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Protein

Olfactory receptor 51Q1

Gene

OR51Q1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 51Q1
Gene namesi
Name:OR51Q1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14851. OR51Q1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence AnalysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini261 – 27515ExtracellularSequence AnalysisAdd
BLAST
Transmembranei276 – 29621Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini297 – 31721CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 317317Olfactory receptor 51Q1PRO_0000150761Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH59.
PRIDEiQ8NH59.

Expressioni

Gene expression databases

BgeeiQ8NH59.
CleanExiHS_OR51Q1.
GenevestigatoriQ8NH59.

Organism-specific databases

HPAiHPA044998.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000300778.

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46377.
GeneTreeiENSGT00780000121866.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH59.
KOiK04257.
OMAiISSEACF.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NH59.
TreeFamiTF342735.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQVTNTTQE GIYFILTDIP GFEASHIWIS IPVCCLYTIS IMGNTTILTV
60 70 80 90 100
IRTEPSVHQR MYLFLSMLAL TDLGLTLTTL PTVMQLLWFN VRRISSEACF
110 120 130 140 150
AQFFFLHGFS FMESSVLLAM SVDCYVAICC PLHYASILTN EVIGRTGLAI
160 170 180 190 200
ICCCVLAVLP SLFLLKRLPF CHSHLLSRSY CLHQDMIRLV CADIRLNSWY
210 220 230 240 250
GFALALLIII VDPLLIVISY TLILKNILGT ATWAERLRAL NNCLSHILAV
260 270 280 290 300
LVLYIPMVGV SMTHRFAKHA SPLVHVIMAN IYLLAPPVMN PIIYSVKNKQ
310
IQWGMLNFLS LKNMHSR
Length:317
Mass (Da):35,747
Last modified:October 30, 2003 - v2
Checksum:iE8E0E761B05848EB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1553CCV → RCI in BAC05778 (Ref. 3) Curated

Polymorphismi

A stop codon at position Arg-236 in the gene coding for this protein is responsible for functional diversity thus producing a pseudogene.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti146 – 1461T → I.1 Publication
Corresponds to variant rs10838092 [ dbSNP | Ensembl ].
VAR_034326
Natural varianti153 – 1531C → R.
Corresponds to variant rs10838093 [ dbSNP | Ensembl ].
VAR_034327
Natural varianti155 – 1551V → I.
Corresponds to variant rs10838094 [ dbSNP | Ensembl ].
VAR_053329
Natural varianti178 – 1781R → H.1 Publication
Corresponds to variant rs10838095 [ dbSNP | Ensembl ].
VAR_034328
Natural varianti211 – 2111V → M.
Corresponds to variant rs2736586 [ dbSNP | Ensembl ].
VAR_024144
Natural varianti308 – 3081F → S.
Corresponds to variant rs2647573 [ dbSNP | Ensembl ].
VAR_053330

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087380 Genomic DNA. No translation available.
BC136999 mRNA. Translation: AAI37000.1.
AB065531 Genomic DNA. Translation: BAC05778.1.
CCDSiCCDS31381.1.
RefSeqiNP_001004757.1. NM_001004757.2.
UniGeneiHs.528592.

Genome annotation databases

EnsembliENST00000300778; ENSP00000300778; ENSG00000167360.
GeneIDi390061.
KEGGihsa:390061.
UCSCiuc010qzd.2. human.

Polymorphism databases

DMDMi38258182.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087380 Genomic DNA. No translation available.
BC136999 mRNA. Translation: AAI37000.1.
AB065531 Genomic DNA. Translation: BAC05778.1.
CCDSiCCDS31381.1.
RefSeqiNP_001004757.1. NM_001004757.2.
UniGeneiHs.528592.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000300778.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi38258182.

Proteomic databases

PaxDbiQ8NH59.
PRIDEiQ8NH59.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300778; ENSP00000300778; ENSG00000167360.
GeneIDi390061.
KEGGihsa:390061.
UCSCiuc010qzd.2. human.

Organism-specific databases

CTDi390061.
GeneCardsiGC11P005443.
H-InvDBHIX0201722.
HGNCiHGNC:14851. OR51Q1.
HPAiHPA044998.
neXtProtiNX_Q8NH59.
PharmGKBiPA32388.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG46377.
GeneTreeiENSGT00780000121866.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH59.
KOiK04257.
OMAiISSEACF.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NH59.
TreeFamiTF342735.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR51Q1.
GenomeRNAii390061.
NextBioi103329.
PROiQ8NH59.

Gene expression databases

BgeeiQ8NH59.
CleanExiHS_OR51Q1.
GenevestigatoriQ8NH59.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-303, VARIANTS ILE-146 AND HIS-178.
  4. "Genetic elucidation of human hyperosmia to isovaleric acid."
    Menashe I., Abaffy T., Hasin Y., Goshen S., Yahalom V., Luetje C.W., Lancet D.
    PLoS Biol. 5:2462-2468(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM.

Entry informationi

Entry nameiO51Q1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH59
Secondary accession number(s): B2RNN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 30, 2003
Last sequence update: October 30, 2003
Last modified: March 31, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.