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Protein

Putative olfactory receptor 10D3

Gene

OR10D3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181230-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative olfactory receptor 10D3
Alternative name(s):
HTPCRX09
Olfactory receptor OR11-293
Gene namesi
Name:OR10D3
Synonyms:OR10D3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8168. OR10D3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 57CytoplasmicSequence analysis10
Transmembranei58 – 78Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini79 – 97ExtracellularSequence analysisAdd BLAST19
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 139CytoplasmicSequence analysisAdd BLAST21
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 218Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini219 – 239CytoplasmicSequence analysisAdd BLAST21
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 266ExtracellularSequence analysis6
Transmembranei267 – 287Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini288 – 312CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197309.

Polymorphism and mutation databases

DMDMi74760322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003492281 – 312Putative olfactory receptor 10D3Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NH80.
PRIDEiQ8NH80.

Expressioni

Gene expression databases

GenevisibleiQ8NH80. HS.

Organism-specific databases

HPAiHPA049991.

Structurei

3D structure databases

ProteinModelPortaliQ8NH80.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE50. Eukaryota.
ENOG4111430. LUCA.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH80.
OMAiYTRITIS.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH80.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM
60 70 80 90 100
SSARLHTPMY FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ
110 120 130 140 150
LFFFHFLGSI ECFLFTVMAY DRFTAICYPL RYTVIMNPRI CVALAVGTWL
160 170 180 190 200
LGCIHSSILT SLTFTLPYCG PNEVDHFFCD IPALLPLACA DTSLAQRVSF
210 220 230 240 250
TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST CSAHLIAILC
260 270 280 290 300
AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK
310
TILHRTGHVP ES
Length:312
Mass (Da):34,812
Last modified:October 1, 2002 - v1
Checksum:i2C08D37947CA71AC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134V → A in X64983 (PubMed:1370859).Curated1
Sequence conflicti202N → S in X64983 (PubMed:1370859).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065509 Genomic DNA. Translation: BAC05757.1.
X64983 mRNA. No translation available.
BK004425 Genomic DNA. Translation: DAA04823.1.
UniGeneiHs.538726.

Genome annotation databases

EnsembliENST00000318666; ENSP00000323895; ENSG00000197309.
UCSCiuc001pzv.3. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065509 Genomic DNA. Translation: BAC05757.1.
X64983 mRNA. No translation available.
BK004425 Genomic DNA. Translation: DAA04823.1.
UniGeneiHs.538726.

3D structure databases

ProteinModelPortaliQ8NH80.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi74760322.

Proteomic databases

PaxDbiQ8NH80.
PRIDEiQ8NH80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318666; ENSP00000323895; ENSG00000197309.
UCSCiuc001pzv.3. human.

Organism-specific databases

GeneCardsiOR10D3.
HGNCiHGNC:8168. OR10D3.
HPAiHPA049991.
neXtProtiNX_Q8NH80.
OpenTargetsiENSG00000197309.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE50. Eukaryota.
ENOG4111430. LUCA.
GeneTreeiENSGT00760000119161.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH80.
OMAiYTRITIS.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH80.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181230-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiQ8NH80.

Gene expression databases

GenevisibleiQ8NH80. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10D3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.