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Q8NH61 (O51F2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 51F2
Alternative name(s):
Olfactory receptor OR11-23
Gene names
Name:OR51F2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length342 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.

Sequence caution

The sequence BAC05776.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 342342Olfactory receptor 51F2
PRO_0000150753

Regions

Topological domain1 – 3939Extracellular Potential
Transmembrane40 – 6021Helical; Name=1; Potential
Topological domain61 – 688Cytoplasmic Potential
Transmembrane69 – 8921Helical; Name=2; Potential
Topological domain90 – 11324Extracellular Potential
Transmembrane114 – 13421Helical; Name=3; Potential
Topological domain135 – 15319Cytoplasmic Potential
Transmembrane154 – 17421Helical; Name=4; Potential
Topological domain175 – 21036Extracellular Potential
Transmembrane211 – 23121Helical; Name=5; Potential
Topological domain232 – 25120Cytoplasmic Potential
Transmembrane252 – 27221Helical; Name=6; Potential
Topological domain273 – 28715Extracellular Potential
Transmembrane288 – 30821Helical; Name=7; Potential
Topological domain309 – 34234Cytoplasmic Potential

Amino acid modifications

Glycosylation171N-linked (GlcNAc...) Potential
Disulfide bond111 ↔ 203 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NH61 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: CA3D91DB7B59EFB8

FASTA34238,518
        10         20         30         40         50         60 
MTETSLSSQC FPMSVLNNTI AEPLIFLLMG IPGLKATQYW ISIPFCLLYV VAVSGNSMIL 

        70         80         90        100        110        120 
FVVLCERSLH KPMYYFLSML SATDLSLSLC TLSTTLGVFW FEAREINLNA CIAQMFFLHG 

       130        140        150        160        170        180 
FTFMESGVLL AMAFDRFVAI CYPLRYTTIL TNARIAKIGM SMLIRNVAVM LPVMLFVKRL 

       190        200        210        220        230        240 
SFCSSMVLSH SYCYHVDLIQ LSCTDNRINS ILGLFALLST TGFDCPCILL SYILIIRSVL 

       250        260        270        280        290        300 
SIASSEERRK AFNTCTSHIS AVSIFYLPLI SLSLVHRYGH SAPPFVHIIM ANVFLLIPPV 

       310        320        330        340 
LNPIIYSVKI KQIQKAIIKV LIQKHSKSNH QLFLIRDKAI YE 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[6]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065529 Genomic DNA. Translation: BAC05776.1. Different initiation.
AC103710 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68826.1.
BC136877 mRNA. Translation: AAI36878.1.
BK004281 Genomic DNA. Translation: DAA04679.1.
RefSeqNP_001004753.1. NM_001004753.1.
UniGeneHs.553562.

3D structure databases

ProteinModelPortalQ8NH61.
SMRQ8NH61. Positions 123-154, 291-322.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000323952.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NH61.

Polymorphism databases

DMDM223590112.

Proteomic databases

PaxDbQ8NH61.
PRIDEQ8NH61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000322110; ENSP00000323952; ENSG00000176925.
GeneID119694.
KEGGhsa:119694.
UCSCuc010qyn.2. human.

Organism-specific databases

CTD119694.
GeneCardsGC11P004842.
HGNCHGNC:15197. OR51F2.
neXtProtNX_Q8NH61.
PharmGKBPA32375.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG76064.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ8NH61.
KOK04257.
OMAAREINLN.
OrthoDBEOG754HPV.
PhylomeDBQ8NH61.
TreeFamTF342735.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR51F2.
GenevestigatorQ8NH61.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR019424. 7TM_GPCR_olfarory/Srsx.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PfamPF10320. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR51F2.
GenomeRNAi119694.
NextBio80465.
PROQ8NH61.

Entry information

Entry nameO51F2_HUMAN
AccessionPrimary (citable) accession number: Q8NH61
Secondary accession number(s): Q6IFI1
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: April 16, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries