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Protein

Olfactory receptor 5W2

Gene

OR5W2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181825-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5W2
Alternative name(s):
Olfactory receptor 5W3
Olfactory receptor OR11-155
Gene namesi
Name:OR5W2
Synonyms:OR5W2P, OR5W3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15299. OR5W2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 310CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi390148.
OpenTargetsiENSG00000187612.
PharmGKBiPA32572.

Polymorphism and mutation databases

BioMutaiOR5W2.
DMDMi74762590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506181 – 310Olfactory receptor 5W2Add BLAST310

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NH69.
PeptideAtlasiQ8NH69.
PRIDEiQ8NH69.

Expressioni

Gene expression databases

CleanExiHS_OR5W2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342448.

Structurei

3D structure databases

ProteinModelPortaliQ8NH69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGY6. Eukaryota.
ENOG4111BJU. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH69.
KOiK04257.
OMAiDYQLHTP.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH69.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWENCSSLT DFFLLGITNN PEMKVTLFAV FLAVYIINFS ANLGMIVLIR
60 70 80 90 100
MDYQLHTPMY FFLSHLSFCD LCYSTATGPK MLVDLLAKNK SIPFYGCALQ
110 120 130 140 150
FLVFCIFADS ECLLLSVMAF DRYKAIINPL LYTVNMSSRV CYLLLTGVYL
160 170 180 190 200
VGIADALIHM TLAFRLCFCG SNEINHFFCD IPPLLLLSRS DTQVNELVLF
210 220 230 240 250
TVFGFIELST ISGVFISYCY IILSVLEIHS AEGRFKALST CTSHLSAVAI
260 270 280 290 300
FQGTLLFMYF RPSSSYSLDQ DKMTSLFYTL VVPMLNPLIY SLRNKDVKEA
310
LKKLKNKILF
Length:310
Mass (Da):35,167
Last modified:October 1, 2002 - v1
Checksum:iFFC0A71D4A2D0768
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05321339F → L.Corresponds to variant rs17511797dbSNPEnsembl.1
Natural variantiVAR_05321465H → R.Corresponds to variant rs12419022dbSNPEnsembl.1
Natural variantiVAR_053215160M → T.Corresponds to variant rs17596519dbSNPEnsembl.1
Natural variantiVAR_034236163A → P.Corresponds to variant rs17148883dbSNPEnsembl.1
Natural variantiVAR_034237189R → C.Corresponds to variant rs2457239dbSNPEnsembl.1
Natural variantiVAR_053216215F → L.Corresponds to variant rs17596422dbSNPEnsembl.1
Natural variantiVAR_062046310F → Y.Corresponds to variant rs34573569dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065520 Genomic DNA. Translation: BAC05768.1.
BK004398 Genomic DNA. Translation: DAA04796.1.
CCDSiCCDS31513.1.
RefSeqiNP_001001960.1. NM_001001960.1.
UniGeneiHs.554526.

Genome annotation databases

EnsembliENST00000344514; ENSP00000342448; ENSG00000187612.
GeneIDi390148.
KEGGihsa:390148.
UCSCiuc010rir.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065520 Genomic DNA. Translation: BAC05768.1.
BK004398 Genomic DNA. Translation: DAA04796.1.
CCDSiCCDS31513.1.
RefSeqiNP_001001960.1. NM_001001960.1.
UniGeneiHs.554526.

3D structure databases

ProteinModelPortaliQ8NH69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342448.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR5W2.
DMDMi74762590.

Proteomic databases

PaxDbiQ8NH69.
PeptideAtlasiQ8NH69.
PRIDEiQ8NH69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344514; ENSP00000342448; ENSG00000187612.
GeneIDi390148.
KEGGihsa:390148.
UCSCiuc010rir.2. human.

Organism-specific databases

CTDi390148.
DisGeNETi390148.
GeneCardsiOR5W2.
HGNCiHGNC:15299. OR5W2.
neXtProtiNX_Q8NH69.
OpenTargetsiENSG00000187612.
PharmGKBiPA32572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGY6. Eukaryota.
ENOG4111BJU. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH69.
KOiK04257.
OMAiDYQLHTP.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH69.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181825-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5W2.
GenomeRNAii390148.
PROiQ8NH69.

Gene expression databases

CleanExiHS_OR5W2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR5W2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.