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Q8NH19

- O10AG_HUMAN

UniProt

Q8NH19 - O10AG_HUMAN

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Protein

Olfactory receptor 10AG1

Gene

OR10AG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10AG1
Alternative name(s):
Olfactory receptor OR11-160
Gene namesi
Name:OR10AG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:19607. OR10AG1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616ExtracellularSequence AnalysisAdd
BLAST
Transmembranei17 – 3721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini38 – 458CytoplasmicSequence Analysis
Transmembranei46 – 6621Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini67 – 9024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei91 – 11121Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini112 – 13019CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei131 – 15121Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini152 – 18837ExtracellularSequence AnalysisAdd
BLAST
Transmembranei189 – 20820Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini209 – 22820CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei229 – 24921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini250 – 26213ExtracellularSequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini284 – 30118CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134929321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Olfactory receptor 10AG1PRO_0000150692Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi82 – 821N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi88 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH19.
PRIDEiQ8NH19.

PTM databases

PhosphoSiteiQ8NH19.

Expressioni

Gene expression databases

CleanExiHS_OR10AG1.
GenevestigatoriQ8NH19.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311477.

Structurei

3D structure databases

ProteinModelPortaliQ8NH19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330472.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH19.
KOiK04257.
OMAiNTTTIME.
OrthoDBiEOG7X9G79.
PhylomeDBiQ8NH19.
TreeFamiTF337350.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH19-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFVLLGFSD IPNLHWMLFS IFLLMYLMIL MCNGIIILLI KIHPALQTPM
60 70 80 90 100
YFFLSNFSLL EICYVTIIIP RMLMDIWTQK GNISLFACAT QMCFFLMLGG
110 120 130 140 150
TECLLLTVMA YDRYVAICKP LQYPLVMNHK VCIQLIIASW TITIPVVIGE
160 170 180 190 200
TCQIFLLPFC GTNTINHFFC DIPPILKLAC GNIFVNEITV HVVAVVFITV
210 220 230 240 250
PFLLIVVSYG KIISNILKLS SARGKAKAFS TCSSHLIVVI LFFGAGTITY
260 270 280 290 300
LQPKPHQFQR MGKLISLFYT ILIPTLNPII YTLRNKDIMV ALRKLLAKLL

T
Length:301
Mass (Da):34,105
Last modified:October 1, 2002 - v1
Checksum:iBDDC23BD2F3D6822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065594 Genomic DNA. Translation: BAC05822.1.
CH471076 Genomic DNA. Translation: EAW73692.1.
BC136890 mRNA. Translation: AAI36891.1.
BC136891 mRNA. Translation: AAI36892.1.
BK004519 Genomic DNA. Translation: DAA04917.1.
CCDSiCCDS31514.1.
RefSeqiNP_001005491.1. NM_001005491.1.
UniGeneiHs.554525.

Genome annotation databases

EnsembliENST00000312345; ENSP00000311477; ENSG00000174970.
GeneIDi282770.
KEGGihsa:282770.
UCSCiuc010rit.2. human.

Polymorphism databases

DMDMi38503050.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065594 Genomic DNA. Translation: BAC05822.1 .
CH471076 Genomic DNA. Translation: EAW73692.1 .
BC136890 mRNA. Translation: AAI36891.1 .
BC136891 mRNA. Translation: AAI36892.1 .
BK004519 Genomic DNA. Translation: DAA04917.1 .
CCDSi CCDS31514.1.
RefSeqi NP_001005491.1. NM_001005491.1.
UniGenei Hs.554525.

3D structure databases

ProteinModelPortali Q8NH19.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000311477.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NH19.

Polymorphism databases

DMDMi 38503050.

Proteomic databases

PaxDbi Q8NH19.
PRIDEi Q8NH19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312345 ; ENSP00000311477 ; ENSG00000174970 .
GeneIDi 282770.
KEGGi hsa:282770.
UCSCi uc010rit.2. human.

Organism-specific databases

CTDi 282770.
GeneCardsi GC11M055737.
HGNCi HGNC:19607. OR10AG1.
neXtProti NX_Q8NH19.
PharmGKBi PA134929321.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG330472.
GeneTreei ENSGT00760000119002.
HOGENOMi HOG000041365.
HOVERGENi HBG017625.
InParanoidi Q8NH19.
KOi K04257.
OMAi NTTTIME.
OrthoDBi EOG7X9G79.
PhylomeDBi Q8NH19.
TreeFami TF337350.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR10AG1.
GenomeRNAii 282770.
NextBioi 93500.
PROi Q8NH19.

Gene expression databases

CleanExi HS_OR10AG1.
Genevestigatori Q8NH19.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: IDENTIFICATION.
  5. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiO10AG_HUMAN
AccessioniPrimary (citable) accession number: Q8NH19
Secondary accession number(s): B2RNH4, Q6IEU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3