ID   O4A16_HUMAN             Reviewed;         328 AA.
AC   Q8NH70; Q6IFL3;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 157.
DE   RecName: Full=Olfactory receptor 4A16;
DE   AltName: Full=Olfactory receptor OR11-117;
GN   Name=OR4A16;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [3]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4A16";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB065519; BAC05767.1; -; Genomic_DNA.
DR   EMBL; BK004249; DAA04647.1; -; Genomic_DNA.
DR   CCDS; CCDS31499.1; -.
DR   RefSeq; NP_001005274.1; NM_001005274.1.
DR   AlphaFoldDB; Q8NH70; -.
DR   SMR; Q8NH70; -.
DR   BioGRID; 123449; 1.
DR   IntAct; Q8NH70; 1.
DR   MINT; Q8NH70; -.
DR   STRING; 9606.ENSP00000325128; -.
DR   GlyCosmos; Q8NH70; 1 site, No reported glycans.
DR   GlyGen; Q8NH70; 1 site.
DR   iPTMnet; Q8NH70; -.
DR   PhosphoSitePlus; Q8NH70; -.
DR   BioMuta; OR4A16; -.
DR   DMDM; 38372821; -.
DR   MassIVE; Q8NH70; -.
DR   PaxDb; 9606-ENSP00000325128; -.
DR   PeptideAtlas; Q8NH70; -.
DR   ProteomicsDB; 73674; -.
DR   Antibodypedia; 58928; 58 antibodies from 15 providers.
DR   DNASU; 81327; -.
DR   Ensembl; ENST00000314721.5; ENSP00000325128.2; ENSG00000181961.5.
DR   GeneID; 81327; -.
DR   KEGG; hsa:81327; -.
DR   MANE-Select; ENST00000314721.5; ENSP00000325128.2; NM_001005274.1; NP_001005274.1.
DR   UCSC; uc010rie.2; human.
DR   AGR; HGNC:15153; -.
DR   CTD; 81327; -.
DR   GeneCards; OR4A16; -.
DR   HGNC; HGNC:15153; OR4A16.
DR   HPA; ENSG00000181961; Not detected.
DR   neXtProt; NX_Q8NH70; -.
DR   PharmGKB; PA32235; -.
DR   VEuPathDB; HostDB:ENSG00000181961; -.
DR   eggNOG; ENOG502SJPV; Eukaryota.
DR   GeneTree; ENSGT00940000158620; -.
DR   HOGENOM; CLU_012526_8_1_1; -.
DR   InParanoid; Q8NH70; -.
DR   OMA; WCEKLSI; -.
DR   OrthoDB; 4052270at2759; -.
DR   PhylomeDB; Q8NH70; -.
DR   TreeFam; TF337251; -.
DR   PathwayCommons; Q8NH70; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 81327; 9 hits in 737 CRISPR screens.
DR   GeneWiki; OR4A16; -.
DR   GenomeRNAi; 81327; -.
DR   Pharos; Q8NH70; Tdark.
DR   PRO; PR:Q8NH70; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NH70; Protein.
DR   Bgee; ENSG00000181961; Expressed in male germ line stem cell (sensu Vertebrata) in testis.
DR   ExpressionAtlas; Q8NH70; baseline and differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15939; 7tmA_OR4A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48002:SF159; OLFACTORY RECEPTOR 4A16; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..328
FT                   /note="Olfactory receptor 4A16"
FT                   /id="PRO_0000150526"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..328
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT   VARIANT         188
FT                   /note="L -> I (in dbSNP:rs11229158)"
FT                   /id="VAR_034187"
FT   VARIANT         232
FT                   /note="H -> R (in dbSNP:rs12807769)"
FT                   /id="VAR_053164"
FT   VARIANT         303
FT                   /note="K -> M (in dbSNP:rs10896659)"
FT                   /id="VAR_034188"
SQ   SEQUENCE   328 AA;  36922 MW;  033C46B6ABA70E62 CRC64;
     MRPSSNVTEF VLLGLTQDPD VKKTLFVMFL LIYIVTMVGN LLIWVTTIGS PSLGSLMYFF
     LAYLSLMDAI YSTAMSPKLM IDLLCDKIAI SLSACMGQLF IEHLLGGAEV FLLVVMAYDR
     YVAISKPLHY LNIMNRLVCI LLLVVAMIGG FVHSVVQIVF LYSLPICGPN VIDHSVCDMY
     PLLELLCLDT YFIGLTVVAN GGIICMVIFT FLLISCGVIL NFLKTYSQEE RHKALPTCIS
     HIIVVALVFV PCIFMYVRPV SNFPFDKLMT VFYSIITLML NPLIYSLRQS EMKNAMKNLW
     CEKLSIVRKR VSPTLNIFIP SSKATNRR
//