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Protein

Olfactory receptor 5W2

Gene

OR5W2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5W2
Alternative name(s):
Olfactory receptor 5W3
Olfactory receptor OR11-155
Gene namesi
Name:OR5W2
Synonyms:OR5W2P, OR5W3P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15299. OR5W2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19636ExtracellularSequence analysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 31018CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32572.

Polymorphism and mutation databases

BioMutaiOR5W2.
DMDMi74762590.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 310310Olfactory receptor 5W2PRO_0000150618Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8NH69.
PRIDEiQ8NH69.

PTM databases

PhosphoSiteiQ8NH69.

Expressioni

Gene expression databases

CleanExiHS_OR5W2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000342448.

Structurei

3D structure databases

ProteinModelPortaliQ8NH69.
SMRiQ8NH69. Positions 55-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGY6. Eukaryota.
ENOG4111BJU. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH69.
KOiK04257.
OMAiDYQLHTP.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH69.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDWENCSSLT DFFLLGITNN PEMKVTLFAV FLAVYIINFS ANLGMIVLIR
60 70 80 90 100
MDYQLHTPMY FFLSHLSFCD LCYSTATGPK MLVDLLAKNK SIPFYGCALQ
110 120 130 140 150
FLVFCIFADS ECLLLSVMAF DRYKAIINPL LYTVNMSSRV CYLLLTGVYL
160 170 180 190 200
VGIADALIHM TLAFRLCFCG SNEINHFFCD IPPLLLLSRS DTQVNELVLF
210 220 230 240 250
TVFGFIELST ISGVFISYCY IILSVLEIHS AEGRFKALST CTSHLSAVAI
260 270 280 290 300
FQGTLLFMYF RPSSSYSLDQ DKMTSLFYTL VVPMLNPLIY SLRNKDVKEA
310
LKKLKNKILF
Length:310
Mass (Da):35,167
Last modified:October 1, 2002 - v1
Checksum:iFFC0A71D4A2D0768
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391F → L.
Corresponds to variant rs17511797 [ dbSNP | Ensembl ].
VAR_053213
Natural varianti65 – 651H → R.
Corresponds to variant rs12419022 [ dbSNP | Ensembl ].
VAR_053214
Natural varianti160 – 1601M → T.
Corresponds to variant rs17596519 [ dbSNP | Ensembl ].
VAR_053215
Natural varianti163 – 1631A → P.
Corresponds to variant rs17148883 [ dbSNP | Ensembl ].
VAR_034236
Natural varianti189 – 1891R → C.
Corresponds to variant rs2457239 [ dbSNP | Ensembl ].
VAR_034237
Natural varianti215 – 2151F → L.
Corresponds to variant rs17596422 [ dbSNP | Ensembl ].
VAR_053216
Natural varianti310 – 3101F → Y.
Corresponds to variant rs34573569 [ dbSNP | Ensembl ].
VAR_062046

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065520 Genomic DNA. Translation: BAC05768.1.
BK004398 Genomic DNA. Translation: DAA04796.1.
CCDSiCCDS31513.1.
RefSeqiNP_001001960.1. NM_001001960.1.
UniGeneiHs.554526.

Genome annotation databases

EnsembliENST00000344514; ENSP00000342448; ENSG00000187612.
GeneIDi390148.
KEGGihsa:390148.
UCSCiuc010rir.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065520 Genomic DNA. Translation: BAC05768.1.
BK004398 Genomic DNA. Translation: DAA04796.1.
CCDSiCCDS31513.1.
RefSeqiNP_001001960.1. NM_001001960.1.
UniGeneiHs.554526.

3D structure databases

ProteinModelPortaliQ8NH69.
SMRiQ8NH69. Positions 55-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000342448.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NH69.

Polymorphism and mutation databases

BioMutaiOR5W2.
DMDMi74762590.

Proteomic databases

PaxDbiQ8NH69.
PRIDEiQ8NH69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344514; ENSP00000342448; ENSG00000187612.
GeneIDi390148.
KEGGihsa:390148.
UCSCiuc010rir.2. human.

Organism-specific databases

CTDi390148.
GeneCardsiOR5W2.
HGNCiHGNC:15299. OR5W2.
neXtProtiNX_Q8NH69.
PharmGKBiPA32572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGY6. Eukaryota.
ENOG4111BJU. LUCA.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH69.
KOiK04257.
OMAiDYQLHTP.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH69.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5W2.
GenomeRNAii390148.
NextBioi103441.
PROiQ8NH69.

Gene expression databases

CleanExiHS_OR5W2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5W2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: February 17, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.