ID   OR4C3_HUMAN             Reviewed;         302 AA.
AC   Q8NH37; B2RNF2; Q6IFB3;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2003, sequence version 2.
DT   24-JAN-2024, entry version 161.
DE   RecName: Full=Olfactory receptor 4C3;
DE   AltName: Full=Olfactory receptor OR11-98;
GN   Name=OR4C3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA   Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT   "Genome-wide discovery and analysis of human seven transmembrane helix
RT   receptor genes.";
RL   Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   IDENTIFICATION.
RX   PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA   Malnic B., Godfrey P.A., Buck L.B.;
RT   "The human olfactory receptor gene family.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN   [5]
RP   ERRATUM OF PUBMED:14983052.
RA   Malnic B., Godfrey P.A., Buck L.B.;
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC   -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI36854.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAI36855.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAC05803.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=DAA04747.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=EAW67868.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC       URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR4C3";
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DR   EMBL; AB065567; BAC05803.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AC023080; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471064; EAW67868.1; ALT_INIT; Genomic_DNA.
DR   EMBL; BC136853; AAI36854.1; ALT_INIT; mRNA.
DR   EMBL; BC136854; AAI36855.1; ALT_INIT; mRNA.
DR   EMBL; BK004349; DAA04747.1; ALT_INIT; Genomic_DNA.
DR   CCDS; CCDS31489.2; -.
DR   RefSeq; NP_001004702.1; NM_001004702.1.
DR   AlphaFoldDB; Q8NH37; -.
DR   SMR; Q8NH37; -.
DR   STRING; 9606.ENSP00000493096; -.
DR   GlyCosmos; Q8NH37; 1 site, No reported glycans.
DR   GlyGen; Q8NH37; 1 site.
DR   iPTMnet; Q8NH37; -.
DR   PhosphoSitePlus; Q8NH37; -.
DR   BioMuta; OR4C3; -.
DR   DMDM; 38372802; -.
DR   MassIVE; Q8NH37; -.
DR   PaxDb; 9606-ENSP00000321419; -.
DR   ProteomicsDB; 73652; -.
DR   Antibodypedia; 63155; 48 antibodies from 17 providers.
DR   DNASU; 256144; -.
DR   Ensembl; ENST00000319856.5; ENSP00000321419.5; ENSG00000176547.11.
DR   GeneID; 256144; -.
DR   KEGG; hsa:256144; -.
DR   MANE-Select; ENST00000319856.5; ENSP00000321419.5; NM_001004702.2; NP_001004702.2.
DR   UCSC; uc010rhv.3; human.
DR   AGR; HGNC:14697; -.
DR   CTD; 256144; -.
DR   DisGeNET; 256144; -.
DR   GeneCards; OR4C3; -.
DR   HGNC; HGNC:14697; OR4C3.
DR   HPA; ENSG00000176547; Not detected.
DR   neXtProt; NX_Q8NH37; -.
DR   PharmGKB; PA32261; -.
DR   VEuPathDB; HostDB:ENSG00000176547; -.
DR   eggNOG; ENOG502TK3X; Eukaryota.
DR   GeneTree; ENSGT00940000163173; -.
DR   HOGENOM; CLU_012526_5_5_1; -.
DR   InParanoid; Q8NH37; -.
DR   OMA; MPHNITE; -.
DR   OrthoDB; 4052270at2759; -.
DR   PhylomeDB; Q8NH37; -.
DR   TreeFam; TF337251; -.
DR   PathwayCommons; Q8NH37; -.
DR   Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR   BioGRID-ORCS; 256144; 7 hits in 736 CRISPR screens.
DR   GeneWiki; OR4C3; -.
DR   GenomeRNAi; 256144; -.
DR   Pharos; Q8NH37; Tdark.
DR   PRO; PR:Q8NH37; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; Q8NH37; Protein.
DR   Bgee; ENSG00000176547; Expressed in cortex of kidney.
DR   ExpressionAtlas; Q8NH37; differential.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR   CDD; cd15939; 7tmA_OR4A-like; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR000725; Olfact_rcpt.
DR   PANTHER; PTHR48002; OLFACTORY RECEPTOR; 1.
DR   PANTHER; PTHR48002:SF40; OLFACTORY RECEPTOR 4C3; 1.
DR   Pfam; PF13853; 7tm_4; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00245; OLFACTORYR.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW   Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW   Transducer; Transmembrane; Transmembrane helix.
FT   CHAIN           1..302
FT                   /note="Olfactory receptor 4C3"
FT                   /id="PRO_0000150529"
FT   TOPO_DOM        1..23
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..47
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        48..55
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..77
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        78..98
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..118
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        119..137
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..156
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        157..193
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        194..217
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        218..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..256
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        257..267
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..287
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        288..302
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        6
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        95..187
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ   SEQUENCE   302 AA;  33726 MW;  2DF2E650E040E4E1 CRC64;
     MDIPQNITEF FMLGLSQNSE VQRVLFVVFL LIYVVTVCGN MLIVVTITSS PTLASPVYFF
     LANLSFIDTF YSSSMAPKLI ADSLYEGRTI SYECCMAQLF GAHFLGGVEI ILLTVMAYDR
     YVAICKPLHN TTIMTRHLCA MLVGVAWLGG FLHSLVQLLL VLWLPFCGPN VINHFACDLY
     PLLEVACTNT YVIGLLVVAN SGLICLLNFL MLAASYIVIL YSLRSHSADG RCKALSTCGA
     HFIVVALFFV PCIFTYVHPF STLPIDKNMA LFYGILTPML NPLIYTLRNE EVKNAMRKLF
     TW
//