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Q8NH76 (O56B4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 56B4
Alternative name(s):
Olfactory receptor OR11-67
Gene names
Name:OR56B4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319Olfactory receptor 56B4
PRO_0000150798

Regions

Topological domain1 – 3131Extracellular Potential
Transmembrane32 – 5221Helical; Name=1; Potential
Topological domain53 – 608Cytoplasmic Potential
Transmembrane61 – 8121Helical; Name=2; Potential
Topological domain82 – 10524Extracellular Potential
Transmembrane106 – 12621Helical; Name=3; Potential
Topological domain127 – 14519Cytoplasmic Potential
Transmembrane146 – 16621Helical; Name=4; Potential
Topological domain167 – 20236Extracellular Potential
Transmembrane203 – 22321Helical; Name=5; Potential
Topological domain224 – 24320Cytoplasmic Potential
Transmembrane244 – 26320Helical; Name=6; Potential
Topological domain264 – 27714Extracellular Potential
Transmembrane278 – 29821Helical; Name=7; Potential
Topological domain299 – 31921Cytoplasmic Potential

Amino acid modifications

Disulfide bond103 ↔ 195 By similarity

Natural variations

Natural variant2771P → S.
Corresponds to variant rs1462983 [ dbSNP | Ensembl ].
VAR_024153

Sequences

Sequence LengthMass (Da)Tools
Q8NH76 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 2D369DB81013EDEC

FASTA31935,454
        10         20         30         40         50         60 
MDTSTSVTYD SSLQISQFIL MGLPGIHEWQ HWLSLPLTLL YLLALGANLL IIITIQHETV 

        70         80         90        100        110        120 
LHEPMYHLLG ILAVVDIGLA TTIMPKILAI FWFDAKAISL PMCFAQIYAI HCFFCIESGI 

       130        140        150        160        170        180 
FLCMAVDRYI AICRPLQYPS IVTKAFVFKA TGFIMLRNGL LTIPVPILAA QRHYCSRNEI 

       190        200        210        220        230        240 
EHCLCSNLGV ISLACDDITV NKFYQLMLAW VLVGSDMALV FSSYAVILHS VLRLNSAEAM 

       250        260        270        280        290        300 
SKALSTCSSH LILILFHTGI IVLSVTHLAE KKIPLIPVFL NVLHNVIPPA LNPLACALRM 

       310 
HKLRLGFQRL LGLGQDVSK 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065513 Genomic DNA. Translation: BAC05761.1.
BC136879 mRNA. Translation: AAI36880.1.
BC136880 mRNA. Translation: AAI36881.1.
BK004325 Genomic DNA. Translation: DAA04723.1.
CCDSCCDS31406.1.
RefSeqNP_001005181.1. NM_001005181.1.
UniGeneHs.632154.

3D structure databases

ProteinModelPortalQ8NH76.
SMRQ8NH76. Positions 31-167.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000321196.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372824.

Proteomic databases

PaxDbQ8NH76.
PRIDEQ8NH76.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000316529; ENSP00000321196; ENSG00000180919.
GeneID196335.
KEGGhsa:196335.
UCSCuc010qzx.2. human.

Organism-specific databases

CTD196335.
GeneCardsGC11P006085.
HGNCHGNC:15248. OR56B4.
neXtProtNX_Q8NH76.
PharmGKBPA32453.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40832.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ8NH76.
KOK04257.
OMAFCMESGI.
OrthoDBEOG7QK0CJ.
PhylomeDBQ8NH76.
TreeFamTF344049.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR56B4.
GenevestigatorQ8NH76.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSPR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR56B4.
GenomeRNAi196335.
NextBio89437.
PROQ8NH76.

Entry information

Entry nameO56B4_HUMAN
AccessionPrimary (citable) accession number: Q8NH76
Secondary accession number(s): Q6IFD7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries