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Protein

Olfactory receptor 4A16

Gene

OR4A16

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4A16
Alternative name(s):
Olfactory receptor OR11-117
Gene namesi
Name:OR4A16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000181961.3
HGNCiHGNC:15153 OR4A16
neXtProtiNX_Q8NH70

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 77Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini78 – 98ExtracellularSequence analysisAdd BLAST21
Transmembranei99 – 118Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini119 – 137CytoplasmicSequence analysisAdd BLAST19
Transmembranei138 – 156Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini157 – 193ExtracellularSequence analysisAdd BLAST37
Transmembranei194 – 217Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini218 – 233CytoplasmicSequence analysisAdd BLAST16
Transmembranei234 – 256Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini257 – 267ExtracellularSequence analysisAdd BLAST11
Transmembranei268 – 287Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini288 – 328CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32235

Polymorphism and mutation databases

BioMutaiOR4A16
DMDMi38372821

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505261 – 328Olfactory receptor 4A16Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH70
PeptideAtlasiQ8NH70
PRIDEiQ8NH70

PTM databases

iPTMnetiQ8NH70
PhosphoSitePlusiQ8NH70

Expressioni

Gene expression databases

BgeeiENSG00000181961
CleanExiHS_OR4A16
ExpressionAtlasiQ8NH70 baseline

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325128

Structurei

3D structure databases

ProteinModelPortaliQ8NH70
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ82 Eukaryota
ENOG41116C3 LUCA
GeneTreeiENSGT00910000144065
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiQ8NH70
KOiK04257
OMAiFRACMGQ
OrthoDBiEOG091G0CY9
PhylomeDBiQ8NH70
TreeFamiTF337251

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPSSNVTEF VLLGLTQDPD VKKTLFVMFL LIYIVTMVGN LLIWVTTIGS
60 70 80 90 100
PSLGSLMYFF LAYLSLMDAI YSTAMSPKLM IDLLCDKIAI SLSACMGQLF
110 120 130 140 150
IEHLLGGAEV FLLVVMAYDR YVAISKPLHY LNIMNRLVCI LLLVVAMIGG
160 170 180 190 200
FVHSVVQIVF LYSLPICGPN VIDHSVCDMY PLLELLCLDT YFIGLTVVAN
210 220 230 240 250
GGIICMVIFT FLLISCGVIL NFLKTYSQEE RHKALPTCIS HIIVVALVFV
260 270 280 290 300
PCIFMYVRPV SNFPFDKLMT VFYSIITLML NPLIYSLRQS EMKNAMKNLW
310 320
CEKLSIVRKR VSPTLNIFIP SSKATNRR
Length:328
Mass (Da):36,922
Last modified:October 1, 2002 - v1
Checksum:i033C46B6ABA70E62
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034187188L → I. Corresponds to variant dbSNP:rs11229158Ensembl.1
Natural variantiVAR_053164232H → R. Corresponds to variant dbSNP:rs12807769Ensembl.1
Natural variantiVAR_034188303K → M. Corresponds to variant dbSNP:rs10896659Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065519 Genomic DNA Translation: BAC05767.1
BK004249 Genomic DNA Translation: DAA04647.1
CCDSiCCDS31499.1
RefSeqiNP_001005274.1, NM_001005274.1
UniGeneiHs.554530

Genome annotation databases

EnsembliENST00000314721; ENSP00000325128; ENSG00000181961
GeneIDi81327
KEGGihsa:81327
UCSCiuc010rie.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO4A16_HUMAN
AccessioniPrimary (citable) accession number: Q8NH70
Secondary accession number(s): Q6IFL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome