Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 5R1

Gene

OR5R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5R1
Alternative name(s):
Olfactory receptor OR11-185
Gene namesi
Name:OR5R1
Synonyms:OR5R1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14841. OR5R1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 32432CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32564.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Olfactory receptor 5R1PRO_0000150612Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi265 – 2651N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH85.
PRIDEiQ8NH85.

PTM databases

PhosphoSiteiQ8NH85.

Expressioni

Gene expression databases

CleanExiHS_OR5R1.
GenevestigatoriQ8NH85.

Organism-specific databases

HPAiHPA049992.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308595.

Structurei

3D structure databases

ProteinModelPortaliQ8NH85.
SMRiQ8NH85. Positions 30-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG146677.
GeneTreeiENSGT00760000118826.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH85.
KOiK04257.
OMAiVNITYVT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH85.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH85-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEVNIIYVT VFILKGITNR PELQAPCFGV FLVIYLVTVL GNLGLITLIK
60 70 80 90 100
IDTRLHTPMY YFLSHLAFVD LCYSSAITPK MMVNFVVERN TIPFHACATQ
110 120 130 140 150
LGCFLTFMIT ECFLLASMAY DCYVAICSPL HYSTLMSRRV CIQLVAVPYI
160 170 180 190 200
YSFLVALFHT VITFRLTYCG PNLINHFYCD DLPFLALSCS DTHMKEILIF
210 220 230 240 250
AFAGFDMISS SSIVLTSYIF IIAAILRIRS TQGQHKAIST CGSHMVTVTI
260 270 280 290 300
FYGTLIFMYL QPKSNHSLDT DKMASVFYTV VIPMLNPLIY SLRNKEVKDA
310 320
SKKALDKGCE NLQILTFLKI RKLY
Length:324
Mass (Da):36,708
Last modified:September 30, 2002 - v1
Checksum:iC26CCA953E8846FE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti7 – 71I → T.
Corresponds to variant rs7931261 [ dbSNP | Ensembl ].
VAR_024102
Natural varianti103 – 1031C → Y.
Corresponds to variant rs7123108 [ dbSNP | Ensembl ].
VAR_053205
Natural varianti121 – 1211D → G.
Corresponds to variant rs7111634 [ dbSNP | Ensembl ].
VAR_053206
Natural varianti122 – 1221C → R.
Corresponds to variant rs6591324 [ dbSNP | Ensembl ].
VAR_024103
Natural varianti128 – 1281S → G.
Corresponds to variant rs7933772 [ dbSNP | Ensembl ].
VAR_053207
Natural varianti132 – 1321Y → H.
Corresponds to variant rs17150578 [ dbSNP | Ensembl ].
VAR_053208
Natural varianti162 – 1621I → T.
Corresponds to variant rs12785840 [ dbSNP | Ensembl ].
VAR_053209
Natural varianti184 – 1841F → L.
Corresponds to variant rs7930678 [ dbSNP | Ensembl ].
VAR_024104
Natural varianti274 – 2741A → V.
Corresponds to variant rs998544 [ dbSNP | Ensembl ].
VAR_024105

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065504 Genomic DNA. Translation: BAC05752.1.
BK004514 Genomic DNA. Translation: DAA04912.1.
CCDSiCCDS31530.1.
RefSeqiNP_001004744.1. NM_001004744.1.
UniGeneiHs.553630.

Genome annotation databases

EnsembliENST00000312253; ENSP00000308595; ENSG00000174942.
ENST00000623216; ENSP00000485063; ENSG00000279961.
ENST00000623286; ENSP00000485324; ENSG00000279961.
GeneIDi219479.
KEGGihsa:219479.
UCSCiuc010rji.2. human.

Polymorphism databases

DMDMi60392877.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065504 Genomic DNA. Translation: BAC05752.1.
BK004514 Genomic DNA. Translation: DAA04912.1.
CCDSiCCDS31530.1.
RefSeqiNP_001004744.1. NM_001004744.1.
UniGeneiHs.553630.

3D structure databases

ProteinModelPortaliQ8NH85.
SMRiQ8NH85. Positions 30-250.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308595.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NH85.

Polymorphism databases

DMDMi60392877.

Proteomic databases

PaxDbiQ8NH85.
PRIDEiQ8NH85.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312253; ENSP00000308595; ENSG00000174942.
ENST00000623216; ENSP00000485063; ENSG00000279961.
ENST00000623286; ENSP00000485324; ENSG00000279961.
GeneIDi219479.
KEGGihsa:219479.
UCSCiuc010rji.2. human.

Organism-specific databases

CTDi219479.
GeneCardsiGC11M056186.
HGNCiHGNC:14841. OR5R1.
HPAiHPA049992.
neXtProtiNX_Q8NH85.
PharmGKBiPA32564.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG146677.
GeneTreeiENSGT00760000118826.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH85.
KOiK04257.
OMAiVNITYVT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH85.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5R1.
GenomeRNAii219479.
NextBioi90649.
PROiQ8NH85.

Gene expression databases

CleanExiHS_OR5R1.
GenevestigatoriQ8NH85.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2003)

Entry informationi

Entry nameiOR5R1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH85
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2005
Last sequence update: September 30, 2002
Last modified: January 6, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.