Olfactory receptor 4C3 - Homo sapiens (Human)

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Q8NH37 (OR4C3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 94. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Olfactory receptor 4C3

Alternative name(s):
Olfactory receptor OR11-98

Gene names

Name:

OR4C3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence AAI36854.1 differs from that shown. Reason: Erroneous initiation. The sequence AAI36855.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC05803.1 differs from that shown. Reason: Erroneous initiation. The sequence DAA04747.1 differs from that shown. Reason: Erroneous initiation. The sequence EAW67868.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 302

302

Olfactory receptor 4C3

PRO_0000150529

Regions

Topological domain

1 – 23

Extracellular Potential

Transmembrane

24 – 47

Helical; Name=1; Potential

Topological domain

48 – 55

Cytoplasmic Potential

Transmembrane

56 – 77

Helical; Name=2; Potential

Topological domain

78 – 98

Extracellular Potential

Transmembrane

99 – 118

Helical; Name=3; Potential

Topological domain

119 – 137

Cytoplasmic Potential

Transmembrane

138 – 156

Helical; Name=4; Potential

Topological domain

157 – 193

Extracellular Potential

Transmembrane

194 – 217

Helical; Name=5; Potential

Topological domain

218 – 233

Cytoplasmic Potential

Transmembrane

234 – 256

Helical; Name=6; Potential

Topological domain

257 – 267

Extracellular Potential

Transmembrane

268 – 287

Helical; Name=7; Potential

Topological domain

288 – 302

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

95 ↔ 187

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q8NH37 [UniParc].

Last modified October 10, 2003. Version 2.
Checksum: 2DF2E650E040E4E1
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FASTA

302

33,726

        10         20         30         40         50         60 
MDIPQNITEF FMLGLSQNSE VQRVLFVVFL LIYVVTVCGN MLIVVTITSS PTLASPVYFF 

        70         80         90        100        110        120 
LANLSFIDTF YSSSMAPKLI ADSLYEGRTI SYECCMAQLF GAHFLGGVEI ILLTVMAYDR 

       130        140        150        160        170        180 
YVAICKPLHN TTIMTRHLCA MLVGVAWLGG FLHSLVQLLL VLWLPFCGPN VINHFACDLY 

       190        200        210        220        230        240 
PLLEVACTNT YVIGLLVVAN SGLICLLNFL MLAASYIVIL YSLRSHSADG RCKALSTCGA 

       250        260        270        280        290        300 
HFIVVALFFV PCIFTYVHPF STLPIDKNMA LFYGILTPML NPLIYTLRNE EVKNAMRKLF 


TW

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065567 Genomic DNA. Translation: BAC05803.1. Different initiation. AC023080 Genomic DNA. No translation available. CH471064 Genomic DNA. Translation: EAW67868.1. Different initiation. BC136853 mRNA. Translation: AAI36854.1. Different initiation. BC136854 mRNA. Translation: AAI36855.1. Different initiation. BK004349 Genomic DNA. Translation: DAA04747.1. Different initiation.
IPI	IPI00169131.
RefSeq	NP_001004702.1. NM_001004702.1.
UniGene	Hs.553656.
3D structure databases
ProteinModelPortal	Q8NH37.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000321419.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NH37.
Polymorphism databases
DMDM	38372802.
Proteomic databases
PaxDb	Q8NH37.
PRIDE	Q8NH37.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000319856; ENSP00000321419; ENSG00000176547.
GeneID	256144.
KEGG	hsa:256144.
UCSC	uc010rhv.2. human.
Organism-specific databases
CTD	256144.
GeneCards	GC11P048346.
HGNC	HGNC:14697. OR4C3.
HPA	HPA049116.
neXtProt	NX_Q8NH37.
PharmGKB	PA32261.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG114884.
HOGENOM	HOG000041362.
HOVERGEN	HBG017625.
InParanoid	Q8NH37.
KO	K04257.
OrthoDB	EOG4ZGPCT.
PhylomeDB	Q8NH37.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR4C3.
Genevestigator	Q8NH37.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PANTHER	PTHR24236. PTHR24236. 1 hit.
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	256144.
NextBio	92730.

Entry information

Entry name

OR4C3_HUMAN

Accession

Primary (citable) accession number: Q8NH37
Secondary accession number(s): B2RNF2, Q6IFB3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
Last sequence update:	October 10, 2003
Last modified:	May 1, 2013
This is version 94 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents