Reviewed,
UniProtKB/Swiss-Prot Q8NH74 (O10A6_HUMAN)
Last modified
July 7, 2009.
Version 58.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Olfactory receptor 10A6 Alternative name(s): Olfactory receptor OR11-96 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 314 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Odorant receptor Potential. |
| Subcellular location | |
| Sequence similarities | Belongs to the G-protein coupled receptor 1 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Olfaction Sensory transduction |
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Molecular function | G-protein coupled receptor Receptor Transducer |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | G-protein coupled receptor protein signaling pathway Inferred from electronic annotation. Source: UniProtKB-KW response to stimulusInferred from electronic annotation. Source: UniProtKB-KW sensory perception of smellInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | olfactory receptor activity Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 314 | 314 | Olfactory receptor 10A6 | PRO_0000150689 | |||||||
Regions | |||||||||||
| Topological domain | 1 – 25 | 25 | Extracellular Potential | ||||||||
| Transmembrane | 26 – 46 | 21 | 1 Potential | ||||||||
| Topological domain | 47 – 54 | 8 | Cytoplasmic Potential | ||||||||
| Transmembrane | 55 – 75 | 21 | 2 Potential | ||||||||
| Topological domain | 76 – 99 | 24 | Extracellular Potential | ||||||||
| Transmembrane | 100 – 120 | 21 | 3 Potential | ||||||||
| Topological domain | 121 – 139 | 19 | Cytoplasmic Potential | ||||||||
| Transmembrane | 140 – 160 | 21 | 4 Potential | ||||||||
| Topological domain | 161 – 197 | 37 | Extracellular Potential | ||||||||
| Transmembrane | 198 – 217 | 20 | 5 Potential | ||||||||
| Topological domain | 218 – 237 | 20 | Cytoplasmic Potential | ||||||||
| Transmembrane | 238 – 258 | 21 | 6 Potential | ||||||||
| Topological domain | 259 – 271 | 13 | Extracellular Potential | ||||||||
| Transmembrane | 272 – 292 | 21 | 7 Potential | ||||||||
| Topological domain | 293 – 314 | 22 | Cytoplasmic Potential | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 5 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 97 ↔ 189 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 117 | 1 | A → V: dbSNP rs7928451. | VAR_053263 | |||||||
| Natural variant | 140 | 1 | V → G: dbSNP rs7933807. | VAR_053264 | |||||||
| Natural variant | 287 | 1 | L → P: dbSNP rs4758258. | VAR_053265 | |||||||
Sequences
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References
| [1] | "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed: 14983052] [Abstract] Cited for: IDENTIFICATION. |
| [3] | Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004) |
Cross-references
Sequence databases | |
|---|---|
| AB065515 Genomic DNA. Translation: BAC05763.1. BK004403 Genomic DNA. Translation: DAA04801.1. | |
| IPI | IPI00169190. |
| RefSeq | NP_001004461.1. |
| UniGene | Hs.528593 |
3D structure databases | |
| ModBase | Search... |
Protein family/group databases | |
| GPCRDB | Search... |
Proteomic databases | |
| PRIDE | Q8NH74. |
Genome annotation databases | |
| Ensembl | ENSG00000175393. Homo sapiens. [Contig view] |
| GeneID | 390093. |
| KEGG | hsa:390093. |
| NMPDR | fig|9606.3.peg.5214. |
| UCSC | uc001mft.1. human. |
Organism-specific databases | |
| GeneCards | GC11M007905. |
| HGNC | HGNC:15132. OR10A6. |
| PharmGKB | PA31954. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q8NH74. |
| HOVERGEN | Q8NH74. |
| OMA | Q8NH74. VQTSWVS. |
Enzyme and pathway databases | |
| Reactome | REACT_14797. Signaling by GPCR. |
Gene expression databases | |
| ArrayExpress | Q8NH74. |
| Bgee | Q8NH74. |
| CleanEx | HS_OR10A6. |
Family and domain databases | |
| InterPro | IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. IPR000725. Olfact_rcpt. [Graphical view] |
| PANTHER | PTHR11398. Olfact_rcpt. 1 hit. |
| Pfam | PF00001. 7tm_1. 1 hit. [Graphical view] |
| PRINTS | PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR. |
| PROSITE | PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 103390. |
Entry information
| Entry name | O10A6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q8NH74 Secondary accession number(s): Q6IF59 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| 7-transmembrane G-linked receptors List of 7-transmembrane G-linked receptor entries |
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


