Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8NH40

- OR6S1_HUMAN

UniProt

Q8NH40 - OR6S1_HUMAN

Protein

Olfactory receptor 6S1

Gene

OR6S1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 6S1
    Alternative name(s):
    Olfactory receptor OR14-37
    Gene namesi
    Name:OR6S1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:15363. OR6S1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32604.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 331331Olfactory receptor 6S1PRO_0000150637Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi99 ↔ 182PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ8NH40.

    Expressioni

    Gene expression databases

    CleanExiHS_OR6S1.
    GenevestigatoriQ8NH40.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000313110.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH40.
    SMRiQ8NH40. Positions 18-312.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 599CytoplasmicSequence Analysis
    Topological domaini81 – 9919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 14727CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini169 – 20739ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini229 – 24214CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini264 – 27411ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini296 – 33136CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei60 – 8021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei148 – 16821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei208 – 22821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei243 – 26321Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei275 – 29521Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150844.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NH40.
    KOiK04257.
    OMAiPLLMNGT.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NH40.
    TreeFamiTF336833.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH40-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSPDGNHSSD PTEFVLAGLP NLNSARVELF SVFLLVYLLN LTGNVLIVGV    50
    VRADTRLQTP MYFFLGNLSC LEILLTSVII PKMLSNFLSR QHTISFAACI 100
    TQFYFYFFLG ASEFLLLAVM SADRYLAICH PLRYPLLMSG AVCFRVALAC 150
    WVGGLVPVLG PTVAVALLPF CKQGAVVQHF FCDSGPLLRL ACTNTKKLEE 200
    TDFVLASLVI VSSLLITAVS YGLIVLAVLS IPSASGRQKA FSTCTSHLIV 250
    VTLFYGSAIF LYVRPSQSGS VDTNWAVTVI TTFVTPLLNP FIYALRNEQV 300
    KEALKDMFRK VVAGVLGNLL LDKCLSEKAV K 331
    Length:331
    Mass (Da):36,127
    Last modified:February 10, 2009 - v2
    Checksum:iD7C1C3F266B336AB
    GO

    Sequence cautioni

    The sequence BAC05799.1 differs from that shown. Reason: Erroneous gene model prediction.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti42 – 421T → I.
    Corresponds to variant rs11622794 [ dbSNP | Ensembl ].
    VAR_057562
    Natural varianti156 – 1561V → I.
    Corresponds to variant rs11622969 [ dbSNP | Ensembl ].
    VAR_057563
    Natural varianti237 – 2371R → H.
    Corresponds to variant rs17277522 [ dbSNP | Ensembl ].
    VAR_057564
    Natural varianti296 – 2961R → C.
    Corresponds to variant rs17114309 [ dbSNP | Ensembl ].
    VAR_057565

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065561 Genomic DNA. Translation: BAC05799.1. Sequence problems.
    BK004263 Genomic DNA. Translation: DAA04661.1.
    CCDSiCCDS32038.1.
    RefSeqiNP_001001968.1. NM_001001968.1.
    UniGeneiHs.513132.

    Genome annotation databases

    EnsembliENST00000320704; ENSP00000313110; ENSG00000181803.
    GeneIDi341799.
    KEGGihsa:341799.
    UCSCiuc001vxv.1. human.

    Polymorphism databases

    DMDMi223590119.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065561 Genomic DNA. Translation: BAC05799.1 . Sequence problems.
    BK004263 Genomic DNA. Translation: DAA04661.1 .
    CCDSi CCDS32038.1.
    RefSeqi NP_001001968.1. NM_001001968.1.
    UniGenei Hs.513132.

    3D structure databases

    ProteinModelPortali Q8NH40.
    SMRi Q8NH40. Positions 18-312.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000313110.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 223590119.

    Proteomic databases

    PRIDEi Q8NH40.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320704 ; ENSP00000313110 ; ENSG00000181803 .
    GeneIDi 341799.
    KEGGi hsa:341799.
    UCSCi uc001vxv.1. human.

    Organism-specific databases

    CTDi 341799.
    GeneCardsi GC14M021109.
    HGNCi HGNC:15363. OR6S1.
    neXtProti NX_Q8NH40.
    PharmGKBi PA32604.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG150844.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NH40.
    KOi K04257.
    OMAi PLLMNGT.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NH40.
    TreeFami TF336833.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR6S1.
    GenomeRNAii 341799.
    NextBioi 98199.
    PROi Q8NH40.

    Gene expression databases

    CleanExi HS_OR6S1.
    Genevestigatori Q8NH40.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR6S1_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH40
    Secondary accession number(s): Q6IFJ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3