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Q8NH55

- O52E5_HUMAN

UniProt

Q8NH55 - O52E5_HUMAN

Protein

Olfactory receptor 52E5

Gene

OR52E5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (13 Nov 2013)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 52E5
    Gene namesi
    Name:OR52E5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:15214. OR52E5.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 327327Olfactory receptor 52E5PRO_0000150774Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH55.
    PRIDEiQ8NH55.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8NH55.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000321398.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH55.
    SMRiQ8NH55. Positions 27-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 565CytoplasmicSequence Analysis
    Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini123 – 14422CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini166 – 19530ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 23822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini294 – 32734CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41008.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NH55.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH55-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLHTNNTQFH PSTFLVVGVP GLEDVHVWIG FPFFAVYLTA LLGNIIILFV    50
    IQTEQSLHQP MFYFLAMLAG TDLGLSTATI PKMLGIFWFN LGEIAFGACI 100
    TQMYTIHICT GLESVVLTVT GIDRYIAICN PLRYSMILTN KVIAILGIVI 150
    IVRTLVFVTP FTFLILRLPF CGVRIIPHTY CEHMGLAKLA CASINVIYGL 200
    IAFSVGYIDI SVIGFSYVQI LRAVFHLPAW DARPKALSTC GSHVCVMLAF 250
    YLPALFSFMT HRFGHNIPHY IHILLANLYV VFPPALNSVI YGVKTKQIRE 300
    QVLRILNPKS FWHFDPKRIF HNNSVRQ 327
    Length:327
    Mass (Da):36,851
    Last modified:November 13, 2013 - v2
    Checksum:i3FA0D6A2EF981C0D
    GO

    Sequence cautioni

    The sequence BAC05782.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti165 – 1651I → T.
    Corresponds to variant rs17234326 [ dbSNP | Ensembl ].
    VAR_034338
    Natural varianti209 – 2091D → G.
    Corresponds to variant rs16926732 [ dbSNP | Ensembl ].
    VAR_034339
    Natural varianti234 – 2341P → L.
    Corresponds to variant rs7106300 [ dbSNP | Ensembl ].
    VAR_034340

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065536 Genomic DNA. Translation: BAC05782.1. Sequence problems.

    Polymorphism databases

    DMDMi557952596.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065536 Genomic DNA. Translation: BAC05782.1 . Sequence problems.

    3D structure databases

    ProteinModelPortali Q8NH55.
    SMRi Q8NH55. Positions 27-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000321398.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 557952596.

    Proteomic databases

    PaxDbi Q8NH55.
    PRIDEi Q8NH55.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    GeneCardsi GC11P005922.
    HGNCi HGNC:15214. OR52E5.
    neXtProti NX_Q8NH55.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41008.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NH55.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    PROi Q8NH55.

    Gene expression databases

    Genevestigatori Q8NH55.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiO52E5_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH55
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: November 13, 2013
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3