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Q8NH70

- O4A16_HUMAN

UniProt

Q8NH70 - O4A16_HUMAN

Protein

Olfactory receptor 4A16

Gene

OR4A16

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4A16
    Alternative name(s):
    Olfactory receptor OR11-117
    Gene namesi
    Name:OR4A16
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15153. OR4A16.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32235.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Olfactory receptor 4A16PRO_0000150526Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ8NH70.
    PRIDEiQ8NH70.

    PTM databases

    PhosphoSiteiQ8NH70.

    Expressioni

    Gene expression databases

    CleanExiHS_OR4A16.
    GenevestigatoriQ8NH70.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000325128.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH70.
    SMRiQ8NH70. Positions 23-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini288 – 32841CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25623Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28720Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145939.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NH70.
    KOiK04257.
    OMAiCISHIIM.
    OrthoDBiEOG754HPT.
    PhylomeDBiQ8NH70.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH70-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPSSNVTEF VLLGLTQDPD VKKTLFVMFL LIYIVTMVGN LLIWVTTIGS    50
    PSLGSLMYFF LAYLSLMDAI YSTAMSPKLM IDLLCDKIAI SLSACMGQLF 100
    IEHLLGGAEV FLLVVMAYDR YVAISKPLHY LNIMNRLVCI LLLVVAMIGG 150
    FVHSVVQIVF LYSLPICGPN VIDHSVCDMY PLLELLCLDT YFIGLTVVAN 200
    GGIICMVIFT FLLISCGVIL NFLKTYSQEE RHKALPTCIS HIIVVALVFV 250
    PCIFMYVRPV SNFPFDKLMT VFYSIITLML NPLIYSLRQS EMKNAMKNLW 300
    CEKLSIVRKR VSPTLNIFIP SSKATNRR 328
    Length:328
    Mass (Da):36,922
    Last modified:October 1, 2002 - v1
    Checksum:i033C46B6ABA70E62
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti188 – 1881L → I.
    Corresponds to variant rs11229158 [ dbSNP | Ensembl ].
    VAR_034187
    Natural varianti232 – 2321H → R.
    Corresponds to variant rs12807769 [ dbSNP | Ensembl ].
    VAR_053164
    Natural varianti303 – 3031K → M.
    Corresponds to variant rs10896659 [ dbSNP | Ensembl ].
    VAR_034188

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065519 Genomic DNA. Translation: BAC05767.1.
    BK004249 Genomic DNA. Translation: DAA04647.1.
    CCDSiCCDS31499.1.
    RefSeqiNP_001005274.1. NM_001005274.1.
    UniGeneiHs.554530.

    Genome annotation databases

    EnsembliENST00000314721; ENSP00000325128; ENSG00000181961.
    GeneIDi81327.
    KEGGihsa:81327.
    UCSCiuc010rie.2. human.

    Polymorphism databases

    DMDMi38372821.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065519 Genomic DNA. Translation: BAC05767.1 .
    BK004249 Genomic DNA. Translation: DAA04647.1 .
    CCDSi CCDS31499.1.
    RefSeqi NP_001005274.1. NM_001005274.1.
    UniGenei Hs.554530.

    3D structure databases

    ProteinModelPortali Q8NH70.
    SMRi Q8NH70. Positions 23-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000325128.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NH70.

    Polymorphism databases

    DMDMi 38372821.

    Proteomic databases

    MaxQBi Q8NH70.
    PRIDEi Q8NH70.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314721 ; ENSP00000325128 ; ENSG00000181961 .
    GeneIDi 81327.
    KEGGi hsa:81327.
    UCSCi uc010rie.2. human.

    Organism-specific databases

    CTDi 81327.
    GeneCardsi GC11P055110.
    HGNCi HGNC:15153. OR4A16.
    neXtProti NX_Q8NH70.
    PharmGKBi PA32235.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145939.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NH70.
    KOi K04257.
    OMAi CISHIIM.
    OrthoDBi EOG754HPT.
    PhylomeDBi Q8NH70.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR4A16.
    GenomeRNAii 81327.
    NextBioi 71594.
    PROi Q8NH70.

    Gene expression databases

    CleanExi HS_OR4A16.
    Genevestigatori Q8NH70.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO4A16_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH70
    Secondary accession number(s): Q6IFL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3