Q8NH19 (O10AG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Olfactory receptor 10AG1

Alternative name(s):
Olfactory receptor OR11-160

Gene names

Name:

OR10AG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Odorant receptor Potential.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Biological process	Olfaction Sensory transduction
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	detection of chemical stimulus involved in sensory perception of smell Inferred from electronic annotation. Source: GOC
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW olfactory receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 301	301	Olfactory receptor 10AG1		PRO_0000150692
Regions
	Topological domain	1 – 16	16	Extracellular Potential
	Transmembrane	17 – 37	21	Helical; Name=1; Potential
	Topological domain	38 – 45	8	Cytoplasmic Potential
	Transmembrane	46 – 66	21	Helical; Name=2; Potential
	Topological domain	67 – 90	24	Extracellular Potential
	Transmembrane	91 – 111	21	Helical; Name=3; Potential
	Topological domain	112 – 130	19	Cytoplasmic Potential
	Transmembrane	131 – 151	21	Helical; Name=4; Potential
	Topological domain	152 – 188	37	Extracellular Potential
	Transmembrane	189 – 208	20	Helical; Name=5; Potential
	Topological domain	209 – 228	20	Cytoplasmic Potential
	Transmembrane	229 – 249	21	Helical; Name=6; Potential
	Topological domain	250 – 262	13	Extracellular Potential
	Transmembrane	263 – 283	21	Helical; Name=7; Potential
	Topological domain	284 – 301	18	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	82	1	N-linked (GlcNAc...) Potential
	Disulfide bond	88 ↔ 180		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8NH19 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: BDDC23BD2F3D6822	FASTA	301	34,105
	10 20 30 40 50 60 MEFVLLGFSD IPNLHWMLFS IFLLMYLMIL MCNGIIILLI KIHPALQTPM YFFLSNFSLL 70 80 90 100 110 120 EICYVTIIIP RMLMDIWTQK GNISLFACAT QMCFFLMLGG TECLLLTVMA YDRYVAICKP 130 140 150 160 170 180 LQYPLVMNHK VCIQLIIASW TITIPVVIGE TCQIFLLPFC GTNTINHFFC DIPPILKLAC 190 200 210 220 230 240 GNIFVNEITV HVVAVVFITV PFLLIVVSYG KIISNILKLS SARGKAKAFS TCSSHLIVVI 250 260 270 280 290 300 LFFGAGTITY LQPKPHQFQR MGKLISLFYT ILIPTLNPII YTLRNKDIMV ALRKLLAKLL T

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes." Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The human olfactory receptor gene family." Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[5]	Erratum Malnic B., Godfrey P.A., Buck L.B. Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Web resources

Human Olfactory Receptor Data Exploratorium (HORDE)

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB065594 Genomic DNA. Translation: BAC05822.1. CH471076 Genomic DNA. Translation: EAW73692.1. BC136890 mRNA. Translation: AAI36891.1. BC136891 mRNA. Translation: AAI36892.1. BK004519 Genomic DNA. Translation: DAA04917.1.
IPI	IPI00303621.
RefSeq	NP_001005491.1. NM_001005491.1.
UniGene	Hs.554525.
3D structure databases
ProteinModelPortal	Q8NH19.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000311477.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q8NH19.
Polymorphism databases
DMDM	38503050.
Proteomic databases
PaxDb	Q8NH19.
PRIDE	Q8NH19.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000312345; ENSP00000311477; ENSG00000174970.
GeneID	282770.
KEGG	hsa:282770.
UCSC	uc010rit.2. human.
Organism-specific databases
CTD	282770.
GeneCards	GC11M055737.
HGNC	HGNC:19607. OR10AG1.
neXtProt	NX_Q8NH19.
PharmGKB	PA134929321.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG330472.
HOGENOM	HOG000041365.
HOVERGEN	HBG017625.
InParanoid	Q8NH19.
KO	K04257.
OMA	NTTTIME.
OrthoDB	EOG4D26QB.
PhylomeDB	Q8NH19.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
CleanEx	HS_OR10AG1.
Genevestigator	Q8NH19.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR000725. Olfact_rcpt. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00245. OLFACTORYR.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	282770.
NextBio	93500.

Entry information

Entry name

O10AG_HUMAN

Accession

Primary (citable) accession number: Q8NH19
Secondary accession number(s): B2RNH4, Q6IEU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 21, 2003
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.