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Q8NH74 (O10A6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10A6
Alternative name(s):
Olfactory receptor OR11-96
Gene names
Name:OR10A6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length314 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 314314Olfactory receptor 10A6
PRO_0000150689

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19737Extracellular Potential
Transmembrane198 – 21720Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31422Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant1171A → V.
Corresponds to variant rs7928451 [ dbSNP | Ensembl ].
VAR_053263
Natural variant1401V → G.
Corresponds to variant rs7933807 [ dbSNP | Ensembl ].
VAR_053264
Natural variant2871L → P.
Corresponds to variant rs4758258 [ dbSNP | Ensembl ].
VAR_053265

Sequences

Sequence LengthMass (Da)Tools
Q8NH74 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 22453498F86381FB

FASTA31435,318
        10         20         30         40         50         60 
MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS LDQSLHVPMY 

        70         80         90        100        110        120 
LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ MYFILLFGGA ECFLLGAMAY 

       130        140        150        160        170        180 
DRFAAICHPL NYQMIMNKGV FMKLIIFSWA LGFMLGTVQT SWVSSFPFCG LNEINHISCE 

       190        200        210        220        230        240 
TPAVLELACA DTFLFEIYAF TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST 

       250        260        270        280        290        300 
CAAHLTSVTL FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA 

       310 
LMKLWRRRVV LHTI 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065515 Genomic DNA. Translation: BAC05763.1.
BK004403 Genomic DNA. Translation: DAA04801.1.
CCDSCCDS31420.1.
RefSeqNP_001004461.1. NM_001004461.1.
UniGeneHs.528593.

3D structure databases

ProteinModelPortalQ8NH74.
SMRQ8NH74. Positions 32-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000312470.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NH74.

Polymorphism databases

DMDM38372823.

Proteomic databases

PaxDbQ8NH74.
PRIDEQ8NH74.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309838; ENSP00000312470; ENSG00000175393.
GeneID390093.
KEGGhsa:390093.
UCSCuc010rbh.2. human.

Organism-specific databases

CTD390093.
GeneCardsGC11M007949.
HGNCHGNC:15132. OR10A6.
neXtProtNX_Q8NH74.
PharmGKBPA31954.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150795.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NH74.
KOK04257.
OMAGLNEINH.
OrthoDBEOG7SXW3S.
PhylomeDBQ8NH74.
TreeFamTF337350.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NH74.
CleanExHS_OR10A6.
GenevestigatorQ8NH74.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10A6.
GenomeRNAi390093.
NextBio103390.
PROQ8NH74.

Entry information

Entry nameO10A6_HUMAN
AccessionPrimary (citable) accession number: Q8NH74
Secondary accession number(s): Q6IF59
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries