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Protein

Olfactory receptor 4L1

Gene

OR4L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176246-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4L1
Alternative name(s):
Olfactory receptor 4L2
Olfactory receptor OR14-28
Gene namesi
Name:OR4L1
Synonyms:OR4L2P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15356. OR4L1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 49Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini50 – 57CytoplasmicSequence analysis8
Transmembranei58 – 79Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini80 – 100ExtracellularSequence analysisAdd BLAST21
Transmembranei101 – 120Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 158Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini159 – 195ExtracellularSequence analysisAdd BLAST37
Transmembranei196 – 219Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini220 – 235CytoplasmicSequence analysisAdd BLAST16
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 269ExtracellularSequence analysisAdd BLAST11
Transmembranei270 – 289Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini290 – 312CytoplasmicSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000176246.
PharmGKBiPA32325.

Polymorphism and mutation databases

BioMutaiOR4L1.
DMDMi38372806.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505601 – 312Olfactory receptor 4L1Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation
Glycosylationi268N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH43.
PeptideAtlasiQ8NH43.
PRIDEiQ8NH43.
TopDownProteomicsiQ8NH43.

PTM databases

iPTMnetiQ8NH43.
PhosphoSitePlusiQ8NH43.

Expressioni

Gene expression databases

CleanExiHS_OR4L1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319217.

Structurei

3D structure databases

ProteinModelPortaliQ8NH43.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFT7. Eukaryota.
ENOG4111DAI. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH43.
KOiK04257.
OMAiMQGAMRK.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NH43.
TreeFamiTF336512.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLKNGSLVT EFILLGFFGR WELQIFFFVT FSLIYGATVM GNILIMVTVT
60 70 80 90 100
CRSTLHSPLY FLLGNLSFLD MCLSTATTPK MIIDLLTDHK TISVWGCVTQ
110 120 130 140 150
MFFMHFFGGA EMTLLIIMAF DRYVAICKPL HYRTIMSHKL LKGFAILSWI
160 170 180 190 200
IGFLHSISQI VLTMNLPFCG HNVINNIFCD LPLVIKLACI ETYTLELFVI
210 220 230 240 250
ADSGLLSFTC FILLLVSYIV ILVSVPKKSS HGLSKALSTL SAHIIVVTLF
260 270 280 290 300
FGPCIFIYVW PFSSLASNKT LAVFYTVITP LLNPSIYTLR NKKMQEAIRK
310
LRFQYVSSAQ NF
Length:312
Mass (Da):35,264
Last modified:October 1, 2002 - v1
Checksum:iC7BFE135301F56F1
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0342012D → N.Corresponds to variant rs1958715dbSNPEnsembl.1
Natural variantiVAR_06203616G → V.Corresponds to variant rs45584133dbSNPEnsembl.1
Natural variantiVAR_03420240M → V.Corresponds to variant rs1958716dbSNPEnsembl.1
Natural variantiVAR_02409452R → S.Corresponds to variant rs1959630dbSNPEnsembl.1
Natural variantiVAR_03420393S → F.Corresponds to variant rs10139756dbSNPEnsembl.1
Natural variantiVAR_034204101M → K.Corresponds to variant rs2775253dbSNPEnsembl.1
Natural variantiVAR_034205109G → S.Corresponds to variant rs2775254dbSNPEnsembl.1
Natural variantiVAR_062037160I → T.Corresponds to variant rs45585336dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065558 Genomic DNA. Translation: BAC05796.1.
BK004467 Genomic DNA. Translation: DAA04865.1.
CCDSiCCDS32029.1.
RefSeqiNP_001004717.1. NM_001004717.1.
UniGeneiHs.553574.

Genome annotation databases

EnsembliENST00000315683; ENSP00000319217; ENSG00000176246.
GeneIDi122742.
KEGGihsa:122742.
UCSCiuc001vwn.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065558 Genomic DNA. Translation: BAC05796.1.
BK004467 Genomic DNA. Translation: DAA04865.1.
CCDSiCCDS32029.1.
RefSeqiNP_001004717.1. NM_001004717.1.
UniGeneiHs.553574.

3D structure databases

ProteinModelPortaliQ8NH43.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319217.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH43.
PhosphoSitePlusiQ8NH43.

Polymorphism and mutation databases

BioMutaiOR4L1.
DMDMi38372806.

Proteomic databases

PaxDbiQ8NH43.
PeptideAtlasiQ8NH43.
PRIDEiQ8NH43.
TopDownProteomicsiQ8NH43.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315683; ENSP00000319217; ENSG00000176246.
GeneIDi122742.
KEGGihsa:122742.
UCSCiuc001vwn.1. human.

Organism-specific databases

CTDi122742.
GeneCardsiOR4L1.
HGNCiHGNC:15356. OR4L1.
neXtProtiNX_Q8NH43.
OpenTargetsiENSG00000176246.
PharmGKBiPA32325.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFT7. Eukaryota.
ENOG4111DAI. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH43.
KOiK04257.
OMAiMQGAMRK.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NH43.
TreeFamiTF336512.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000176246-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4L1.
GenomeRNAii122742.
PROiQ8NH43.

Gene expression databases

CleanExiHS_OR4L1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4L1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH43
Secondary accession number(s): Q6IEZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.