Reviewed, UniProtKB/Swiss-Prot Q8NH74 (O10A6_HUMAN)

Names and origin

Protein names

Recommended name:
    Olfactory receptor 10A6
Alternative name(s):
    Olfactory receptor OR11-96

Gene names

Name:

OR10A6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to stimulus Inferred from electronic annotation. Source: UniProtKB-KW sensory perception of smell Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Olfactory receptor 10A6		PRO_0000150689
Regions
	Topological domain	1 – 25	25	Extracellular Potential
	Transmembrane	26 – 46	21	1 Potential
	Topological domain	47 – 54	8	Cytoplasmic Potential
	Transmembrane	55 – 75	21	2 Potential
	Topological domain	76 – 99	24	Extracellular Potential
	Transmembrane	100 – 120	21	3 Potential
	Topological domain	121 – 139	19	Cytoplasmic Potential
	Transmembrane	140 – 160	21	4 Potential
	Topological domain	161 – 197	37	Extracellular Potential
	Transmembrane	198 – 217	20	5 Potential
	Topological domain	218 – 237	20	Cytoplasmic Potential
	Transmembrane	238 – 258	21	6 Potential
	Topological domain	259 – 271	13	Extracellular Potential
	Transmembrane	272 – 292	21	7 Potential
	Topological domain	293 – 314	22	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	5	1	N-linked (GlcNAc...) Potential
	Disulfide bond	97 ↔ 189		By similarity
Natural variations
	Natural variant	117	1	A → V: dbSNP rs7928451.		VAR_053263
	Natural variant	140	1	V → G: dbSNP rs7933807.		VAR_053264
	Natural variant	287	1	L → P: dbSNP rs4758258.		VAR_053265

Sequences

	Sequence		Length	Mass (Da)
	Q8NH74-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 22453498F86381FB	FASTA	314	35,318
	10 20 30 40 50 60 MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS LDQSLHVPMY 70 80 90 100 110 120 LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ MYFILLFGGA ECFLLGAMAY 130 140 150 160 170 180 DRFAAICHPL NYQMIMNKGV FMKLIIFSWA LGFMLGTVQT SWVSSFPFCG LNEINHISCE 190 200 210 220 230 240 TPAVLELACA DTFLFEIYAF TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST 250 260 270 280 290 300 CAAHLTSVTL FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA 310 LMKLWRRRVV LHTI

References

[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed: 14983052] [Abstract] Cited for: IDENTIFICATION.
[3]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB065515 Genomic DNA. Translation: BAC05763.1. BK004403 Genomic DNA. Translation: DAA04801.1.
IPI	IPI00169190.
RefSeq	NP_001004461.1.
UniGene	Hs.528593
3D structure databases
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
Proteomic databases
PRIDE	Q8NH74.
Genome annotation databases
Ensembl	ENSG00000175393. Homo sapiens. [Contig view]
GeneID	390093.
KEGG	hsa:390093.
NMPDR	fig|9606.3.peg.5214.
UCSC	uc001mft.1. human.
Organism-specific databases
GeneCards	GC11M007905.
HGNC	HGNC:15132. OR10A6.
PharmGKB	PA31954.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q8NH74.
HOVERGEN	Q8NH74.
OMA	Q8NH74. VQTSWVS.
Enzyme and pathway databases
Reactome	REACT_14797. Signaling by GPCR.
Gene expression databases
ArrayExpress	Q8NH74.
Bgee	Q8NH74.
CleanEx	HS_OR10A6.
Family and domain databases
InterPro	IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR11398. Olfact_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	103390.

Entry information

Entry name

O10A6_HUMAN

Accession

Primary (citable) accession number: Q8NH74
Secondary accession number(s): Q6IF59

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	July 7, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)