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Q8NH56

- O52N5_HUMAN

UniProt

Q8NH56 - O52N5_HUMAN

Protein

Olfactory receptor 52N5

Gene

OR52N5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 2 (04 Nov 2008)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 52N5
    Alternative name(s):
    Olfactory receptor OR11-62
    Gene namesi
    Name:OR52N5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:15231. OR52N5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32429.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 324324Olfactory receptor 52N5PRO_0000150789Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi106 ↔ 198PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ8NH56.
    PRIDEiQ8NH56.

    Expressioni

    Gene expression databases

    CleanExiHS_OR52N5.
    GenevestigatoriQ8NH56.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000322866.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH56.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini55 – 628CytoplasmicSequence Analysis
    Topological domaini85 – 10824ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini130 – 14819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini170 – 20536ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 24620CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 28316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini305 – 32420CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei63 – 8422Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei247 – 26721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei284 – 30421Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG68125.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NH56.
    KOiK04257.
    OMAiLIYYEES.
    OrthoDBiEOG754HPV.
    PhylomeDBiQ8NH56.
    TreeFamiTF343679.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH56-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLFNSLCWF PTIHVTPPSF ILNGIPGLER VHVWISLPLC TMYIIFLVGN    50
    LGLVYLIYYE ESLHHPMYFF FGHALSLIDL LTCTTTLPNA LCIFWFSLKE 100
    INFNACLAQM FFVHGFTGVE SGVLMLMALD RYVAICYPLR YATTLTNPII 150
    AKAELATFLR GVLLMIPFPF LVKRLPFCQS NIISHTYCDH MSVVKLSCAS 200
    IKVNVIYGLM VALLIGVFDI CCISLSYTLI LKAAISLSSS DARQKAFSTC 250
    TAHISAIIIT YVPAFFTFFA HRFGGHTIPP SLHIIVANLY LLLPPTLNPI 300
    VYGVKTKQIR KSVIKFFQGD KGAG 324
    Length:324
    Mass (Da):36,212
    Last modified:November 4, 2008 - v2
    Checksum:i71FAC1869435A50F
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331V → I.1 Publication
    Corresponds to variant rs12360738 [ dbSNP | Ensembl ].
    VAR_047147

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065535 Genomic DNA. Translation: BAC05781.1.
    CH471064 Genomic DNA. Translation: EAW68762.1.
    BC136979 mRNA. Translation: AAI36980.1.
    BC136981 mRNA. Translation: AAI36982.1.
    BK004300 Genomic DNA. Translation: DAA04698.1.
    CCDSiCCDS31397.1.
    RefSeqiNP_001001922.2. NM_001001922.2.
    UniGeneiHs.690207.

    Genome annotation databases

    EnsembliENST00000317093; ENSP00000322866; ENSG00000181009.
    GeneIDi390075.
    KEGGihsa:390075.
    UCSCiuc010qzn.2. human.

    Polymorphism databases

    DMDMi212276449.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065535 Genomic DNA. Translation: BAC05781.1 .
    CH471064 Genomic DNA. Translation: EAW68762.1 .
    BC136979 mRNA. Translation: AAI36980.1 .
    BC136981 mRNA. Translation: AAI36982.1 .
    BK004300 Genomic DNA. Translation: DAA04698.1 .
    CCDSi CCDS31397.1.
    RefSeqi NP_001001922.2. NM_001001922.2.
    UniGenei Hs.690207.

    3D structure databases

    ProteinModelPortali Q8NH56.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000322866.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 212276449.

    Proteomic databases

    PaxDbi Q8NH56.
    PRIDEi Q8NH56.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317093 ; ENSP00000322866 ; ENSG00000181009 .
    GeneIDi 390075.
    KEGGi hsa:390075.
    UCSCi uc010qzn.2. human.

    Organism-specific databases

    CTDi 390075.
    GeneCardsi GC11M005755.
    HGNCi HGNC:15231. OR52N5.
    neXtProti NX_Q8NH56.
    PharmGKBi PA32429.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68125.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NH56.
    KOi K04257.
    OMAi LIYYEES.
    OrthoDBi EOG754HPV.
    PhylomeDBi Q8NH56.
    TreeFami TF343679.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR52N5.
    GenomeRNAii 390075.
    NextBioi 103355.
    PROi Q8NH56.

    Gene expression databases

    CleanExi HS_OR52N5.
    Genevestigatori Q8NH56.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-133.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO52N5_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH56
    Secondary accession number(s): B9EH12, Q6IFG2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 4, 2008
    Last modified: October 1, 2014
    This is version 98 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3