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Q8NH72

- OR4C6_HUMAN

UniProt

Q8NH72 - OR4C6_HUMAN

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Protein
Olfactory receptor 4C6
Gene
OR4C6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C6
Alternative name(s):
Olfactory receptor OR11-138
Gene namesi
Name:OR4C6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14743. OR4C6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed prediction
Add
BLAST
Transmembranei24 – 4724Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini48 – 558Cytoplasmic Reviewed prediction
Transmembranei56 – 7722Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini78 – 9821Extracellular Reviewed prediction
Add
BLAST
Transmembranei99 – 11820Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini119 – 13719Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei138 – 15619Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini157 – 19337Extracellular Reviewed prediction
Add
BLAST
Transmembranei194 – 21724Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini218 – 23316Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei234 – 25623Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini257 – 26711Extracellular Reviewed prediction
Add
BLAST
Transmembranei268 – 28720Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini288 – 30922Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32264.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 4C6
PRO_0000150531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH72.
PRIDEiQ8NH72.

Expressioni

Gene expression databases

BgeeiQ8NH72.
CleanExiHS_OR4C6.
GenevestigatoriQ8NH72.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324769.

Structurei

3D structure databases

ProteinModelPortaliQ8NH72.
SMRiQ8NH72. Positions 22-148.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG136221.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH72.
KOiK04257.
OMAiFMHAMIQ.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NH72.
TreeFamiTF352732.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH72-1 [UniParc]FASTAAdd to Basket

« Hide

MENQNNVTEF ILLGLTENLE LWKIFSAVFL VMYVATVLEN LLIVVTIITS    50
QSLRSPMYFF LTFLSLLDVM FSSVVAPKVI VDTLSKSTTI SLKGCLTQLF 100
VEHFFGGVGI ILLTVMAYDR YVAICKPLHY TIIMSPRVCC LMVGGAWVGG 150
FMHAMIQLLF MYQIPFCGPN IIDHFICDLF QLLTLACTDT HILGLLVTLN 200
SGMMCVAIFL ILIASYTVIL CSLKSYSSKG RHKALSTCSS HLTVVVLFFV 250
PCIFLYMRPV VTHPIDKAMA VSDSIITPML NPLIYTLRNA EVKSAMKKLW 300
MKWEALAGK 309
Length:309
Mass (Da):34,558
Last modified:October 1, 2002 - v1
Checksum:iC481E2356F227426
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331I → T.
Corresponds to variant rs11230600 [ dbSNP | Ensembl ].
VAR_034191

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065517 Genomic DNA. Translation: BAC05765.1.
CH471076 Genomic DNA. Translation: EAW73679.1.
BC137216 mRNA. Translation: AAI37217.1.
BC137218 mRNA. Translation: AAI37219.1.
BK004330 Genomic DNA. Translation: DAA04728.1.
CCDSiCCDS31506.1.
RefSeqiNP_001004704.1. NM_001004704.1.
UniGeneiHs.511921.

Genome annotation databases

EnsembliENST00000314259; ENSP00000324769; ENSG00000181903.
GeneIDi219432.
KEGGihsa:219432.
UCSCiuc010rik.2. human.

Polymorphism databases

DMDMi38372822.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065517 Genomic DNA. Translation: BAC05765.1 .
CH471076 Genomic DNA. Translation: EAW73679.1 .
BC137216 mRNA. Translation: AAI37217.1 .
BC137218 mRNA. Translation: AAI37219.1 .
BK004330 Genomic DNA. Translation: DAA04728.1 .
CCDSi CCDS31506.1.
RefSeqi NP_001004704.1. NM_001004704.1.
UniGenei Hs.511921.

3D structure databases

ProteinModelPortali Q8NH72.
SMRi Q8NH72. Positions 22-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000324769.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372822.

Proteomic databases

PaxDbi Q8NH72.
PRIDEi Q8NH72.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314259 ; ENSP00000324769 ; ENSG00000181903 .
GeneIDi 219432.
KEGGi hsa:219432.
UCSCi uc010rik.2. human.

Organism-specific databases

CTDi 219432.
GeneCardsi GC11P055432.
HGNCi HGNC:14743. OR4C6.
neXtProti NX_Q8NH72.
PharmGKBi PA32264.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG136221.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NH72.
KOi K04257.
OMAi FMHAMIQ.
OrthoDBi EOG754HPT.
PhylomeDBi Q8NH72.
TreeFami TF352732.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR4C6.
GenomeRNAii 219432.
NextBioi 90607.
PROi Q8NH72.

Gene expression databases

Bgeei Q8NH72.
CleanExi HS_OR4C6.
Genevestigatori Q8NH72.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4C6_HUMAN
AccessioniPrimary (citable) accession number: Q8NH72
Secondary accession number(s): B2RP11, Q6IFD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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