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Q8NH37

- OR4C3_HUMAN

UniProt

Q8NH37 - OR4C3_HUMAN

Protein

Olfactory receptor 4C3

Gene

OR4C3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (10 Oct 2003)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 4C3
    Alternative name(s):
    Olfactory receptor OR11-98
    Gene namesi
    Name:OR4C3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:14697. OR4C3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32261.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Olfactory receptor 4C3PRO_0000150529Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH37.
    PRIDEiQ8NH37.

    PTM databases

    PhosphoSiteiQ8NH37.

    Expressioni

    Gene expression databases

    CleanExiHS_OR4C3.
    GenevestigatoriQ8NH37.

    Organism-specific databases

    HPAiHPA049116.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000321419.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH37.
    SMRiQ8NH37. Positions 4-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 558CytoplasmicSequence Analysis
    Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini257 – 26711ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini288 – 30215CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei234 – 25623Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei268 – 28720Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG114884.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NH37.
    KOiK04257.
    OrthoDBiEOG754HPT.
    PhylomeDBiQ8NH37.
    TreeFamiTF337251.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH37-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDIPQNITEF FMLGLSQNSE VQRVLFVVFL LIYVVTVCGN MLIVVTITSS    50
    PTLASPVYFF LANLSFIDTF YSSSMAPKLI ADSLYEGRTI SYECCMAQLF 100
    GAHFLGGVEI ILLTVMAYDR YVAICKPLHN TTIMTRHLCA MLVGVAWLGG 150
    FLHSLVQLLL VLWLPFCGPN VINHFACDLY PLLEVACTNT YVIGLLVVAN 200
    SGLICLLNFL MLAASYIVIL YSLRSHSADG RCKALSTCGA HFIVVALFFV 250
    PCIFTYVHPF STLPIDKNMA LFYGILTPML NPLIYTLRNE EVKNAMRKLF 300
    TW 302
    Length:302
    Mass (Da):33,726
    Last modified:October 10, 2003 - v2
    Checksum:i2DF2E650E040E4E1
    GO

    Sequence cautioni

    The sequence AAI36854.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAI36855.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC05803.1 differs from that shown. Reason: Erroneous initiation.
    The sequence DAA04747.1 differs from that shown. Reason: Erroneous initiation.
    The sequence EAW67868.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065567 Genomic DNA. Translation: BAC05803.1. Different initiation.
    AC023080 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW67868.1. Different initiation.
    BC136853 mRNA. Translation: AAI36854.1. Different initiation.
    BC136854 mRNA. Translation: AAI36855.1. Different initiation.
    BK004349 Genomic DNA. Translation: DAA04747.1. Different initiation.
    RefSeqiNP_001004702.1. NM_001004702.1.
    UniGeneiHs.553656.

    Genome annotation databases

    EnsembliENST00000319856; ENSP00000321419; ENSG00000176547.
    GeneIDi256144.
    KEGGihsa:256144.
    UCSCiuc010rhv.2. human.

    Polymorphism databases

    DMDMi38372802.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065567 Genomic DNA. Translation: BAC05803.1 . Different initiation.
    AC023080 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW67868.1 . Different initiation.
    BC136853 mRNA. Translation: AAI36854.1 . Different initiation.
    BC136854 mRNA. Translation: AAI36855.1 . Different initiation.
    BK004349 Genomic DNA. Translation: DAA04747.1 . Different initiation.
    RefSeqi NP_001004702.1. NM_001004702.1.
    UniGenei Hs.553656.

    3D structure databases

    ProteinModelPortali Q8NH37.
    SMRi Q8NH37. Positions 4-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000321419.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NH37.

    Polymorphism databases

    DMDMi 38372802.

    Proteomic databases

    PaxDbi Q8NH37.
    PRIDEi Q8NH37.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000319856 ; ENSP00000321419 ; ENSG00000176547 .
    GeneIDi 256144.
    KEGGi hsa:256144.
    UCSCi uc010rhv.2. human.

    Organism-specific databases

    CTDi 256144.
    GeneCardsi GC11P048346.
    HGNCi HGNC:14697. OR4C3.
    HPAi HPA049116.
    neXtProti NX_Q8NH37.
    PharmGKBi PA32261.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG114884.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NH37.
    KOi K04257.
    OrthoDBi EOG754HPT.
    PhylomeDBi Q8NH37.
    TreeFami TF337251.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR4C3.
    GenomeRNAii 256144.
    NextBioi 92730.
    PROi Q8NH37.

    Gene expression databases

    CleanExi HS_OR4C3.
    Genevestigatori Q8NH37.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR4C3_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH37
    Secondary accession number(s): B2RNF2, Q6IFB3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 10, 2003
    Last sequence update: October 10, 2003
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3