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Protein

Olfactory receptor 52N5

Gene

OR52N5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52N5
Alternative name(s):
Olfactory receptor OR11-62
Gene namesi
Name:OR52N5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15231. OR52N5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3333ExtracellularSequence AnalysisAdd
BLAST
Transmembranei34 – 5421Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini55 – 628CytoplasmicSequence Analysis
Transmembranei63 – 8422Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini85 – 10824ExtracellularSequence AnalysisAdd
BLAST
Transmembranei109 – 12921Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini130 – 14819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei149 – 16921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini170 – 20536ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini227 – 24620CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei247 – 26721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini268 – 28316ExtracellularSequence AnalysisAdd
BLAST
Transmembranei284 – 30421Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini305 – 32420CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32429.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Olfactory receptor 52N5PRO_0000150789Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi106 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NH56.
PRIDEiQ8NH56.

Expressioni

Gene expression databases

CleanExiHS_OR52N5.
GenevestigatoriQ8NH56.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322866.

Structurei

3D structure databases

ProteinModelPortaliQ8NH56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG68125.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH56.
KOiK04257.
OMAiYLIYYEE.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NH56.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLFNSLCWF PTIHVTPPSF ILNGIPGLER VHVWISLPLC TMYIIFLVGN
60 70 80 90 100
LGLVYLIYYE ESLHHPMYFF FGHALSLIDL LTCTTTLPNA LCIFWFSLKE
110 120 130 140 150
INFNACLAQM FFVHGFTGVE SGVLMLMALD RYVAICYPLR YATTLTNPII
160 170 180 190 200
AKAELATFLR GVLLMIPFPF LVKRLPFCQS NIISHTYCDH MSVVKLSCAS
210 220 230 240 250
IKVNVIYGLM VALLIGVFDI CCISLSYTLI LKAAISLSSS DARQKAFSTC
260 270 280 290 300
TAHISAIIIT YVPAFFTFFA HRFGGHTIPP SLHIIVANLY LLLPPTLNPI
310 320
VYGVKTKQIR KSVIKFFQGD KGAG
Length:324
Mass (Da):36,212
Last modified:November 4, 2008 - v2
Checksum:i71FAC1869435A50F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti133 – 1331V → I.1 Publication
Corresponds to variant rs12360738 [ dbSNP | Ensembl ].
VAR_047147

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065535 Genomic DNA. Translation: BAC05781.1.
CH471064 Genomic DNA. Translation: EAW68762.1.
BC136979 mRNA. Translation: AAI36980.1.
BC136981 mRNA. Translation: AAI36982.1.
BK004300 Genomic DNA. Translation: DAA04698.1.
CCDSiCCDS31397.1.
RefSeqiNP_001001922.2. NM_001001922.2.
UniGeneiHs.690207.

Genome annotation databases

EnsembliENST00000317093; ENSP00000322866; ENSG00000181009.
GeneIDi390075.
KEGGihsa:390075.
UCSCiuc010qzn.2. human.

Polymorphism databases

DMDMi212276449.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065535 Genomic DNA. Translation: BAC05781.1.
CH471064 Genomic DNA. Translation: EAW68762.1.
BC136979 mRNA. Translation: AAI36980.1.
BC136981 mRNA. Translation: AAI36982.1.
BK004300 Genomic DNA. Translation: DAA04698.1.
CCDSiCCDS31397.1.
RefSeqiNP_001001922.2. NM_001001922.2.
UniGeneiHs.690207.

3D structure databases

ProteinModelPortaliQ8NH56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322866.

Protein family/group databases

GPCRDBiSearch...

Polymorphism databases

DMDMi212276449.

Proteomic databases

PaxDbiQ8NH56.
PRIDEiQ8NH56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317093; ENSP00000322866; ENSG00000181009.
GeneIDi390075.
KEGGihsa:390075.
UCSCiuc010qzn.2. human.

Organism-specific databases

CTDi390075.
GeneCardsiGC11M005755.
HGNCiHGNC:15231. OR52N5.
neXtProtiNX_Q8NH56.
PharmGKBiPA32429.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG68125.
GeneTreeiENSGT00760000118843.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH56.
KOiK04257.
OMAiYLIYYEE.
OrthoDBiEOG754HPV.
PhylomeDBiQ8NH56.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52N5.
GenomeRNAii390075.
NextBioi103355.
PROiQ8NH56.

Gene expression databases

CleanExiHS_OR52N5.
GenevestigatoriQ8NH56.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-133.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52N5_HUMAN
AccessioniPrimary (citable) accession number: Q8NH56
Secondary accession number(s): B9EH12, Q6IFG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: January 7, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.