Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8NH37 (OR4C3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 4C3
Alternative name(s):
Olfactory receptor OR11-98
Gene names
Name:OR4C3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length302 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAI36854.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAI36855.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAC05803.1 differs from that shown. Reason: Erroneous initiation.

The sequence DAA04747.1 differs from that shown. Reason: Erroneous initiation.

The sequence EAW67868.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 302302Olfactory receptor 4C3
PRO_0000150529

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4724Helical; Name=1; Potential
Topological domain48 – 558Cytoplasmic Potential
Transmembrane56 – 7722Helical; Name=2; Potential
Topological domain78 – 9821Extracellular Potential
Transmembrane99 – 11820Helical; Name=3; Potential
Topological domain119 – 13719Cytoplasmic Potential
Transmembrane138 – 15619Helical; Name=4; Potential
Topological domain157 – 19337Extracellular Potential
Transmembrane194 – 21724Helical; Name=5; Potential
Topological domain218 – 23316Cytoplasmic Potential
Transmembrane234 – 25623Helical; Name=6; Potential
Topological domain257 – 26711Extracellular Potential
Transmembrane268 – 28720Helical; Name=7; Potential
Topological domain288 – 30215Cytoplasmic Potential

Amino acid modifications

Glycosylation61N-linked (GlcNAc...) Potential
Disulfide bond95 ↔ 187 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NH37 [UniParc].

Last modified October 10, 2003. Version 2.
Checksum: 2DF2E650E040E4E1

FASTA30233,726
        10         20         30         40         50         60 
MDIPQNITEF FMLGLSQNSE VQRVLFVVFL LIYVVTVCGN MLIVVTITSS PTLASPVYFF 

        70         80         90        100        110        120 
LANLSFIDTF YSSSMAPKLI ADSLYEGRTI SYECCMAQLF GAHFLGGVEI ILLTVMAYDR 

       130        140        150        160        170        180 
YVAICKPLHN TTIMTRHLCA MLVGVAWLGG FLHSLVQLLL VLWLPFCGPN VINHFACDLY 

       190        200        210        220        230        240 
PLLEVACTNT YVIGLLVVAN SGLICLLNFL MLAASYIVIL YSLRSHSADG RCKALSTCGA 

       250        260        270        280        290        300 
HFIVVALFFV PCIFTYVHPF STLPIDKNMA LFYGILTPML NPLIYTLRNE EVKNAMRKLF 


TW 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065567 Genomic DNA. Translation: BAC05803.1. Different initiation.
AC023080 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW67868.1. Different initiation.
BC136853 mRNA. Translation: AAI36854.1. Different initiation.
BC136854 mRNA. Translation: AAI36855.1. Different initiation.
BK004349 Genomic DNA. Translation: DAA04747.1. Different initiation.
RefSeqNP_001004702.1. NM_001004702.1.
UniGeneHs.553656.

3D structure databases

ProteinModelPortalQ8NH37.
SMRQ8NH37. Positions 4-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000321419.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NH37.

Polymorphism databases

DMDM38372802.

Proteomic databases

PaxDbQ8NH37.
PRIDEQ8NH37.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000319856; ENSP00000321419; ENSG00000176547.
GeneID256144.
KEGGhsa:256144.
UCSCuc010rhv.2. human.

Organism-specific databases

CTD256144.
GeneCardsGC11P048346.
HGNCHGNC:14697. OR4C3.
HPAHPA049116.
neXtProtNX_Q8NH37.
PharmGKBPA32261.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG114884.
HOGENOMHOG000041362.
HOVERGENHBG017625.
InParanoidQ8NH37.
KOK04257.
OrthoDBEOG754HPT.
PhylomeDBQ8NH37.
TreeFamTF337251.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR4C3.
GenevestigatorQ8NH37.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR4C3.
GenomeRNAi256144.
NextBio92730.
PROQ8NH37.

Entry information

Entry nameOR4C3_HUMAN
AccessionPrimary (citable) accession number: Q8NH37
Secondary accession number(s): B2RNF2, Q6IFB3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 10, 2003
Last modified: June 11, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries