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Q8NH55

- O52E5_HUMAN

UniProt

Q8NH55 - O52E5_HUMAN

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Protein

Olfactory receptor 52E5

Gene

OR52E5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52E5
Gene namesi
Name:OR52E5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:15214. OR52E5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5121HelicalSequence AnalysisAdd
BLAST
Topological domaini52 – 565CytoplasmicSequence Analysis
Transmembranei57 – 7721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini123 – 14422CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei145 – 16521Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini166 – 19530ExtracellularSequence AnalysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini217 – 23822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei239 – 25921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini260 – 27213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei273 – 29321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini294 – 32734CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 327327Olfactory receptor 52E5PRO_0000150774Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH55.
PRIDEiQ8NH55.

Expressioni

Gene expression databases

GenevestigatoriQ8NH55.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321398.

Structurei

3D structure databases

ProteinModelPortaliQ8NH55.
SMRiQ8NH55. Positions 27-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41008.
GeneTreeiENSGT00760000118952.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH55.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLHTNNTQFH PSTFLVVGVP GLEDVHVWIG FPFFAVYLTA LLGNIIILFV
60 70 80 90 100
IQTEQSLHQP MFYFLAMLAG TDLGLSTATI PKMLGIFWFN LGEIAFGACI
110 120 130 140 150
TQMYTIHICT GLESVVLTVT GIDRYIAICN PLRYSMILTN KVIAILGIVI
160 170 180 190 200
IVRTLVFVTP FTFLILRLPF CGVRIIPHTY CEHMGLAKLA CASINVIYGL
210 220 230 240 250
IAFSVGYIDI SVIGFSYVQI LRAVFHLPAW DARPKALSTC GSHVCVMLAF
260 270 280 290 300
YLPALFSFMT HRFGHNIPHY IHILLANLYV VFPPALNSVI YGVKTKQIRE
310 320
QVLRILNPKS FWHFDPKRIF HNNSVRQ
Length:327
Mass (Da):36,851
Last modified:November 13, 2013 - v2
Checksum:i3FA0D6A2EF981C0D
GO

Sequence cautioni

The sequence BAC05782.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti165 – 1651I → T.
Corresponds to variant rs17234326 [ dbSNP | Ensembl ].
VAR_034338
Natural varianti209 – 2091D → G.
Corresponds to variant rs16926732 [ dbSNP | Ensembl ].
VAR_034339
Natural varianti234 – 2341P → L.
Corresponds to variant rs7106300 [ dbSNP | Ensembl ].
VAR_034340

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065536 Genomic DNA. Translation: BAC05782.1. Sequence problems.

Genome annotation databases

EnsembliENST00000610445; ENSP00000480583; ENSG00000277932.

Polymorphism databases

DMDMi557952596.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065536 Genomic DNA. Translation: BAC05782.1 . Sequence problems.

3D structure databases

ProteinModelPortali Q8NH55.
SMRi Q8NH55. Positions 27-160.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000321398.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 557952596.

Proteomic databases

PaxDbi Q8NH55.
PRIDEi Q8NH55.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000610445 ; ENSP00000480583 ; ENSG00000277932 .

Organism-specific databases

GeneCardsi GC11P005922.
HGNCi HGNC:15214. OR52E5.
neXtProti NX_Q8NH55.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG41008.
GeneTreei ENSGT00760000118952.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q8NH55.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

PROi Q8NH55.

Gene expression databases

Genevestigatori Q8NH55.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiO52E5_HUMAN
AccessioniPrimary (citable) accession number: Q8NH55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: November 13, 2013
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3