – 538CytoplasmicSequence Analysis
    Topological domaini75 – 9824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini160 – 19637ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini258 – 27013ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 30514CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21620Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei237 – 25721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei271 – 29121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46352.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NH87.
    KOiK04257.
    OMAiCNDNIID.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NH87.
    TreeFamiTF352735.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH87-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRSNHTVTE FILLGFTTDP GMQLGLFVVF LGVYSLTVVG NSTLIVLICN    50
    DSCLHTPMYF FTGNLSFLDL WYSSVYTPKI LVTCISEDKS ISFAGCLCQF 100
    FFSAGLAYSE CYLLAAVAYD RYVAISKPLL YAQAMSIKLC ALLVAVSYCG 150
    GFINSSIITK KTFSFNFCRE NIIDDFFCDL LPLVELACGE KGGYKIMMYF 200
    LLASNVICPA VLILASYLFI ITSVLRISSS KGYLKAFSTC SSHLTSVTLY 250
    YGSILYIYAL PRSSYSFDMD KIVSTFYTVV FPMLNLMIYS LRNKDVKEAL 300
    KKLLP 305
    Length:305
    Mass (Da):34,071
    Last modified:October 1, 2002 - v1
    Checksum:iB6452BB0DAAF5523
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531C → H in DAA04911. 1 PublicationCurated
    Sequence conflicti53 – 531C → H in BAC05960. 1 PublicationCurated
    Sequence conflicti62 – 621T → V in DAA04911. 1 PublicationCurated
    Sequence conflicti62 – 621T → V in BAC05960. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti53 – 531C → R.
    Corresponds to variant rs532637 [ dbSNP | Ensembl ].
    VAR_032777
    Natural varianti53 – 531C → Y.
    Corresponds to variant rs532635 [ dbSNP | Ensembl ].
    VAR_060017
    Natural varianti61 – 611F → V.
    Corresponds to variant rs3975155 [ dbSNP | Ensembl ].
    VAR_032778
    Natural varianti62 – 621T → I.
    Corresponds to variant rs2865520 [ dbSNP | Ensembl ].
    VAR_060018
    Natural varianti83 – 831T → I.
    Corresponds to variant rs602224 [ dbSNP | Ensembl ].
    VAR_032779
    Natural varianti98 – 981C → G.
    Corresponds to variant rs11228732 [ dbSNP | Ensembl ].
    VAR_060019
    Natural varianti112 – 1121Y → C.
    Corresponds to variant rs4990194 [ dbSNP | Ensembl ].
    VAR_032780
    Natural varianti117 – 1171V → M.
    Corresponds to variant rs591369 [ dbSNP | Ensembl ].
    VAR_032781
    Natural varianti169 – 1691R → C.
    Corresponds to variant rs11228733 [ dbSNP | Ensembl ].
    VAR_053254
    Natural varianti185 – 1851E → K.
    Corresponds to variant rs11228735 [ dbSNP | Ensembl ].
    VAR_053255
    Natural varianti231 – 2311K → Q.
    Corresponds to variant rs12420076 [ dbSNP | Ensembl ].
    VAR_053256
    Natural varianti233 – 2331Y → C.
    Corresponds to variant rs10896517 [ dbSNP | Ensembl ].
    VAR_060020
    Natural varianti233 – 2331Y → H.
    Corresponds to variant rs10896516 [ dbSNP | Ensembl ].
    VAR_060021
    Natural varianti259 – 2591A → S.
    Corresponds to variant rs7121276 [ dbSNP | Ensembl ].
    VAR_034276

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065500 Genomic DNA. Translation: BAC05750.1.
    AB065739 Genomic DNA. Translation: BAC05960.1.
    BK004513 Genomic DNA. Translation: DAA04911.1.
    CCDSiCCDS31536.1.
    RefSeqiNP_001005213.1. NM_001005213.1.
    UniGeneiHs.553752.

    Genome annotation databases

    EnsembliENST00000312153; ENSP00000309012; ENSG00000174914.
    GeneIDi390174.
    KEGGihsa:390174.

    Polymorphism databases

    DMDMi38372827.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065500 Genomic DNA. Translation: BAC05750.1 .
    AB065739 Genomic DNA. Translation: BAC05960.1 .
    BK004513 Genomic DNA. Translation: DAA04911.1 .
    CCDSi CCDS31536.1.
    RefSeqi NP_001005213.1. NM_001005213.1.
    UniGenei Hs.553752.

    3D structure databases

    ProteinModelPortali Q8NH87.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NH87.

    Polymorphism databases

    DMDMi 38372827.

    Proteomic databases

    PaxDbi Q8NH87.
    PRIDEi Q8NH87.

    Protocols and materials databases

    DNASUi 390174.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312153 ; ENSP00000309012 ; ENSG00000174914 .
    GeneIDi 390174.
    KEGGi hsa:390174.

    Organism-specific databases

    CTDi 390174.
    GeneCardsi GC11P056469.
    HGNCi HGNC:15319. OR9G1.
    neXtProti NX_Q8NH87.
    PharmGKBi PA32788.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46352.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NH87.
    KOi K04257.
    OMAi CNDNIID.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NH87.
    TreeFami TF352735.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR9G1.
    NextBioi 103482.
    PROi Q8NH87.

    Gene expression databases

    CleanExi HS_OR9G1.
    Genevestigatori Q8NH87.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR9G1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH87
    Secondary accession number(s): Q6IEU9, Q8NGQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3