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Q8NH37

- OR4C3_HUMAN

UniProt

Q8NH37 - OR4C3_HUMAN

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Protein

Olfactory receptor 4C3

Gene

OR4C3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 4C3
Alternative name(s):
Olfactory receptor OR11-98
Gene namesi
Name:OR4C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:14697. OR4C3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 558CytoplasmicSequence Analysis
Transmembranei56 – 7722Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini78 – 9821ExtracellularSequence AnalysisAdd
BLAST
Transmembranei99 – 11820Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini119 – 13719CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei138 – 15619Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini157 – 19337ExtracellularSequence AnalysisAdd
BLAST
Transmembranei194 – 21724Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23316CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei234 – 25623Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini257 – 26711ExtracellularSequence AnalysisAdd
BLAST
Transmembranei268 – 28720Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini288 – 30215CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32261.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Olfactory receptor 4C3PRO_0000150529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 187PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH37.
PRIDEiQ8NH37.

PTM databases

PhosphoSiteiQ8NH37.

Expressioni

Gene expression databases

CleanExiHS_OR4C3.
GenevestigatoriQ8NH37.

Organism-specific databases

HPAiHPA049116.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000321419.

Structurei

3D structure databases

ProteinModelPortaliQ8NH37.
SMRiQ8NH37. Positions 4-296.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG114884.
GeneTreeiENSGT00760000118773.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH37.
KOiK04257.
OrthoDBiEOG754HPT.
PhylomeDBiQ8NH37.
TreeFamiTF337251.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH37-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDIPQNITEF FMLGLSQNSE VQRVLFVVFL LIYVVTVCGN MLIVVTITSS
60 70 80 90 100
PTLASPVYFF LANLSFIDTF YSSSMAPKLI ADSLYEGRTI SYECCMAQLF
110 120 130 140 150
GAHFLGGVEI ILLTVMAYDR YVAICKPLHN TTIMTRHLCA MLVGVAWLGG
160 170 180 190 200
FLHSLVQLLL VLWLPFCGPN VINHFACDLY PLLEVACTNT YVIGLLVVAN
210 220 230 240 250
SGLICLLNFL MLAASYIVIL YSLRSHSADG RCKALSTCGA HFIVVALFFV
260 270 280 290 300
PCIFTYVHPF STLPIDKNMA LFYGILTPML NPLIYTLRNE EVKNAMRKLF

TW
Length:302
Mass (Da):33,726
Last modified:October 10, 2003 - v2
Checksum:i2DF2E650E040E4E1
GO

Sequence cautioni

The sequence AAI36854.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AAI36855.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC05803.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence DAA04747.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence EAW67868.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065567 Genomic DNA. Translation: BAC05803.1. Different initiation.
AC023080 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67868.1. Different initiation.
BC136853 mRNA. Translation: AAI36854.1. Different initiation.
BC136854 mRNA. Translation: AAI36855.1. Different initiation.
BK004349 Genomic DNA. Translation: DAA04747.1. Different initiation.
RefSeqiNP_001004702.1. NM_001004702.1.
UniGeneiHs.553656.

Genome annotation databases

EnsembliENST00000319856; ENSP00000321419; ENSG00000176547.
GeneIDi256144.
KEGGihsa:256144.
UCSCiuc010rhv.2. human.

Polymorphism databases

DMDMi38372802.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065567 Genomic DNA. Translation: BAC05803.1 . Different initiation.
AC023080 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67868.1 . Different initiation.
BC136853 mRNA. Translation: AAI36854.1 . Different initiation.
BC136854 mRNA. Translation: AAI36855.1 . Different initiation.
BK004349 Genomic DNA. Translation: DAA04747.1 . Different initiation.
RefSeqi NP_001004702.1. NM_001004702.1.
UniGenei Hs.553656.

3D structure databases

ProteinModelPortali Q8NH37.
SMRi Q8NH37. Positions 4-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000321419.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NH37.

Polymorphism databases

DMDMi 38372802.

Proteomic databases

PaxDbi Q8NH37.
PRIDEi Q8NH37.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000319856 ; ENSP00000321419 ; ENSG00000176547 .
GeneIDi 256144.
KEGGi hsa:256144.
UCSCi uc010rhv.2. human.

Organism-specific databases

CTDi 256144.
GeneCardsi GC11P048346.
HGNCi HGNC:14697. OR4C3.
HPAi HPA049116.
neXtProti NX_Q8NH37.
PharmGKBi PA32261.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG114884.
GeneTreei ENSGT00760000118773.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NH37.
KOi K04257.
OrthoDBi EOG754HPT.
PhylomeDBi Q8NH37.
TreeFami TF337251.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR4C3.
GenomeRNAii 256144.
NextBioi 92730.
PROi Q8NH37.

Gene expression databases

CleanExi HS_OR4C3.
Genevestigatori Q8NH37.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR4C3_HUMAN
AccessioniPrimary (citable) accession number: Q8NH37
Secondary accession number(s): B2RNF2, Q6IFB3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: October 29, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3