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Protein

Olfactory receptor 4S2

Gene

OR4S2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4S2
Alternative name(s):
Olfactory receptor OR11-137
Gene namesi
Name:OR4S2
Synonyms:OR4S2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000174982.2.
HGNCiHGNC:15183. OR4S2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 311CytoplasmicSequence analysisAdd BLAST24

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174982.
PharmGKBiPA32345.

Polymorphism and mutation databases

BioMutaiOR4S2.
DMDMi296439253.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505691 – 311Olfactory receptor 4S2Add BLAST311

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH73.
PeptideAtlasiQ8NH73.
PRIDEiQ8NH73.

PTM databases

iPTMnetiQ8NH73.
PhosphoSitePlusiQ8NH73.

Expressioni

Gene expression databases

ExpressionAtlasiQ8NH73. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi128532. 3 interactors.
STRINGi9606.ENSP00000310337.

Structurei

3D structure databases

ProteinModelPortaliQ8NH73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVIK. Eukaryota.
ENOG410YB9C. LUCA.
GeneTreeiENSGT00840000129716.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH73.
KOiK04257.
OMAiKVCFVVF.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NH73.
TreeFamiTF336512.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NH73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKINNVTEF IFWGLSQSPE IEKVCFVVFS FFYIIILLGN LLIMLTVCLS
60 70 80 90 100
NLFKSPMYFF LSFLSFVDIC YSSVTAPKMI VDLLAKDKTI SYVGCMLQLF
110 120 130 140 150
GVHFFGCTEI FILTVMAYDR YVAICKPLHY MTIMNRETCN KMLLGTWVGG
160 170 180 190 200
FLHSIIQVAL VVQLPFCGPN EIDHYFCDVH PVLKLACTET YIVGVVVTAN
210 220 230 240 250
SGTIALGSFV ILLISYSIIL VSLRKQSAEG RRKALSTCGS HIAMVVIFFG
260 270 280 290 300
PCTFMYMRPD TTFSEDKMVA VFYTIITPML NPLIYTLRNA EVKNAMKKLW
310
GRNVFLEAKG K
Length:311
Mass (Da):35,172
Last modified:May 18, 2010 - v2
Checksum:iDAA0084EA91026D1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100F → L in BAC05764 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05754772S → T. Corresponds to variant dbSNP:rs17146960Ensembl.1
Natural variantiVAR_057548195V → G. Corresponds to variant dbSNP:rs7949664Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065516 Genomic DNA. Translation: BAC05764.1.
AP006437 Genomic DNA. No translation available.
BK004390 Genomic DNA. Translation: DAA04788.1.
CCDSiCCDS31505.1.
RefSeqiNP_001004059.2. NM_001004059.2.
UniGeneiHs.553621.

Genome annotation databases

EnsembliENST00000312422; ENSP00000310337; ENSG00000174982.
ENST00000641692; ENSP00000493389; ENSG00000174982.
GeneIDi219431.
KEGGihsa:219431.
UCSCiuc001nhs.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4S2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH73
Secondary accession number(s): Q6IF72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: May 18, 2010
Last modified: November 22, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families