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Protein

Olfactory receptor 52I2

Gene

OR52I2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52I2
Alternative name(s):
Olfactory receptor OR11-12
Gene namesi
Name:OR52I2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15221. OR52I2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5555ExtracellularSequence analysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini77 – 848CytoplasmicSequence analysis
Transmembranei85 – 10521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini106 – 12924ExtracellularSequence analysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini151 – 16919CytoplasmicSequence analysisAdd
BLAST
Transmembranei170 – 19021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini191 – 22636ExtracellularSequence analysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini248 – 26720CytoplasmicSequence analysisAdd
BLAST
Transmembranei268 – 28821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini289 – 30416ExtracellularSequence analysisAdd
BLAST
Transmembranei305 – 32521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini326 – 35025CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32413.

Polymorphism and mutation databases

BioMutaiOR52I2.
DMDMi218512129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Olfactory receptor 52I2PRO_0000150779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi127 ↔ 219PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH67.
PeptideAtlasiQ8NH67.
PRIDEiQ8NH67.
TopDownProteomicsiQ8NH67.

PTM databases

iPTMnetiQ8NH67.
PhosphoSiteiQ8NH67.

Expressioni

Gene expression databases

CleanExiHS_OR52I2.

Organism-specific databases

HPAiHPA049343.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308764.

Structurei

3D structure databases

ProteinModelPortaliQ8NH67.
SMRiQ8NH67. Positions 46-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIRM. Eukaryota.
ENOG41114NG. LUCA.
GeneTreeiENSGT00810000125507.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH67.
KOiK04257.
OMAiQIRERAW.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NH67.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCQQILRDCI LLIHHLCINR KKVSLVMLGP AYNHTMETPA SFLLVGIPGL
60 70 80 90 100
QSSHLWLAIS LSAMYIIALL GNTIIVTAIW MDSTRHEPMY CFLCVLAAVD
110 120 130 140 150
IVMASSVVPK MVSIFCSGDS SISFSACFTQ MFFVHLATAV ETGLLLTMAF
160 170 180 190 200
DRYVAICKPL HYKRILTPQV MLGMSMAITI RAIIAITPLS WMVSHLPFCG
210 220 230 240 250
SNVVVHSYCE HIALARLACA DPVPSSLYSL IGSSLMVGSD VAFIAASYIL
260 270 280 290 300
ILKAVFGLSS KTAQLKALST CGSHVGVMAL YYLPGMASIY AAWLGQDVVP
310 320 330 340 350
LHTQVLLADL YVIIPATLNP IIYGMRTKQL RERIWSYLMH VLFDHSNLGS
Length:350
Mass (Da):38,353
Last modified:December 16, 2008 - v3
Checksum:i66102900C9929875
GO

Sequence cautioni

The sequence BAC05770.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti25 – 251L → P.
Corresponds to variant rs7128702 [ dbSNP | Ensembl ].
VAR_048082
Natural varianti74 – 741I → L.1 Publication
Corresponds to variant rs12793957 [ dbSNP | Ensembl ].
VAR_048083
Natural varianti167 – 1671T → M.
Corresponds to variant rs1847632 [ dbSNP | Ensembl ].
VAR_048084
Natural varianti178 – 1781I → V.
Corresponds to variant rs7947426 [ dbSNP | Ensembl ].
VAR_048085
Natural varianti183 – 1831I → V.
Corresponds to variant rs7947432 [ dbSNP | Ensembl ].
VAR_048086

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065522 Genomic DNA. Translation: BAC05770.1. Different initiation.
BC136921 mRNA. Translation: AAI36922.1.
BC151144 mRNA. Translation: AAI51145.1.
BK004264 Genomic DNA. Translation: DAA04662.1.
CCDSiCCDS31355.1.
RefSeqiNP_001005170.1. NM_001005170.2.
UniGeneiHs.553607.

Genome annotation databases

EnsembliENST00000312614; ENSP00000308764; ENSG00000226288.
GeneIDi143502.
KEGGihsa:143502.
UCSCiuc010qyh.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065522 Genomic DNA. Translation: BAC05770.1. Different initiation.
BC136921 mRNA. Translation: AAI36922.1.
BC151144 mRNA. Translation: AAI51145.1.
BK004264 Genomic DNA. Translation: DAA04662.1.
CCDSiCCDS31355.1.
RefSeqiNP_001005170.1. NM_001005170.2.
UniGeneiHs.553607.

3D structure databases

ProteinModelPortaliQ8NH67.
SMRiQ8NH67. Positions 46-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308764.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH67.
PhosphoSiteiQ8NH67.

Polymorphism and mutation databases

BioMutaiOR52I2.
DMDMi218512129.

Proteomic databases

PaxDbiQ8NH67.
PeptideAtlasiQ8NH67.
PRIDEiQ8NH67.
TopDownProteomicsiQ8NH67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312614; ENSP00000308764; ENSG00000226288.
GeneIDi143502.
KEGGihsa:143502.
UCSCiuc010qyh.2. human.

Organism-specific databases

CTDi143502.
GeneCardsiOR52I2.
HGNCiHGNC:15221. OR52I2.
HPAiHPA049343.
neXtProtiNX_Q8NH67.
PharmGKBiPA32413.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIRM. Eukaryota.
ENOG41114NG. LUCA.
GeneTreeiENSGT00810000125507.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH67.
KOiK04257.
OMAiQIRERAW.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NH67.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52I2.
GenomeRNAii143502.
PROiQ8NH67.

Gene expression databases

CleanExiHS_OR52I2.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-74.
    Tissue: Testis.
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52I2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH67
Secondary accession number(s): B2RNJ5, B9EKV8, Q6IFJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: December 16, 2008
Last modified: July 6, 2016
This is version 114 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-27 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.