Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 51F2

Gene

OR51F2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51F2
Alternative name(s):
Olfactory receptor OR11-23
Gene namesi
Name:OR51F2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000176925.6.
HGNCiHGNC:15197. OR51F2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 68CytoplasmicSequence analysis8
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 113ExtracellularSequence analysisAdd BLAST24
Transmembranei114 – 134Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini135 – 153CytoplasmicSequence analysisAdd BLAST19
Transmembranei154 – 174Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini175 – 210ExtracellularSequence analysisAdd BLAST36
Transmembranei211 – 231Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini232 – 251CytoplasmicSequence analysisAdd BLAST20
Transmembranei252 – 272Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini273 – 287ExtracellularSequence analysisAdd BLAST15
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 342CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176925.
PharmGKBiPA32375.

Polymorphism and mutation databases

BioMutaiOR51F2.
DMDMi223590112.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507531 – 342Olfactory receptor 51F2Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi17N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 203PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH61.
PRIDEiQ8NH61.

PTM databases

iPTMnetiQ8NH61.
PhosphoSitePlusiQ8NH61.

Expressioni

Gene expression databases

BgeeiENSG00000176925.
CleanExiHS_OR51F2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000323952.

Structurei

3D structure databases

ProteinModelPortaliQ8NH61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9RU. Eukaryota.
ENOG41115KG. LUCA.
GeneTreeiENSGT00890000139335.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH61.
KOiK04257.
OMAiSFCSSMV.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH61.
TreeFamiTF342735.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PfamiView protein in Pfam
PF13853. 7tm_4. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NH61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETSLSSQC FPMSVLNNTI AEPLIFLLMG IPGLKATQYW ISIPFCLLYV
60 70 80 90 100
VAVSGNSMIL FVVLCERSLH KPMYYFLSML SATDLSLSLC TLSTTLGVFW
110 120 130 140 150
FEAREINLNA CIAQMFFLHG FTFMESGVLL AMAFDRFVAI CYPLRYTTIL
160 170 180 190 200
TNARIAKIGM SMLIRNVAVM LPVMLFVKRL SFCSSMVLSH SYCYHVDLIQ
210 220 230 240 250
LSCTDNRINS ILGLFALLST TGFDCPCILL SYILIIRSVL SIASSEERRK
260 270 280 290 300
AFNTCTSHIS AVSIFYLPLI SLSLVHRYGH SAPPFVHIIM ANVFLLIPPV
310 320 330 340
LNPIIYSVKI KQIQKAIIKV LIQKHSKSNH QLFLIRDKAI YE
Length:342
Mass (Da):38,518
Last modified:February 10, 2009 - v2
Checksum:iCA3D91DB7B59EFB8
GO

Sequence cautioni

The sequence BAC05776 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065529 Genomic DNA. Translation: BAC05776.1. Different initiation.
AC103710 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68826.1.
BC136877 mRNA. Translation: AAI36878.1.
BK004281 Genomic DNA. Translation: DAA04679.1.
CCDSiCCDS31361.1.
RefSeqiNP_001004753.1. NM_001004753.1.
UniGeneiHs.553562.

Genome annotation databases

EnsembliENST00000641672; ENSP00000493050; ENSG00000176925.
GeneIDi119694.
KEGGihsa:119694.
UCSCiuc010qyn.2. human.

Similar proteinsi

Entry informationi

Entry nameiO51F2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH61
Secondary accession number(s): Q6IFI1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: November 22, 2017
This is version 131 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-13 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families