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Protein

Olfactory receptor 10A6

Gene

OR10A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A6
Alternative name(s):
Olfactory receptor OR11-96
Gene namesi
Name:OR10A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:15132. OR10A6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence AnalysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31422CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31954.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 10A6PRO_0000150689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH74.
PRIDEiQ8NH74.

PTM databases

PhosphoSiteiQ8NH74.

Expressioni

Gene expression databases

BgeeiQ8NH74.
CleanExiHS_OR10A6.
GenevestigatoriQ8NH74.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312470.

Structurei

3D structure databases

ProteinModelPortaliQ8NH74.
SMRiQ8NH74. Positions 32-310.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150795.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH74.
KOiK04257.
OMAiFMLGTVQ.
OrthoDBiEOG7SXW3S.
PhylomeDBiQ8NH74.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS
60 70 80 90 100
LDQSLHVPMY LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ
110 120 130 140 150
MYFILLFGGA ECFLLGAMAY DRFAAICHPL NYQMIMNKGV FMKLIIFSWA
160 170 180 190 200
LGFMLGTVQT SWVSSFPFCG LNEINHISCE TPAVLELACA DTFLFEIYAF
210 220 230 240 250
TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST CAAHLTSVTL
260 270 280 290 300
FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA
310
LMKLWRRRVV LHTI
Length:314
Mass (Da):35,318
Last modified:October 1, 2002 - v1
Checksum:i22453498F86381FB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti117 – 1171A → V.
Corresponds to variant rs7928451 [ dbSNP | Ensembl ].
VAR_053263
Natural varianti140 – 1401V → G.
Corresponds to variant rs7933807 [ dbSNP | Ensembl ].
VAR_053264
Natural varianti287 – 2871L → P.
Corresponds to variant rs4758258 [ dbSNP | Ensembl ].
VAR_053265

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065515 Genomic DNA. Translation: BAC05763.1.
BK004403 Genomic DNA. Translation: DAA04801.1.
CCDSiCCDS31420.1.
RefSeqiNP_001004461.1. NM_001004461.1.
UniGeneiHs.528593.

Genome annotation databases

EnsembliENST00000309838; ENSP00000312470; ENSG00000175393.
ENST00000622207; ENSP00000478945; ENSG00000276451.
ENST00000623813; ENSP00000485676; ENSG00000279000.
ENST00000623991; ENSP00000485518; ENSG00000279000.
GeneIDi390093.
KEGGihsa:390093.
UCSCiuc010rbh.2. human.

Polymorphism databases

DMDMi38372823.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065515 Genomic DNA. Translation: BAC05763.1.
BK004403 Genomic DNA. Translation: DAA04801.1.
CCDSiCCDS31420.1.
RefSeqiNP_001004461.1. NM_001004461.1.
UniGeneiHs.528593.

3D structure databases

ProteinModelPortaliQ8NH74.
SMRiQ8NH74. Positions 32-310.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312470.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NH74.

Polymorphism databases

DMDMi38372823.

Proteomic databases

PaxDbiQ8NH74.
PRIDEiQ8NH74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309838; ENSP00000312470; ENSG00000175393.
ENST00000622207; ENSP00000478945; ENSG00000276451.
ENST00000623813; ENSP00000485676; ENSG00000279000.
ENST00000623991; ENSP00000485518; ENSG00000279000.
GeneIDi390093.
KEGGihsa:390093.
UCSCiuc010rbh.2. human.

Organism-specific databases

CTDi390093.
GeneCardsiGC11M007949.
HGNCiHGNC:15132. OR10A6.
neXtProtiNX_Q8NH74.
PharmGKBiPA31954.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG150795.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH74.
KOiK04257.
OMAiFMLGTVQ.
OrthoDBiEOG7SXW3S.
PhylomeDBiQ8NH74.
TreeFamiTF337350.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10A6.
GenomeRNAii390093.
NextBioi103390.
PROiQ8NH74.

Gene expression databases

BgeeiQ8NH74.
CleanExiHS_OR10A6.
GenevestigatoriQ8NH74.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10A6_HUMAN
AccessioniPrimary (citable) accession number: Q8NH74
Secondary accession number(s): Q6IF59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.