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Protein

Olfactory receptor 10A6

Gene

OR10A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175393-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10A6
Alternative name(s):
Olfactory receptor OR11-96
Gene namesi
Name:OR10A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15132. OR10A6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 314CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000276451.
ENSG00000279000.
ENSG00000280899.
PharmGKBiPA31954.

Polymorphism and mutation databases

BioMutaiOR10A6.
DMDMi38372823.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506891 – 314Olfactory receptor 10A6Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH74.
PRIDEiQ8NH74.

Expressioni

Gene expression databases

BgeeiENSG00000175393.
CleanExiHS_OR10A6.

Organism-specific databases

HPAiCAB025507.
CAB073546.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000312470.

Structurei

3D structure databases

ProteinModelPortaliQ8NH74.
SMRiQ8NH74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKK8. Eukaryota.
ENOG410YDA3. LUCA.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH74.
KOiK04257.
OMAiGLNEINH.
OrthoDBiEOG091G0FFM.
PhylomeDBiQ8NH74.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERQNQSCVV EFILLGFSNY PELQGQLFVA FLVIYLVTLI GNAIIIVIVS
60 70 80 90 100
LDQSLHVPMY LFLLNLSVVD LSFSAVIMPE MLVVLSTEKT TISFGGCFAQ
110 120 130 140 150
MYFILLFGGA ECFLLGAMAY DRFAAICHPL NYQMIMNKGV FMKLIIFSWA
160 170 180 190 200
LGFMLGTVQT SWVSSFPFCG LNEINHISCE TPAVLELACA DTFLFEIYAF
210 220 230 240 250
TGTFLIILVP FLLILLSYIR VLFAILKMPS TTGRQKAFST CAAHLTSVTL
260 270 280 290 300
FYGTASMTYL QPKSGYSPET KKVMSLSYSL LTPLLNLLIY SLRNSEMKRA
310
LMKLWRRRVV LHTI
Length:314
Mass (Da):35,318
Last modified:October 1, 2002 - v1
Checksum:i22453498F86381FB
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053263117A → V.Corresponds to variant rs7928451dbSNPEnsembl.1
Natural variantiVAR_053264140V → G.Corresponds to variant rs7933807dbSNPEnsembl.1
Natural variantiVAR_053265287L → P.Corresponds to variant rs4758258dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065515 Genomic DNA. Translation: BAC05763.1.
BK004403 Genomic DNA. Translation: DAA04801.1.
RefSeqiNP_001004461.1. NM_001004461.1.
UniGeneiHs.528593.

Genome annotation databases

EnsembliENST00000622207; ENSP00000478945; ENSG00000276451.
ENST00000623991; ENSP00000485518; ENSG00000279000.
ENST00000625231; ENSP00000486810; ENSG00000280899.
GeneIDi390093.
KEGGihsa:390093.
UCSCiuc010rbh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065515 Genomic DNA. Translation: BAC05763.1.
BK004403 Genomic DNA. Translation: DAA04801.1.
RefSeqiNP_001004461.1. NM_001004461.1.
UniGeneiHs.528593.

3D structure databases

ProteinModelPortaliQ8NH74.
SMRiQ8NH74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000312470.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR10A6.
DMDMi38372823.

Proteomic databases

PaxDbiQ8NH74.
PRIDEiQ8NH74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000622207; ENSP00000478945; ENSG00000276451.
ENST00000623991; ENSP00000485518; ENSG00000279000.
ENST00000625231; ENSP00000486810; ENSG00000280899.
GeneIDi390093.
KEGGihsa:390093.
UCSCiuc010rbh.2. human.

Organism-specific databases

CTDi390093.
GeneCardsiOR10A6.
HGNCiHGNC:15132. OR10A6.
HPAiCAB025507.
CAB073546.
neXtProtiNX_Q8NH74.
OpenTargetsiENSG00000276451.
ENSG00000279000.
ENSG00000280899.
PharmGKBiPA31954.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKK8. Eukaryota.
ENOG410YDA3. LUCA.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH74.
KOiK04257.
OMAiGLNEINH.
OrthoDBiEOG091G0FFM.
PhylomeDBiQ8NH74.
TreeFamiTF337350.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175393-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10A6.
GenomeRNAii390093.
PROiQ8NH74.

Gene expression databases

BgeeiENSG00000175393.
CleanExiHS_OR10A6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10A6_HUMAN
AccessioniPrimary (citable) accession number: Q8NH74
Secondary accession number(s): Q6IF59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.