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Q8NH80

- O10D3_HUMAN

UniProt

Q8NH80 - O10D3_HUMAN

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Protein

Putative olfactory receptor 10D3

Gene

OR10D3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 10D3
Alternative name(s):
HTPCRX09
Olfactory receptor OR11-293
Gene namesi
Name:OR10D3
Synonyms:OR10D3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:8168. OR10D3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
BLAST
Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 5710CytoplasmicSequence Analysis
Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9719ExtracellularSequence AnalysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23921CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 2666ExtracellularSequence Analysis
Transmembranei267 – 28721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini288 – 31225CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Putative olfactory receptor 10D3PRO_0000349228Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NH80.
PRIDEiQ8NH80.

Expressioni

Gene expression databases

GenevestigatoriQ8NH80.

Organism-specific databases

HPAiHPA049991.

Structurei

3D structure databases

ProteinModelPortaliQ8NH80.
SMRiQ8NH80. Positions 25-151.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG115464.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH80.
OMAiFLPFYAC.
OrthoDBiEOG7ZD1VN.
PhylomeDBiQ8NH80.
TreeFamiTF336512.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH80-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM
60 70 80 90 100
SSARLHTPMY FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ
110 120 130 140 150
LFFFHFLGSI ECFLFTVMAY DRFTAICYPL RYTVIMNPRI CVALAVGTWL
160 170 180 190 200
LGCIHSSILT SLTFTLPYCG PNEVDHFFCD IPALLPLACA DTSLAQRVSF
210 220 230 240 250
TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST CSAHLIAILC
260 270 280 290 300
AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK
310
TILHRTGHVP ES
Length:312
Mass (Da):34,812
Last modified:October 1, 2002 - v1
Checksum:i2C08D37947CA71AC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341V → A in X64983. (PubMed:1370859)Curated
Sequence conflicti202 – 2021N → S in X64983. (PubMed:1370859)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065509 Genomic DNA. Translation: BAC05757.1.
X64983 mRNA. No translation available.
BK004425 Genomic DNA. Translation: DAA04823.1.
UniGeneiHs.538726.

Genome annotation databases

EnsembliENST00000318666; ENSP00000323895; ENSG00000197309.
UCSCiuc001pzv.2. human.

Polymorphism databases

DMDMi74760322.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065509 Genomic DNA. Translation: BAC05757.1 .
X64983 mRNA. No translation available.
BK004425 Genomic DNA. Translation: DAA04823.1 .
UniGenei Hs.538726.

3D structure databases

ProteinModelPortali Q8NH80.
SMRi Q8NH80. Positions 25-151.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 74760322.

Proteomic databases

PaxDbi Q8NH80.
PRIDEi Q8NH80.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000318666 ; ENSP00000323895 ; ENSG00000197309 .
UCSCi uc001pzv.2. human.

Organism-specific databases

GeneCardsi GC11P124055.
HGNCi HGNC:8168. OR10D3.
HPAi HPA049991.
neXtProti NX_Q8NH80.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG115464.
GeneTreei ENSGT00760000119161.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NH80.
OMAi FLPFYAC.
OrthoDBi EOG7ZD1VN.
PhylomeDBi Q8NH80.
TreeFami TF336512.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

PROi Q8NH80.

Gene expression databases

Genevestigatori Q8NH80.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10D3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3