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Protein

Olfactory receptor 6X1

Gene

OR6X1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6X1
Alternative name(s):
Olfactory receptor OR11-270
Gene namesi
Name:OR6X1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000221931.2
HGNCiHGNC:14737 OR6X1
neXtProtiNX_Q8NH79

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 44Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini45 – 52CytoplasmicSequence analysis8
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 97ExtracellularSequence analysisAdd BLAST24
Transmembranei98 – 118Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 215Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini216 – 235CytoplasmicSequence analysisAdd BLAST20
Transmembranei236 – 256Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini257 – 269ExtracellularSequence analysisAdd BLAST13
Transmembranei270 – 290Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini291 – 312CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221931
PharmGKBiPA32609

Polymorphism and mutation databases

BioMutaiOR6X1
DMDMi38372825

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506401 – 312Olfactory receptor 6X1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH79
PeptideAtlasiQ8NH79
PRIDEiQ8NH79

PTM databases

iPTMnetiQ8NH79
PhosphoSitePlusiQ8NH79

Expressioni

Gene expression databases

CleanExiHS_OR6X1
ExpressionAtlasiQ8NH79 differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333724

Structurei

3D structure databases

ProteinModelPortaliQ8NH79
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ISHC Eukaryota
ENOG410Z9YX LUCA
GeneTreeiENSGT00760000119169
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH79
KOiK04257
OMAiYLRPTAH
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH79
TreeFamiTF337475

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNGTVITEF ILLGFPVIQG LQTPLFIAIF LTYILTLAGN GLIIATVWAE
60 70 80 90 100
PRLQIPMYFF LCNLSFLEIW YTTTVIPKLL GTFVVARTVI CMSCCLLQAF
110 120 130 140 150
FHFFVGTTEF LILTIMSFDR YLTICNPLHH PTIMTSKLCL QLALSSWVVG
160 170 180 190 200
FTIVFCQTML LIQLPFCGNN VISHFYCDVG PSLKAACIDT SILELLGVIA
210 220 230 240 250
TILVIPGSLL FNMISYIYIL SAILRIPSAT GHQKTFSTCA SHLTVVSLLY
260 270 280 290 300
GAVLFMYLRP TAHSSFKINK VVSVLNTILT PLLNPFIYTI RNKEVKGALR
310
KAMTCPKTGH AK
Length:312
Mass (Da):34,727
Last modified:October 1, 2002 - v1
Checksum:i4A4E176923A167A1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024110190T → N. Corresponds to variant dbSNP:rs12364099Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065510 Genomic DNA Translation: BAC05758.1
CH471065 Genomic DNA Translation: EAW67555.1
BC136855 mRNA Translation: AAI36856.1
BC136856 mRNA Translation: AAI36857.1
BK004362 Genomic DNA Translation: DAA04760.1
CCDSiCCDS31695.1
RefSeqiNP_001005188.1, NM_001005188.1
UniGeneiHs.553759

Genome annotation databases

EnsembliENST00000327930; ENSP00000333724; ENSG00000221931
GeneIDi390260
KEGGihsa:390260
UCSCiuc010rzy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR6X1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH79
Secondary accession number(s): B9EGW9, Q6IFA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families
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