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Q8NH85

- OR5R1_HUMAN

UniProt

Q8NH85 - OR5R1_HUMAN

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Protein

Olfactory receptor 5R1

Gene
OR5R1, OR5R1P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5R1
Alternative name(s):
Olfactory receptor OR11-185
Gene namesi
Name:OR5R1
Synonyms:OR5R1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14841. OR5R1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525Extracellular Reviewed predictionAdd
BLAST
Transmembranei26 – 4621Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini47 – 548Cytoplasmic Reviewed prediction
Transmembranei55 – 7521Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini76 – 9924Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 13919Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei140 – 16021Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini161 – 19636Extracellular Reviewed predictionAdd
BLAST
Transmembranei197 – 21721Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini218 – 23720Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei238 – 25821Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini259 – 27113Extracellular Reviewed predictionAdd
BLAST
Transmembranei272 – 29221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini293 – 32432Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Olfactory receptor 5R1PRO_0000150612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 189 By similarity
Glycosylationi265 – 2651N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH85.
PRIDEiQ8NH85.

PTM databases

PhosphoSiteiQ8NH85.

Expressioni

Gene expression databases

CleanExiHS_OR5R1.
GenevestigatoriQ8NH85.

Organism-specific databases

HPAiHPA049992.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308595.

Structurei

3D structure databases

ProteinModelPortaliQ8NH85.
SMRiQ8NH85. Positions 30-250.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146677.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH85.
KOiK04257.
OMAiVNITYVT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH85.
TreeFamiTF352753.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH85-1 [UniParc]FASTAAdd to Basket

« Hide

MAEVNIIYVT VFILKGITNR PELQAPCFGV FLVIYLVTVL GNLGLITLIK    50
IDTRLHTPMY YFLSHLAFVD LCYSSAITPK MMVNFVVERN TIPFHACATQ 100
LGCFLTFMIT ECFLLASMAY DCYVAICSPL HYSTLMSRRV CIQLVAVPYI 150
YSFLVALFHT VITFRLTYCG PNLINHFYCD DLPFLALSCS DTHMKEILIF 200
AFAGFDMISS SSIVLTSYIF IIAAILRIRS TQGQHKAIST CGSHMVTVTI 250
FYGTLIFMYL QPKSNHSLDT DKMASVFYTV VIPMLNPLIY SLRNKEVKDA 300
SKKALDKGCE NLQILTFLKI RKLY 324
Length:324
Mass (Da):36,708
Last modified:October 1, 2002 - v1
Checksum:iC26CCA953E8846FE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71I → T.
Corresponds to variant rs7931261 [ dbSNP | Ensembl ].
VAR_024102
Natural varianti103 – 1031C → Y.
Corresponds to variant rs7123108 [ dbSNP | Ensembl ].
VAR_053205
Natural varianti121 – 1211D → G.
Corresponds to variant rs7111634 [ dbSNP | Ensembl ].
VAR_053206
Natural varianti122 – 1221C → R.
Corresponds to variant rs6591324 [ dbSNP | Ensembl ].
VAR_024103
Natural varianti128 – 1281S → G.
Corresponds to variant rs7933772 [ dbSNP | Ensembl ].
VAR_053207
Natural varianti132 – 1321Y → H.
Corresponds to variant rs17150578 [ dbSNP | Ensembl ].
VAR_053208
Natural varianti162 – 1621I → T.
Corresponds to variant rs12785840 [ dbSNP | Ensembl ].
VAR_053209
Natural varianti184 – 1841F → L.
Corresponds to variant rs7930678 [ dbSNP | Ensembl ].
VAR_024104
Natural varianti274 – 2741A → V.
Corresponds to variant rs998544 [ dbSNP | Ensembl ].
VAR_024105

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065504 Genomic DNA. Translation: BAC05752.1.
BK004514 Genomic DNA. Translation: DAA04912.1.
CCDSiCCDS31530.1.
RefSeqiNP_001004744.1. NM_001004744.1.
UniGeneiHs.553630.

Genome annotation databases

EnsembliENST00000312253; ENSP00000308595; ENSG00000174942.
GeneIDi219479.
KEGGihsa:219479.
UCSCiuc010rji.2. human.

Polymorphism databases

DMDMi60392877.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065504 Genomic DNA. Translation: BAC05752.1 .
BK004514 Genomic DNA. Translation: DAA04912.1 .
CCDSi CCDS31530.1.
RefSeqi NP_001004744.1. NM_001004744.1.
UniGenei Hs.553630.

3D structure databases

ProteinModelPortali Q8NH85.
SMRi Q8NH85. Positions 30-250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000308595.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NH85.

Polymorphism databases

DMDMi 60392877.

Proteomic databases

PaxDbi Q8NH85.
PRIDEi Q8NH85.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312253 ; ENSP00000308595 ; ENSG00000174942 .
GeneIDi 219479.
KEGGi hsa:219479.
UCSCi uc010rji.2. human.

Organism-specific databases

CTDi 219479.
GeneCardsi GC11M056186.
HGNCi HGNC:14841. OR5R1.
HPAi HPA049992.
neXtProti NX_Q8NH85.
PharmGKBi PA32564.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG146677.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NH85.
KOi K04257.
OMAi VNITYVT.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NH85.
TreeFami TF352753.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR5R1.
GenomeRNAii 219479.
NextBioi 90649.
PROi Q8NH85.

Gene expression databases

CleanExi HS_OR5R1.
Genevestigatori Q8NH85.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5R1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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