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Protein

Olfactory receptor 9G1

Gene

OR9G1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174914-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 9G1
Alternative name(s):
Olfactory receptor 9G5
Olfactory receptor OR11-114
Gene namesi
Name:OR9G1
Synonyms:OR9G5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15319. OR9G1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 53CytoplasmicSequence analysis8
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 98ExtracellularSequence analysisAdd BLAST24
Transmembranei99 – 119Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 159Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini160 – 196ExtracellularSequence analysisAdd BLAST37
Transmembranei197 – 216Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini217 – 236CytoplasmicSequence analysisAdd BLAST20
Transmembranei237 – 257Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini258 – 270ExtracellularSequence analysisAdd BLAST13
Transmembranei271 – 291Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini292 – 305CytoplasmicSequence analysisAdd BLAST14

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174914.
PharmGKBiPA32788.

Polymorphism and mutation databases

BioMutaiOR9G1.
DMDMi38372827.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506781 – 305Olfactory receptor 9G1Add BLAST305

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH87.
PeptideAtlasiQ8NH87.
PRIDEiQ8NH87.

PTM databases

iPTMnetiQ8NH87.
PhosphoSitePlusiQ8NH87.

Expressioni

Gene expression databases

CleanExiHS_OR9G1.

Structurei

3D structure databases

ProteinModelPortaliQ8NH87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHAM. Eukaryota.
ENOG4111CQM. LUCA.
GeneTreeiENSGT00800000124117.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH87.
KOiK04257.
OMAiCNDNIID.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH87.
TreeFamiTF352735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRSNHTVTE FILLGFTTDP GMQLGLFVVF LGVYSLTVVG NSTLIVLICN
60 70 80 90 100
DSCLHTPMYF FTGNLSFLDL WYSSVYTPKI LVTCISEDKS ISFAGCLCQF
110 120 130 140 150
FFSAGLAYSE CYLLAAVAYD RYVAISKPLL YAQAMSIKLC ALLVAVSYCG
160 170 180 190 200
GFINSSIITK KTFSFNFCRE NIIDDFFCDL LPLVELACGE KGGYKIMMYF
210 220 230 240 250
LLASNVICPA VLILASYLFI ITSVLRISSS KGYLKAFSTC SSHLTSVTLY
260 270 280 290 300
YGSILYIYAL PRSSYSFDMD KIVSTFYTVV FPMLNLMIYS LRNKDVKEAL

KKLLP
Length:305
Mass (Da):34,071
Last modified:October 1, 2002 - v1
Checksum:iB6452BB0DAAF5523
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti53C → H in DAA04911 (Ref. 1) Curated1
Sequence conflicti53C → H in BAC05960 (Ref. 1) Curated1
Sequence conflicti62T → V in DAA04911 (Ref. 1) Curated1
Sequence conflicti62T → V in BAC05960 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03277753C → R.Corresponds to variant rs532637dbSNPEnsembl.1
Natural variantiVAR_06001753C → Y.Corresponds to variant rs532635dbSNPEnsembl.1
Natural variantiVAR_03277861F → V.Corresponds to variant rs3975155dbSNPEnsembl.1
Natural variantiVAR_06001862T → I.Corresponds to variant rs2865520dbSNPEnsembl.1
Natural variantiVAR_03277983T → I.Corresponds to variant rs602224dbSNPEnsembl.1
Natural variantiVAR_06001998C → G.Corresponds to variant rs11228732dbSNPEnsembl.1
Natural variantiVAR_032780112Y → C.Corresponds to variant rs4990194dbSNPEnsembl.1
Natural variantiVAR_032781117V → M.Corresponds to variant rs591369dbSNPEnsembl.1
Natural variantiVAR_053254169R → C.Corresponds to variant rs11228733dbSNPEnsembl.1
Natural variantiVAR_053255185E → K.Corresponds to variant rs11228735dbSNPEnsembl.1
Natural variantiVAR_053256231K → Q.Corresponds to variant rs12420076dbSNPEnsembl.1
Natural variantiVAR_060020233Y → C.Corresponds to variant rs10896517dbSNPEnsembl.1
Natural variantiVAR_060021233Y → H.Corresponds to variant rs10896516dbSNPEnsembl.1
Natural variantiVAR_034276259A → S.Corresponds to variant rs7121276dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065500 Genomic DNA. Translation: BAC05750.1.
AB065739 Genomic DNA. Translation: BAC05960.1.
BK004513 Genomic DNA. Translation: DAA04911.1.
CCDSiCCDS31536.1.
RefSeqiNP_001005213.1. NM_001005213.1.
UniGeneiHs.553752.

Genome annotation databases

EnsembliENST00000312153; ENSP00000309012; ENSG00000174914.
GeneIDi390174.
KEGGihsa:390174.
UCSCiuc010rjn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065500 Genomic DNA. Translation: BAC05750.1.
AB065739 Genomic DNA. Translation: BAC05960.1.
BK004513 Genomic DNA. Translation: DAA04911.1.
CCDSiCCDS31536.1.
RefSeqiNP_001005213.1. NM_001005213.1.
UniGeneiHs.553752.

3D structure databases

ProteinModelPortaliQ8NH87.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH87.
PhosphoSitePlusiQ8NH87.

Polymorphism and mutation databases

BioMutaiOR9G1.
DMDMi38372827.

Proteomic databases

PaxDbiQ8NH87.
PeptideAtlasiQ8NH87.
PRIDEiQ8NH87.

Protocols and materials databases

DNASUi390174.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312153; ENSP00000309012; ENSG00000174914.
GeneIDi390174.
KEGGihsa:390174.
UCSCiuc010rjn.2. human.

Organism-specific databases

CTDi390174.
GeneCardsiOR9G1.
HGNCiHGNC:15319. OR9G1.
neXtProtiNX_Q8NH87.
OpenTargetsiENSG00000174914.
PharmGKBiPA32788.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHAM. Eukaryota.
ENOG4111CQM. LUCA.
GeneTreeiENSGT00800000124117.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH87.
KOiK04257.
OMAiCNDNIID.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH87.
TreeFamiTF352735.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174914-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR9G1.
GenomeRNAii390174.
PROiQ8NH87.

Gene expression databases

CleanExiHS_OR9G1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR9G1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH87
Secondary accession number(s): Q6IEU9, Q8NGQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.