Q8NH74 (O10A6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10A6

Alternative name(s):
Olfactory receptor OR11-96

Gene names

Name:

OR10A6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Olfactory receptor 10A6		PRO_0000150689
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	Helical; Name=1; Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	Helical; Name=2; Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	Helical; Name=3; Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	Helical; Name=5; Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	Helical; Name=6; Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	Helical; Name=7; Potential
	Topological domain	293 – 314	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	117	1	A → V. Corresponds to variant rs7928451 [ dbSNP | Ensembl ].		VAR_053263
	Natural variant	140	1	V → G. Corresponds to variant rs7933807 [ dbSNP | Ensembl ].		VAR_053264
	Natural variant	287	1	L → P. Corresponds to variant rs4758258 [ dbSNP | Ensembl ].		VAR_053265

Sequences

	Sequence		Length	Mass (Da)
	Q8NH74 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 22453498F86381FB	FASTA	314	35,318
	10 20 30 40 50 60 MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS LDQSLHVPMY 70 80 90 100 110 120 LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ MYFILLFGGA ECFLLGAMAY 130 140 150 160 170 180 DRFAAICHPL NYQMIMNKGV FMKLIIFSWA LGFMLGTVQT SWVSSFPFCG LNEINHISCE 190 200 210 220 230 240 TPAVLELACA DTFLFEIYAF TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST 250 260 270 280 290 300 CAAHLTSVTL FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA 310 LMKLWRRRVV LHTI

References

[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[3]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065515 Genomic DNA. Translation: BAC05763.1. BK004403 Genomic DNA. Translation: DAA04801.1.
IPI	IPI00169190.
RefSeq	NP_001004461.1. NM_001004461.1.
UniGene	Hs.528593.
3D structure databases
ProteinModelPortal	Q8NH74.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000312470.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NH74.
Polymorphism databases
DMDM	38372823.
Proteomic databases
PaxDb	Q8NH74.
PRIDE	Q8NH74.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309838; ENSP00000312470; ENSG00000175393.
GeneID	390093.
KEGG	hsa:390093.
UCSC	uc010rbh.2. human.
Organism-specific databases
CTD	390093.
GeneCards	GC11M007949.
HGNC	HGNC:15132. OR10A6.
neXtProt	NX_Q8NH74.
PharmGKB	PA31954.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG150795.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q8NH74.
KO	K04257.
OMA	FMLGTVQ.
OrthoDB	EOG4VX25P.
PhylomeDB	Q8NH74.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
Bgee	Q8NH74.
CleanEx	HS_OR10A6.
Genevestigator	Q8NH74.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	390093.
NextBio	103390.

Entry information

Entry name

O10A6_HUMAN

Accession

Primary (citable) accession number: Q8NH74
Secondary accession number(s): Q6IF59

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.