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Q8NH59

- O51Q1_HUMAN

UniProt

Q8NH59 - O51Q1_HUMAN

Protein

Olfactory receptor 51Q1

Gene

OR51Q1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (31 Oct 2003)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 51Q1
    Gene namesi
    Name:OR51Q1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14851. OR51Q1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32388.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 317317Olfactory receptor 51Q1PRO_0000150761Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH59.
    PRIDEiQ8NH59.

    Expressioni

    Gene expression databases

    BgeeiQ8NH59.
    CleanExiHS_OR51Q1.
    GenevestigatoriQ8NH59.

    Organism-specific databases

    HPAiHPA044998.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000300778.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH59.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini163 – 19836ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini261 – 27515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini297 – 31721CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG46377.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NH59.
    KOiK04257.
    OMAiISSEACF.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ8NH59.
    TreeFamiTF342735.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQVTNTTQE GIYFILTDIP GFEASHIWIS IPVCCLYTIS IMGNTTILTV    50
    IRTEPSVHQR MYLFLSMLAL TDLGLTLTTL PTVMQLLWFN VRRISSEACF 100
    AQFFFLHGFS FMESSVLLAM SVDCYVAICC PLHYASILTN EVIGRTGLAI 150
    ICCCVLAVLP SLFLLKRLPF CHSHLLSRSY CLHQDMIRLV CADIRLNSWY 200
    GFALALLIII VDPLLIVISY TLILKNILGT ATWAERLRAL NNCLSHILAV 250
    LVLYIPMVGV SMTHRFAKHA SPLVHVIMAN IYLLAPPVMN PIIYSVKNKQ 300
    IQWGMLNFLS LKNMHSR 317
    Length:317
    Mass (Da):35,747
    Last modified:October 31, 2003 - v2
    Checksum:iE8E0E761B05848EB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti153 – 1553CCV → RCI in BAC05778. 1 PublicationCurated

    Polymorphismi

    A stop codon at position Arg-236 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti146 – 1461T → I.1 Publication
    Corresponds to variant rs10838092 [ dbSNP | Ensembl ].
    VAR_034326
    Natural varianti153 – 1531C → R.
    Corresponds to variant rs10838093 [ dbSNP | Ensembl ].
    VAR_034327
    Natural varianti155 – 1551V → I.
    Corresponds to variant rs10838094 [ dbSNP | Ensembl ].
    VAR_053329
    Natural varianti178 – 1781R → H.1 Publication
    Corresponds to variant rs10838095 [ dbSNP | Ensembl ].
    VAR_034328
    Natural varianti211 – 2111V → M.
    Corresponds to variant rs2736586 [ dbSNP | Ensembl ].
    VAR_024144
    Natural varianti308 – 3081F → S.
    Corresponds to variant rs2647573 [ dbSNP | Ensembl ].
    VAR_053330

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC087380 Genomic DNA. No translation available.
    BC136999 mRNA. Translation: AAI37000.1.
    AB065531 Genomic DNA. Translation: BAC05778.1.
    CCDSiCCDS31381.1.
    RefSeqiNP_001004757.1. NM_001004757.2.
    UniGeneiHs.528592.

    Genome annotation databases

    EnsembliENST00000300778; ENSP00000300778; ENSG00000167360.
    GeneIDi390061.
    KEGGihsa:390061.
    UCSCiuc010qzd.2. human.

    Polymorphism databases

    DMDMi38258182.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC087380 Genomic DNA. No translation available.
    BC136999 mRNA. Translation: AAI37000.1 .
    AB065531 Genomic DNA. Translation: BAC05778.1 .
    CCDSi CCDS31381.1.
    RefSeqi NP_001004757.1. NM_001004757.2.
    UniGenei Hs.528592.

    3D structure databases

    ProteinModelPortali Q8NH59.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000300778.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38258182.

    Proteomic databases

    PaxDbi Q8NH59.
    PRIDEi Q8NH59.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000300778 ; ENSP00000300778 ; ENSG00000167360 .
    GeneIDi 390061.
    KEGGi hsa:390061.
    UCSCi uc010qzd.2. human.

    Organism-specific databases

    CTDi 390061.
    GeneCardsi GC11P005443.
    H-InvDB HIX0201722.
    HGNCi HGNC:14851. OR51Q1.
    HPAi HPA044998.
    neXtProti NX_Q8NH59.
    PharmGKBi PA32388.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG46377.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NH59.
    KOi K04257.
    OMAi ISSEACF.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q8NH59.
    TreeFami TF342735.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR51Q1.
    GenomeRNAii 390061.
    NextBioi 103329.
    PROi Q8NH59.

    Gene expression databases

    Bgeei Q8NH59.
    CleanExi HS_OR51Q1.
    Genevestigatori Q8NH59.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-303, VARIANTS ILE-146 AND HIS-178.
    4. "Genetic elucidation of human hyperosmia to isovaleric acid."
      Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W., Lancet D.
      PLoS Biol. 5:2462-2468(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM.

    Entry informationi

    Entry nameiO51Q1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH59
    Secondary accession number(s): B2RNN1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: October 31, 2003
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3