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Protein

Olfactory receptor 51F2

Gene

OR51F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51F2
Alternative name(s):
Olfactory receptor OR11-23
Gene namesi
Name:OR51F2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15197. OR51F2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
BLAST
Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini61 – 688CytoplasmicSequence Analysis
Transmembranei69 – 8921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini90 – 11324ExtracellularSequence AnalysisAdd
BLAST
Transmembranei114 – 13421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini135 – 15319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei154 – 17421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini175 – 21036ExtracellularSequence AnalysisAdd
BLAST
Transmembranei211 – 23121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini232 – 25120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei252 – 27221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini273 – 28715ExtracellularSequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 34234CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32375.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 342342Olfactory receptor 51F2PRO_0000150753Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi111 ↔ 203PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH61.
PRIDEiQ8NH61.

PTM databases

PhosphoSiteiQ8NH61.

Expressioni

Gene expression databases

CleanExiHS_OR51F2.
GenevestigatoriQ8NH61.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323952.

Structurei

3D structure databases

ProteinModelPortaliQ8NH61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG76064.
GeneTreeiENSGT00770000120456.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH61.
KOiK04257.
OMAiRAAQVWI.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NH61.
TreeFamiTF342735.

Family and domain databases

InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH61-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTETSLSSQC FPMSVLNNTI AEPLIFLLMG IPGLKATQYW ISIPFCLLYV
60 70 80 90 100
VAVSGNSMIL FVVLCERSLH KPMYYFLSML SATDLSLSLC TLSTTLGVFW
110 120 130 140 150
FEAREINLNA CIAQMFFLHG FTFMESGVLL AMAFDRFVAI CYPLRYTTIL
160 170 180 190 200
TNARIAKIGM SMLIRNVAVM LPVMLFVKRL SFCSSMVLSH SYCYHVDLIQ
210 220 230 240 250
LSCTDNRINS ILGLFALLST TGFDCPCILL SYILIIRSVL SIASSEERRK
260 270 280 290 300
AFNTCTSHIS AVSIFYLPLI SLSLVHRYGH SAPPFVHIIM ANVFLLIPPV
310 320 330 340
LNPIIYSVKI KQIQKAIIKV LIQKHSKSNH QLFLIRDKAI YE
Length:342
Mass (Da):38,518
Last modified:February 10, 2009 - v2
Checksum:iCA3D91DB7B59EFB8
GO

Sequence cautioni

The sequence BAC05776.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065529 Genomic DNA. Translation: BAC05776.1. Different initiation.
AC103710 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68826.1.
BC136877 mRNA. Translation: AAI36878.1.
BK004281 Genomic DNA. Translation: DAA04679.1.
CCDSiCCDS31361.1.
RefSeqiNP_001004753.1. NM_001004753.1.
UniGeneiHs.553562.

Genome annotation databases

EnsembliENST00000322110; ENSP00000323952; ENSG00000176925.
GeneIDi119694.
KEGGihsa:119694.
UCSCiuc010qyn.2. human.

Polymorphism databases

DMDMi223590112.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065529 Genomic DNA. Translation: BAC05776.1. Different initiation.
AC103710 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68826.1.
BC136877 mRNA. Translation: AAI36878.1.
BK004281 Genomic DNA. Translation: DAA04679.1.
CCDSiCCDS31361.1.
RefSeqiNP_001004753.1. NM_001004753.1.
UniGeneiHs.553562.

3D structure databases

ProteinModelPortaliQ8NH61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000323952.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NH61.

Polymorphism databases

DMDMi223590112.

Proteomic databases

PaxDbiQ8NH61.
PRIDEiQ8NH61.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000322110; ENSP00000323952; ENSG00000176925.
GeneIDi119694.
KEGGihsa:119694.
UCSCiuc010qyn.2. human.

Organism-specific databases

CTDi119694.
GeneCardsiGC11P004842.
HGNCiHGNC:15197. OR51F2.
neXtProtiNX_Q8NH61.
PharmGKBiPA32375.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG76064.
GeneTreeiENSGT00770000120456.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH61.
KOiK04257.
OMAiRAAQVWI.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NH61.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51F2.
GenomeRNAii119694.
NextBioi80465.
PROiQ8NH61.

Gene expression databases

CleanExiHS_OR51F2.
GenevestigatoriQ8NH61.

Family and domain databases

InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: IDENTIFICATION.
  6. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO51F2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH61
Secondary accession number(s): Q6IFI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.