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Protein

Olfactory receptor 52N1

Gene

OR52N1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181001-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 52N1
Alternative name(s):
Olfactory receptor OR11-61
Gene namesi
Name:OR52N1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14853. OR52N1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularSequence analysisAdd BLAST27
Transmembranei28 – 48Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 77Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini78 – 101ExtracellularSequence analysisAdd BLAST24
Transmembranei102 – 122Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini123 – 141CytoplasmicSequence analysisAdd BLAST19
Transmembranei142 – 162Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini163 – 198ExtracellularSequence analysisAdd BLAST36
Transmembranei199 – 219Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini220 – 239CytoplasmicSequence analysisAdd BLAST20
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 276ExtracellularSequence analysisAdd BLAST16
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 320CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000181001.
PharmGKBiPA32425.

Polymorphism and mutation databases

BioMutaiOR52N1.
DMDMi38372811.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001507861 – 320Olfactory receptor 52N1Add BLAST320

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi99 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH53.
PRIDEiQ8NH53.

PTM databases

iPTMnetiQ8NH53.
PhosphoSitePlusiQ8NH53.

Expressioni

Gene expression databases

CleanExiHS_OR52N1.

Organism-specific databases

HPAiHPA054028.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000322823.

Structurei

3D structure databases

ProteinModelPortaliQ8NH53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVDV. Eukaryota.
ENOG410YASE. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH53.
KOiK04257.
OMAiEIDFKAC.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH53.
TreeFamiTF343679.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLNGTSLT PASFILNGIP GLEDVHLWIS FPLCTMYSIA ITGNFGLMYL
60 70 80 90 100
IYCDEALHRP MYVFLALLSF TDVLMCTSTL PNTLFILWFN LKEIDFKACL
110 120 130 140 150
AQMFFVHTFT GMESGVLMLM ALDHCVAICF PLRYATILTN SVIAKAGFLT
160 170 180 190 200
FLRGVMLVIP STFLTKRLPY CKGNVIPHTY CDHMSVAKIS CGNVRVNAIY
210 220 230 240 250
GLIVALLIGG FDILCITISY TMILQAVVSL SSADARQKAF STCTAHFCAI
260 270 280 290 300
VLTYVPAFFT FFTHHFGGHT IPLHIHIIMA NLYLLMPPTM NPIVYGVKTR
310 320
QVRESVIRFF LKGKDNSHNF
Length:320
Mass (Da):35,785
Last modified:October 1, 2002 - v1
Checksum:i37718814BE6B6D2E
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05333579T → N.Corresponds to variant rs12365487dbSNPEnsembl.1
Natural variantiVAR_053336101A → T.Corresponds to variant rs10742787dbSNPEnsembl.1
Natural variantiVAR_053337125C → Y.Corresponds to variant rs10769224dbSNPEnsembl.1
Natural variantiVAR_024149167R → C.Corresponds to variant rs7948009dbSNPEnsembl.1
Natural variantiVAR_034351247F → I.Corresponds to variant rs7934670dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065538 Genomic DNA. Translation: BAC05784.1.
BK004306 Genomic DNA. Translation: DAA04704.1.
CCDSiCCDS31398.1.
RefSeqiNP_001001913.1. NM_001001913.1.
UniGeneiHs.690209.

Genome annotation databases

EnsembliENST00000317078; ENSP00000322823; ENSG00000181001.
GeneIDi79473.
KEGGihsa:79473.
UCSCiuc010qzo.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065538 Genomic DNA. Translation: BAC05784.1.
BK004306 Genomic DNA. Translation: DAA04704.1.
CCDSiCCDS31398.1.
RefSeqiNP_001001913.1. NM_001001913.1.
UniGeneiHs.690209.

3D structure databases

ProteinModelPortaliQ8NH53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000322823.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH53.
PhosphoSitePlusiQ8NH53.

Polymorphism and mutation databases

BioMutaiOR52N1.
DMDMi38372811.

Proteomic databases

PaxDbiQ8NH53.
PRIDEiQ8NH53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317078; ENSP00000322823; ENSG00000181001.
GeneIDi79473.
KEGGihsa:79473.
UCSCiuc010qzo.2. human.

Organism-specific databases

CTDi79473.
GeneCardsiOR52N1.
HGNCiHGNC:14853. OR52N1.
HPAiHPA054028.
neXtProtiNX_Q8NH53.
OpenTargetsiENSG00000181001.
PharmGKBiPA32425.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVDV. Eukaryota.
ENOG410YASE. LUCA.
GeneTreeiENSGT00840000129702.
HOGENOMiHOG000041363.
HOVERGENiHBG017625.
InParanoidiQ8NH53.
KOiK04257.
OMAiEIDFKAC.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH53.
TreeFamiTF343679.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000181001-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR52N1.
GenomeRNAii79473.
PROiQ8NH53.

Gene expression databases

CleanExiHS_OR52N1.

Family and domain databases

InterProiIPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO52N1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH53
Secondary accession number(s): Q6IFF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.