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Q8NH70 (O4A16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4A16
Alternative name(s):
Olfactory receptor OR11-117
Gene names
Name:OR4A16
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length328 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 328328Olfactory receptor 4A16
PRO_0000150526

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4724Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7722Helical; Name=2; Potential
Topological domain78 – 9821Extracellular Potential
Transmembrane99 – 11820Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15619Helical; Name=4; Potential
Topological domain157 – 19337Extracellular Potential
Transmembrane194 – 21724Helical; Name=5; Potential
Topological domain218 – 23316Cytoplasmic Potential
Transmembrane234 – 25623Helical; Name=6; Potential
Topological domain257 – 26711Extracellular Potential
Transmembrane268 – 28720Helical; Name=7; Potential
Topological domain288 – 32841Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 187 By similarity

Natural variations

Natural variant1881L → I.
Corresponds to variant rs11229158 [ dbSNP | Ensembl ].
VAR_034187
Natural variant2321H → R.
Corresponds to variant rs12807769 [ dbSNP | Ensembl ].
VAR_053164
Natural variant3031K → M.
Corresponds to variant rs10896659 [ dbSNP | Ensembl ].
VAR_034188

Sequences

Sequence LengthMass (Da)Tools
Q8NH70 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 033C46B6ABA70E62

FASTA32836,922
        10         20         30         40         50         60 
MRPSSNVTEF VLLGLTQDPD VKKTLFVMFL LIYIVTMVGN LLIWVTTIGS PSLGSLMYFF 

        70         80         90        100        110        120 
LAYLSLMDAI YSTAMSPKLM IDLLCDKIAI SLSACMGQLF IEHLLGGAEV FLLVVMAYDR 

       130        140        150        160        170        180 
YVAISKPLHY LNIMNRLVCI LLLVVAMIGG FVHSVVQIVF LYSLPICGPN VIDHSVCDMY 

       190        200        210        220        230        240 
PLLELLCLDT YFIGLTVVAN GGIICMVIFT FLLISCGVIL NFLKTYSQEE RHKALPTCIS 

       250        260        270        280        290        300 
HIIVVALVFV PCIFMYVRPV SNFPFDKLMT VFYSIITLML NPLIYSLRQS EMKNAMKNLW 

       310        320 
CEKLSIVRKR VSPTLNIFIP SSKATNRR 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065519 Genomic DNA. Translation: BAC05767.1.
BK004249 Genomic DNA. Translation: DAA04647.1.
CCDSCCDS31499.1.
RefSeqNP_001005274.1. NM_001005274.1.
UniGeneHs.554530.

3D structure databases

ProteinModelPortalQ8NH70.
SMRQ8NH70. Positions 23-170.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000325128.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NH70.

Polymorphism databases

DMDM38372821.

Proteomic databases

MaxQBQ8NH70.
PRIDEQ8NH70.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314721; ENSP00000325128; ENSG00000181961.
GeneID81327.
KEGGhsa:81327.
UCSCuc010rie.2. human.

Organism-specific databases

CTD81327.
GeneCardsGC11P055110.
HGNCHGNC:15153. OR4A16.
neXtProtNX_Q8NH70.
PharmGKBPA32235.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145939.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NH70.
KOK04257.
OMACISHIIM.
OrthoDBEOG754HPT.
PhylomeDBQ8NH70.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR4A16.
GenevestigatorQ8NH70.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR4A16.
GenomeRNAi81327.
NextBio71594.
PROQ8NH70.

Entry information

Entry nameO4A16_HUMAN
AccessionPrimary (citable) accession number: Q8NH70
Secondary accession number(s): Q6IFL3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries