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Protein

Olfactory receptor 52I2

Gene

OR52I2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175609-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52I2
Alternative name(s):
Olfactory receptor OR11-12
Gene namesi
Name:OR52I2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15221. OR52I2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 55ExtracellularSequence analysisAdd BLAST55
Transmembranei56 – 76Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini77 – 84CytoplasmicSequence analysis8
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 129ExtracellularSequence analysisAdd BLAST24
Transmembranei130 – 150Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini151 – 169CytoplasmicSequence analysisAdd BLAST19
Transmembranei170 – 190Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini191 – 226ExtracellularSequence analysisAdd BLAST36
Transmembranei227 – 247Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini248 – 267CytoplasmicSequence analysisAdd BLAST20
Transmembranei268 – 288Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini289 – 304ExtracellularSequence analysisAdd BLAST16
Transmembranei305 – 325Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini326 – 350CytoplasmicSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000226288.
PharmGKBiPA32413.

Polymorphism and mutation databases

BioMutaiOR52I2.
DMDMi218512129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507791 – 350Olfactory receptor 52I2Add BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi33N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi127 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH67.
PeptideAtlasiQ8NH67.
PRIDEiQ8NH67.
TopDownProteomicsiQ8NH67.

PTM databases

iPTMnetiQ8NH67.
PhosphoSitePlusiQ8NH67.

Expressioni

Gene expression databases

CleanExiHS_OR52I2.

Organism-specific databases

HPAiHPA049343.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308764.

Structurei

3D structure databases

ProteinModelPortaliQ8NH67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIRM. Eukaryota.
ENOG41114NG. LUCA.
GeneTreeiENSGT00810000125507.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH67.
KOiK04257.
OMAiHTVETPA.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH67.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCQQILRDCI LLIHHLCINR KKVSLVMLGP AYNHTMETPA SFLLVGIPGL
60 70 80 90 100
QSSHLWLAIS LSAMYIIALL GNTIIVTAIW MDSTRHEPMY CFLCVLAAVD
110 120 130 140 150
IVMASSVVPK MVSIFCSGDS SISFSACFTQ MFFVHLATAV ETGLLLTMAF
160 170 180 190 200
DRYVAICKPL HYKRILTPQV MLGMSMAITI RAIIAITPLS WMVSHLPFCG
210 220 230 240 250
SNVVVHSYCE HIALARLACA DPVPSSLYSL IGSSLMVGSD VAFIAASYIL
260 270 280 290 300
ILKAVFGLSS KTAQLKALST CGSHVGVMAL YYLPGMASIY AAWLGQDVVP
310 320 330 340 350
LHTQVLLADL YVIIPATLNP IIYGMRTKQL RERIWSYLMH VLFDHSNLGS
Length:350
Mass (Da):38,353
Last modified:December 16, 2008 - v3
Checksum:i66102900C9929875
GO

Sequence cautioni

The sequence BAC05770 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04808225L → P.Corresponds to variant rs7128702dbSNPEnsembl.1
Natural variantiVAR_04808374I → L.1 PublicationCorresponds to variant rs12793957dbSNPEnsembl.1
Natural variantiVAR_048084167T → M.Corresponds to variant rs1847632dbSNPEnsembl.1
Natural variantiVAR_048085178I → V.Corresponds to variant rs7947426dbSNPEnsembl.1
Natural variantiVAR_048086183I → V.Corresponds to variant rs7947432dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065522 Genomic DNA. Translation: BAC05770.1. Different initiation.
BC136921 mRNA. Translation: AAI36922.1.
BC151144 mRNA. Translation: AAI51145.1.
BK004264 Genomic DNA. Translation: DAA04662.1.
CCDSiCCDS31355.1.
RefSeqiNP_001005170.1. NM_001005170.2.
UniGeneiHs.553607.

Genome annotation databases

EnsembliENST00000312614; ENSP00000308764; ENSG00000226288.
GeneIDi143502.
KEGGihsa:143502.
UCSCiuc010qyh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065522 Genomic DNA. Translation: BAC05770.1. Different initiation.
BC136921 mRNA. Translation: AAI36922.1.
BC151144 mRNA. Translation: AAI51145.1.
BK004264 Genomic DNA. Translation: DAA04662.1.
CCDSiCCDS31355.1.
RefSeqiNP_001005170.1. NM_001005170.2.
UniGeneiHs.553607.

3D structure databases

ProteinModelPortaliQ8NH67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308764.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH67.
PhosphoSitePlusiQ8NH67.

Polymorphism and mutation databases

BioMutaiOR52I2.
DMDMi218512129.

Proteomic databases

PaxDbiQ8NH67.
PeptideAtlasiQ8NH67.
PRIDEiQ8NH67.
TopDownProteomicsiQ8NH67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312614; ENSP00000308764; ENSG00000226288.
GeneIDi143502.
KEGGihsa:143502.
UCSCiuc010qyh.2. human.

Organism-specific databases

CTDi143502.
GeneCardsiOR52I2.
HGNCiHGNC:15221. OR52I2.
HPAiHPA049343.
neXtProtiNX_Q8NH67.
OpenTargetsiENSG00000226288.
PharmGKBiPA32413.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIRM. Eukaryota.
ENOG41114NG. LUCA.
GeneTreeiENSGT00810000125507.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH67.
KOiK04257.
OMAiHTVETPA.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH67.
TreeFamiTF343679.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000175609-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52I2.
GenomeRNAii143502.
PROiQ8NH67.

Gene expression databases

CleanExiHS_OR52I2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52I2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH67
Secondary accession number(s): B2RNJ5, B9EKV8, Q6IFJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: November 2, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.