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Protein

Olfactory receptor 4A5

Gene

OR4A5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4A5
Alternative name(s):
Olfactory receptor OR11-111
Gene namesi
Name:OR4A5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000221840.3.
HGNCiHGNC:15162. OR4A5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 192ExtracellularSequence analysisAdd BLAST36
Transmembranei193 – 216Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini217 – 232CytoplasmicSequence analysisAdd BLAST16
Transmembranei233 – 255Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini256 – 266ExtracellularSequence analysisAdd BLAST11
Transmembranei267 – 286Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini287 – 315CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221840.

Polymorphism and mutation databases

BioMutaiOR4A5.
DMDMi327478606.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505241 – 315Olfactory receptor 4A5Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH83.
PeptideAtlasiQ8NH83.
PRIDEiQ8NH83.

PTM databases

iPTMnetiQ8NH83.
PhosphoSitePlusiQ8NH83.

Expressioni

Gene expression databases

CleanExiHS_OR4A5.
ExpressionAtlasiQ8NH83. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367664.

Structurei

3D structure databases

ProteinModelPortaliQ8NH83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ82. Eukaryota.
ENOG41116C3. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH83.
KOiK04257.
OMAiFQACMVQ.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NH83.
TreeFamiTF337251.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NH83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQNNNITEF VLLGFSQDPG VQKALFVMFL LTYLVTVVGN LLIVVDIIAS
60 70 80 90 100
PSLGSPMYFF LACLSFIDAA YSTTISPKLI VGLFCDKKTI SFQGCMGQLF
110 120 130 140 150
IDHFFGGAEV FLLVVMACDR YVAICKPLHY LTIMNRQVCF LLLVVAMIGG
160 170 180 190 200
FVHSAFQIVV YSLPFCGPNV IVHFSCDMHP LLELACTDTY FIGLTVVVNS
210 220 230 240 250
GAICMVIFNL LLISYGVILS SLKTYSQEKR GKALSTCSSG STVVVLFFVP
260 270 280 290 300
CIFIYVRPVS NFPTDKFMTV FYTIITHMLS PLIYTLRNSE MRNAIEKLLG
310
KKLTIFIIGG VSVLM
Length:315
Mass (Da):34,915
Last modified:April 5, 2011 - v4
Checksum:iE0659F90F54E9921
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16S → F in BAC05754 (Ref. 1) Curated1
Sequence conflicti48 – 49IA → FS in BAC05754 (Ref. 1) Curated2
Sequence conflicti54 – 56GSP → CSA in BAC05754 (Ref. 1) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0317416N → S. Corresponds to variant dbSNP:rs10902343Ensembl.1
Natural variantiVAR_06203323K → N. Corresponds to variant dbSNP:rs56302591Ensembl.1
Natural variantiVAR_062034219L → Q. Corresponds to variant dbSNP:rs35083184Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065506 Genomic DNA. Translation: BAC05754.1.
AC087377 Genomic DNA. No translation available.
BK004378 Genomic DNA. Translation: DAA04776.1.
CCDSiCCDS73289.1.
RefSeqiNP_001005272.3. NM_001005272.3.
UniGeneiHs.554531.

Genome annotation databases

EnsembliENST00000319760; ENSP00000367664; ENSG00000221840.
GeneIDi81318.
KEGGihsa:81318.
UCSCiuc001nhi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4A5_HUMAN
AccessioniPrimary (citable) accession number: Q8NH83
Secondary accession number(s): Q6IF84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: April 5, 2011
Last modified: September 27, 2017
This is version 129 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families