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Protein

Olfactory receptor 5B3

Gene

OR5B3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5B3
Alternative name(s):
Olfactory receptor 5B13
Olfactory receptor OR11-239
Gene namesi
Name:OR5B3
Synonyms:OR5B13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:8324. OR5B3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence analysisAdd
BLAST
Transmembranei24 – 4421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini45 – 528CytoplasmicSequence analysis
Transmembranei53 – 7321Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini74 – 9724ExtracellularSequence analysisAdd
BLAST
Transmembranei98 – 11821Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini119 – 13113CytoplasmicSequence analysisAdd
BLAST
Transmembranei132 – 15221Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini153 – 19442ExtracellularSequence analysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini216 – 23520CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini257 – 26913ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 29021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini291 – 31424CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32491.

Polymorphism and mutation databases

BioMutaiOR5B3.
DMDMi38372807.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 314314Olfactory receptor 5B3PRO_0000150586Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation
Glycosylationi153 – 1531N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH48.
PRIDEiQ8NH48.

PTM databases

PhosphoSiteiQ8NH48.

Expressioni

Gene expression databases

CleanExiHS_OR5B3.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000308270.

Structurei

3D structure databases

ProteinModelPortaliQ8NH48.
SMRiQ8NH48. Positions 32-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVUX. Eukaryota.
ENOG41117FD. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH48.
KOiK04257.
OMAiQMYIFVA.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH48.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENKTEVTQF ILLGLTNDSE LQVPLFITFP FIYIITLVGN LGIIVLIFWD
60 70 80 90 100
SCLHNPMYFF LSNLSLVDFC YSSAVTPIVM AGFLIEDKVI SYNACAAQMY
110 120 130 140 150
IFVAFATVEN YLLASMAYDR YAAVCKPLHY TTTMTTTVCA RLAIGSYLCG
160 170 180 190 200
FLNASIHTGD TFSLSFCKSN EVHHFFCDIP AVMVLSCSDR HISELVLIYV
210 220 230 240 250
VSFNIFIALL VILISYTFIF ITILKMHSAS VYQKPLSTCA SHFIAVGIFY
260 270 280 290 300
GTIIFMYLQP SSSHSMDTDK MAPVFYTMVI PMLNPLVYSL RNKEVKSAFK
310
KVVEKAKLSV GWSV
Length:314
Mass (Da):35,258
Last modified:October 1, 2002 - v1
Checksum:i4E856ECC1F1154CF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301P → L.
Corresponds to variant rs17152661 [ dbSNP | Ensembl ].
VAR_053183
Natural varianti35 – 351I → F.
Corresponds to variant rs17152659 [ dbSNP | Ensembl ].
VAR_053184
Natural varianti49 – 491W → R.
Corresponds to variant rs11229413 [ dbSNP | Ensembl ].
VAR_053185
Natural varianti170 – 1701N → S.
Corresponds to variant rs12280114 [ dbSNP | Ensembl ].
VAR_053186
Natural varianti181 – 1811A → T.
Corresponds to variant rs11229411 [ dbSNP | Ensembl ].
VAR_053187
Natural varianti198 – 1981I → V.
Corresponds to variant rs11229410 [ dbSNP | Ensembl ].
VAR_053188
Natural varianti247 – 2471G → A.
Corresponds to variant rs11229409 [ dbSNP | Ensembl ].
VAR_053189
Natural varianti296 – 2961K → R.
Corresponds to variant rs12279895 [ dbSNP | Ensembl ].
VAR_053190

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065545 Genomic DNA. Translation: BAC05790.1.
BK004506 Genomic DNA. Translation: DAA04904.1.
CCDSiCCDS31549.1.
RefSeqiNP_001005469.1. NM_001005469.1.
UniGeneiHs.553826.

Genome annotation databases

EnsembliENST00000309403; ENSP00000308270; ENSG00000172769.
GeneIDi441608.
KEGGihsa:441608.
UCSCiuc010rkf.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065545 Genomic DNA. Translation: BAC05790.1.
BK004506 Genomic DNA. Translation: DAA04904.1.
CCDSiCCDS31549.1.
RefSeqiNP_001005469.1. NM_001005469.1.
UniGeneiHs.553826.

3D structure databases

ProteinModelPortaliQ8NH48.
SMRiQ8NH48. Positions 32-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000308270.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NH48.

Polymorphism and mutation databases

BioMutaiOR5B3.
DMDMi38372807.

Proteomic databases

PaxDbiQ8NH48.
PRIDEiQ8NH48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309403; ENSP00000308270; ENSG00000172769.
GeneIDi441608.
KEGGihsa:441608.
UCSCiuc010rkf.3. human.

Organism-specific databases

CTDi441608.
GeneCardsiOR5B3.
HGNCiHGNC:8324. OR5B3.
neXtProtiNX_Q8NH48.
PharmGKBiPA32491.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVUX. Eukaryota.
ENOG41117FD. LUCA.
GeneTreeiENSGT00760000118941.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH48.
KOiK04257.
OMAiQMYIFVA.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH48.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR5B3.
GenomeRNAii441608.
NextBioi110332.
PROiQ8NH48.

Gene expression databases

CleanExiHS_OR5B3.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5B3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH48
Secondary accession number(s): Q6IEV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: March 16, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.