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Q8NH76

- O56B4_HUMAN

UniProt

Q8NH76 - O56B4_HUMAN

Protein

Olfactory receptor 56B4

Gene

OR56B4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 56B4
    Alternative name(s):
    Olfactory receptor OR11-67
    Gene namesi
    Name:OR56B4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15248. OR56B4.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32453.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319Olfactory receptor 56B4PRO_0000150798Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi103 ↔ 195PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ8NH76.
    PRIDEiQ8NH76.

    Expressioni

    Gene expression databases

    CleanExiHS_OR56B4.
    GenevestigatoriQ8NH76.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000321196.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH76.
    SMRiQ8NH76. Positions 31-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 608CytoplasmicSequence Analysis
    Topological domaini82 – 10524ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini127 – 14519CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini167 – 20236ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 24320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 27714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 31921CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei106 – 12621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei146 – 16621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei244 – 26320Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40832.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NH76.
    KOiK04257.
    OMAiFCMESGI.
    OrthoDBiEOG7QK0CJ.
    PhylomeDBiQ8NH76.
    TreeFamiTF344049.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view]
    PRINTSiPR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH76-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDTSTSVTYD SSLQISQFIL MGLPGIHEWQ HWLSLPLTLL YLLALGANLL    50
    IIITIQHETV LHEPMYHLLG ILAVVDIGLA TTIMPKILAI FWFDAKAISL 100
    PMCFAQIYAI HCFFCIESGI FLCMAVDRYI AICRPLQYPS IVTKAFVFKA 150
    TGFIMLRNGL LTIPVPILAA QRHYCSRNEI EHCLCSNLGV ISLACDDITV 200
    NKFYQLMLAW VLVGSDMALV FSSYAVILHS VLRLNSAEAM SKALSTCSSH 250
    LILILFHTGI IVLSVTHLAE KKIPLIPVFL NVLHNVIPPA LNPLACALRM 300
    HKLRLGFQRL LGLGQDVSK 319
    Length:319
    Mass (Da):35,454
    Last modified:October 1, 2002 - v1
    Checksum:i2D369DB81013EDEC
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti277 – 2771P → S.
    Corresponds to variant rs1462983 [ dbSNP | Ensembl ].
    VAR_024153

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065513 Genomic DNA. Translation: BAC05761.1.
    BC136879 mRNA. Translation: AAI36880.1.
    BC136880 mRNA. Translation: AAI36881.1.
    BK004325 Genomic DNA. Translation: DAA04723.1.
    CCDSiCCDS31406.1.
    RefSeqiNP_001005181.1. NM_001005181.1.
    UniGeneiHs.632154.

    Genome annotation databases

    EnsembliENST00000316529; ENSP00000321196; ENSG00000180919.
    GeneIDi196335.
    KEGGihsa:196335.
    UCSCiuc010qzx.2. human.

    Polymorphism databases

    DMDMi38372824.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065513 Genomic DNA. Translation: BAC05761.1 .
    BC136879 mRNA. Translation: AAI36880.1 .
    BC136880 mRNA. Translation: AAI36881.1 .
    BK004325 Genomic DNA. Translation: DAA04723.1 .
    CCDSi CCDS31406.1.
    RefSeqi NP_001005181.1. NM_001005181.1.
    UniGenei Hs.632154.

    3D structure databases

    ProteinModelPortali Q8NH76.
    SMRi Q8NH76. Positions 31-167.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000321196.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372824.

    Proteomic databases

    PaxDbi Q8NH76.
    PRIDEi Q8NH76.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000316529 ; ENSP00000321196 ; ENSG00000180919 .
    GeneIDi 196335.
    KEGGi hsa:196335.
    UCSCi uc010qzx.2. human.

    Organism-specific databases

    CTDi 196335.
    GeneCardsi GC11P006085.
    HGNCi HGNC:15248. OR56B4.
    neXtProti NX_Q8NH76.
    PharmGKBi PA32453.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40832.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NH76.
    KOi K04257.
    OMAi FCMESGI.
    OrthoDBi EOG7QK0CJ.
    PhylomeDBi Q8NH76.
    TreeFami TF344049.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR56B4.
    GenomeRNAii 196335.
    NextBioi 89437.
    PROi Q8NH76.

    Gene expression databases

    CleanExi HS_OR56B4.
    Genevestigatori Q8NH76.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    Pfami PF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view ]
    PRINTSi PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO56B4_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH76
    Secondary accession number(s): Q6IFD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3