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Q8NH72 (OR4C6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4C6
Alternative name(s):
Olfactory receptor OR11-138
Gene names
Name:OR4C6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Olfactory receptor 4C6
PRO_0000150531

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4724Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7722Helical; Name=2; Potential
Topological domain78 – 9821Extracellular Potential
Transmembrane99 – 11820Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15619Helical; Name=4; Potential
Topological domain157 – 19337Extracellular Potential
Transmembrane194 – 21724Helical; Name=5; Potential
Topological domain218 – 23316Cytoplasmic Potential
Transmembrane234 – 25623Helical; Name=6; Potential
Topological domain257 – 26711Extracellular Potential
Transmembrane268 – 28720Helical; Name=7; Potential
Topological domain288 – 30922Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 187 By similarity

Natural variations

Natural variant1331I → T.
Corresponds to variant rs11230600 [ dbSNP | Ensembl ].
VAR_034191

Sequences

Sequence LengthMass (Da)Tools
Q8NH72 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: C481E2356F227426

FASTA30934,558
        10         20         30         40         50         60 
MENQNNVTEF ILLGLTENLE LWKIFSAVFL VMYVATVLEN LLIVVTIITS QSLRSPMYFF 

        70         80         90        100        110        120 
LTFLSLLDVM FSSVVAPKVI VDTLSKSTTI SLKGCLTQLF VEHFFGGVGI ILLTVMAYDR 

       130        140        150        160        170        180 
YVAICKPLHY TIIMSPRVCC LMVGGAWVGG FMHAMIQLLF MYQIPFCGPN IIDHFICDLF 

       190        200        210        220        230        240 
QLLTLACTDT HILGLLVTLN SGMMCVAIFL ILIASYTVIL CSLKSYSSKG RHKALSTCSS 

       250        260        270        280        290        300 
HLTVVVLFFV PCIFLYMRPV VTHPIDKAMA VSDSIITPML NPLIYTLRNA EVKSAMKKLW 


MKWEALAGK 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065517 Genomic DNA. Translation: BAC05765.1.
CH471076 Genomic DNA. Translation: EAW73679.1.
BC137216 mRNA. Translation: AAI37217.1.
BC137218 mRNA. Translation: AAI37219.1.
BK004330 Genomic DNA. Translation: DAA04728.1.
RefSeqNP_001004704.1. NM_001004704.1.
UniGeneHs.511921.

3D structure databases

ProteinModelPortalQ8NH72.
SMRQ8NH72. Positions 108-138, 273-301.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000324769.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372822.

Proteomic databases

PaxDbQ8NH72.
PRIDEQ8NH72.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314259; ENSP00000324769; ENSG00000181903.
GeneID219432.
KEGGhsa:219432.
UCSCuc010rik.2. human.

Organism-specific databases

CTD219432.
GeneCardsGC11P055432.
HGNCHGNC:14743. OR4C6.
neXtProtNX_Q8NH72.
PharmGKBPA32264.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG136221.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NH72.
KOK04257.
OMAFMHAMIQ.
OrthoDBEOG754HPT.
PhylomeDBQ8NH72.
TreeFamTF352732.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

BgeeQ8NH72.
CleanExHS_OR4C6.
GenevestigatorQ8NH72.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR4C6.
GenomeRNAi219432.
NextBio90607.
PROQ8NH72.

Entry information

Entry nameOR4C6_HUMAN
AccessionPrimary (citable) accession number: Q8NH72
Secondary accession number(s): B2RP11, Q6IFD2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries