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Q8NH72

- OR4C6_HUMAN

UniProt

Q8NH72 - OR4C6_HUMAN

Protein

Olfactory receptor 4C6

Gene

OR4C6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4C6
    Alternative name(s):
    Olfactory receptor OR11-138
    Gene namesi
    Name:OR4C6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14743. OR4C6.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32264.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Olfactory receptor 4C6PRO_0000150531Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH72.
    PRIDEiQ8NH72.

    Expressioni

    Gene expression databases

    BgeeiQ8NH72.
    CleanExiHS_OR4C6.
    GenevestigatoriQ8NH72.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000324769.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH72.
    SMRiQ8NH72. Positions 22-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini288 – 30922CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25623Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28720Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG136221.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NH72.
    KOiK04257.
    OMAiFMHAMIQ.
    OrthoDBiEOG754HPT.
    PhylomeDBiQ8NH72.
    TreeFamiTF352732.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENQNNVTEF ILLGLTENLE LWKIFSAVFL VMYVATVLEN LLIVVTIITS    50
    QSLRSPMYFF LTFLSLLDVM FSSVVAPKVI VDTLSKSTTI SLKGCLTQLF 100
    VEHFFGGVGI ILLTVMAYDR YVAICKPLHY TIIMSPRVCC LMVGGAWVGG 150
    FMHAMIQLLF MYQIPFCGPN IIDHFICDLF QLLTLACTDT HILGLLVTLN 200
    SGMMCVAIFL ILIASYTVIL CSLKSYSSKG RHKALSTCSS HLTVVVLFFV 250
    PCIFLYMRPV VTHPIDKAMA VSDSIITPML NPLIYTLRNA EVKSAMKKLW 300
    MKWEALAGK 309
    Length:309
    Mass (Da):34,558
    Last modified:October 1, 2002 - v1
    Checksum:iC481E2356F227426
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331I → T.
    Corresponds to variant rs11230600 [ dbSNP | Ensembl ].
    VAR_034191

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065517 Genomic DNA. Translation: BAC05765.1.
    CH471076 Genomic DNA. Translation: EAW73679.1.
    BC137216 mRNA. Translation: AAI37217.1.
    BC137218 mRNA. Translation: AAI37219.1.
    BK004330 Genomic DNA. Translation: DAA04728.1.
    CCDSiCCDS31506.1.
    RefSeqiNP_001004704.1. NM_001004704.1.
    UniGeneiHs.511921.

    Genome annotation databases

    EnsembliENST00000314259; ENSP00000324769; ENSG00000181903.
    GeneIDi219432.
    KEGGihsa:219432.
    UCSCiuc010rik.2. human.

    Polymorphism databases

    DMDMi38372822.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065517 Genomic DNA. Translation: BAC05765.1 .
    CH471076 Genomic DNA. Translation: EAW73679.1 .
    BC137216 mRNA. Translation: AAI37217.1 .
    BC137218 mRNA. Translation: AAI37219.1 .
    BK004330 Genomic DNA. Translation: DAA04728.1 .
    CCDSi CCDS31506.1.
    RefSeqi NP_001004704.1. NM_001004704.1.
    UniGenei Hs.511921.

    3D structure databases

    ProteinModelPortali Q8NH72.
    SMRi Q8NH72. Positions 22-148.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000324769.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372822.

    Proteomic databases

    PaxDbi Q8NH72.
    PRIDEi Q8NH72.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314259 ; ENSP00000324769 ; ENSG00000181903 .
    GeneIDi 219432.
    KEGGi hsa:219432.
    UCSCi uc010rik.2. human.

    Organism-specific databases

    CTDi 219432.
    GeneCardsi GC11P055432.
    HGNCi HGNC:14743. OR4C6.
    neXtProti NX_Q8NH72.
    PharmGKBi PA32264.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG136221.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NH72.
    KOi K04257.
    OMAi FMHAMIQ.
    OrthoDBi EOG754HPT.
    PhylomeDBi Q8NH72.
    TreeFami TF352732.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR4C6.
    GenomeRNAii 219432.
    NextBioi 90607.
    PROi Q8NH72.

    Gene expression databases

    Bgeei Q8NH72.
    CleanExi HS_OR4C6.
    Genevestigatori Q8NH72.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR4C6_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH72
    Secondary accession number(s): B2RP11, Q6IFD2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3