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Q8NH74

- O10A6_HUMAN

UniProt

Q8NH74 - O10A6_HUMAN

Protein

Olfactory receptor 10A6

Gene

OR10A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10A6
    Alternative name(s):
    Olfactory receptor OR11-96
    Gene namesi
    Name:OR10A6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15132. OR10A6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31954.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Olfactory receptor 10A6PRO_0000150689Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH74.
    PRIDEiQ8NH74.

    PTM databases

    PhosphoSiteiQ8NH74.

    Expressioni

    Gene expression databases

    BgeeiQ8NH74.
    CleanExiHS_OR10A6.
    GenevestigatoriQ8NH74.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000312470.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH74.
    SMRiQ8NH74. Positions 32-310.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150795.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NH74.
    KOiK04257.
    OMAiGLNEINH.
    OrthoDBiEOG7SXW3S.
    PhylomeDBiQ8NH74.
    TreeFamiTF337350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH74-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS    50
    LDQSLHVPMY LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ 100
    MYFILLFGGA ECFLLGAMAY DRFAAICHPL NYQMIMNKGV FMKLIIFSWA 150
    LGFMLGTVQT SWVSSFPFCG LNEINHISCE TPAVLELACA DTFLFEIYAF 200
    TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST CAAHLTSVTL 250
    FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA 300
    LMKLWRRRVV LHTI 314
    Length:314
    Mass (Da):35,318
    Last modified:October 1, 2002 - v1
    Checksum:i22453498F86381FB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti117 – 1171A → V.
    Corresponds to variant rs7928451 [ dbSNP | Ensembl ].
    VAR_053263
    Natural varianti140 – 1401V → G.
    Corresponds to variant rs7933807 [ dbSNP | Ensembl ].
    VAR_053264
    Natural varianti287 – 2871L → P.
    Corresponds to variant rs4758258 [ dbSNP | Ensembl ].
    VAR_053265

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065515 Genomic DNA. Translation: BAC05763.1.
    BK004403 Genomic DNA. Translation: DAA04801.1.
    CCDSiCCDS31420.1.
    RefSeqiNP_001004461.1. NM_001004461.1.
    UniGeneiHs.528593.

    Genome annotation databases

    EnsembliENST00000309838; ENSP00000312470; ENSG00000175393.
    GeneIDi390093.
    KEGGihsa:390093.
    UCSCiuc010rbh.2. human.

    Polymorphism databases

    DMDMi38372823.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065515 Genomic DNA. Translation: BAC05763.1 .
    BK004403 Genomic DNA. Translation: DAA04801.1 .
    CCDSi CCDS31420.1.
    RefSeqi NP_001004461.1. NM_001004461.1.
    UniGenei Hs.528593.

    3D structure databases

    ProteinModelPortali Q8NH74.
    SMRi Q8NH74. Positions 32-310.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000312470.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NH74.

    Polymorphism databases

    DMDMi 38372823.

    Proteomic databases

    PaxDbi Q8NH74.
    PRIDEi Q8NH74.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309838 ; ENSP00000312470 ; ENSG00000175393 .
    GeneIDi 390093.
    KEGGi hsa:390093.
    UCSCi uc010rbh.2. human.

    Organism-specific databases

    CTDi 390093.
    GeneCardsi GC11M007949.
    HGNCi HGNC:15132. OR10A6.
    neXtProti NX_Q8NH74.
    PharmGKBi PA31954.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150795.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NH74.
    KOi K04257.
    OMAi GLNEINH.
    OrthoDBi EOG7SXW3S.
    PhylomeDBi Q8NH74.
    TreeFami TF337350.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10A6.
    GenomeRNAii 390093.
    NextBioi 103390.
    PROi Q8NH74.

    Gene expression databases

    Bgeei Q8NH74.
    CleanExi HS_OR10A6.
    Genevestigatori Q8NH74.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10A6_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH74
    Secondary accession number(s): Q6IF59
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3