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Protein

Olfactory receptor 56A3

Gene

OR56A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56A3
Alternative name(s):
Olfactory receptor 56A6
Gene namesi
Name:OR56A3
Synonyms:OR56A3P, OR56A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000184478.6
HGNCiHGNC:14786 OR56A3
neXtProtiNX_Q8NH54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 103ExtracellularSequence analysisAdd BLAST24
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 200ExtracellularSequence analysisAdd BLAST36
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 241CytoplasmicSequence analysisAdd BLAST20
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 277ExtracellularSequence analysisAdd BLAST15
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 315CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32445

Polymorphism and mutation databases

BioMutaiOR56A3
DMDMi38372812

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507941 – 315Olfactory receptor 56A3Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH54
PRIDEiQ8NH54
ProteomicsDBi73662

PTM databases

iPTMnetiQ8NH54
PhosphoSitePlusiQ8NH54

Expressioni

Gene expression databases

BgeeiENSG00000184478
CleanExiHS_OR56A3
ExpressionAtlasiQ8NH54 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331572

Structurei

3D structure databases

ProteinModelPortaliQ8NH54
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II2D Eukaryota
ENOG410YAIE LUCA
GeneTreeiENSGT00550000074576
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NH54
KOiK04257
OMAiQLRYCGR
OrthoDBiEOG091G0H8A
PhylomeDBiQ8NH54
TreeFamiTF344049

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTHRNDTLS TEASDFLLNC FVRSPSWQHW LSLPLSLLFL LAVGANTTLL
60 70 80 90 100
MTIWLEASLH QPLYYLLSLL SLLDIVLCLT VIPKVLTIFW FDLRPISFPA
110 120 130 140 150
CFLQMYIMNC FLAMESCTFM VMAYDRYVAI CHPLRYPSII TDHFVVKAAM
160 170 180 190 200
FILTRNVLMT LPIPILSAQL RYCGRNVIEN CICANMSVSR LSCDDVTINH
210 220 230 240 250
LYQFAGGWTL LGSDLILIFL SYTFILRAVL RLKAEGAVAK ALSTCGSHFM
260 270 280 290 300
LILFFSTILL VFVLTHVAKK KVSPDVPVLL NVLHHVIPAA LNPIIYGVRT
310
QEIKQGMQRL LKKGC
Length:315
Mass (Da):35,611
Last modified:October 10, 2003 - v2
Checksum:i66DEE7264A41BD0F
GO

Sequence cautioni

The sequence BAC05783 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02415251M → T. Corresponds to variant dbSNP:rs1840178Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065537 Genomic DNA Translation: BAC05783.1 Sequence problems.
AC025016 Genomic DNA No translation available.
BK004305 Genomic DNA Translation: DAA04703.1
CCDSiCCDS41614.1
RefSeqiNP_001003443.2, NM_001003443.2
UniGeneiHs.553741

Genome annotation databases

EnsembliENST00000329564; ENSP00000331572; ENSG00000184478
ENST00000641160; ENSP00000493059; ENSG00000184478
ENST00000641905; ENSP00000493319; ENSG00000184478
GeneIDi390083
KEGGihsa:390083
UCSCiuc010qzt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO56A3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH54
Secondary accession number(s): A6NN77, Q6IFF7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 20, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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