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Q8NH54 (O56A3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 56A3
Alternative name(s):
Olfactory receptor 56A6
Gene names
Name:OR56A3
Synonyms:OR56A3P, OR56A6
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length315 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05783.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 315315Olfactory receptor 56A3
PRO_0000150794

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 588Cytoplasmic Potential
Transmembrane59 – 7921Helical; Name=2; Potential
Topological domain80 – 10324Extracellular Potential
Transmembrane104 – 12421Helical; Name=3; Potential
Topological domain125 – 14319Cytoplasmic Potential
Transmembrane144 – 16421Helical; Name=4; Potential
Topological domain165 – 20036Extracellular Potential
Transmembrane201 – 22121Helical; Name=5; Potential
Topological domain222 – 24120Cytoplasmic Potential
Transmembrane242 – 26221Helical; Name=6; Potential
Topological domain263 – 27715Extracellular Potential
Transmembrane278 – 29821Helical; Name=7; Potential
Topological domain299 – 31517Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Disulfide bond101 ↔ 193 By similarity

Natural variations

Natural variant511M → T.
Corresponds to variant rs1840178 [ dbSNP | Ensembl ].
VAR_024152

Sequences

Sequence LengthMass (Da)Tools
Q8NH54 [UniParc].

Last modified October 10, 2003. Version 2.
Checksum: 66DEE7264A41BD0F

FASTA31535,611
        10         20         30         40         50         60 
MTTHRNDTLS TEASDFLLNC FVRSPSWQHW LSLPLSLLFL LAVGANTTLL MTIWLEASLH 

        70         80         90        100        110        120 
QPLYYLLSLL SLLDIVLCLT VIPKVLTIFW FDLRPISFPA CFLQMYIMNC FLAMESCTFM 

       130        140        150        160        170        180 
VMAYDRYVAI CHPLRYPSII TDHFVVKAAM FILTRNVLMT LPIPILSAQL RYCGRNVIEN 

       190        200        210        220        230        240 
CICANMSVSR LSCDDVTINH LYQFAGGWTL LGSDLILIFL SYTFILRAVL RLKAEGAVAK 

       250        260        270        280        290        300 
ALSTCGSHFM LILFFSTILL VFVLTHVAKK KVSPDVPVLL NVLHHVIPAA LNPIIYGVRT 

       310 
QEIKQGMQRL LKKGC 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[4]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065537 Genomic DNA. Translation: BAC05783.1. Sequence problems.
AC025016 Genomic DNA. No translation available.
BK004305 Genomic DNA. Translation: DAA04703.1.
RefSeqNP_001003443.2. NM_001003443.2.
UniGeneHs.553741.

3D structure databases

ProteinModelPortalQ8NH54.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000331572.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NH54.

Polymorphism databases

DMDM38372812.

Proteomic databases

PaxDbQ8NH54.
PRIDEQ8NH54.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000329564; ENSP00000331572; ENSG00000184478.
GeneID390083.
KEGGhsa:390083.
UCSCuc010qzt.2. human.

Organism-specific databases

CTD390083.
GeneCardsGC11P005968.
HGNCHGNC:14786. OR56A3.
neXtProtNX_Q8NH54.
PharmGKBPA32445.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40290.
HOGENOMHOG000041363.
HOVERGENHBG017625.
InParanoidQ8NH54.
KOK04257.
OMAKVLTIFW.
OrthoDBEOG7Q5HDX.
PhylomeDBQ8NH54.
TreeFamTF344049.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR56A3.
GenevestigatorQ8NH54.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR56A3.
NextBio103379.
PROQ8NH54.

Entry information

Entry nameO56A3_HUMAN
AccessionPrimary (citable) accession number: Q8NH54
Secondary accession number(s): A6NN77, Q6IFF7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: April 16, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries