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Q8NH70

- O4A16_HUMAN

UniProt

Q8NH70 - O4A16_HUMAN

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Protein
Olfactory receptor 4A16
Gene
OR4A16
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4A16
Alternative name(s):
Olfactory receptor OR11-117
Gene namesi
Name:OR4A16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15153. OR4A16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Extracellular Reviewed prediction
Add
BLAST
Transmembranei24 – 4724Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini48 – 558Cytoplasmic Reviewed prediction
Transmembranei56 – 7722Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini78 – 9821Extracellular Reviewed prediction
Add
BLAST
Transmembranei99 – 11820Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini119 – 13719Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei138 – 15619Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini157 – 19337Extracellular Reviewed prediction
Add
BLAST
Transmembranei194 – 21724Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini218 – 23316Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei234 – 25623Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini257 – 26711Extracellular Reviewed prediction
Add
BLAST
Transmembranei268 – 28720Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini288 – 32841Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32235.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 328328Olfactory receptor 4A16
PRO_0000150526Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 187 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ8NH70.
PRIDEiQ8NH70.

PTM databases

PhosphoSiteiQ8NH70.

Expressioni

Gene expression databases

CleanExiHS_OR4A16.
GenevestigatoriQ8NH70.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000325128.

Structurei

3D structure databases

ProteinModelPortaliQ8NH70.
SMRiQ8NH70. Positions 23-170.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145939.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH70.
KOiK04257.
OMAiCISHIIM.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NH70.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH70-1 [UniParc]FASTAAdd to Basket

« Hide

MRPSSNVTEF VLLGLTQDPD VKKTLFVMFL LIYIVTMVGN LLIWVTTIGS    50
PSLGSLMYFF LAYLSLMDAI YSTAMSPKLM IDLLCDKIAI SLSACMGQLF 100
IEHLLGGAEV FLLVVMAYDR YVAISKPLHY LNIMNRLVCI LLLVVAMIGG 150
FVHSVVQIVF LYSLPICGPN VIDHSVCDMY PLLELLCLDT YFIGLTVVAN 200
GGIICMVIFT FLLISCGVIL NFLKTYSQEE RHKALPTCIS HIIVVALVFV 250
PCIFMYVRPV SNFPFDKLMT VFYSIITLML NPLIYSLRQS EMKNAMKNLW 300
CEKLSIVRKR VSPTLNIFIP SSKATNRR 328
Length:328
Mass (Da):36,922
Last modified:October 1, 2002 - v1
Checksum:i033C46B6ABA70E62
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti188 – 1881L → I.
Corresponds to variant rs11229158 [ dbSNP | Ensembl ].
VAR_034187
Natural varianti232 – 2321H → R.
Corresponds to variant rs12807769 [ dbSNP | Ensembl ].
VAR_053164
Natural varianti303 – 3031K → M.
Corresponds to variant rs10896659 [ dbSNP | Ensembl ].
VAR_034188

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065519 Genomic DNA. Translation: BAC05767.1.
BK004249 Genomic DNA. Translation: DAA04647.1.
CCDSiCCDS31499.1.
RefSeqiNP_001005274.1. NM_001005274.1.
UniGeneiHs.554530.

Genome annotation databases

EnsembliENST00000314721; ENSP00000325128; ENSG00000181961.
GeneIDi81327.
KEGGihsa:81327.
UCSCiuc010rie.2. human.

Polymorphism databases

DMDMi38372821.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065519 Genomic DNA. Translation: BAC05767.1 .
BK004249 Genomic DNA. Translation: DAA04647.1 .
CCDSi CCDS31499.1.
RefSeqi NP_001005274.1. NM_001005274.1.
UniGenei Hs.554530.

3D structure databases

ProteinModelPortali Q8NH70.
SMRi Q8NH70. Positions 23-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000325128.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NH70.

Polymorphism databases

DMDMi 38372821.

Proteomic databases

MaxQBi Q8NH70.
PRIDEi Q8NH70.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314721 ; ENSP00000325128 ; ENSG00000181961 .
GeneIDi 81327.
KEGGi hsa:81327.
UCSCi uc010rie.2. human.

Organism-specific databases

CTDi 81327.
GeneCardsi GC11P055110.
HGNCi HGNC:15153. OR4A16.
neXtProti NX_Q8NH70.
PharmGKBi PA32235.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145939.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NH70.
KOi K04257.
OMAi CISHIIM.
OrthoDBi EOG754HPT.
PhylomeDBi Q8NH70.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR4A16.
GenomeRNAii 81327.
NextBioi 71594.
PROi Q8NH70.

Gene expression databases

CleanExi HS_OR4A16.
Genevestigatori Q8NH70.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO4A16_HUMAN
AccessioniPrimary (citable) accession number: Q8NH70
Secondary accession number(s): Q6IFL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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