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Protein

Olfactory receptor 56B4

Gene

OR56B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56B4
Alternative name(s):
Olfactory receptor OR11-67
Gene namesi
Name:OR56B4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15248. OR56B4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 52Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 81Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini82 – 105ExtracellularSequence analysisAdd BLAST24
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 145CytoplasmicSequence analysisAdd BLAST19
Transmembranei146 – 166Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini167 – 202ExtracellularSequence analysisAdd BLAST36
Transmembranei203 – 223Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini224 – 243CytoplasmicSequence analysisAdd BLAST20
Transmembranei244 – 263Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini264 – 277ExtracellularSequence analysisAdd BLAST14
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 319CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32453.

Polymorphism and mutation databases

BioMutaiOR56B4.
DMDMi38372824.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507981 – 319Olfactory receptor 56B4Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi103 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NH76.
PeptideAtlasiQ8NH76.
PRIDEiQ8NH76.

PTM databases

PhosphoSitePlusiQ8NH76.

Expressioni

Gene expression databases

BgeeiENSG00000180919.
CleanExiHS_OR56B4.

Interactioni

Protein-protein interaction databases

BioGridi128197. 1 interactor.
STRINGi9606.ENSP00000321196.

Structurei

3D structure databases

ProteinModelPortaliQ8NH76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDZQ. Eukaryota.
ENOG4111EHJ. LUCA.
GeneTreeiENSGT00550000074576.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH76.
KOiK04257.
OMAiFLCMESG.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH76.
TreeFamiTF344049.

Family and domain databases

InterProiView protein in InterPro
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NH76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTSTSVTYD SSLQISQFIL MGLPGIHEWQ HWLSLPLTLL YLLALGANLL
60 70 80 90 100
IIITIQHETV LHEPMYHLLG ILAVVDIGLA TTIMPKILAI FWFDAKAISL
110 120 130 140 150
PMCFAQIYAI HCFFCIESGI FLCMAVDRYI AICRPLQYPS IVTKAFVFKA
160 170 180 190 200
TGFIMLRNGL LTIPVPILAA QRHYCSRNEI EHCLCSNLGV ISLACDDITV
210 220 230 240 250
NKFYQLMLAW VLVGSDMALV FSSYAVILHS VLRLNSAEAM SKALSTCSSH
260 270 280 290 300
LILILFHTGI IVLSVTHLAE KKIPLIPVFL NVLHNVIPPA LNPLACALRM
310
HKLRLGFQRL LGLGQDVSK
Length:319
Mass (Da):35,454
Last modified:October 1, 2002 - v1
Checksum:i2D369DB81013EDEC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024153277P → S. Corresponds to variant dbSNP:rs1462983Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065513 Genomic DNA. Translation: BAC05761.1.
BC136879 mRNA. Translation: AAI36880.1.
BC136880 mRNA. Translation: AAI36881.1.
BK004325 Genomic DNA. Translation: DAA04723.1.
CCDSiCCDS31406.1.
RefSeqiNP_001005181.1. NM_001005181.2.
UniGeneiHs.632154.

Genome annotation databases

EnsembliENST00000316529; ENSP00000321196; ENSG00000180919.
GeneIDi196335.
KEGGihsa:196335.
UCSCiuc010qzx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO56B4_HUMAN
AccessioniPrimary (citable) accession number: Q8NH76
Secondary accession number(s): Q6IFD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: August 30, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families