Q8NH80 (O10D3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative olfactory receptor 10D3

Alternative name(s):
HTPCRX09
Olfactory receptor OR11-293

Gene names

Name:	OR10D3
Synonyms:	OR10D3P

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	312 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Caution	Could be the product of a pseudogene.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 312	312	Putative olfactory receptor 10D3		PRO_0000349228
Regions
	Topological domain	1 – 26	26	Extracellular Potential
	Transmembrane	27 – 47	21	Helical; Name=1; Potential
	Topological domain	48 – 57	10	Cytoplasmic Potential
	Transmembrane	58 – 78	21	Helical; Name=2; Potential
	Topological domain	79 – 97	19	Extracellular Potential
	Transmembrane	98 – 118	21	Helical; Name=3; Potential
	Topological domain	119 – 139	21	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 218	21	Helical; Name=5; Potential
	Topological domain	219 – 239	21	Cytoplasmic Potential
	Transmembrane	240 – 260	21	Helical; Name=6; Potential
	Topological domain	261 – 266	6	Extracellular Potential
	Transmembrane	267 – 287	21	Helical; Name=7; Potential
	Topological domain	288 – 312	25	Cytoplasmic Potential
Amino acid modifications
	Disulfide bond	97 ↔ 179		By similarity
Experimental info
	Sequence conflict	134	1	V → A in X64983. Ref.2
	Sequence conflict	202	1	N → S in X64983. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q8NH80 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 2C08D37947CA71AC	FASTA	312	34,812
	10 20 30 40 50 60 MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM SSARLHTPMY 70 80 90 100 110 120 FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ LFFFHFLGSI ECFLFTVMAY 130 140 150 160 170 180 DRFTAICYPL RYTVIMNPRI CVALAVGTWL LGCIHSSILT SLTFTLPYCG PNEVDHFFCD 190 200 210 220 230 240 IPALLPLACA DTSLAQRVSF TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST 250 260 270 280 290 300 CSAHLIAILC AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK 310 TILHRTGHVP ES

References

[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Expression of members of the putative olfactory receptor gene family in mammalian germ cells." Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G. Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
[3]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[4]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065509 Genomic DNA. Translation: BAC05757.1. X64983 mRNA. No translation available. BK004425 Genomic DNA. Translation: DAA04823.1.
IPI	IPI00169200.
UniGene	Hs.538726.
3D structure databases
ProteinModelPortal	Q8NH80.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	74760322.
Proteomic databases
PaxDb	Q8NH80.
PRIDE	Q8NH80.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000318666; ENSP00000323895; ENSG00000197309.
UCSC	uc001pzv.2. human.
Organism-specific databases
GeneCards	GC11P124055.
HGNC	HGNC:8168. OR10D3.
HPA	HPA049991.
neXtProt	NX_Q8NH80.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG115464.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	Q8NH80.
OMA	FLPFYAC.
OrthoDB	EOG4N30PV.
PhylomeDB	Q8NH80.
Gene expression databases
Genevestigator	Q8NH80.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

O10D3_HUMAN

Accession

Primary (citable) accession number: Q8NH80

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.