ID OR6S1_HUMAN Reviewed; 331 AA. AC Q8NH40; Q6IFJ9; DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot. DT 10-FEB-2009, sequence version 2. DT 27-MAR-2024, entry version 151. DE RecName: Full=Olfactory receptor 6S1; DE AltName: Full=Olfactory receptor OR14-37; GN Name=OR6S1; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.; RT "Genome-wide discovery and analysis of human seven transmembrane helix RT receptor genes."; RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases. RN [2] RP IDENTIFICATION. RX PubMed=14983052; DOI=10.1073/pnas.0307882100; RA Malnic B., Godfrey P.A., Buck L.B.; RT "The human olfactory receptor gene family."; RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004). RN [3] RP ERRATUM OF PUBMED:14983052. RA Malnic B., Godfrey P.A., Buck L.B.; RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004). CC -!- FUNCTION: Odorant receptor. {ECO:0000305}. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC -!- SEQUENCE CAUTION: CC Sequence=BAC05799.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE); CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR6S1"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB065561; BAC05799.1; ALT_SEQ; Genomic_DNA. DR EMBL; BK004263; DAA04661.1; -; Genomic_DNA. DR CCDS; CCDS32038.1; -. DR RefSeq; NP_001001968.1; NM_001001968.1. DR AlphaFoldDB; Q8NH40; -. DR SMR; Q8NH40; -. DR BioGRID; 131156; 1. DR STRING; 9606.ENSP00000313110; -. DR GlyCosmos; Q8NH40; 1 site, No reported glycans. DR GlyGen; Q8NH40; 1 site. DR BioMuta; OR6S1; -. DR DMDM; 223590119; -. DR MassIVE; Q8NH40; -. DR PaxDb; 9606-ENSP00000313110; -. DR ProteomicsDB; 73653; -. DR Antibodypedia; 57711; 110 antibodies from 20 providers. DR DNASU; 341799; -. DR Ensembl; ENST00000320704.3; ENSP00000313110.3; ENSG00000181803.3. DR GeneID; 341799; -. DR KEGG; hsa:341799; -. DR MANE-Select; ENST00000320704.3; ENSP00000313110.3; NM_001001968.1; NP_001001968.1. DR UCSC; uc001vxv.1; human. DR AGR; HGNC:15363; -. DR CTD; 341799; -. DR GeneCards; OR6S1; -. DR HGNC; HGNC:15363; OR6S1. DR HPA; ENSG00000181803; Not detected. DR neXtProt; NX_Q8NH40; -. DR PharmGKB; PA32604; -. DR VEuPathDB; HostDB:ENSG00000181803; -. DR eggNOG; ENOG502SFXX; Eukaryota. DR GeneTree; ENSGT01090000260086; -. DR HOGENOM; CLU_012526_0_1_1; -. DR InParanoid; Q8NH40; -. DR OMA; NWAVTVI; -. DR OrthoDB; 5401587at2759; -. DR PhylomeDB; Q8NH40; -. DR TreeFam; TF336833; -. DR PathwayCommons; Q8NH40; -. DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors. DR BioGRID-ORCS; 341799; 7 hits in 749 CRISPR screens. DR GeneWiki; OR6S1; -. DR GenomeRNAi; 341799; -. DR Pharos; Q8NH40; Tdark. DR PRO; PR:Q8NH40; -. DR Proteomes; UP000005640; Chromosome 14. DR RNAct; Q8NH40; Protein. DR Bgee; ENSG00000181803; Expressed in lymph node and 1 other cell type or tissue. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW. DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central. DR CDD; cd15912; 7tmA_OR6C-like; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR InterPro; IPR000725; Olfact_rcpt. DR InterPro; IPR047132; Olfact_rcpt_6C-like. DR PANTHER; PTHR26454; OLFACTORY RECEPTOR; 1. DR PANTHER; PTHR26454:SF7; OLFACTORY RECEPTOR 6S1; 1. DR Pfam; PF13853; 7tm_4; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR PRINTS; PR00245; OLFACTORYR. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 3: Inferred from homology; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction; KW Transducer; Transmembrane; Transmembrane helix. FT CHAIN 1..331 FT /note="Olfactory receptor 6S1" FT /id="PRO_0000150637" FT TOPO_DOM 1..29 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 30..50 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 51..59 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 60..80 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 81..99 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 100..120 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 121..147 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 148..168 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 169..207 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 208..228 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 229..242 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 243..263 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 264..274 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 275..295 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 296..331 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 6 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 99..182 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" FT VARIANT 42 FT /note="T -> I (in dbSNP:rs11622794)" FT /id="VAR_057562" FT VARIANT 156 FT /note="V -> I (in dbSNP:rs11622969)" FT /id="VAR_057563" FT VARIANT 237 FT /note="R -> H (in dbSNP:rs17277522)" FT /id="VAR_057564" FT VARIANT 296 FT /note="R -> C (in dbSNP:rs17114309)" FT /id="VAR_057565" SQ SEQUENCE 331 AA; 36127 MW; D7C1C3F266B336AB CRC64; MSPDGNHSSD PTEFVLAGLP NLNSARVELF SVFLLVYLLN LTGNVLIVGV VRADTRLQTP MYFFLGNLSC LEILLTSVII PKMLSNFLSR QHTISFAACI TQFYFYFFLG ASEFLLLAVM SADRYLAICH PLRYPLLMSG AVCFRVALAC WVGGLVPVLG PTVAVALLPF CKQGAVVQHF FCDSGPLLRL ACTNTKKLEE TDFVLASLVI VSSLLITAVS YGLIVLAVLS IPSASGRQKA FSTCTSHLIV VTLFYGSAIF LYVRPSQSGS VDTNWAVTVI TTFVTPLLNP FIYALRNEQV KEALKDMFRK VVAGVLGNLL LDKCLSEKAV K //