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Protein

Olfactory receptor 4K15

Gene

OR4K15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K15
Alternative name(s):
Olfactory receptor OR14-20
Gene namesi
Name:OR4K15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15353. OR4K15.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4949ExtracellularSequence analysisAdd
BLAST
Transmembranei50 – 7324Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini74 – 818CytoplasmicSequence analysis
Transmembranei82 – 10322Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini104 – 12421ExtracellularSequence analysisAdd
BLAST
Transmembranei125 – 14420Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini145 – 16319CytoplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18219Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini183 – 21937ExtracellularSequence analysisAdd
BLAST
Transmembranei220 – 24324Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini244 – 25916CytoplasmicSequence analysisAdd
BLAST
Transmembranei260 – 28223Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini283 – 29311ExtracellularSequence analysisAdd
BLAST
Transmembranei294 – 31320Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini314 – 34835CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32314.

Polymorphism and mutation databases

BioMutaiOR4K15.
DMDMi229462931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Olfactory receptor 4K15PRO_0000150558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence analysis
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Disulfide bondi121 ↔ 213PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH41.
PeptideAtlasiQ8NH41.
PRIDEiQ8NH41.

PTM databases

iPTMnetiQ8NH41.
PhosphoSiteiQ8NH41.

Expressioni

Gene expression databases

CleanExiHS_OR4K15.

Organism-specific databases

HPAiHPA055732.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304077.

Structurei

3D structure databases

ProteinModelPortaliQ8NH41.
SMRiQ8NH41. Positions 50-325.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJT. Eukaryota.
ENOG41113GX. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH41.
KOiK04257.
OMAiPKSMNET.
OrthoDBiEOG7034HF.
PhylomeDBiQ8NH41.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSLTDLCF SPIQVAEIKS LPKSMNETNH SRVTEFVLLG LSSSRELQPF
60 70 80 90 100
LFLTFSLLYL AILLGNFLII LTVTSDSRLH TPMYFLLANL SFIDVCVASF
110 120 130 140 150
ATPKMIADFL VERKTISFDA CLAQIFFVHL FTGSEMVLLV SMAYDRYVAI
160 170 180 190 200
CKPLHYMTVM SRRVCVVLVL ISWFVGFIHT TSQLAFTVNL PFCGPNKVDS
210 220 230 240 250
FFCDLPLVTK LACIDTYVVS LLIVADSGFL SLSSFLLLVV SYTVILVTVR
260 270 280 290 300
NRSSASMAKA RSTLTAHITV VTLFFGPCIF IYVWPFSSYS VDKVLAVFYT
310 320 330 340
IFTLILNPVI YTLRNKEVKA AMSKLKSRYL KPSQVSVVIR NVLFLETK
Length:348
Mass (Da):39,088
Last modified:May 5, 2009 - v2
Checksum:iDD01134EFC5D5F91
GO

Sequence cautioni

The sequence BAC05798.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti89 – 891N → S.1 Publication
Corresponds to variant rs4060024 [ dbSNP | Ensembl ].
VAR_055060
Natural varianti112 – 1121E → V.1 Publication
Corresponds to variant rs3861512 [ dbSNP | Ensembl ].
VAR_055061
Natural varianti117 – 1171S → A.1 Publication
Corresponds to variant rs3861513 [ dbSNP | Ensembl ].
VAR_055062
Natural varianti255 – 2551A → E.1 Publication
Corresponds to variant rs10135246 [ dbSNP | Ensembl ].
VAR_055063
Natural varianti304 – 3041L → P.1 Publication
Corresponds to variant rs2153466 [ dbSNP | Ensembl ].
VAR_055064
Natural varianti310 – 3101I → M.1 Publication
Corresponds to variant rs10135467 [ dbSNP | Ensembl ].
VAR_055065

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065560 Genomic DNA. Translation: BAC05798.1. Different initiation.
AL359218 Genomic DNA. No translation available.
BC140726 mRNA. Translation: AAI40727.1.
BK004468 Genomic DNA. Translation: DAA04866.1.
CCDSiCCDS32026.1.
RefSeqiNP_001005486.1. NM_001005486.1.
UniGeneiHs.554583.

Genome annotation databases

EnsembliENST00000305051; ENSP00000304077; ENSG00000169488.
GeneIDi81127.
KEGGihsa:81127.
UCSCiuc010tkx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065560 Genomic DNA. Translation: BAC05798.1. Different initiation.
AL359218 Genomic DNA. No translation available.
BC140726 mRNA. Translation: AAI40727.1.
BK004468 Genomic DNA. Translation: DAA04866.1.
CCDSiCCDS32026.1.
RefSeqiNP_001005486.1. NM_001005486.1.
UniGeneiHs.554583.

3D structure databases

ProteinModelPortaliQ8NH41.
SMRiQ8NH41. Positions 50-325.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000304077.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH41.
PhosphoSiteiQ8NH41.

Polymorphism and mutation databases

BioMutaiOR4K15.
DMDMi229462931.

Proteomic databases

PaxDbiQ8NH41.
PeptideAtlasiQ8NH41.
PRIDEiQ8NH41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305051; ENSP00000304077; ENSG00000169488.
GeneIDi81127.
KEGGihsa:81127.
UCSCiuc010tkx.3. human.

Organism-specific databases

CTDi81127.
GeneCardsiOR4K15.
HGNCiHGNC:15353. OR4K15.
HPAiHPA055732.
neXtProtiNX_Q8NH41.
PharmGKBiPA32314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHJT. Eukaryota.
ENOG41113GX. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH41.
KOiK04257.
OMAiPKSMNET.
OrthoDBiEOG7034HF.
PhylomeDBiQ8NH41.
TreeFamiTF337251.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4K15.
GenomeRNAii81127.
PROiQ8NH41.

Gene expression databases

CleanExiHS_OR4K15.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-89; VAL-112; ALA-117; GLU-255; PRO-304 AND MET-310.
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4KF_HUMAN
AccessioniPrimary (citable) accession number: Q8NH41
Secondary accession number(s): B9EIL3, Q6IEZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: July 6, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.