ID   O10A6_HUMAN             Reviewed;         314 AA.
AC   Q8NH74; Q6IF59;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 164.
DE   RecName: Full=Olfactory receptor 10A6;
DE   AltName: Full=Olfactory receptor OR11-96;
GN   Name=OR10A6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [3]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR10A6";
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DR   EMBL; AB065515; BAC05763.1; -; Genomic_DNA.
DR   EMBL; BK004403; DAA04801.1; -; Genomic_DNA.
DR   RefSeq; NP_001004461.1; NM_001004461.1.
DR   AlphaFoldDB; Q8NH74; -.
DR   SMR; Q8NH74; -.
DR   STRING; 9606.ENSP00000492919; -.
DR   GlyCosmos; Q8NH74; 1 site, No reported glycans.
DR   GlyGen; Q8NH74; 1 site.
DR   PhosphoSitePlus; Q8NH74; -.
DR   BioMuta; OR10A6; -.
DR   DMDM; 38372823; -.
DR   PaxDb; 9606-ENSP00000312470; -.
DR   Antibodypedia; 78355; 64 antibodies from 16 providers.
DR   DNASU; 390093; -.
DR   Ensembl; ENST00000622207.2; ENSP00000478945.1; ENSG00000276451.2.
DR   Ensembl; ENST00000625231.2; ENSP00000486810.1; ENSG00000280899.3.
DR   Ensembl; ENST00000641238.1; ENSP00000493068.1; ENSG00000279000.4.
DR   Ensembl; ENST00000641640.1; ENSP00000493246.1; ENSG00000280899.3.
DR   Ensembl; ENST00000641884.1; ENSP00000493158.1; ENSG00000280899.3.
DR   Ensembl; ENST00000642108.1; ENSP00000492919.1; ENSG00000279000.4.
DR   GeneID; 390093; -.
DR   KEGG; hsa:390093; -.
DR   MANE-Select; ENST00000641238.1; ENSP00000493068.1; NM_001004461.2; NP_001004461.1.
DR   UCSC; uc010rbh.2; human.
DR   AGR; HGNC:15132; -.
DR   CTD; 390093; -.
DR   GeneCards; OR10A6; -.
DR   HGNC; HGNC:15132; OR10A6.
DR   HPA; ENSG00000279000; Not detected.
DR   neXtProt; NX_Q8NH74; -.
DR   PharmGKB; PA31954; -.
DR   VEuPathDB; HostDB:ENSG00000279000; -.
DR   eggNOG; ENOG502QVH7; Eukaryota.
DR   GeneTree; ENSGT01040000240406; -.
DR   HOGENOM; CLU_012526_1_0_1; -.
DR   InParanoid; Q8NH74; -.
DR   OMA; KLLMMSW; -.
DR   OrthoDB; 4811967at2759; -.
DR   PhylomeDB; Q8NH74; -.
DR   TreeFam; TF337350; -.
DR   PathwayCommons; Q8NH74; -.
DR   Reactome; R-HSA-381753; Olfactory Signaling Pathway.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 390093; 3 hits in 728 CRISPR screens.
DR   GeneWiki; OR10A6; -.
DR   GenomeRNAi; 390093; -.
DR   Pharos; Q8NH74; Tdark.
DR   PRO; PR:Q8NH74; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NH74; Protein.
DR   Bgee; ENSG00000279000; Expressed in skin of leg and 4 other cell types or tissues.
DR   ExpressionAtlas; Q8NH74; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   GO; GO:0050911; P:detection of chemical stimulus involved in sensory perception of smell; IBA:GO_Central.
DR   CDD; cd15225; 7tmA_OR10A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR26453; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR26453:SF722; OLFACTORY RECEPTOR 10A6; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..314
FT                   /note="Olfactory receptor 10A6"
FT                   /id="PRO_0000150689"
FT   TOPO_DOM        1..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        47..54
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        76..99
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        121..139
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        140..160
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        161..197
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        198..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..237
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..271
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        293..314
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        5
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        97..189
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         117
FT                   /note="A -> V (in dbSNP:rs7928451)"
FT                   /id="VAR_053263"
FT   VARIANT         140
FT                   /note="V -> G (in dbSNP:rs7933807)"
FT                   /id="VAR_053264"
FT   VARIANT         287
FT                   /note="L -> P (in dbSNP:rs4758258)"
FT                   /id="VAR_053265"
SQ   SEQUENCE   314 AA;  35318 MW;  22453498F86381FB CRC64;
     MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS LDQSLHVPMY
     LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ MYFILLFGGA ECFLLGAMAY
     DRFAAICHPL NYQMIMNKGV FMKLIIFSWA LGFMLGTVQT SWVSSFPFCG LNEINHISCE
     TPAVLELACA DTFLFEIYAF TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST
     CAAHLTSVTL FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA
     LMKLWRRRVV LHTI
//