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Protein

Olfactory receptor 6S1

Gene

OR6S1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6S1
Alternative name(s):
Olfactory receptor OR14-37
Gene namesi
Name:OR6S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000181803.3
HGNCiHGNC:15363 OR6S1
neXtProtiNX_Q8NH40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 59CytoplasmicSequence analysis9
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 99ExtracellularSequence analysisAdd BLAST19
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 147CytoplasmicSequence analysisAdd BLAST27
Transmembranei148 – 168Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini169 – 207ExtracellularSequence analysisAdd BLAST39
Transmembranei208 – 228Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini229 – 242CytoplasmicSequence analysisAdd BLAST14
Transmembranei243 – 263Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini264 – 274ExtracellularSequence analysisAdd BLAST11
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 331CytoplasmicSequence analysisAdd BLAST36

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32604

Polymorphism and mutation databases

BioMutaiOR6S1
DMDMi223590119

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506371 – 331Olfactory receptor 6S1Add BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH40
PeptideAtlasiQ8NH40
PRIDEiQ8NH40

Expressioni

Gene expression databases

BgeeiENSG00000181803
CleanExiHS_OR6S1

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000313110

Structurei

3D structure databases

ProteinModelPortaliQ8NH40
SMRiQ8NH40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEEI Eukaryota
ENOG410ZJUC LUCA
GeneTreeiENSGT00760000119169
HOGENOMiHOG000041365
HOVERGENiHBG017625
InParanoidiQ8NH40
KOiK04257
OMAiAACITQF
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH40
TreeFamiTF336833

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPDGNHSSD PTEFVLAGLP NLNSARVELF SVFLLVYLLN LTGNVLIVGV
60 70 80 90 100
VRADTRLQTP MYFFLGNLSC LEILLTSVII PKMLSNFLSR QHTISFAACI
110 120 130 140 150
TQFYFYFFLG ASEFLLLAVM SADRYLAICH PLRYPLLMSG AVCFRVALAC
160 170 180 190 200
WVGGLVPVLG PTVAVALLPF CKQGAVVQHF FCDSGPLLRL ACTNTKKLEE
210 220 230 240 250
TDFVLASLVI VSSLLITAVS YGLIVLAVLS IPSASGRQKA FSTCTSHLIV
260 270 280 290 300
VTLFYGSAIF LYVRPSQSGS VDTNWAVTVI TTFVTPLLNP FIYALRNEQV
310 320 330
KEALKDMFRK VVAGVLGNLL LDKCLSEKAV K
Length:331
Mass (Da):36,127
Last modified:February 10, 2009 - v2
Checksum:iD7C1C3F266B336AB
GO

Sequence cautioni

The sequence BAC05799 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05756242T → I. Corresponds to variant dbSNP:rs11622794Ensembl.1
Natural variantiVAR_057563156V → I. Corresponds to variant dbSNP:rs11622969Ensembl.1
Natural variantiVAR_057564237R → H. Corresponds to variant dbSNP:rs17277522Ensembl.1
Natural variantiVAR_057565296R → C. Corresponds to variant dbSNP:rs17114309Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065561 Genomic DNA Translation: BAC05799.1 Sequence problems.
BK004263 Genomic DNA Translation: DAA04661.1
CCDSiCCDS32038.1
RefSeqiNP_001001968.1, NM_001001968.1
UniGeneiHs.513132

Genome annotation databases

EnsembliENST00000320704; ENSP00000313110; ENSG00000181803
GeneIDi341799
KEGGihsa:341799
UCSCiuc001vxv.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR6S1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH40
Secondary accession number(s): Q6IFJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: March 28, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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