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Q8NH56 (O52N5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 52N5
Alternative name(s):
Olfactory receptor OR11-62
Gene names
Name:OR52N5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 324324Olfactory receptor 52N5
PRO_0000150789

Regions

Topological domain1 – 3333Extracellular Potential
Transmembrane34 – 5421Helical; Name=1; Potential
Topological domain55 – 628Cytoplasmic Potential
Transmembrane63 – 8422Helical; Name=2; Potential
Topological domain85 – 10824Extracellular Potential
Transmembrane109 – 12921Helical; Name=3; Potential
Topological domain130 – 14819Cytoplasmic Potential
Transmembrane149 – 16921Helical; Name=4; Potential
Topological domain170 – 20536Extracellular Potential
Transmembrane206 – 22621Helical; Name=5; Potential
Topological domain227 – 24620Cytoplasmic Potential
Transmembrane247 – 26721Helical; Name=6; Potential
Topological domain268 – 28316Extracellular Potential
Transmembrane284 – 30421Helical; Name=7; Potential
Topological domain305 – 32420Cytoplasmic Potential

Amino acid modifications

Disulfide bond106 ↔ 198 By similarity

Natural variations

Natural variant1331V → I. Ref.1
Corresponds to variant rs12360738 [ dbSNP | Ensembl ].
VAR_047147

Sequences

Sequence LengthMass (Da)Tools
Q8NH56 [UniParc].

Last modified November 4, 2008. Version 2.
Checksum: 71FAC1869435A50F

FASTA32436,212
        10         20         30         40         50         60 
MPLFNSLCWF PTIHVTPPSF ILNGIPGLER VHVWISLPLC TMYIIFLVGN LGLVYLIYYE 

        70         80         90        100        110        120 
ESLHHPMYFF FGHALSLIDL LTCTTTLPNA LCIFWFSLKE INFNACLAQM FFVHGFTGVE 

       130        140        150        160        170        180 
SGVLMLMALD RYVAICYPLR YATTLTNPII AKAELATFLR GVLLMIPFPF LVKRLPFCQS 

       190        200        210        220        230        240 
NIISHTYCDH MSVVKLSCAS IKVNVIYGLM VALLIGVFDI CCISLSYTLI LKAAISLSSS 

       250        260        270        280        290        300 
DARQKAFSTC TAHISAIIIT YVPAFFTFFA HRFGGHTIPP SLHIIVANLY LLLPPTLNPI 

       310        320 
VYGVKTKQIR KSVIKFFQGD KGAG 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ILE-133.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065535 Genomic DNA. Translation: BAC05781.1.
CH471064 Genomic DNA. Translation: EAW68762.1.
BC136979 mRNA. Translation: AAI36980.1.
BC136981 mRNA. Translation: AAI36982.1.
BK004300 Genomic DNA. Translation: DAA04698.1.
CCDSCCDS31397.1.
RefSeqNP_001001922.2. NM_001001922.2.
UniGeneHs.690207.

3D structure databases

ProteinModelPortalQ8NH56.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000322866.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM212276449.

Proteomic databases

PaxDbQ8NH56.
PRIDEQ8NH56.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000317093; ENSP00000322866; ENSG00000181009.
GeneID390075.
KEGGhsa:390075.
UCSCuc010qzn.2. human.

Organism-specific databases

CTD390075.
GeneCardsGC11M005755.
HGNCHGNC:15231. OR52N5.
neXtProtNX_Q8NH56.
PharmGKBPA32429.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG68125.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ8NH56.
KOK04257.
OMALIYYEES.
OrthoDBEOG754HPV.
PhylomeDBQ8NH56.
TreeFamTF343679.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR52N5.
GenevestigatorQ8NH56.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR52N5.
GenomeRNAi390075.
NextBio103355.
PROQ8NH56.

Entry information

Entry nameO52N5_HUMAN
AccessionPrimary (citable) accession number: Q8NH56
Secondary accession number(s): B9EH12, Q6IFG2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: July 9, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries