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Q8NH19

- O10AG_HUMAN

UniProt

Q8NH19 - O10AG_HUMAN

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Protein
Olfactory receptor 10AG1
Gene
OR10AG1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 10AG1
    Alternative name(s):
    Olfactory receptor OR11-160
    Gene namesi
    Name:OR10AG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19607. OR10AG1.

    Subcellular locationi

    Topology

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1616Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei17 – 3721Helical; Name=1; Reviewed prediction
    Add
    BLAST
    Topological domaini38 – 458Cytoplasmic Reviewed prediction
    Transmembranei46 – 6621Helical; Name=2; Reviewed prediction
    Add
    BLAST
    Topological domaini67 – 9024Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei91 – 11121Helical; Name=3; Reviewed prediction
    Add
    BLAST
    Topological domaini112 – 13019Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei131 – 15121Helical; Name=4; Reviewed prediction
    Add
    BLAST
    Topological domaini152 – 18837Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei189 – 20820Helical; Name=5; Reviewed prediction
    Add
    BLAST
    Topological domaini209 – 22820Cytoplasmic Reviewed prediction
    Add
    BLAST
    Transmembranei229 – 24921Helical; Name=6; Reviewed prediction
    Add
    BLAST
    Topological domaini250 – 26213Extracellular Reviewed prediction
    Add
    BLAST
    Transmembranei263 – 28321Helical; Name=7; Reviewed prediction
    Add
    BLAST
    Topological domaini284 – 30118Cytoplasmic Reviewed prediction
    Add
    BLAST

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    Complete GO annotation...

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134929321.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301Olfactory receptor 10AG1
    PRO_0000150692Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi82 – 821N-linked (GlcNAc...) Reviewed prediction
    Disulfide bondi88 ↔ 180 By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH19.
    PRIDEiQ8NH19.

    PTM databases

    PhosphoSiteiQ8NH19.

    Expressioni

    Gene expression databases

    CleanExiHS_OR10AG1.
    GenevestigatoriQ8NH19.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000311477.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH19.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG330472.
    HOGENOMiHOG000041365.
    HOVERGENiHBG017625.
    InParanoidiQ8NH19.
    KOiK04257.
    OMAiNTTTIME.
    OrthoDBiEOG7X9G79.
    PhylomeDBiQ8NH19.
    TreeFamiTF337350.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH19-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFVLLGFSD IPNLHWMLFS IFLLMYLMIL MCNGIIILLI KIHPALQTPM    50
    YFFLSNFSLL EICYVTIIIP RMLMDIWTQK GNISLFACAT QMCFFLMLGG 100
    TECLLLTVMA YDRYVAICKP LQYPLVMNHK VCIQLIIASW TITIPVVIGE 150
    TCQIFLLPFC GTNTINHFFC DIPPILKLAC GNIFVNEITV HVVAVVFITV 200
    PFLLIVVSYG KIISNILKLS SARGKAKAFS TCSSHLIVVI LFFGAGTITY 250
    LQPKPHQFQR MGKLISLFYT ILIPTLNPII YTLRNKDIMV ALRKLLAKLL 300
    T 301
    Length:301
    Mass (Da):34,105
    Last modified:October 1, 2002 - v1
    Checksum:iBDDC23BD2F3D6822
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065594 Genomic DNA. Translation: BAC05822.1.
    CH471076 Genomic DNA. Translation: EAW73692.1.
    BC136890 mRNA. Translation: AAI36891.1.
    BC136891 mRNA. Translation: AAI36892.1.
    BK004519 Genomic DNA. Translation: DAA04917.1.
    CCDSiCCDS31514.1.
    RefSeqiNP_001005491.1. NM_001005491.1.
    UniGeneiHs.554525.

    Genome annotation databases

    EnsembliENST00000312345; ENSP00000311477; ENSG00000174970.
    GeneIDi282770.
    KEGGihsa:282770.
    UCSCiuc010rit.2. human.

    Polymorphism databases

    DMDMi38503050.

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065594 Genomic DNA. Translation: BAC05822.1 .
    CH471076 Genomic DNA. Translation: EAW73692.1 .
    BC136890 mRNA. Translation: AAI36891.1 .
    BC136891 mRNA. Translation: AAI36892.1 .
    BK004519 Genomic DNA. Translation: DAA04917.1 .
    CCDSi CCDS31514.1.
    RefSeqi NP_001005491.1. NM_001005491.1.
    UniGenei Hs.554525.

    3D structure databases

    ProteinModelPortali Q8NH19.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000311477.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NH19.

    Polymorphism databases

    DMDMi 38503050.

    Proteomic databases

    PaxDbi Q8NH19.
    PRIDEi Q8NH19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312345 ; ENSP00000311477 ; ENSG00000174970 .
    GeneIDi 282770.
    KEGGi hsa:282770.
    UCSCi uc010rit.2. human.

    Organism-specific databases

    CTDi 282770.
    GeneCardsi GC11M055737.
    HGNCi HGNC:19607. OR10AG1.
    neXtProti NX_Q8NH19.
    PharmGKBi PA134929321.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG330472.
    HOGENOMi HOG000041365.
    HOVERGENi HBG017625.
    InParanoidi Q8NH19.
    KOi K04257.
    OMAi NTTTIME.
    OrthoDBi EOG7X9G79.
    PhylomeDBi Q8NH19.
    TreeFami TF337350.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR10AG1.
    GenomeRNAii 282770.
    NextBioi 93500.
    PROi Q8NH19.

    Gene expression databases

    CleanExi HS_OR10AG1.
    Genevestigatori Q8NH19.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: IDENTIFICATION.
    5. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiO10AG_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH19
    Secondary accession number(s): B2RNH4, Q6IEU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 21, 2003
    Last sequence update: October 1, 2002
    Last modified: September 3, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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