ID   OR4C6_HUMAN             Reviewed;         309 AA.
AC   Q8NH72; B2RP11; Q6IFD2;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 156.
DE   RecName: Full=Olfactory receptor 4C6;
DE   AltName: Full=Olfactory receptor OR11-138;
GN   Name=OR4C6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C6";
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DR   EMBL; AB065517; BAC05765.1; -; Genomic_DNA.
DR   EMBL; CH471076; EAW73679.1; -; Genomic_DNA.
DR   EMBL; BC137216; AAI37217.1; -; mRNA.
DR   EMBL; BC137218; AAI37219.1; -; mRNA.
DR   EMBL; BK004330; DAA04728.1; -; Genomic_DNA.
DR   CCDS; CCDS31506.1; -.
DR   RefSeq; NP_001004704.1; NM_001004704.1.
DR   AlphaFoldDB; Q8NH72; -.
DR   SMR; Q8NH72; -.
DR   STRING; 9606.ENSP00000493334; -.
DR   GlyCosmos; Q8NH72; 1 site, No reported glycans.
DR   GlyGen; Q8NH72; 1 site.
DR   iPTMnet; Q8NH72; -.
DR   PhosphoSitePlus; Q8NH72; -.
DR   BioMuta; OR4C6; -.
DR   DMDM; 38372822; -.
DR   PaxDb; 9606-ENSP00000324769; -.
DR   PeptideAtlas; Q8NH72; -.
DR   Antibodypedia; 58938; 56 antibodies from 14 providers.
DR   DNASU; 219432; -.
DR   Ensembl; ENST00000314259.5; ENSP00000324769.3; ENSG00000181903.7.
DR   Ensembl; ENST00000690330.1; ENSP00000508428.1; ENSG00000181903.7.
DR   GeneID; 219432; -.
DR   KEGG; hsa:219432; -.
DR   MANE-Select; ENST00000314259.5; ENSP00000324769.3; NM_001004704.2; NP_001004704.1.
DR   UCSC; uc010rik.2; human.
DR   AGR; HGNC:14743; -.
DR   CTD; 219432; -.
DR   GeneCards; OR4C6; -.
DR   HGNC; HGNC:14743; OR4C6.
DR   HPA; ENSG00000181903; Not detected.
DR   neXtProt; NX_Q8NH72; -.
DR   OpenTargets; ENSG00000181903; -.
DR   PharmGKB; PA32264; -.
DR   VEuPathDB; HostDB:ENSG00000181903; -.
DR   eggNOG; ENOG502T8YI; Eukaryota.
DR   GeneTree; ENSGT00940000158647; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NH72; -.
DR   OMA; VTMITSQ; -.
DR   OrthoDB; 4052270at2759; -.
DR   PhylomeDB; Q8NH72; -.
DR   TreeFam; TF352732; -.
DR   PathwayCommons; Q8NH72; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 219432; 56 hits in 741 CRISPR screens.
DR   GeneWiki; OR4C6; -.
DR   GenomeRNAi; 219432; -.
DR   Pharos; Q8NH72; Tdark.
DR   PRO; PR:Q8NH72; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NH72; Protein.
DR   Bgee; ENSG00000181903; Expressed in tonsil and 2 other cell types or tissues.
DR   ExpressionAtlas; Q8NH72; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15939; 7tmA_OR4A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48002:SF128; OLFACTORY RECEPTOR 4C6; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..309
FT                   /note="Olfactory receptor 4C6"
FT                   /id="PRO_0000150531"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         133
FT                   /note="I -> T (in dbSNP:rs11230600)"
FT                   /id="VAR_034191"
SQ   SEQUENCE   309 AA;  34558 MW;  C481E2356F227426 CRC64;
     MENQNNVTEF ILLGLTENLE LWKIFSAVFL VMYVATVLEN LLIVVTIITS QSLRSPMYFF
     LTFLSLLDVM FSSVVAPKVI VDTLSKSTTI SLKGCLTQLF VEHFFGGVGI ILLTVMAYDR
     YVAICKPLHY TIIMSPRVCC LMVGGAWVGG FMHAMIQLLF MYQIPFCGPN IIDHFICDLF
     QLLTLACTDT HILGLLVTLN SGMMCVAIFL ILIASYTVIL CSLKSYSSKG RHKALSTCSS
     HLTVVVLFFV PCIFLYMRPV VTHPIDKAMA VSDSIITPML NPLIYTLRNA EVKSAMKKLW
     MKWEALAGK
//