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Q8NH80 (O10D3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative olfactory receptor 10D3
Alternative name(s):
HTPCRX09
Olfactory receptor OR11-293
Gene names
Name:OR10D3
Synonyms:OR10D3P
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

Could be the product of a pseudogene.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Putative olfactory receptor 10D3
PRO_0000349228

Regions

Topological domain1 – 2626Extracellular Potential
Transmembrane27 – 4721Helical; Name=1; Potential
Topological domain48 – 5710Cytoplasmic Potential
Transmembrane58 – 7821Helical; Name=2; Potential
Topological domain79 – 9719Extracellular Potential
Transmembrane98 – 11821Helical; Name=3; Potential
Topological domain119 – 13921Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21821Helical; Name=5; Potential
Topological domain219 – 23921Cytoplasmic Potential
Transmembrane240 – 26021Helical; Name=6; Potential
Topological domain261 – 2666Extracellular Potential
Transmembrane267 – 28721Helical; Name=7; Potential
Topological domain288 – 31225Cytoplasmic Potential

Amino acid modifications

Disulfide bond97 ↔ 179 By similarity

Experimental info

Sequence conflict1341V → A in X64983. Ref.2
Sequence conflict2021N → S in X64983. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8NH80 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 2C08D37947CA71AC

FASTA31234,812
        10         20         30         40         50         60 
MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM SSARLHTPMY 

        70         80         90        100        110        120 
FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ LFFFHFLGSI ECFLFTVMAY 

       130        140        150        160        170        180 
DRFTAICYPL RYTVIMNPRI CVALAVGTWL LGCIHSSILT SLTFTLPYCG PNEVDHFFCD 

       190        200        210        220        230        240 
IPALLPLACA DTSLAQRVSF TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST 

       250        260        270        280        290        300 
CSAHLIAILC AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK 

       310 
TILHRTGHVP ES 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065509 Genomic DNA. Translation: BAC05757.1.
X64983 mRNA. No translation available.
BK004425 Genomic DNA. Translation: DAA04823.1.
UniGeneHs.538726.

3D structure databases

ProteinModelPortalQ8NH80.
SMRQ8NH80. Positions 25-151.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM74760322.

Proteomic databases

PaxDbQ8NH80.
PRIDEQ8NH80.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000318666; ENSP00000323895; ENSG00000197309.
UCSCuc001pzv.2. human.

Organism-specific databases

GeneCardsGC11P124055.
HGNCHGNC:8168. OR10D3.
HPAHPA049991.
neXtProtNX_Q8NH80.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG115464.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NH80.
OMAFLPFYAC.
OrthoDBEOG7ZD1VN.
PhylomeDBQ8NH80.
TreeFamTF336512.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

GenevestigatorQ8NH80.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8NH80.

Entry information

Entry nameO10D3_HUMAN
AccessionPrimary (citable) accession number: Q8NH80
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries