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Q8NH76

- O56B4_HUMAN

UniProt

Q8NH76 - O56B4_HUMAN

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Protein

Olfactory receptor 56B4

Gene

OR56B4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56B4
Alternative name(s):
Olfactory receptor OR11-67
Gene namesi
Name:OR56B4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15248. OR56B4.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32453.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319Olfactory receptor 56B4PRO_0000150798Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi103 ↔ 195PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NH76.
PRIDEiQ8NH76.

Expressioni

Gene expression databases

CleanExiHS_OR56B4.
GenevestigatoriQ8NH76.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321196.

Structurei

3D structure databases

ProteinModelPortaliQ8NH76.
SMRiQ8NH76. Positions 31-167.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Topological domaini53 – 608CytoplasmicSequence Analysis
Topological domaini82 – 10524ExtracellularSequence AnalysisAdd
BLAST
Topological domaini127 – 14519CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini167 – 20236ExtracellularSequence AnalysisAdd
BLAST
Topological domaini224 – 24320CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini264 – 27714ExtracellularSequence AnalysisAdd
BLAST
Topological domaini299 – 31921CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei61 – 8121Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei106 – 12621Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei146 – 16621Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei203 – 22321Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei244 – 26320Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40832.
GeneTreeiENSGT00550000074576.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH76.
KOiK04257.
OMAiFCMESGI.
OrthoDBiEOG7QK0CJ.
PhylomeDBiQ8NH76.
TreeFamiTF344049.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH76-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDTSTSVTYD SSLQISQFIL MGLPGIHEWQ HWLSLPLTLL YLLALGANLL
60 70 80 90 100
IIITIQHETV LHEPMYHLLG ILAVVDIGLA TTIMPKILAI FWFDAKAISL
110 120 130 140 150
PMCFAQIYAI HCFFCIESGI FLCMAVDRYI AICRPLQYPS IVTKAFVFKA
160 170 180 190 200
TGFIMLRNGL LTIPVPILAA QRHYCSRNEI EHCLCSNLGV ISLACDDITV
210 220 230 240 250
NKFYQLMLAW VLVGSDMALV FSSYAVILHS VLRLNSAEAM SKALSTCSSH
260 270 280 290 300
LILILFHTGI IVLSVTHLAE KKIPLIPVFL NVLHNVIPPA LNPLACALRM
310
HKLRLGFQRL LGLGQDVSK
Length:319
Mass (Da):35,454
Last modified:October 1, 2002 - v1
Checksum:i2D369DB81013EDEC
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti277 – 2771P → S.
Corresponds to variant rs1462983 [ dbSNP | Ensembl ].
VAR_024153

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065513 Genomic DNA. Translation: BAC05761.1.
BC136879 mRNA. Translation: AAI36880.1.
BC136880 mRNA. Translation: AAI36881.1.
BK004325 Genomic DNA. Translation: DAA04723.1.
CCDSiCCDS31406.1.
RefSeqiNP_001005181.1. NM_001005181.1.
UniGeneiHs.632154.

Genome annotation databases

EnsembliENST00000316529; ENSP00000321196; ENSG00000180919.
GeneIDi196335.
KEGGihsa:196335.
UCSCiuc010qzx.2. human.

Polymorphism databases

DMDMi38372824.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065513 Genomic DNA. Translation: BAC05761.1 .
BC136879 mRNA. Translation: AAI36880.1 .
BC136880 mRNA. Translation: AAI36881.1 .
BK004325 Genomic DNA. Translation: DAA04723.1 .
CCDSi CCDS31406.1.
RefSeqi NP_001005181.1. NM_001005181.1.
UniGenei Hs.632154.

3D structure databases

ProteinModelPortali Q8NH76.
SMRi Q8NH76. Positions 31-167.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000321196.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372824.

Proteomic databases

PaxDbi Q8NH76.
PRIDEi Q8NH76.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316529 ; ENSP00000321196 ; ENSG00000180919 .
GeneIDi 196335.
KEGGi hsa:196335.
UCSCi uc010qzx.2. human.

Organism-specific databases

CTDi 196335.
GeneCardsi GC11P006085.
HGNCi HGNC:15248. OR56B4.
neXtProti NX_Q8NH76.
PharmGKBi PA32453.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40832.
GeneTreei ENSGT00550000074576.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q8NH76.
KOi K04257.
OMAi FCMESGI.
OrthoDBi EOG7QK0CJ.
PhylomeDBi Q8NH76.
TreeFami TF344049.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR56B4.
GenomeRNAii 196335.
NextBioi 89437.
PROi Q8NH76.

Gene expression databases

CleanExi HS_OR56B4.
Genevestigatori Q8NH76.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR019424. 7TM_GPCR_olfarory/Srsx.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
Pfami PF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view ]
PRINTSi PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO56B4_HUMAN
AccessioniPrimary (citable) accession number: Q8NH76
Secondary accession number(s): Q6IFD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3