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Protein

Olfactory receptor 52N5

Gene

OR52N5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181009-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52N5
Alternative name(s):
Olfactory receptor OR11-62
Gene namesi
Name:OR52N5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:15231. OR52N5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 62CytoplasmicSequence analysis8
Transmembranei63 – 84Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini85 – 108ExtracellularSequence analysisAdd BLAST24
Transmembranei109 – 129Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini130 – 148CytoplasmicSequence analysisAdd BLAST19
Transmembranei149 – 169Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini170 – 205ExtracellularSequence analysisAdd BLAST36
Transmembranei206 – 226Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini227 – 246CytoplasmicSequence analysisAdd BLAST20
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 283ExtracellularSequence analysisAdd BLAST16
Transmembranei284 – 304Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini305 – 324CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181009.
PharmGKBiPA32429.

Polymorphism and mutation databases

BioMutaiOR52N5.
DMDMi212276449.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507891 – 324Olfactory receptor 52N5Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ8NH56.
PeptideAtlasiQ8NH56.
PRIDEiQ8NH56.

Expressioni

Gene expression databases

CleanExiHS_OR52N5.
ExpressionAtlasiQ8NH56. baseline and differential.

Organism-specific databases

HPAiCAB012421.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322866.

Structurei

3D structure databases

ProteinModelPortaliQ8NH56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE74. Eukaryota.
ENOG41117GK. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH56.
KOiK04257.
OMAiYLIYYEE.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH56.
TreeFamiTF343679.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLFNSLCWF PTIHVTPPSF ILNGIPGLER VHVWISLPLC TMYIIFLVGN
60 70 80 90 100
LGLVYLIYYE ESLHHPMYFF FGHALSLIDL LTCTTTLPNA LCIFWFSLKE
110 120 130 140 150
INFNACLAQM FFVHGFTGVE SGVLMLMALD RYVAICYPLR YATTLTNPII
160 170 180 190 200
AKAELATFLR GVLLMIPFPF LVKRLPFCQS NIISHTYCDH MSVVKLSCAS
210 220 230 240 250
IKVNVIYGLM VALLIGVFDI CCISLSYTLI LKAAISLSSS DARQKAFSTC
260 270 280 290 300
TAHISAIIIT YVPAFFTFFA HRFGGHTIPP SLHIIVANLY LLLPPTLNPI
310 320
VYGVKTKQIR KSVIKFFQGD KGAG
Length:324
Mass (Da):36,212
Last modified:November 4, 2008 - v2
Checksum:i71FAC1869435A50F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047147133V → I.1 PublicationCorresponds to variant rs12360738dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065535 Genomic DNA. Translation: BAC05781.1.
CH471064 Genomic DNA. Translation: EAW68762.1.
BC136979 mRNA. Translation: AAI36980.1.
BC136981 mRNA. Translation: AAI36982.1.
BK004300 Genomic DNA. Translation: DAA04698.1.
CCDSiCCDS31397.1.
RefSeqiNP_001001922.2. NM_001001922.2.
UniGeneiHs.690207.

Genome annotation databases

EnsembliENST00000317093; ENSP00000322866; ENSG00000181009.
GeneIDi390075.
KEGGihsa:390075.
UCSCiuc010qzn.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065535 Genomic DNA. Translation: BAC05781.1.
CH471064 Genomic DNA. Translation: EAW68762.1.
BC136979 mRNA. Translation: AAI36980.1.
BC136981 mRNA. Translation: AAI36982.1.
BK004300 Genomic DNA. Translation: DAA04698.1.
CCDSiCCDS31397.1.
RefSeqiNP_001001922.2. NM_001001922.2.
UniGeneiHs.690207.

3D structure databases

ProteinModelPortaliQ8NH56.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322866.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR52N5.
DMDMi212276449.

Proteomic databases

PaxDbiQ8NH56.
PeptideAtlasiQ8NH56.
PRIDEiQ8NH56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317093; ENSP00000322866; ENSG00000181009.
GeneIDi390075.
KEGGihsa:390075.
UCSCiuc010qzn.2. human.

Organism-specific databases

CTDi390075.
GeneCardsiOR52N5.
HGNCiHGNC:15231. OR52N5.
HPAiCAB012421.
neXtProtiNX_Q8NH56.
OpenTargetsiENSG00000181009.
PharmGKBiPA32429.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE74. Eukaryota.
ENOG41117GK. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH56.
KOiK04257.
OMAiYLIYYEE.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH56.
TreeFamiTF343679.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181009-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52N5.
GenomeRNAii390075.
PROiQ8NH56.

Gene expression databases

CleanExiHS_OR52N5.
ExpressionAtlasiQ8NH56. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52N5_HUMAN
AccessioniPrimary (citable) accession number: Q8NH56
Secondary accession number(s): B9EH12, Q6IFG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 4, 2008
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.