Q8NH85 (OR5R1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 5R1

Alternative name(s):
Olfactory receptor OR11-185

Gene names

Name:	OR5R1
Synonyms:	OR5R1P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 324	324	Olfactory receptor 5R1		PRO_0000150612
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 196	36	Extracellular Potential
	Transmembrane	197 – 217	21	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 324	32	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	265	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	7	1	I → T. Corresponds to variant rs7931261 [ dbSNP | Ensembl ].		VAR_024102
	Natural variant	103	1	C → Y. Corresponds to variant rs7123108 [ dbSNP | Ensembl ].		VAR_053205
	Natural variant	121	1	D → G. Corresponds to variant rs7111634 [ dbSNP | Ensembl ].		VAR_053206
	Natural variant	122	1	C → R. Corresponds to variant rs6591324 [ dbSNP | Ensembl ].		VAR_024103
	Natural variant	128	1	S → G. Corresponds to variant rs7933772 [ dbSNP | Ensembl ].		VAR_053207
	Natural variant	132	1	Y → H. Corresponds to variant rs17150578 [ dbSNP | Ensembl ].		VAR_053208
	Natural variant	162	1	I → T. Corresponds to variant rs12785840 [ dbSNP | Ensembl ].		VAR_053209
	Natural variant	184	1	F → L. Corresponds to variant rs7930678 [ dbSNP | Ensembl ].		VAR_024104
	Natural variant	274	1	A → V. Corresponds to variant rs998544 [ dbSNP | Ensembl ].		VAR_024105

Sequences

	Sequence		Length	Mass (Da)
	Q8NH85 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: C26CCA953E8846FE	FASTA	324	36,708
	10 20 30 40 50 60 MAEVNIIYVT VFILKGITNR PELQAPCFGV FLVIYLVTVL GNLGLITLIK IDTRLHTPMY 70 80 90 100 110 120 YFLSHLAFVD LCYSSAITPK MMVNFVVERN TIPFHACATQ LGCFLTFMIT ECFLLASMAY 130 140 150 160 170 180 DCYVAICSPL HYSTLMSRRV CIQLVAVPYI YSFLVALFHT VITFRLTYCG PNLINHFYCD 190 200 210 220 230 240 DLPFLALSCS DTHMKEILIF AFAGFDMISS SSIVLTSYIF IIAAILRIRS TQGQHKAIST 250 260 270 280 290 300 CGSHMVTVTI FYGTLIFMYL QPKSNHSLDT DKMASVFYTV VIPMLNPLIY SLRNKEVKDA 310 320 SKKALDKGCE NLQILTFLKI RKLY

References

[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[3]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065504 Genomic DNA. Translation: BAC05752.1. BK004514 Genomic DNA. Translation: DAA04912.1.
IPI	IPI00169209.
RefSeq	NP_001004744.1. NM_001004744.1.
UniGene	Hs.553630.
3D structure databases
ProteinModelPortal	Q8NH85.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000308595.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NH85.
Polymorphism databases
DMDM	60392877.
Proteomic databases
PaxDb	Q8NH85.
PRIDE	Q8NH85.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312253; ENSP00000308595; ENSG00000174942.
GeneID	219479.
KEGG	hsa:219479.
UCSC	uc010rji.2. human.
Organism-specific databases
CTD	219479.
GeneCards	GC11M056186.
HGNC	HGNC:14841. OR5R1.
HPA	HPA049992.
neXtProt	NX_Q8NH85.
PharmGKB	PA32564.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG146677.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q8NH85.
KO	K04257.
OMA	KALDKGC.
OrthoDB	EOG4C2H9W.
PhylomeDB	Q8NH85.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR5R1.
Genevestigator	Q8NH85.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	219479.
NextBio	90649.

Entry information

Entry name

OR5R1_HUMAN

Accession

Primary (citable) accession number: Q8NH85

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.