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Protein

Olfactory receptor 4K13

Gene

OR4K13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K13
Alternative name(s):
Olfactory receptor OR14-27
Gene namesi
Name:OR4K13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15351. OR4K13.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4924Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini50 – 578CytoplasmicSequence analysis
Transmembranei58 – 7922Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini80 – 10021ExtracellularSequence analysisAdd
BLAST
Transmembranei101 – 12020Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 15819Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 19537ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21924Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini220 – 23516CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 26911ExtracellularSequence analysisAdd
BLAST
Transmembranei270 – 28920Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini290 – 30415CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32312.

Polymorphism and mutation databases

BioMutaiOR4K13.
DMDMi38372805.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Olfactory receptor 4K13PRO_0000150556Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH42.
PRIDEiQ8NH42.

PTM databases

iPTMnetiQ8NH42.

Expressioni

Gene expression databases

CleanExiHS_OR4K13.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000319322.

Structurei

3D structure databases

ProteinModelPortaliQ8NH42.
SMRiQ8NH42. Positions 34-303.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J93M. Eukaryota.
ENOG4111DRE. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH42.
KOiK04257.
OMAiVIIFSVR.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH42.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERANHSVVS EFILLGLSKS QNLQILFFLG FSVVFVGIVL GNLLILVTVT
60 70 80 90 100
FDSLLHTPMY FLLSNLSCID MILASFATPK MIVDFLRERK TISWWGCYSQ
110 120 130 140 150
MFFMHLLGGS EMMLLVAMAI DRYVAICKPL HYMTIMSPRV LTGLLLSSYA
160 170 180 190 200
VGFVHSSSQM AFMLTLPFCG PNVIDSFFCD LPLVIKLACK DTYILQLLVI
210 220 230 240 250
ADSGLLSLVC FLLLLVSYGV IIFSVRYRAA SRSSKAFSTL SAHITVVTLF
260 270 280 290 300
FAPCVFIYVW PFSRYSVDKI LSVFYTIFTP LLNPIIYTLR NQEVKAAIKK

RLCI
Length:304
Mass (Da):34,261
Last modified:October 1, 2002 - v1
Checksum:iCF943D6F010C80C9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti292 – 2921Q → K.
Corresponds to variant rs17277025 [ dbSNP | Ensembl ].
VAR_053172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065559 Genomic DNA. Translation: BAC05797.1.
BK004449 Genomic DNA. Translation: DAA04847.1.
CCDSiCCDS32028.1.
RefSeqiNP_001004714.1. NM_001004714.1.
UniGeneiHs.553573.

Genome annotation databases

EnsembliENST00000315693; ENSP00000319322; ENSG00000176253.
GeneIDi390433.
KEGGihsa:390433.
UCSCiuc010tkz.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065559 Genomic DNA. Translation: BAC05797.1.
BK004449 Genomic DNA. Translation: DAA04847.1.
CCDSiCCDS32028.1.
RefSeqiNP_001004714.1. NM_001004714.1.
UniGeneiHs.553573.

3D structure databases

ProteinModelPortaliQ8NH42.
SMRiQ8NH42. Positions 34-303.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000319322.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH42.

Polymorphism and mutation databases

BioMutaiOR4K13.
DMDMi38372805.

Proteomic databases

PaxDbiQ8NH42.
PRIDEiQ8NH42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000315693; ENSP00000319322; ENSG00000176253.
GeneIDi390433.
KEGGihsa:390433.
UCSCiuc010tkz.3. human.

Organism-specific databases

CTDi390433.
GeneCardsiOR4K13.
HGNCiHGNC:15351. OR4K13.
neXtProtiNX_Q8NH42.
PharmGKBiPA32312.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J93M. Eukaryota.
ENOG4111DRE. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH42.
KOiK04257.
OMAiVIIFSVR.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH42.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4K13.
GenomeRNAii390433.
PROiQ8NH42.

Gene expression databases

CleanExiHS_OR4K13.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4KD_HUMAN
AccessioniPrimary (citable) accession number: Q8NH42
Secondary accession number(s): Q6IF13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.