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Q8NH85

- OR5R1_HUMAN

UniProt

Q8NH85 - OR5R1_HUMAN

Protein

Olfactory receptor 5R1

Gene

OR5R1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5R1
    Alternative name(s):
    Olfactory receptor OR11-185
    Gene namesi
    Name:OR5R1
    Synonyms:OR5R1P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14841. OR5R1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32564.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Olfactory receptor 5R1PRO_0000150612Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
    Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH85.
    PRIDEiQ8NH85.

    PTM databases

    PhosphoSiteiQ8NH85.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5R1.
    GenevestigatoriQ8NH85.

    Organism-specific databases

    HPAiHPA049992.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308595.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH85.
    SMRiQ8NH85. Positions 30-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 32432CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG146677.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NH85.
    KOiK04257.
    OMAiVNITYVT.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NH85.
    TreeFamiTF352753.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH85-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEVNIIYVT VFILKGITNR PELQAPCFGV FLVIYLVTVL GNLGLITLIK    50
    IDTRLHTPMY YFLSHLAFVD LCYSSAITPK MMVNFVVERN TIPFHACATQ 100
    LGCFLTFMIT ECFLLASMAY DCYVAICSPL HYSTLMSRRV CIQLVAVPYI 150
    YSFLVALFHT VITFRLTYCG PNLINHFYCD DLPFLALSCS DTHMKEILIF 200
    AFAGFDMISS SSIVLTSYIF IIAAILRIRS TQGQHKAIST CGSHMVTVTI 250
    FYGTLIFMYL QPKSNHSLDT DKMASVFYTV VIPMLNPLIY SLRNKEVKDA 300
    SKKALDKGCE NLQILTFLKI RKLY 324
    Length:324
    Mass (Da):36,708
    Last modified:October 1, 2002 - v1
    Checksum:iC26CCA953E8846FE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti7 – 71I → T.
    Corresponds to variant rs7931261 [ dbSNP | Ensembl ].
    VAR_024102
    Natural varianti103 – 1031C → Y.
    Corresponds to variant rs7123108 [ dbSNP | Ensembl ].
    VAR_053205
    Natural varianti121 – 1211D → G.
    Corresponds to variant rs7111634 [ dbSNP | Ensembl ].
    VAR_053206
    Natural varianti122 – 1221C → R.
    Corresponds to variant rs6591324 [ dbSNP | Ensembl ].
    VAR_024103
    Natural varianti128 – 1281S → G.
    Corresponds to variant rs7933772 [ dbSNP | Ensembl ].
    VAR_053207
    Natural varianti132 – 1321Y → H.
    Corresponds to variant rs17150578 [ dbSNP | Ensembl ].
    VAR_053208
    Natural varianti162 – 1621I → T.
    Corresponds to variant rs12785840 [ dbSNP | Ensembl ].
    VAR_053209
    Natural varianti184 – 1841F → L.
    Corresponds to variant rs7930678 [ dbSNP | Ensembl ].
    VAR_024104
    Natural varianti274 – 2741A → V.
    Corresponds to variant rs998544 [ dbSNP | Ensembl ].
    VAR_024105

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065504 Genomic DNA. Translation: BAC05752.1.
    BK004514 Genomic DNA. Translation: DAA04912.1.
    CCDSiCCDS31530.1.
    RefSeqiNP_001004744.1. NM_001004744.1.
    UniGeneiHs.553630.

    Genome annotation databases

    EnsembliENST00000312253; ENSP00000308595; ENSG00000174942.
    GeneIDi219479.
    KEGGihsa:219479.
    UCSCiuc010rji.2. human.

    Polymorphism databases

    DMDMi60392877.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065504 Genomic DNA. Translation: BAC05752.1 .
    BK004514 Genomic DNA. Translation: DAA04912.1 .
    CCDSi CCDS31530.1.
    RefSeqi NP_001004744.1. NM_001004744.1.
    UniGenei Hs.553630.

    3D structure databases

    ProteinModelPortali Q8NH85.
    SMRi Q8NH85. Positions 30-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308595.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NH85.

    Polymorphism databases

    DMDMi 60392877.

    Proteomic databases

    PaxDbi Q8NH85.
    PRIDEi Q8NH85.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312253 ; ENSP00000308595 ; ENSG00000174942 .
    GeneIDi 219479.
    KEGGi hsa:219479.
    UCSCi uc010rji.2. human.

    Organism-specific databases

    CTDi 219479.
    GeneCardsi GC11M056186.
    HGNCi HGNC:14841. OR5R1.
    HPAi HPA049992.
    neXtProti NX_Q8NH85.
    PharmGKBi PA32564.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG146677.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NH85.
    KOi K04257.
    OMAi VNITYVT.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NH85.
    TreeFami TF352753.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5R1.
    GenomeRNAii 219479.
    NextBioi 90649.
    PROi Q8NH85.

    Gene expression databases

    CleanExi HS_OR5R1.
    Genevestigatori Q8NH85.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR5R1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH85
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3