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Q8NH54

- O56A3_HUMAN

UniProt

Q8NH54 - O56A3_HUMAN

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Protein

Olfactory receptor 56A3

Gene

OR56A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56A3
Alternative name(s):
Olfactory receptor 56A6
Gene namesi
Name:OR56A3
Synonyms:OR56A3P, OR56A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14786. OR56A3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini51 – 588CytoplasmicSequence Analysis
Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10324ExtracellularSequence AnalysisAdd
BLAST
Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14319CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini165 – 20036ExtracellularSequence AnalysisAdd
BLAST
Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini222 – 24120CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini263 – 27715ExtracellularSequence AnalysisAdd
BLAST
Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini299 – 31517CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 315315Olfactory receptor 56A3PRO_0000150794Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation
Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH54.
PRIDEiQ8NH54.

PTM databases

PhosphoSiteiQ8NH54.

Expressioni

Gene expression databases

CleanExiHS_OR56A3.
GenevestigatoriQ8NH54.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331572.

Structurei

3D structure databases

ProteinModelPortaliQ8NH54.
SMRiQ8NH54. Positions 29-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40290.
GeneTreeiENSGT00550000074576.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH54.
KOiK04257.
OMAiKVLTIFW.
OrthoDBiEOG7Q5HDX.
PhylomeDBiQ8NH54.
TreeFamiTF344049.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTTHRNDTLS TEASDFLLNC FVRSPSWQHW LSLPLSLLFL LAVGANTTLL
60 70 80 90 100
MTIWLEASLH QPLYYLLSLL SLLDIVLCLT VIPKVLTIFW FDLRPISFPA
110 120 130 140 150
CFLQMYIMNC FLAMESCTFM VMAYDRYVAI CHPLRYPSII TDHFVVKAAM
160 170 180 190 200
FILTRNVLMT LPIPILSAQL RYCGRNVIEN CICANMSVSR LSCDDVTINH
210 220 230 240 250
LYQFAGGWTL LGSDLILIFL SYTFILRAVL RLKAEGAVAK ALSTCGSHFM
260 270 280 290 300
LILFFSTILL VFVLTHVAKK KVSPDVPVLL NVLHHVIPAA LNPIIYGVRT
310
QEIKQGMQRL LKKGC
Length:315
Mass (Da):35,611
Last modified:October 10, 2003 - v2
Checksum:i66DEE7264A41BD0F
GO

Sequence cautioni

The sequence BAC05783.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti51 – 511M → T.
Corresponds to variant rs1840178 [ dbSNP | Ensembl ].
VAR_024152

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065537 Genomic DNA. Translation: BAC05783.1. Sequence problems.
AC025016 Genomic DNA. No translation available.
BK004305 Genomic DNA. Translation: DAA04703.1.
CCDSiCCDS41614.1.
RefSeqiNP_001003443.2. NM_001003443.2.
UniGeneiHs.553741.

Genome annotation databases

EnsembliENST00000329564; ENSP00000331572; ENSG00000184478.
GeneIDi390083.
KEGGihsa:390083.
UCSCiuc010qzt.2. human.

Polymorphism databases

DMDMi38372812.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065537 Genomic DNA. Translation: BAC05783.1 . Sequence problems.
AC025016 Genomic DNA. No translation available.
BK004305 Genomic DNA. Translation: DAA04703.1 .
CCDSi CCDS41614.1.
RefSeqi NP_001003443.2. NM_001003443.2.
UniGenei Hs.553741.

3D structure databases

ProteinModelPortali Q8NH54.
SMRi Q8NH54. Positions 29-165.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000331572.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NH54.

Polymorphism databases

DMDMi 38372812.

Proteomic databases

PaxDbi Q8NH54.
PRIDEi Q8NH54.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000329564 ; ENSP00000331572 ; ENSG00000184478 .
GeneIDi 390083.
KEGGi hsa:390083.
UCSCi uc010qzt.2. human.

Organism-specific databases

CTDi 390083.
GeneCardsi GC11P005968.
HGNCi HGNC:14786. OR56A3.
neXtProti NX_Q8NH54.
PharmGKBi PA32445.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40290.
GeneTreei ENSGT00550000074576.
HOGENOMi HOG000041363.
HOVERGENi HBG017625.
InParanoidi Q8NH54.
KOi K04257.
OMAi KVLTIFW.
OrthoDBi EOG7Q5HDX.
PhylomeDBi Q8NH54.
TreeFami TF344049.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR56A3.
GenomeRNAii 390083.
NextBioi 103379.
PROi Q8NH54.

Gene expression databases

CleanExi HS_OR56A3.
Genevestigatori Q8NH54.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: IDENTIFICATION.
  4. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO56A3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH54
Secondary accession number(s): A6NN77, Q6IFF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: October 29, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3