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Protein

Olfactory receptor 4X1

Gene

OR4X1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4X1
Alternative name(s):
Olfactory receptor OR11-104
Gene namesi
Name:OR4X1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:14854. OR4X1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence analysis
Transmembranei56 – 7722Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence analysisAdd
BLAST
Transmembranei99 – 11820Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence analysisAdd
BLAST
Transmembranei138 – 15619Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence analysisAdd
BLAST
Transmembranei194 – 21724Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23316CytoplasmicSequence analysisAdd
BLAST
Transmembranei234 – 25623Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini257 – 26711ExtracellularSequence analysisAdd
BLAST
Transmembranei268 – 28720Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini288 – 30518CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32350.

Polymorphism and mutation databases

BioMutaiOR4X1.
DMDMi38372808.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Olfactory receptor 4X1PRO_0000150570Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH49.
PRIDEiQ8NH49.

Expressioni

Gene expression databases

CleanExiHS_OR4X1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321506.

Structurei

3D structure databases

ProteinModelPortaliQ8NH49.
SMRiQ8NH49. Positions 107-138.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J8UZ. Eukaryota.
ENOG41115MI. LUCA.
GeneTreeiENSGT00840000129716.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH49.
KOiK04257.
OMAiFMERKVI.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NH49.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVATNNVTEI IFVGFSQNWS EQRVISVMFL LMYTAVVLGN GLIVVTILAS
60 70 80 90 100
KVLTSPMYFF LSYLSFVEIC YCSVMAPKLI FDSFIKRKVI SLKGCLTQMF
110 120 130 140 150
SLHFFGGTEA FLLMVMAYDR YVAICKPLHY MAIMNQRMCG LLVRIAWGGG
160 170 180 190 200
LLHSVGQTFL IFQLPFCGPN IMDHYFCDVH PVLELACADT FFISLLIITN
210 220 230 240 250
GGSISVVSFF VLMASYLIIL HFLRSHNLEG QHKALSTCAS HVTVVDLFFI
260 270 280 290 300
PCSLVYIRPC VTLPADKIVA VFYTVVTPLL NPVIYSFRNA EVKNAMRRFI

GGKVI
Length:305
Mass (Da):34,222
Last modified:October 1, 2002 - v1
Checksum:i730C81DE29E63D92
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti144 – 1441R → G.
Corresponds to variant rs1503193 [ dbSNP | Ensembl ].
VAR_053178
Natural varianti165 – 1651P → L.
Corresponds to variant rs16905753 [ dbSNP | Ensembl ].
VAR_034210
Natural varianti196 – 1961L → Q.
Corresponds to variant rs12798361 [ dbSNP | Ensembl ].
VAR_053179
Natural varianti246 – 2461D → N.
Corresponds to variant rs17199104 [ dbSNP | Ensembl ].
VAR_034211
Natural varianti282 – 2821P → S.
Corresponds to variant rs10838852 [ dbSNP | Ensembl ].
VAR_034212

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065544 Genomic DNA. Translation: BAC05789.1.
BK004388 Genomic DNA. Translation: DAA04786.1.
CCDSiCCDS31487.1.
RefSeqiNP_001004726.1. NM_001004726.1.
UniGeneiHs.553742.

Genome annotation databases

EnsembliENST00000320048; ENSP00000321506; ENSG00000176567.
ENST00000624144; ENSP00000485255; ENSG00000279260.
ENST00000624797; ENSP00000485503; ENSG00000279260.
GeneIDi390113.
KEGGihsa:390113.
UCSCiuc010rht.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065544 Genomic DNA. Translation: BAC05789.1.
BK004388 Genomic DNA. Translation: DAA04786.1.
CCDSiCCDS31487.1.
RefSeqiNP_001004726.1. NM_001004726.1.
UniGeneiHs.553742.

3D structure databases

ProteinModelPortaliQ8NH49.
SMRiQ8NH49. Positions 107-138.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000321506.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR4X1.
DMDMi38372808.

Proteomic databases

PaxDbiQ8NH49.
PRIDEiQ8NH49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320048; ENSP00000321506; ENSG00000176567.
ENST00000624144; ENSP00000485255; ENSG00000279260.
ENST00000624797; ENSP00000485503; ENSG00000279260.
GeneIDi390113.
KEGGihsa:390113.
UCSCiuc010rht.2. human.

Organism-specific databases

CTDi390113.
GeneCardsiOR4X1.
HGNCiHGNC:14854. OR4X1.
neXtProtiNX_Q8NH49.
PharmGKBiPA32350.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J8UZ. Eukaryota.
ENOG41115MI. LUCA.
GeneTreeiENSGT00840000129716.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH49.
KOiK04257.
OMAiFMERKVI.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NH49.
TreeFamiTF337350.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4X1.
GenomeRNAii390113.
PROiQ8NH49.

Gene expression databases

CleanExiHS_OR4X1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4X1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH49
Secondary accession number(s): Q6IF74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.