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Protein

Olfactory receptor 56A3

Gene

OR56A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-33694-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 56A3
Alternative name(s):
Olfactory receptor 56A6
Gene namesi
Name:OR56A3
Synonyms:OR56A3P, OR56A6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14786. OR56A3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 58CytoplasmicSequence analysis8
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 103ExtracellularSequence analysisAdd BLAST24
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 143CytoplasmicSequence analysisAdd BLAST19
Transmembranei144 – 164Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini165 – 200ExtracellularSequence analysisAdd BLAST36
Transmembranei201 – 221Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini222 – 241CytoplasmicSequence analysisAdd BLAST20
Transmembranei242 – 262Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini263 – 277ExtracellularSequence analysisAdd BLAST15
Transmembranei278 – 298Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini299 – 315CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000184478.
PharmGKBiPA32445.

Polymorphism and mutation databases

BioMutaiOR56A3.
DMDMi38372812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507941 – 315Olfactory receptor 56A3Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi101 ↔ 193PROSITE-ProRule annotation
Glycosylationi185N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH54.
PRIDEiQ8NH54.

PTM databases

iPTMnetiQ8NH54.
PhosphoSitePlusiQ8NH54.

Expressioni

Gene expression databases

CleanExiHS_OR56A3.
ExpressionAtlasiQ8NH54. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000331572.

Structurei

3D structure databases

ProteinModelPortaliQ8NH54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II2D. Eukaryota.
ENOG410YAIE. LUCA.
GeneTreeiENSGT00550000074576.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH54.
KOiK04257.
OMAiKVLTIFW.
OrthoDBiEOG091G0H8A.
PhylomeDBiQ8NH54.
TreeFamiTF344049.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTHRNDTLS TEASDFLLNC FVRSPSWQHW LSLPLSLLFL LAVGANTTLL
60 70 80 90 100
MTIWLEASLH QPLYYLLSLL SLLDIVLCLT VIPKVLTIFW FDLRPISFPA
110 120 130 140 150
CFLQMYIMNC FLAMESCTFM VMAYDRYVAI CHPLRYPSII TDHFVVKAAM
160 170 180 190 200
FILTRNVLMT LPIPILSAQL RYCGRNVIEN CICANMSVSR LSCDDVTINH
210 220 230 240 250
LYQFAGGWTL LGSDLILIFL SYTFILRAVL RLKAEGAVAK ALSTCGSHFM
260 270 280 290 300
LILFFSTILL VFVLTHVAKK KVSPDVPVLL NVLHHVIPAA LNPIIYGVRT
310
QEIKQGMQRL LKKGC
Length:315
Mass (Da):35,611
Last modified:October 10, 2003 - v2
Checksum:i66DEE7264A41BD0F
GO

Sequence cautioni

The sequence BAC05783 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02415251M → T.Corresponds to variant rs1840178dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065537 Genomic DNA. Translation: BAC05783.1. Sequence problems.
AC025016 Genomic DNA. No translation available.
BK004305 Genomic DNA. Translation: DAA04703.1.
CCDSiCCDS41614.1.
RefSeqiNP_001003443.2. NM_001003443.2.
UniGeneiHs.553741.

Genome annotation databases

EnsembliENST00000329564; ENSP00000331572; ENSG00000184478.
GeneIDi390083.
KEGGihsa:390083.
UCSCiuc010qzt.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065537 Genomic DNA. Translation: BAC05783.1. Sequence problems.
AC025016 Genomic DNA. No translation available.
BK004305 Genomic DNA. Translation: DAA04703.1.
CCDSiCCDS41614.1.
RefSeqiNP_001003443.2. NM_001003443.2.
UniGeneiHs.553741.

3D structure databases

ProteinModelPortaliQ8NH54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000331572.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH54.
PhosphoSitePlusiQ8NH54.

Polymorphism and mutation databases

BioMutaiOR56A3.
DMDMi38372812.

Proteomic databases

PaxDbiQ8NH54.
PRIDEiQ8NH54.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329564; ENSP00000331572; ENSG00000184478.
GeneIDi390083.
KEGGihsa:390083.
UCSCiuc010qzt.3. human.

Organism-specific databases

CTDi390083.
GeneCardsiOR56A3.
HGNCiHGNC:14786. OR56A3.
neXtProtiNX_Q8NH54.
OpenTargetsiENSG00000184478.
PharmGKBiPA32445.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II2D. Eukaryota.
ENOG410YAIE. LUCA.
GeneTreeiENSGT00550000074576.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH54.
KOiK04257.
OMAiKVLTIFW.
OrthoDBiEOG091G0H8A.
PhylomeDBiQ8NH54.
TreeFamiTF344049.

Enzyme and pathway databases

BioCyciZFISH:G66-33694-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR56A3.
GenomeRNAii390083.
PROiQ8NH54.

Gene expression databases

CleanExiHS_OR56A3.
ExpressionAtlasiQ8NH54. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO56A3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH54
Secondary accession number(s): A6NN77, Q6IFF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: November 30, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.