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Protein

Olfactory receptor 4C6

Gene

OR4C6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
  3. transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

  1. detection of chemical stimulus involved in sensory perception Source: GO_Central
  2. G-protein coupled receptor signaling pathway Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C6
Alternative name(s):
Olfactory receptor OR11-138
Gene namesi
Name:OR4C6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14743. OR4C6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25623Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini257 – 26711ExtracellularSequence AnalysisAdd
BLAST
Transmembranei268 – 28720Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini288 – 30922CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: GO_Central
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32264.

Polymorphism and mutation databases

BioMutaiOR4C6.
DMDMi38372822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 4C6PRO_0000150531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH72.
PRIDEiQ8NH72.

Expressioni

Gene expression databases

BgeeiQ8NH72.
CleanExiHS_OR4C6.
GenevestigatoriQ8NH72.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324769.

Structurei

3D structure databases

ProteinModelPortaliQ8NH72.
SMRiQ8NH72. Positions 22-148.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG136221.
GeneTreeiENSGT00760000118773.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH72.
KOiK04257.
OMAiFMHAMIQ.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NH72.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENQNNVTEF ILLGLTENLE LWKIFSAVFL VMYVATVLEN LLIVVTIITS
60 70 80 90 100
QSLRSPMYFF LTFLSLLDVM FSSVVAPKVI VDTLSKSTTI SLKGCLTQLF
110 120 130 140 150
VEHFFGGVGI ILLTVMAYDR YVAICKPLHY TIIMSPRVCC LMVGGAWVGG
160 170 180 190 200
FMHAMIQLLF MYQIPFCGPN IIDHFICDLF QLLTLACTDT HILGLLVTLN
210 220 230 240 250
SGMMCVAIFL ILIASYTVIL CSLKSYSSKG RHKALSTCSS HLTVVVLFFV
260 270 280 290 300
PCIFLYMRPV VTHPIDKAMA VSDSIITPML NPLIYTLRNA EVKSAMKKLW

MKWEALAGK
Length:309
Mass (Da):34,558
Last modified:October 1, 2002 - v1
Checksum:iC481E2356F227426
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331I → T.
Corresponds to variant rs11230600 [ dbSNP | Ensembl ].
VAR_034191

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065517 Genomic DNA. Translation: BAC05765.1.
CH471076 Genomic DNA. Translation: EAW73679.1.
BC137216 mRNA. Translation: AAI37217.1.
BC137218 mRNA. Translation: AAI37219.1.
BK004330 Genomic DNA. Translation: DAA04728.1.
CCDSiCCDS31506.1.
RefSeqiNP_001004704.1. NM_001004704.1.
UniGeneiHs.511921.

Genome annotation databases

EnsembliENST00000314259; ENSP00000324769; ENSG00000181903.
GeneIDi219432.
KEGGihsa:219432.
UCSCiuc010rik.2. human.

Polymorphism and mutation databases

BioMutaiOR4C6.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065517 Genomic DNA. Translation: BAC05765.1.
CH471076 Genomic DNA. Translation: EAW73679.1.
BC137216 mRNA. Translation: AAI37217.1.
BC137218 mRNA. Translation: AAI37219.1.
BK004330 Genomic DNA. Translation: DAA04728.1.
CCDSiCCDS31506.1.
RefSeqiNP_001004704.1. NM_001004704.1.
UniGeneiHs.511921.

3D structure databases

ProteinModelPortaliQ8NH72.
SMRiQ8NH72. Positions 22-148.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000324769.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR4C6.
DMDMi38372822.

Proteomic databases

PaxDbiQ8NH72.
PRIDEiQ8NH72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314259; ENSP00000324769; ENSG00000181903.
GeneIDi219432.
KEGGihsa:219432.
UCSCiuc010rik.2. human.

Organism-specific databases

CTDi219432.
GeneCardsiGC11P055432.
HGNCiHGNC:14743. OR4C6.
neXtProtiNX_Q8NH72.
PharmGKBiPA32264.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG136221.
GeneTreeiENSGT00760000118773.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH72.
KOiK04257.
OMAiFMHAMIQ.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NH72.
TreeFamiTF352732.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4C6.
GenomeRNAii219432.
NextBioi90607.
PROiQ8NH72.

Gene expression databases

BgeeiQ8NH72.
CleanExiHS_OR4C6.
GenevestigatoriQ8NH72.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4C6_HUMAN
AccessioniPrimary (citable) accession number: Q8NH72
Secondary accession number(s): B2RP11, Q6IFD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 29, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.