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Protein

Olfactory receptor 51Q1

Gene

OR51Q1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176195-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51Q1
Gene namesi
Name:OR51Q1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14851. OR51Q1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 275ExtracellularSequence analysisAdd BLAST15
Transmembranei276 – 296Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini297 – 317CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167360.
PharmGKBiPA32388.

Polymorphism and mutation databases

BioMutaiOR51Q1.
DMDMi38258182.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507611 – 317Olfactory receptor 51Q1Add BLAST317

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH59.
PeptideAtlasiQ8NH59.
PRIDEiQ8NH59.

PTM databases

iPTMnetiQ8NH59.
PhosphoSitePlusiQ8NH59.

Expressioni

Gene expression databases

BgeeiENSG00000167360.
CleanExiHS_OR51Q1.

Organism-specific databases

HPAiHPA044998.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000300778.

Structurei

3D structure databases

ProteinModelPortaliQ8NH59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEQH. Eukaryota.
ENOG41115T5. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH59.
KOiK04257.
OMAiISSEACF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH59.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQVTNTTQE GIYFILTDIP GFEASHIWIS IPVCCLYTIS IMGNTTILTV
60 70 80 90 100
IRTEPSVHQR MYLFLSMLAL TDLGLTLTTL PTVMQLLWFN VRRISSEACF
110 120 130 140 150
AQFFFLHGFS FMESSVLLAM SVDCYVAICC PLHYASILTN EVIGRTGLAI
160 170 180 190 200
ICCCVLAVLP SLFLLKRLPF CHSHLLSRSY CLHQDMIRLV CADIRLNSWY
210 220 230 240 250
GFALALLIII VDPLLIVISY TLILKNILGT ATWAERLRAL NNCLSHILAV
260 270 280 290 300
LVLYIPMVGV SMTHRFAKHA SPLVHVIMAN IYLLAPPVMN PIIYSVKNKQ
310
IQWGMLNFLS LKNMHSR
Length:317
Mass (Da):35,747
Last modified:October 31, 2003 - v2
Checksum:iE8E0E761B05848EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153 – 155CCV → RCI in BAC05778 (Ref. 3) Curated3

Polymorphismi

A stop codon at position Arg-236 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034326146T → I.1 PublicationCorresponds to variant rs10838092dbSNPEnsembl.1
Natural variantiVAR_034327153C → R.Corresponds to variant rs10838093dbSNPEnsembl.1
Natural variantiVAR_053329155V → I.Corresponds to variant rs10838094dbSNPEnsembl.1
Natural variantiVAR_034328178R → H.1 PublicationCorresponds to variant rs10838095dbSNPEnsembl.1
Natural variantiVAR_024144211V → M.Corresponds to variant rs2736586dbSNPEnsembl.1
Natural variantiVAR_053330308F → S.Corresponds to variant rs2647573dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087380 Genomic DNA. No translation available.
BC136999 mRNA. Translation: AAI37000.1.
AB065531 Genomic DNA. Translation: BAC05778.1.
CCDSiCCDS31381.1.
RefSeqiNP_001004757.1. NM_001004757.2.
UniGeneiHs.528592.

Genome annotation databases

EnsembliENST00000300778; ENSP00000300778; ENSG00000167360.
GeneIDi390061.
KEGGihsa:390061.
UCSCiuc010qzd.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087380 Genomic DNA. No translation available.
BC136999 mRNA. Translation: AAI37000.1.
AB065531 Genomic DNA. Translation: BAC05778.1.
CCDSiCCDS31381.1.
RefSeqiNP_001004757.1. NM_001004757.2.
UniGeneiHs.528592.

3D structure databases

ProteinModelPortaliQ8NH59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000300778.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH59.
PhosphoSitePlusiQ8NH59.

Polymorphism and mutation databases

BioMutaiOR51Q1.
DMDMi38258182.

Proteomic databases

PaxDbiQ8NH59.
PeptideAtlasiQ8NH59.
PRIDEiQ8NH59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300778; ENSP00000300778; ENSG00000167360.
GeneIDi390061.
KEGGihsa:390061.
UCSCiuc010qzd.2. human.

Organism-specific databases

CTDi390061.
GeneCardsiOR51Q1.
H-InvDBHIX0201722.
HGNCiHGNC:14851. OR51Q1.
HPAiHPA044998.
neXtProtiNX_Q8NH59.
OpenTargetsiENSG00000167360.
PharmGKBiPA32388.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEQH. Eukaryota.
ENOG41115T5. LUCA.
GeneTreeiENSGT00840000129672.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH59.
KOiK04257.
OMAiISSEACF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH59.
TreeFamiTF342735.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176195-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51Q1.
GenomeRNAii390061.
PROiQ8NH59.

Gene expression databases

BgeeiENSG00000167360.
CleanExiHS_OR51Q1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO51Q1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH59
Secondary accession number(s): B2RNN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.