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Protein

Olfactory receptor 52I2

Gene

OR52I2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52I2
Alternative name(s):
Olfactory receptor OR11-12
Gene namesi
Name:OR52I2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000226288.1
HGNCiHGNC:15221 OR52I2
neXtProtiNX_Q8NH67

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini77 – 84CytoplasmicSequence analysis8
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 129ExtracellularSequence analysisAdd BLAST24
Transmembranei130 – 150Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini151 – 169CytoplasmicSequence analysisAdd BLAST19
Transmembranei170 – 190Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini191 – 226ExtracellularSequence analysisAdd BLAST36
Transmembranei227 – 247Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini248 – 267CytoplasmicSequence analysisAdd BLAST20
Transmembranei268 – 288Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini289 – 304ExtracellularSequence analysisAdd BLAST16
Transmembranei305 – 325Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini326 – 350CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000226288
PharmGKBiPA32413

Polymorphism and mutation databases

BioMutaiOR52I2
DMDMi218512129

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507791 – 350Olfactory receptor 52I2Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi127 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH67
PeptideAtlasiQ8NH67
PRIDEiQ8NH67
TopDownProteomicsiQ8NH67

PTM databases

iPTMnetiQ8NH67
PhosphoSitePlusiQ8NH67

Expressioni

Gene expression databases

CleanExiHS_OR52I2
ExpressionAtlasiQ8NH67 baseline and differential

Organism-specific databases

HPAiHPA049343

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308764

Structurei

3D structure databases

ProteinModelPortaliQ8NH67
SMRiQ8NH67
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIRM Eukaryota
ENOG41114NG LUCA
GeneTreeiENSGT00810000125507
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NH67
KOiK04257
OMAiPKMVNIF
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH67
TreeFamiTF343679

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCQQILRDCI LLIHHLCINR KKVSLVMLGP AYNHTMETPA SFLLVGIPGL
60 70 80 90 100
QSSHLWLAIS LSAMYIIALL GNTIIVTAIW MDSTRHEPMY CFLCVLAAVD
110 120 130 140 150
IVMASSVVPK MVSIFCSGDS SISFSACFTQ MFFVHLATAV ETGLLLTMAF
160 170 180 190 200
DRYVAICKPL HYKRILTPQV MLGMSMAITI RAIIAITPLS WMVSHLPFCG
210 220 230 240 250
SNVVVHSYCE HIALARLACA DPVPSSLYSL IGSSLMVGSD VAFIAASYIL
260 270 280 290 300
ILKAVFGLSS KTAQLKALST CGSHVGVMAL YYLPGMASIY AAWLGQDVVP
310 320 330 340 350
LHTQVLLADL YVIIPATLNP IIYGMRTKQL RERIWSYLMH VLFDHSNLGS
Length:350
Mass (Da):38,353
Last modified:December 16, 2008 - v3
Checksum:i66102900C9929875
GO

Sequence cautioni

The sequence BAC05770 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04808225L → P. Corresponds to variant dbSNP:rs7128702Ensembl.1
Natural variantiVAR_04808374I → L1 PublicationCorresponds to variant dbSNP:rs12793957Ensembl.1
Natural variantiVAR_048084167T → M. Corresponds to variant dbSNP:rs1847632Ensembl.1
Natural variantiVAR_048085178I → V. Corresponds to variant dbSNP:rs7947426Ensembl.1
Natural variantiVAR_048086183I → V. Corresponds to variant dbSNP:rs7947432Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065522 Genomic DNA Translation: BAC05770.1 Different initiation.
BC136921 mRNA Translation: AAI36922.1
BC151144 mRNA Translation: AAI51145.1
BK004264 Genomic DNA Translation: DAA04662.1
CCDSiCCDS31355.1
RefSeqiNP_001005170.1, NM_001005170.2
UniGeneiHs.553607

Genome annotation databases

EnsembliENST00000312614; ENSP00000308764; ENSG00000226288
GeneIDi143502
KEGGihsa:143502
UCSCiuc010qyh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52I2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH67
Secondary accession number(s): B2RNJ5, B9EKV8, Q6IFJ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: March 28, 2018
This is version 126 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome