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Q8NH54

- O56A3_HUMAN

UniProt

Q8NH54 - O56A3_HUMAN

Protein

Olfactory receptor 56A3

Gene

OR56A3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 56A3
    Alternative name(s):
    Olfactory receptor 56A6
    Gene namesi
    Name:OR56A3
    Synonyms:OR56A3P, OR56A6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14786. OR56A3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32445.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 315315Olfactory receptor 56A3PRO_0000150794Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi101 ↔ 193PROSITE-ProRule annotation
    Glycosylationi185 – 1851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH54.
    PRIDEiQ8NH54.

    PTM databases

    PhosphoSiteiQ8NH54.

    Expressioni

    Gene expression databases

    CleanExiHS_OR56A3.
    GenevestigatoriQ8NH54.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000331572.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH54.
    SMRiQ8NH54. Positions 29-165.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 588CytoplasmicSequence Analysis
    Topological domaini80 – 10324ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14319CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini165 – 20036ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini222 – 24120CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 27715ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini299 – 31517CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei104 – 12421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei201 – 22121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei242 – 26221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei278 – 29821Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40290.
    HOGENOMiHOG000041363.
    HOVERGENiHBG017625.
    InParanoidiQ8NH54.
    KOiK04257.
    OMAiKVLTIFW.
    OrthoDBiEOG7Q5HDX.
    PhylomeDBiQ8NH54.
    TreeFamiTF344049.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTHRNDTLS TEASDFLLNC FVRSPSWQHW LSLPLSLLFL LAVGANTTLL    50
    MTIWLEASLH QPLYYLLSLL SLLDIVLCLT VIPKVLTIFW FDLRPISFPA 100
    CFLQMYIMNC FLAMESCTFM VMAYDRYVAI CHPLRYPSII TDHFVVKAAM 150
    FILTRNVLMT LPIPILSAQL RYCGRNVIEN CICANMSVSR LSCDDVTINH 200
    LYQFAGGWTL LGSDLILIFL SYTFILRAVL RLKAEGAVAK ALSTCGSHFM 250
    LILFFSTILL VFVLTHVAKK KVSPDVPVLL NVLHHVIPAA LNPIIYGVRT 300
    QEIKQGMQRL LKKGC 315
    Length:315
    Mass (Da):35,611
    Last modified:October 10, 2003 - v2
    Checksum:i66DEE7264A41BD0F
    GO

    Sequence cautioni

    The sequence BAC05783.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti51 – 511M → T.
    Corresponds to variant rs1840178 [ dbSNP | Ensembl ].
    VAR_024152

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065537 Genomic DNA. Translation: BAC05783.1. Sequence problems.
    AC025016 Genomic DNA. No translation available.
    BK004305 Genomic DNA. Translation: DAA04703.1.
    CCDSiCCDS41614.1.
    RefSeqiNP_001003443.2. NM_001003443.2.
    UniGeneiHs.553741.

    Genome annotation databases

    EnsembliENST00000329564; ENSP00000331572; ENSG00000184478.
    GeneIDi390083.
    KEGGihsa:390083.
    UCSCiuc010qzt.2. human.

    Polymorphism databases

    DMDMi38372812.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065537 Genomic DNA. Translation: BAC05783.1 . Sequence problems.
    AC025016 Genomic DNA. No translation available.
    BK004305 Genomic DNA. Translation: DAA04703.1 .
    CCDSi CCDS41614.1.
    RefSeqi NP_001003443.2. NM_001003443.2.
    UniGenei Hs.553741.

    3D structure databases

    ProteinModelPortali Q8NH54.
    SMRi Q8NH54. Positions 29-165.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000331572.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NH54.

    Polymorphism databases

    DMDMi 38372812.

    Proteomic databases

    PaxDbi Q8NH54.
    PRIDEi Q8NH54.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000329564 ; ENSP00000331572 ; ENSG00000184478 .
    GeneIDi 390083.
    KEGGi hsa:390083.
    UCSCi uc010qzt.2. human.

    Organism-specific databases

    CTDi 390083.
    GeneCardsi GC11P005968.
    HGNCi HGNC:14786. OR56A3.
    neXtProti NX_Q8NH54.
    PharmGKBi PA32445.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40290.
    HOGENOMi HOG000041363.
    HOVERGENi HBG017625.
    InParanoidi Q8NH54.
    KOi K04257.
    OMAi KVLTIFW.
    OrthoDBi EOG7Q5HDX.
    PhylomeDBi Q8NH54.
    TreeFami TF344049.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR56A3.
    NextBioi 103379.
    PROi Q8NH54.

    Gene expression databases

    CleanExi HS_OR56A3.
    Genevestigatori Q8NH54.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: IDENTIFICATION.
    4. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO56A3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH54
    Secondary accession number(s): A6NN77, Q6IFF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 106 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3