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Q8NH40 (OR6S1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 6S1
Alternative name(s):
Olfactory receptor OR14-37
Gene names
Name:OR6S1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAC05799.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 331331Olfactory receptor 6S1
PRO_0000150637

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 599Cytoplasmic Potential
Transmembrane60 – 8021Helical; Name=2; Potential
Topological domain81 – 9919Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 14727Cytoplasmic Potential
Transmembrane148 – 16821Helical; Name=4; Potential
Topological domain169 – 20739Extracellular Potential
Transmembrane208 – 22821Helical; Name=5; Potential
Topological domain229 – 24214Cytoplasmic Potential
Transmembrane243 – 26321Helical; Name=6; Potential
Topological domain264 – 27411Extracellular Potential
Transmembrane275 – 29521Helical; Name=7; Potential
Topological domain296 – 33136Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond99 ↔ 182 By similarity

Natural variations

Natural variant421T → I.
Corresponds to variant rs11622794 [ dbSNP | Ensembl ].
VAR_057562
Natural variant1561V → I.
Corresponds to variant rs11622969 [ dbSNP | Ensembl ].
VAR_057563
Natural variant2371R → H.
Corresponds to variant rs17277522 [ dbSNP | Ensembl ].
VAR_057564
Natural variant2961R → C.
Corresponds to variant rs17114309 [ dbSNP | Ensembl ].
VAR_057565

Sequences

Sequence LengthMass (Da)Tools
Q8NH40 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: D7C1C3F266B336AB

FASTA33136,127
        10         20         30         40         50         60 
MSPDGNHSSD PTEFVLAGLP NLNSARVELF SVFLLVYLLN LTGNVLIVGV VRADTRLQTP 

        70         80         90        100        110        120 
MYFFLGNLSC LEILLTSVII PKMLSNFLSR QHTISFAACI TQFYFYFFLG ASEFLLLAVM 

       130        140        150        160        170        180 
SADRYLAICH PLRYPLLMSG AVCFRVALAC WVGGLVPVLG PTVAVALLPF CKQGAVVQHF 

       190        200        210        220        230        240 
FCDSGPLLRL ACTNTKKLEE TDFVLASLVI VSSLLITAVS YGLIVLAVLS IPSASGRQKA 

       250        260        270        280        290        300 
FSTCTSHLIV VTLFYGSAIF LYVRPSQSGS VDTNWAVTVI TTFVTPLLNP FIYALRNEQV 

       310        320        330 
KEALKDMFRK VVAGVLGNLL LDKCLSEKAV K 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065561 Genomic DNA. Translation: BAC05799.1. Sequence problems.
BK004263 Genomic DNA. Translation: DAA04661.1.
CCDSCCDS32038.1.
RefSeqNP_001001968.1. NM_001001968.1.
UniGeneHs.513132.

3D structure databases

ProteinModelPortalQ8NH40.
SMRQ8NH40. Positions 18-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000313110.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM223590119.

Proteomic databases

PRIDEQ8NH40.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320704; ENSP00000313110; ENSG00000181803.
GeneID341799.
KEGGhsa:341799.
UCSCuc001vxv.1. human.

Organism-specific databases

CTD341799.
GeneCardsGC14M021109.
HGNCHGNC:15363. OR6S1.
neXtProtNX_Q8NH40.
PharmGKBPA32604.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG150844.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NH40.
KOK04257.
OMAPLLMNGT.
OrthoDBEOG71K63J.
PhylomeDBQ8NH40.
TreeFamTF336833.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR6S1.
GenevestigatorQ8NH40.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR6S1.
GenomeRNAi341799.
NextBio98199.
PROQ8NH40.

Entry information

Entry nameOR6S1_HUMAN
AccessionPrimary (citable) accession number: Q8NH40
Secondary accession number(s): Q6IFJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: July 9, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries