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Protein

Olfactory receptor 4K15

Gene

OR4K15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169488-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4K15
Alternative name(s):
Olfactory receptor OR14-20
Gene namesi
Name:OR4K15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:15353. OR4K15.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 49ExtracellularSequence analysisAdd BLAST49
Transmembranei50 – 73Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini74 – 81CytoplasmicSequence analysis8
Transmembranei82 – 103Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini104 – 124ExtracellularSequence analysisAdd BLAST21
Transmembranei125 – 144Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini145 – 163CytoplasmicSequence analysisAdd BLAST19
Transmembranei164 – 182Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini183 – 219ExtracellularSequence analysisAdd BLAST37
Transmembranei220 – 243Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini244 – 259CytoplasmicSequence analysisAdd BLAST16
Transmembranei260 – 282Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini283 – 293ExtracellularSequence analysisAdd BLAST11
Transmembranei294 – 313Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini314 – 348CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000169488.
PharmGKBiPA32314.

Polymorphism and mutation databases

BioMutaiOR4K15.
DMDMi229462931.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505581 – 348Olfactory receptor 4K15Add BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi121 ↔ 213PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH41.
PeptideAtlasiQ8NH41.
PRIDEiQ8NH41.

PTM databases

iPTMnetiQ8NH41.
PhosphoSitePlusiQ8NH41.

Expressioni

Gene expression databases

CleanExiHS_OR4K15.

Organism-specific databases

HPAiHPA055732.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304077.

Structurei

3D structure databases

ProteinModelPortaliQ8NH41.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJT. Eukaryota.
ENOG41113GX. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH41.
KOiK04257.
OMAiPKSMNET.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NH41.
TreeFamiTF337251.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH41-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTSLTDLCF SPIQVAEIKS LPKSMNETNH SRVTEFVLLG LSSSRELQPF
60 70 80 90 100
LFLTFSLLYL AILLGNFLII LTVTSDSRLH TPMYFLLANL SFIDVCVASF
110 120 130 140 150
ATPKMIADFL VERKTISFDA CLAQIFFVHL FTGSEMVLLV SMAYDRYVAI
160 170 180 190 200
CKPLHYMTVM SRRVCVVLVL ISWFVGFIHT TSQLAFTVNL PFCGPNKVDS
210 220 230 240 250
FFCDLPLVTK LACIDTYVVS LLIVADSGFL SLSSFLLLVV SYTVILVTVR
260 270 280 290 300
NRSSASMAKA RSTLTAHITV VTLFFGPCIF IYVWPFSSYS VDKVLAVFYT
310 320 330 340
IFTLILNPVI YTLRNKEVKA AMSKLKSRYL KPSQVSVVIR NVLFLETK
Length:348
Mass (Da):39,088
Last modified:May 5, 2009 - v2
Checksum:iDD01134EFC5D5F91
GO

Sequence cautioni

The sequence BAC05798 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05506089N → S.1 PublicationCorresponds to variant rs4060024dbSNPEnsembl.1
Natural variantiVAR_055061112E → V.1 PublicationCorresponds to variant rs3861512dbSNPEnsembl.1
Natural variantiVAR_055062117S → A.1 PublicationCorresponds to variant rs3861513dbSNPEnsembl.1
Natural variantiVAR_055063255A → E.1 PublicationCorresponds to variant rs10135246dbSNPEnsembl.1
Natural variantiVAR_055064304L → P.1 PublicationCorresponds to variant rs2153466dbSNPEnsembl.1
Natural variantiVAR_055065310I → M.1 PublicationCorresponds to variant rs10135467dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065560 Genomic DNA. Translation: BAC05798.1. Different initiation.
AL359218 Genomic DNA. No translation available.
BC140726 mRNA. Translation: AAI40727.1.
BK004468 Genomic DNA. Translation: DAA04866.1.
CCDSiCCDS32026.1.
RefSeqiNP_001005486.1. NM_001005486.1.
UniGeneiHs.554583.

Genome annotation databases

EnsembliENST00000305051; ENSP00000304077; ENSG00000169488.
GeneIDi81127.
KEGGihsa:81127.
UCSCiuc010tkx.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065560 Genomic DNA. Translation: BAC05798.1. Different initiation.
AL359218 Genomic DNA. No translation available.
BC140726 mRNA. Translation: AAI40727.1.
BK004468 Genomic DNA. Translation: DAA04866.1.
CCDSiCCDS32026.1.
RefSeqiNP_001005486.1. NM_001005486.1.
UniGeneiHs.554583.

3D structure databases

ProteinModelPortaliQ8NH41.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000304077.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH41.
PhosphoSitePlusiQ8NH41.

Polymorphism and mutation databases

BioMutaiOR4K15.
DMDMi229462931.

Proteomic databases

PaxDbiQ8NH41.
PeptideAtlasiQ8NH41.
PRIDEiQ8NH41.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305051; ENSP00000304077; ENSG00000169488.
GeneIDi81127.
KEGGihsa:81127.
UCSCiuc010tkx.3. human.

Organism-specific databases

CTDi81127.
GeneCardsiOR4K15.
HGNCiHGNC:15353. OR4K15.
HPAiHPA055732.
neXtProtiNX_Q8NH41.
OpenTargetsiENSG00000169488.
PharmGKBiPA32314.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHJT. Eukaryota.
ENOG41113GX. LUCA.
GeneTreeiENSGT00760000118815.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH41.
KOiK04257.
OMAiPKSMNET.
OrthoDBiEOG091G0CY9.
PhylomeDBiQ8NH41.
TreeFamiTF337251.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169488-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR4K15.
GenomeRNAii81127.
PROiQ8NH41.

Gene expression databases

CleanExiHS_OR4K15.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR4KF_HUMAN
AccessioniPrimary (citable) accession number: Q8NH41
Secondary accession number(s): B9EIL3, Q6IEZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: May 5, 2009
Last modified: November 2, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.