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Q8NH85 (OR5R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5R1
Alternative name(s):
Olfactory receptor OR11-185
Gene names
Name:OR5R1
Synonyms:OR5R1P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Olfactory receptor 5R1
PRO_0000150612

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19636Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 32432Cytoplasmic Potential

Amino acid modifications

Glycosylation2651N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant71I → T.
Corresponds to variant rs7931261 [ dbSNP | Ensembl ].
VAR_024102
Natural variant1031C → Y.
Corresponds to variant rs7123108 [ dbSNP | Ensembl ].
VAR_053205
Natural variant1211D → G.
Corresponds to variant rs7111634 [ dbSNP | Ensembl ].
VAR_053206
Natural variant1221C → R.
Corresponds to variant rs6591324 [ dbSNP | Ensembl ].
VAR_024103
Natural variant1281S → G.
Corresponds to variant rs7933772 [ dbSNP | Ensembl ].
VAR_053207
Natural variant1321Y → H.
Corresponds to variant rs17150578 [ dbSNP | Ensembl ].
VAR_053208
Natural variant1621I → T.
Corresponds to variant rs12785840 [ dbSNP | Ensembl ].
VAR_053209
Natural variant1841F → L.
Corresponds to variant rs7930678 [ dbSNP | Ensembl ].
VAR_024104
Natural variant2741A → V.
Corresponds to variant rs998544 [ dbSNP | Ensembl ].
VAR_024105

Sequences

Sequence LengthMass (Da)Tools
Q8NH85 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: C26CCA953E8846FE

FASTA32436,708
        10         20         30         40         50         60 
MAEVNIIYVT VFILKGITNR PELQAPCFGV FLVIYLVTVL GNLGLITLIK IDTRLHTPMY 

        70         80         90        100        110        120 
YFLSHLAFVD LCYSSAITPK MMVNFVVERN TIPFHACATQ LGCFLTFMIT ECFLLASMAY 

       130        140        150        160        170        180 
DCYVAICSPL HYSTLMSRRV CIQLVAVPYI YSFLVALFHT VITFRLTYCG PNLINHFYCD 

       190        200        210        220        230        240 
DLPFLALSCS DTHMKEILIF AFAGFDMISS SSIVLTSYIF IIAAILRIRS TQGQHKAIST 

       250        260        270        280        290        300 
CGSHMVTVTI FYGTLIFMYL QPKSNHSLDT DKMASVFYTV VIPMLNPLIY SLRNKEVKDA 

       310        320 
SKKALDKGCE NLQILTFLKI RKLY 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065504 Genomic DNA. Translation: BAC05752.1.
BK004514 Genomic DNA. Translation: DAA04912.1.
CCDSCCDS31530.1.
RefSeqNP_001004744.1. NM_001004744.1.
UniGeneHs.553630.

3D structure databases

ProteinModelPortalQ8NH85.
SMRQ8NH85. Positions 30-250.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308595.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NH85.

Polymorphism databases

DMDM60392877.

Proteomic databases

PaxDbQ8NH85.
PRIDEQ8NH85.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312253; ENSP00000308595; ENSG00000174942.
GeneID219479.
KEGGhsa:219479.
UCSCuc010rji.2. human.

Organism-specific databases

CTD219479.
GeneCardsGC11M056186.
HGNCHGNC:14841. OR5R1.
HPAHPA049992.
neXtProtNX_Q8NH85.
PharmGKBPA32564.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG146677.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NH85.
KOK04257.
OMAVNITYVT.
OrthoDBEOG71K63J.
PhylomeDBQ8NH85.
TreeFamTF352753.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5R1.
GenevestigatorQ8NH85.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5R1.
GenomeRNAi219479.
NextBio90649.
PROQ8NH85.

Entry information

Entry nameOR5R1_HUMAN
AccessionPrimary (citable) accession number: Q8NH85
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries