Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NH61

- O51F2_HUMAN

UniProt

Q8NH61 - O51F2_HUMAN

Protein

Olfactory receptor 51F2

Gene

OR51F2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 51F2
    Alternative name(s):
    Olfactory receptor OR11-23
    Gene namesi
    Name:OR51F2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15197. OR51F2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32375.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 342342Olfactory receptor 51F2PRO_0000150753Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi17 – 171N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi111 ↔ 203PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH61.
    PRIDEiQ8NH61.

    PTM databases

    PhosphoSiteiQ8NH61.

    Expressioni

    Gene expression databases

    CleanExiHS_OR51F2.
    GenevestigatoriQ8NH61.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000323952.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH61.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3939ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini61 – 688CytoplasmicSequence Analysis
    Topological domaini90 – 11324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini135 – 15319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini175 – 21036ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini232 – 25120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini273 – 28715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 34234CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei40 – 6021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei69 – 8921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei154 – 17421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei211 – 23121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei252 – 27221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG76064.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NH61.
    KOiK04257.
    OMAiAREINLN.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ8NH61.
    TreeFamiTF342735.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PfamiPF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH61-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTETSLSSQC FPMSVLNNTI AEPLIFLLMG IPGLKATQYW ISIPFCLLYV    50
    VAVSGNSMIL FVVLCERSLH KPMYYFLSML SATDLSLSLC TLSTTLGVFW 100
    FEAREINLNA CIAQMFFLHG FTFMESGVLL AMAFDRFVAI CYPLRYTTIL 150
    TNARIAKIGM SMLIRNVAVM LPVMLFVKRL SFCSSMVLSH SYCYHVDLIQ 200
    LSCTDNRINS ILGLFALLST TGFDCPCILL SYILIIRSVL SIASSEERRK 250
    AFNTCTSHIS AVSIFYLPLI SLSLVHRYGH SAPPFVHIIM ANVFLLIPPV 300
    LNPIIYSVKI KQIQKAIIKV LIQKHSKSNH QLFLIRDKAI YE 342
    Length:342
    Mass (Da):38,518
    Last modified:February 10, 2009 - v2
    Checksum:iCA3D91DB7B59EFB8
    GO

    Sequence cautioni

    The sequence BAC05776.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065529 Genomic DNA. Translation: BAC05776.1. Different initiation.
    AC103710 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68826.1.
    BC136877 mRNA. Translation: AAI36878.1.
    BK004281 Genomic DNA. Translation: DAA04679.1.
    CCDSiCCDS31361.1.
    RefSeqiNP_001004753.1. NM_001004753.1.
    UniGeneiHs.553562.

    Genome annotation databases

    EnsembliENST00000322110; ENSP00000323952; ENSG00000176925.
    GeneIDi119694.
    KEGGihsa:119694.
    UCSCiuc010qyn.2. human.

    Polymorphism databases

    DMDMi223590112.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065529 Genomic DNA. Translation: BAC05776.1 . Different initiation.
    AC103710 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68826.1 .
    BC136877 mRNA. Translation: AAI36878.1 .
    BK004281 Genomic DNA. Translation: DAA04679.1 .
    CCDSi CCDS31361.1.
    RefSeqi NP_001004753.1. NM_001004753.1.
    UniGenei Hs.553562.

    3D structure databases

    ProteinModelPortali Q8NH61.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000323952.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NH61.

    Polymorphism databases

    DMDMi 223590112.

    Proteomic databases

    PaxDbi Q8NH61.
    PRIDEi Q8NH61.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000322110 ; ENSP00000323952 ; ENSG00000176925 .
    GeneIDi 119694.
    KEGGi hsa:119694.
    UCSCi uc010qyn.2. human.

    Organism-specific databases

    CTDi 119694.
    GeneCardsi GC11P004842.
    HGNCi HGNC:15197. OR51F2.
    neXtProti NX_Q8NH61.
    PharmGKBi PA32375.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG76064.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NH61.
    KOi K04257.
    OMAi AREINLN.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q8NH61.
    TreeFami TF342735.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR51F2.
    GenomeRNAii 119694.
    NextBioi 80465.
    PROi Q8NH61.

    Gene expression databases

    CleanExi HS_OR51F2.
    Genevestigatori Q8NH61.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR019424. 7TM_GPCR_olfarory/Srsx.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    Pfami PF10320. 7TM_GPCR_Srsx. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. Cited for: IDENTIFICATION.
    6. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO51F2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH61
    Secondary accession number(s): Q6IFI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-13 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3