ID   O10D3_HUMAN             Reviewed;         312 AA.
AC   Q8NH80;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 138.
DE   RecName: Full=Olfactory receptor 10D3 {ECO:0000305};
DE   AltName: Full=HTPCRX09 {ECO:0000312|HGNC:HGNC:8168};
DE   AltName: Full=Olfactory receptor OR11-293;
GN   Name=OR10D3 {ECO:0000312|HGNC:HGNC:8168};
GN   Synonyms=OR10D3P {ECO:0000312|HGNC:HGNC:8168};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
RX   PubMed=1370859; DOI=10.1038/355453a0;
RA   Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA   Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA   Vassart G.;
RT   "Expression of members of the putative olfactory receptor gene family in
RT   mammalian germ cells.";
RL   Nature 355:453-455(1992).
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [4]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10D3P";
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DR   EMBL; AB065509; BAC05757.1; -; Genomic_DNA.
DR   EMBL; X64983; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BK004425; DAA04823.1; -; Genomic_DNA.
DR   CCDS; CCDS86257.1; -.
DR   AlphaFoldDB; Q8NH80; -.
DR   SMR; Q8NH80; -.
DR   STRING; 9606.ENSP00000493231; -.
DR   BioMuta; OR10D3; -.
DR   DMDM; 74760322; -.
DR   PaxDb; 9606-ENSP00000323895; -.
DR   PeptideAtlas; Q8NH80; -.
DR   Antibodypedia; 65551; 7 antibodies from 7 providers.
DR   Ensembl; ENST00000318666.6; ENSP00000323895.6; ENSG00000197309.5.
DR   Ensembl; ENST00000641351.3; ENSP00000493028.1; ENSG00000197309.5.
DR   Ensembl; ENST00000641546.1; ENSP00000493231.1; ENSG00000197309.5.
DR   MANE-Select; ENST00000641351.3; ENSP00000493028.1; NM_001355213.3; NP_001342142.1.
DR   UCSC; uc001pzv.3; human.
DR   AGR; HGNC:8168; -.
DR   GeneCards; OR10D3; -.
DR   HGNC; HGNC:8168; OR10D3.
DR   HPA; ENSG00000197309; Not detected.
DR   neXtProt; NX_Q8NH80; -.
DR   VEuPathDB; HostDB:ENSG00000197309; -.
DR   eggNOG; ENOG502SH9P; Eukaryota.
DR   GeneTree; ENSGT01050000244869; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NH80; -.
DR   OMA; FALPYCG; -.
DR   OrthoDB; 4307986at2759; -.
DR   PhylomeDB; Q8NH80; -.
DR   TreeFam; TF336512; -.
DR   PathwayCommons; Q8NH80; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   SignaLink; Q8NH80; -.
DR   ChiTaRS; OR10D3; human.
DR   Pharos; Q8NH80; Tdark.
DR   PRO; PR:Q8NH80; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NH80; Protein.
DR   Bgee; ENSG00000197309; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 4 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15228; 7tmA_OR10D-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF221; OLFACTORY RECEPTOR 10D3-RELATED; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   Genevisible; Q8NH80; HS.
PE   5: Uncertain;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW   Olfaction; Receptor; Reference proteome; Sensory transduction; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Olfactory receptor 10D3"
FT                   /id="PRO_0000349228"
FT   TOPO_DOM        1..26
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        27..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        79..97
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..218
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        219..239
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        240..260
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        261..266
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..179
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   CONFLICT        134
FT                   /note="V -> A (in Ref. 2; X64983)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        202
FT                   /note="N -> S (in Ref. 2; X64983)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   312 AA;  34812 MW;  2C08D37947CA71AC CRC64;
     MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM SSARLHTPMY
     FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ LFFFHFLGSI ECFLFTVMAY
     DRFTAICYPL RYTVIMNPRI CVALAVGTWL LGCIHSSILT SLTFTLPYCG PNEVDHFFCD
     IPALLPLACA DTSLAQRVSF TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST
     CSAHLIAILC AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK
     TILHRTGHVP ES
//