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Protein

Olfactory receptor 4C6

Gene

OR4C6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181903-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C6
Alternative name(s):
Olfactory receptor OR11-138
Gene namesi
Name:OR4C6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14743. OR4C6.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 309CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi219432.
OpenTargetsiENSG00000181903.
PharmGKBiPA32264.

Polymorphism and mutation databases

BioMutaiOR4C6.
DMDMi38372822.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505311 – 309Olfactory receptor 4C6Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH72.
PeptideAtlasiQ8NH72.
PRIDEiQ8NH72.

PTM databases

iPTMnetiQ8NH72.
PhosphoSitePlusiQ8NH72.

Expressioni

Gene expression databases

BgeeiENSG00000181903.
CleanExiHS_OR4C6.
ExpressionAtlasiQ8NH72. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324769.

Structurei

3D structure databases

ProteinModelPortaliQ8NH72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIPZ. Eukaryota.
ENOG41113GR. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH72.
KOiK04257.
OMAiFMHAMIQ.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NH72.
TreeFamiTF352732.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENQNNVTEF ILLGLTENLE LWKIFSAVFL VMYVATVLEN LLIVVTIITS
60 70 80 90 100
QSLRSPMYFF LTFLSLLDVM FSSVVAPKVI VDTLSKSTTI SLKGCLTQLF
110 120 130 140 150
VEHFFGGVGI ILLTVMAYDR YVAICKPLHY TIIMSPRVCC LMVGGAWVGG
160 170 180 190 200
FMHAMIQLLF MYQIPFCGPN IIDHFICDLF QLLTLACTDT HILGLLVTLN
210 220 230 240 250
SGMMCVAIFL ILIASYTVIL CSLKSYSSKG RHKALSTCSS HLTVVVLFFV
260 270 280 290 300
PCIFLYMRPV VTHPIDKAMA VSDSIITPML NPLIYTLRNA EVKSAMKKLW

MKWEALAGK
Length:309
Mass (Da):34,558
Last modified:October 1, 2002 - v1
Checksum:iC481E2356F227426
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034191133I → T.Corresponds to variant rs11230600dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065517 Genomic DNA. Translation: BAC05765.1.
CH471076 Genomic DNA. Translation: EAW73679.1.
BC137216 mRNA. Translation: AAI37217.1.
BC137218 mRNA. Translation: AAI37219.1.
BK004330 Genomic DNA. Translation: DAA04728.1.
CCDSiCCDS31506.1.
RefSeqiNP_001004704.1. NM_001004704.1.
UniGeneiHs.511921.

Genome annotation databases

EnsembliENST00000314259; ENSP00000324769; ENSG00000181903.
GeneIDi219432.
KEGGihsa:219432.
UCSCiuc010rik.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065517 Genomic DNA. Translation: BAC05765.1.
CH471076 Genomic DNA. Translation: EAW73679.1.
BC137216 mRNA. Translation: AAI37217.1.
BC137218 mRNA. Translation: AAI37219.1.
BK004330 Genomic DNA. Translation: DAA04728.1.
CCDSiCCDS31506.1.
RefSeqiNP_001004704.1. NM_001004704.1.
UniGeneiHs.511921.

3D structure databases

ProteinModelPortaliQ8NH72.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000324769.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH72.
PhosphoSitePlusiQ8NH72.

Polymorphism and mutation databases

BioMutaiOR4C6.
DMDMi38372822.

Proteomic databases

PaxDbiQ8NH72.
PeptideAtlasiQ8NH72.
PRIDEiQ8NH72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314259; ENSP00000324769; ENSG00000181903.
GeneIDi219432.
KEGGihsa:219432.
UCSCiuc010rik.2. human.

Organism-specific databases

CTDi219432.
DisGeNETi219432.
GeneCardsiOR4C6.
HGNCiHGNC:14743. OR4C6.
neXtProtiNX_Q8NH72.
OpenTargetsiENSG00000181903.
PharmGKBiPA32264.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIPZ. Eukaryota.
ENOG41113GR. LUCA.
GeneTreeiENSGT00840000129693.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH72.
KOiK04257.
OMAiFMHAMIQ.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NH72.
TreeFamiTF352732.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181903-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4C6.
GenomeRNAii219432.
PROiQ8NH72.

Gene expression databases

BgeeiENSG00000181903.
CleanExiHS_OR4C6.
ExpressionAtlasiQ8NH72. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4C6_HUMAN
AccessioniPrimary (citable) accession number: Q8NH72
Secondary accession number(s): B2RP11, Q6IFD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.