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Protein

Olfactory receptor 52N1

Gene

OR52N1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52N1
Alternative name(s):
Olfactory receptor OR11-61
Gene namesi
Name:OR52N1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000181001.1
HGNCiHGNC:14853 OR52N1
neXtProtiNX_Q8NH53

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 276ExtracellularSequence analysisAdd BLAST16
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 320CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181001
PharmGKBiPA32425

Polymorphism and mutation databases

BioMutaiOR52N1
DMDMi38372811

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507861 – 320Olfactory receptor 52N1Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH53
PRIDEiQ8NH53
ProteomicsDBi73661

PTM databases

iPTMnetiQ8NH53
PhosphoSitePlusiQ8NH53

Expressioni

Gene expression databases

BgeeiENSG00000181001
CleanExiHS_OR52N1

Organism-specific databases

HPAiHPA054028

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322823

Structurei

3D structure databases

ProteinModelPortaliQ8NH53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVDV Eukaryota
ENOG410YASE LUCA
GeneTreeiENSGT00900000140922
HOGENOMiHOG000041363
HOVERGENiHBG017625
InParanoidiQ8NH53
KOiK04257
OMAiEIDFKAC
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH53
TreeFamiTF343679

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLNGTSLT PASFILNGIP GLEDVHLWIS FPLCTMYSIA ITGNFGLMYL
60 70 80 90 100
IYCDEALHRP MYVFLALLSF TDVLMCTSTL PNTLFILWFN LKEIDFKACL
110 120 130 140 150
AQMFFVHTFT GMESGVLMLM ALDHCVAICF PLRYATILTN SVIAKAGFLT
160 170 180 190 200
FLRGVMLVIP STFLTKRLPY CKGNVIPHTY CDHMSVAKIS CGNVRVNAIY
210 220 230 240 250
GLIVALLIGG FDILCITISY TMILQAVVSL SSADARQKAF STCTAHFCAI
260 270 280 290 300
VLTYVPAFFT FFTHHFGGHT IPLHIHIIMA NLYLLMPPTM NPIVYGVKTR
310 320
QVRESVIRFF LKGKDNSHNF
Length:320
Mass (Da):35,785
Last modified:October 1, 2002 - v1
Checksum:i37718814BE6B6D2E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05333579T → N. Corresponds to variant dbSNP:rs12365487Ensembl.1
Natural variantiVAR_053336101A → T. Corresponds to variant dbSNP:rs10742787Ensembl.1
Natural variantiVAR_053337125C → Y. Corresponds to variant dbSNP:rs10769224Ensembl.1
Natural variantiVAR_024149167R → C. Corresponds to variant dbSNP:rs7948009Ensembl.1
Natural variantiVAR_034351247F → I. Corresponds to variant dbSNP:rs7934670Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065538 Genomic DNA Translation: BAC05784.1
BK004306 Genomic DNA Translation: DAA04704.1
CCDSiCCDS31398.1
RefSeqiNP_001001913.1, NM_001001913.1
UniGeneiHs.690209

Genome annotation databases

EnsembliENST00000317078; ENSP00000322823; ENSG00000181001
ENST00000641645; ENSP00000493272; ENSG00000181001
GeneIDi79473
KEGGihsa:79473
UCSCiuc010qzo.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiO52N1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH53
Secondary accession number(s): Q6IFF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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