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Q8NH19 (O10AG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 10AG1
Alternative name(s):
Olfactory receptor OR11-160
Gene names
Name:OR10AG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301Olfactory receptor 10AG1
PRO_0000150692

Regions

Topological domain1 – 1616Extracellular Potential
Transmembrane17 – 3721Helical; Name=1; Potential
Topological domain38 – 458Cytoplasmic Potential
Transmembrane46 – 6621Helical; Name=2; Potential
Topological domain67 – 9024Extracellular Potential
Transmembrane91 – 11121Helical; Name=3; Potential
Topological domain112 – 13019Cytoplasmic Potential
Transmembrane131 – 15121Helical; Name=4; Potential
Topological domain152 – 18837Extracellular Potential
Transmembrane189 – 20820Helical; Name=5; Potential
Topological domain209 – 22820Cytoplasmic Potential
Transmembrane229 – 24921Helical; Name=6; Potential
Topological domain250 – 26213Extracellular Potential
Transmembrane263 – 28321Helical; Name=7; Potential
Topological domain284 – 30118Cytoplasmic Potential

Amino acid modifications

Glycosylation821N-linked (GlcNAc...) Potential
Disulfide bond88 ↔ 180 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8NH19 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: BDDC23BD2F3D6822

FASTA30134,105
        10         20         30         40         50         60 
MEFVLLGFSD IPNLHWMLFS IFLLMYLMIL MCNGIIILLI KIHPALQTPM YFFLSNFSLL 

        70         80         90        100        110        120 
EICYVTIIIP RMLMDIWTQK GNISLFACAT QMCFFLMLGG TECLLLTVMA YDRYVAICKP 

       130        140        150        160        170        180 
LQYPLVMNHK VCIQLIIASW TITIPVVIGE TCQIFLLPFC GTNTINHFFC DIPPILKLAC 

       190        200        210        220        230        240 
GNIFVNEITV HVVAVVFITV PFLLIVVSYG KIISNILKLS SARGKAKAFS TCSSHLIVVI 

       250        260        270        280        290        300 
LFFGAGTITY LQPKPHQFQR MGKLISLFYT ILIPTLNPII YTLRNKDIMV ALRKLLAKLL 


T 

« Hide

References

« Hide 'large scale' references
[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[5]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065594 Genomic DNA. Translation: BAC05822.1.
CH471076 Genomic DNA. Translation: EAW73692.1.
BC136890 mRNA. Translation: AAI36891.1.
BC136891 mRNA. Translation: AAI36892.1.
BK004519 Genomic DNA. Translation: DAA04917.1.
RefSeqNP_001005491.1. NM_001005491.1.
UniGeneHs.554525.

3D structure databases

ProteinModelPortalQ8NH19.
SMRQ8NH19. Positions 100-131, 270-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000311477.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8NH19.

Polymorphism databases

DMDM38503050.

Proteomic databases

PaxDbQ8NH19.
PRIDEQ8NH19.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312345; ENSP00000311477; ENSG00000174970.
GeneID282770.
KEGGhsa:282770.
UCSCuc010rit.2. human.

Organism-specific databases

CTD282770.
GeneCardsGC11M055737.
HGNCHGNC:19607. OR10AG1.
neXtProtNX_Q8NH19.
PharmGKBPA134929321.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG330472.
HOGENOMHOG000041365.
HOVERGENHBG017625.
InParanoidQ8NH19.
KOK04257.
OMANTTTIME.
OrthoDBEOG7X9G79.
PhylomeDBQ8NH19.
TreeFamTF337350.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR10AG1.
GenevestigatorQ8NH19.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR10AG1.
GenomeRNAi282770.
NextBio93500.
PROQ8NH19.

Entry information

Entry nameO10AG_HUMAN
AccessionPrimary (citable) accession number: Q8NH19
Secondary accession number(s): B2RNH4, Q6IEU3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries