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Q8NH40

- OR6S1_HUMAN

UniProt

Q8NH40 - OR6S1_HUMAN

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Protein

Olfactory receptor 6S1

Gene
OR6S1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 6S1
Alternative name(s):
Olfactory receptor OR14-37
Gene namesi
Name:OR6S1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:15363. OR6S1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929Extracellular Reviewed predictionAdd
BLAST
Transmembranei30 – 5021Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini51 – 599Cytoplasmic Reviewed prediction
Transmembranei60 – 8021Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini81 – 9919Extracellular Reviewed predictionAdd
BLAST
Transmembranei100 – 12021Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini121 – 14727Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei148 – 16821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini169 – 20739Extracellular Reviewed predictionAdd
BLAST
Transmembranei208 – 22821Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini229 – 24214Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei243 – 26321Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini264 – 27411Extracellular Reviewed predictionAdd
BLAST
Transmembranei275 – 29521Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini296 – 33136Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32604.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Olfactory receptor 6S1PRO_0000150637Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi99 ↔ 182 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NH40.

Expressioni

Gene expression databases

CleanExiHS_OR6S1.
GenevestigatoriQ8NH40.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000313110.

Structurei

3D structure databases

ProteinModelPortaliQ8NH40.
SMRiQ8NH40. Positions 18-312.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150844.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH40.
KOiK04257.
OMAiPLLMNGT.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH40.
TreeFamiTF336833.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH40-1 [UniParc]FASTAAdd to Basket

« Hide

MSPDGNHSSD PTEFVLAGLP NLNSARVELF SVFLLVYLLN LTGNVLIVGV    50
VRADTRLQTP MYFFLGNLSC LEILLTSVII PKMLSNFLSR QHTISFAACI 100
TQFYFYFFLG ASEFLLLAVM SADRYLAICH PLRYPLLMSG AVCFRVALAC 150
WVGGLVPVLG PTVAVALLPF CKQGAVVQHF FCDSGPLLRL ACTNTKKLEE 200
TDFVLASLVI VSSLLITAVS YGLIVLAVLS IPSASGRQKA FSTCTSHLIV 250
VTLFYGSAIF LYVRPSQSGS VDTNWAVTVI TTFVTPLLNP FIYALRNEQV 300
KEALKDMFRK VVAGVLGNLL LDKCLSEKAV K 331
Length:331
Mass (Da):36,127
Last modified:February 10, 2009 - v2
Checksum:iD7C1C3F266B336AB
GO

Sequence cautioni

The sequence BAC05799.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti42 – 421T → I.
Corresponds to variant rs11622794 [ dbSNP | Ensembl ].
VAR_057562
Natural varianti156 – 1561V → I.
Corresponds to variant rs11622969 [ dbSNP | Ensembl ].
VAR_057563
Natural varianti237 – 2371R → H.
Corresponds to variant rs17277522 [ dbSNP | Ensembl ].
VAR_057564
Natural varianti296 – 2961R → C.
Corresponds to variant rs17114309 [ dbSNP | Ensembl ].
VAR_057565

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065561 Genomic DNA. Translation: BAC05799.1. Sequence problems.
BK004263 Genomic DNA. Translation: DAA04661.1.
CCDSiCCDS32038.1.
RefSeqiNP_001001968.1. NM_001001968.1.
UniGeneiHs.513132.

Genome annotation databases

EnsembliENST00000320704; ENSP00000313110; ENSG00000181803.
GeneIDi341799.
KEGGihsa:341799.
UCSCiuc001vxv.1. human.

Polymorphism databases

DMDMi223590119.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065561 Genomic DNA. Translation: BAC05799.1 . Sequence problems.
BK004263 Genomic DNA. Translation: DAA04661.1 .
CCDSi CCDS32038.1.
RefSeqi NP_001001968.1. NM_001001968.1.
UniGenei Hs.513132.

3D structure databases

ProteinModelPortali Q8NH40.
SMRi Q8NH40. Positions 18-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000313110.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 223590119.

Proteomic databases

PRIDEi Q8NH40.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320704 ; ENSP00000313110 ; ENSG00000181803 .
GeneIDi 341799.
KEGGi hsa:341799.
UCSCi uc001vxv.1. human.

Organism-specific databases

CTDi 341799.
GeneCardsi GC14M021109.
HGNCi HGNC:15363. OR6S1.
neXtProti NX_Q8NH40.
PharmGKBi PA32604.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG150844.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NH40.
KOi K04257.
OMAi PLLMNGT.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NH40.
TreeFami TF336833.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR6S1.
GenomeRNAii 341799.
NextBioi 98199.
PROi Q8NH40.

Gene expression databases

CleanExi HS_OR6S1.
Genevestigatori Q8NH40.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR6S1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH40
Secondary accession number(s): Q6IFJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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