Q8NH48 (OR5B3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 5B3

Alternative name(s):
Olfactory receptor 5B13
Olfactory receptor OR11-239

Gene names

Name:	OR5B3
Synonyms:	OR5B13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	314 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 314	314	Olfactory receptor 5B3		PRO_0000150586
Regions
	Topological domain	1 – 23	23	Extracellular Potential
	Transmembrane	24 – 44	21	Helical; Name=1; Potential
	Topological domain	45 – 52	8	Cytoplasmic Potential
	Transmembrane	53 – 73	21	Helical; Name=2; Potential
	Topological domain	74 – 97	24	Extracellular Potential
	Transmembrane	98 – 118	21	Helical; Name=3; Potential
	Topological domain	119 – 131	13	Cytoplasmic Potential
	Transmembrane	132 – 152	21	Helical; Name=4; Potential
	Topological domain	153 – 194	42	Extracellular Potential
	Transmembrane	195 – 215	21	Helical; Name=5; Potential
	Topological domain	216 – 235	20	Cytoplasmic Potential
	Transmembrane	236 – 256	21	Helical; Name=6; Potential
	Topological domain	257 – 269	13	Extracellular Potential
	Transmembrane	270 – 290	21	Helical; Name=7; Potential
	Topological domain	291 – 314	24	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Glycosylation	17	1	N-linked (GlcNAc...) Potential
	Glycosylation	153	1	N-linked (GlcNAc...) Potential
	Disulfide bond	95 ↔ 187		By similarity
Natural variations
	Natural variant	30	1	P → L. Corresponds to variant rs17152661 [ dbSNP | Ensembl ].		VAR_053183
	Natural variant	35	1	I → F. Corresponds to variant rs17152659 [ dbSNP | Ensembl ].		VAR_053184
	Natural variant	49	1	W → R. Corresponds to variant rs11229413 [ dbSNP | Ensembl ].		VAR_053185
	Natural variant	170	1	N → S. Corresponds to variant rs12280114 [ dbSNP | Ensembl ].		VAR_053186
	Natural variant	181	1	A → T. Corresponds to variant rs11229411 [ dbSNP | Ensembl ].		VAR_053187
	Natural variant	198	1	I → V. Corresponds to variant rs11229410 [ dbSNP | Ensembl ].		VAR_053188
	Natural variant	247	1	G → A. Corresponds to variant rs11229409 [ dbSNP | Ensembl ].		VAR_053189
	Natural variant	296	1	K → R. Corresponds to variant rs12279895 [ dbSNP | Ensembl ].		VAR_053190

Sequences

	Sequence		Length	Mass (Da)
	Q8NH48 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 4E856ECC1F1154CF	FASTA	314	35,258
	10 20 30 40 50 60 MENKTEVTQF ILLGLTNDSE LQVPLFITFP FIYIITLVGN LGIIVLIFWD SCLHNPMYFF 70 80 90 100 110 120 LSNLSLVDFC YSSAVTPIVM AGFLIEDKVI SYNACAAQMY IFVAFATVEN YLLASMAYDR 130 140 150 160 170 180 YAAVCKPLHY TTTMTTTVCA RLAIGSYLCG FLNASIHTGD TFSLSFCKSN EVHHFFCDIP 190 200 210 220 230 240 AVMVLSCSDR HISELVLIYV VSFNIFIALL VILISYTFIF ITILKMHSAS VYQKPLSTCA 250 260 270 280 290 300 SHFIAVGIFY GTIIFMYLQP SSSHSMDTDK MAPVFYTMVI PMLNPLVYSL RNKEVKSAFK 310 KVVEKAKLSV GWSV

References

[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[3]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065545 Genomic DNA. Translation: BAC05790.1. BK004506 Genomic DNA. Translation: DAA04904.1.
IPI	IPI00169148.
RefSeq	NP_001005469.1. NM_001005469.1.
UniGene	Hs.553826.
3D structure databases
ProteinModelPortal	Q8NH48.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000308270.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NH48.
Polymorphism databases
DMDM	38372807.
Proteomic databases
PaxDb	Q8NH48.
PRIDE	Q8NH48.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309403; ENSP00000308270; ENSG00000172769.
GeneID	441608.
KEGG	hsa:441608.
UCSC	uc010rkf.2. human.
Organism-specific databases
CTD	441608.
GeneCards	GC11M058169.
HGNC	HGNC:8324. OR5B3.
neXtProt	NX_Q8NH48.
PharmGKB	PA32491.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG45899.
HOGENOM	HOG000041364.
HOVERGEN	HBG017625.
InParanoid	Q8NH48.
KO	K04257.
OMA	FIYIITL.
OrthoDB	EOG4WDDC9.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR5B3.
Genevestigator	Q8NH48.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	441608.
NextBio	110332.

Entry information

Entry name

OR5B3_HUMAN

Accession

Primary (citable) accession number: Q8NH48
Secondary accession number(s): Q6IEV6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 93 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.