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Protein

Olfactory receptor 4C6

Gene

OR4C6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C6
Alternative name(s):
Olfactory receptor OR11-138
Gene namesi
Name:OR4C6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000181903.4
HGNCiHGNC:14743 OR4C6
neXtProtiNX_Q8NH72

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 309CytoplasmicSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181903
PharmGKBiPA32264

Polymorphism and mutation databases

BioMutaiOR4C6
DMDMi38372822

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505311 – 309Olfactory receptor 4C6Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH72
PRIDEiQ8NH72

PTM databases

iPTMnetiQ8NH72
PhosphoSitePlusiQ8NH72

Expressioni

Gene expression databases

BgeeiENSG00000181903
CleanExiHS_OR4C6
ExpressionAtlasiQ8NH72 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000324769

Structurei

3D structure databases

ProteinModelPortaliQ8NH72
SMRiQ8NH72
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIPZ Eukaryota
ENOG41113GR LUCA
GeneTreeiENSGT00910000144032
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH72
KOiK04257
OMAiHPIDKAM
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NH72
TreeFamiTF352732

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENQNNVTEF ILLGLTENLE LWKIFSAVFL VMYVATVLEN LLIVVTIITS
60 70 80 90 100
QSLRSPMYFF LTFLSLLDVM FSSVVAPKVI VDTLSKSTTI SLKGCLTQLF
110 120 130 140 150
VEHFFGGVGI ILLTVMAYDR YVAICKPLHY TIIMSPRVCC LMVGGAWVGG
160 170 180 190 200
FMHAMIQLLF MYQIPFCGPN IIDHFICDLF QLLTLACTDT HILGLLVTLN
210 220 230 240 250
SGMMCVAIFL ILIASYTVIL CSLKSYSSKG RHKALSTCSS HLTVVVLFFV
260 270 280 290 300
PCIFLYMRPV VTHPIDKAMA VSDSIITPML NPLIYTLRNA EVKSAMKKLW

MKWEALAGK
Length:309
Mass (Da):34,558
Last modified:October 1, 2002 - v1
Checksum:iC481E2356F227426
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034191133I → T. Corresponds to variant dbSNP:rs11230600Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065517 Genomic DNA Translation: BAC05765.1
CH471076 Genomic DNA Translation: EAW73679.1
BC137216 mRNA Translation: AAI37217.1
BC137218 mRNA Translation: AAI37219.1
BK004330 Genomic DNA Translation: DAA04728.1
CCDSiCCDS31506.1
RefSeqiNP_001004704.1, NM_001004704.1
UniGeneiHs.511921

Genome annotation databases

EnsembliENST00000314259; ENSP00000324769; ENSG00000181903
ENST00000641251; ENSP00000493334; ENSG00000181903
GeneIDi219432
KEGGihsa:219432
UCSCiuc010rik.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR4C6_HUMAN
AccessioniPrimary (citable) accession number: Q8NH72
Secondary accession number(s): B2RP11, Q6IFD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome