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Q8NH80

- O10D3_HUMAN

UniProt

Q8NH80 - O10D3_HUMAN

Protein

Putative olfactory receptor 10D3

Gene

OR10D3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative olfactory receptor 10D3
    Alternative name(s):
    HTPCRX09
    Olfactory receptor OR11-293
    Gene namesi
    Name:OR10D3
    Synonyms:OR10D3P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8168. OR10D3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Putative olfactory receptor 10D3PRO_0000349228Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi97 ↔ 179PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ8NH80.
    PRIDEiQ8NH80.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8NH80.

    Organism-specific databases

    HPAiHPA049991.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH80.
    SMRiQ8NH80. Positions 25-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2626ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 5710CytoplasmicSequence Analysis
    Topological domaini79 – 9719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23921CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 2666ExtracellularSequence Analysis
    Topological domaini288 – 31225CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei27 – 4721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei58 – 7821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG115464.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NH80.
    OMAiFLPFYAC.
    OrthoDBiEOG7ZD1VN.
    PhylomeDBiQ8NH80.
    TreeFamiTF336512.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH80-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVKNCCMVT EFILLGIPHT EGLEMTLFVL FLPFYACTLL GNVSILVAVM    50
    SSARLHTPMY FFLGNLSVFD MGFSSVTCPK MLLYLMGLSR LISYKDCVCQ 100
    LFFFHFLGSI ECFLFTVMAY DRFTAICYPL RYTVIMNPRI CVALAVGTWL 150
    LGCIHSSILT SLTFTLPYCG PNEVDHFFCD IPALLPLACA DTSLAQRVSF 200
    TNVGLISLVC FLLILLSYTR ITISILSIRT TEGRRRAFST CSAHLIAILC 250
    AYGPIITVYL QPTPNPMLGT VVQILMNLVG PMLNPLIYTL RNKEVKTALK 300
    TILHRTGHVP ES 312
    Length:312
    Mass (Da):34,812
    Last modified:October 1, 2002 - v1
    Checksum:i2C08D37947CA71AC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti134 – 1341V → A in X64983. (PubMed:1370859)Curated
    Sequence conflicti202 – 2021N → S in X64983. (PubMed:1370859)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065509 Genomic DNA. Translation: BAC05757.1.
    X64983 mRNA. No translation available.
    BK004425 Genomic DNA. Translation: DAA04823.1.
    UniGeneiHs.538726.

    Genome annotation databases

    EnsembliENST00000318666; ENSP00000323895; ENSG00000197309.
    UCSCiuc001pzv.2. human.

    Polymorphism databases

    DMDMi74760322.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065509 Genomic DNA. Translation: BAC05757.1 .
    X64983 mRNA. No translation available.
    BK004425 Genomic DNA. Translation: DAA04823.1 .
    UniGenei Hs.538726.

    3D structure databases

    ProteinModelPortali Q8NH80.
    SMRi Q8NH80. Positions 25-151.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 74760322.

    Proteomic databases

    PaxDbi Q8NH80.
    PRIDEi Q8NH80.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000318666 ; ENSP00000323895 ; ENSG00000197309 .
    UCSCi uc001pzv.2. human.

    Organism-specific databases

    GeneCardsi GC11P124055.
    HGNCi HGNC:8168. OR10D3.
    HPAi HPA049991.
    neXtProti NX_Q8NH80.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG115464.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NH80.
    OMAi FLPFYAC.
    OrthoDBi EOG7ZD1VN.
    PhylomeDBi Q8NH80.
    TreeFami TF336512.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    PROi Q8NH80.

    Gene expression databases

    Genevestigatori Q8NH80.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
      Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
      Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-239.
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10D3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3