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Q8NH55 (O52E5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 52E5
Gene names
Name:OR52E5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05782.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 327327Olfactory receptor 52E5
PRO_0000150774

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Potential
Topological domain52 – 565Cytoplasmic Potential
Transmembrane57 – 7721Helical; Name=2; Potential
Topological domain78 – 10124Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 14422Cytoplasmic Potential
Transmembrane145 – 16521Helical; Name=4; Potential
Topological domain166 – 19530Extracellular Potential
Transmembrane196 – 21621Helical; Name=5; Potential
Topological domain217 – 23822Cytoplasmic Potential
Transmembrane239 – 25921Helical; Name=6; Potential
Topological domain260 – 27213Extracellular Potential
Transmembrane273 – 29321Helical; Name=7; Potential
Topological domain294 – 32734Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 191 By similarity

Natural variations

Natural variant1651I → T.
Corresponds to variant rs17234326 [ dbSNP | Ensembl ].
VAR_034338
Natural variant2091D → G.
Corresponds to variant rs16926732 [ dbSNP | Ensembl ].
VAR_034339
Natural variant2341P → L.
Corresponds to variant rs7106300 [ dbSNP | Ensembl ].
VAR_034340

Sequences

Sequence LengthMass (Da)Tools
Q8NH55 [UniParc].

Last modified November 13, 2013. Version 2.
Checksum: 3FA0D6A2EF981C0D

FASTA32736,851
        10         20         30         40         50         60 
MLHTNNTQFH PSTFLVVGVP GLEDVHVWIG FPFFAVYLTA LLGNIIILFV IQTEQSLHQP 

        70         80         90        100        110        120 
MFYFLAMLAG TDLGLSTATI PKMLGIFWFN LGEIAFGACI TQMYTIHICT GLESVVLTVT 

       130        140        150        160        170        180 
GIDRYIAICN PLRYSMILTN KVIAILGIVI IVRTLVFVTP FTFLILRLPF CGVRIIPHTY 

       190        200        210        220        230        240 
CEHMGLAKLA CASINVIYGL IAFSVGYIDI SVIGFSYVQI LRAVFHLPAW DARPKALSTC 

       250        260        270        280        290        300 
GSHVCVMLAF YLPALFSFMT HRFGHNIPHY IHILLANLYV VFPPALNSVI YGVKTKQIRE 

       310        320 
QVLRILNPKS FWHFDPKRIF HNNSVRQ 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065536 Genomic DNA. Translation: BAC05782.1. Sequence problems.

3D structure databases

ProteinModelPortalQ8NH55.
SMRQ8NH55. Positions 27-160.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000321398.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM557952596.

Proteomic databases

PaxDbQ8NH55.
PRIDEQ8NH55.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC11P005922.
HGNCHGNC:15214. OR52E5.
neXtProtNX_Q8NH55.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41008.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ8NH55.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

GenevestigatorQ8NH55.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8NH55.

Entry information

Entry nameO52E5_HUMAN
AccessionPrimary (citable) accession number: Q8NH55
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 13, 2013
Last modified: June 11, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries