Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 52N1

Gene

OR52N1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52N1
Alternative name(s):
Olfactory receptor OR11-61
Gene namesi
Name:OR52N1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14853. OR52N1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence analysis
Transmembranei57 – 7721Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 10124ExtracellularSequence analysisAdd
BLAST
Transmembranei102 – 12221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini123 – 14119CytoplasmicSequence analysisAdd
BLAST
Transmembranei142 – 16221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini163 – 19836ExtracellularSequence analysisAdd
BLAST
Transmembranei199 – 21921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23920CytoplasmicSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini261 – 27616ExtracellularSequence analysisAdd
BLAST
Transmembranei277 – 29721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini298 – 32023CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32425.

Polymorphism and mutation databases

BioMutaiOR52N1.
DMDMi38372811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Olfactory receptor 52N1PRO_0000150786Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH53.
PRIDEiQ8NH53.

PTM databases

iPTMnetiQ8NH53.
PhosphoSiteiQ8NH53.

Expressioni

Gene expression databases

CleanExiHS_OR52N1.

Organism-specific databases

HPAiHPA054028.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322823.

Structurei

3D structure databases

ProteinModelPortaliQ8NH53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVDV. Eukaryota.
ENOG410YASE. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH53.
KOiK04257.
OMAiEIDFKAC.
OrthoDBiEOG7327P6.
PhylomeDBiQ8NH53.
TreeFamiTF343679.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLNGTSLT PASFILNGIP GLEDVHLWIS FPLCTMYSIA ITGNFGLMYL
60 70 80 90 100
IYCDEALHRP MYVFLALLSF TDVLMCTSTL PNTLFILWFN LKEIDFKACL
110 120 130 140 150
AQMFFVHTFT GMESGVLMLM ALDHCVAICF PLRYATILTN SVIAKAGFLT
160 170 180 190 200
FLRGVMLVIP STFLTKRLPY CKGNVIPHTY CDHMSVAKIS CGNVRVNAIY
210 220 230 240 250
GLIVALLIGG FDILCITISY TMILQAVVSL SSADARQKAF STCTAHFCAI
260 270 280 290 300
VLTYVPAFFT FFTHHFGGHT IPLHIHIIMA NLYLLMPPTM NPIVYGVKTR
310 320
QVRESVIRFF LKGKDNSHNF
Length:320
Mass (Da):35,785
Last modified:October 1, 2002 - v1
Checksum:i37718814BE6B6D2E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti79 – 791T → N.
Corresponds to variant rs12365487 [ dbSNP | Ensembl ].
VAR_053335
Natural varianti101 – 1011A → T.
Corresponds to variant rs10742787 [ dbSNP | Ensembl ].
VAR_053336
Natural varianti125 – 1251C → Y.
Corresponds to variant rs10769224 [ dbSNP | Ensembl ].
VAR_053337
Natural varianti167 – 1671R → C.
Corresponds to variant rs7948009 [ dbSNP | Ensembl ].
VAR_024149
Natural varianti247 – 2471F → I.
Corresponds to variant rs7934670 [ dbSNP | Ensembl ].
VAR_034351

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065538 Genomic DNA. Translation: BAC05784.1.
BK004306 Genomic DNA. Translation: DAA04704.1.
CCDSiCCDS31398.1.
RefSeqiNP_001001913.1. NM_001001913.1.
UniGeneiHs.690209.

Genome annotation databases

EnsembliENST00000317078; ENSP00000322823; ENSG00000181001.
GeneIDi79473.
KEGGihsa:79473.
UCSCiuc010qzo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065538 Genomic DNA. Translation: BAC05784.1.
BK004306 Genomic DNA. Translation: DAA04704.1.
CCDSiCCDS31398.1.
RefSeqiNP_001001913.1. NM_001001913.1.
UniGeneiHs.690209.

3D structure databases

ProteinModelPortaliQ8NH53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322823.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH53.
PhosphoSiteiQ8NH53.

Polymorphism and mutation databases

BioMutaiOR52N1.
DMDMi38372811.

Proteomic databases

PaxDbiQ8NH53.
PRIDEiQ8NH53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317078; ENSP00000322823; ENSG00000181001.
GeneIDi79473.
KEGGihsa:79473.
UCSCiuc010qzo.2. human.

Organism-specific databases

CTDi79473.
GeneCardsiOR52N1.
HGNCiHGNC:14853. OR52N1.
HPAiHPA054028.
neXtProtiNX_Q8NH53.
PharmGKBiPA32425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVDV. Eukaryota.
ENOG410YASE. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH53.
KOiK04257.
OMAiEIDFKAC.
OrthoDBiEOG7327P6.
PhylomeDBiQ8NH53.
TreeFamiTF343679.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52N1.
GenomeRNAii79473.
PROiQ8NH53.

Gene expression databases

CleanExiHS_OR52N1.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO52N1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH53
Secondary accession number(s): Q6IFF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.