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Protein

Olfactory receptor 10AG1

Gene

OR10AG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174970-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 10AG1
Alternative name(s):
Olfactory receptor OR11-160
Gene namesi
Name:OR10AG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19607. OR10AG1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini38 – 45CytoplasmicSequence analysis8
Transmembranei46 – 66Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini67 – 90ExtracellularSequence analysisAdd BLAST24
Transmembranei91 – 111Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini112 – 130CytoplasmicSequence analysisAdd BLAST19
Transmembranei131 – 151Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini152 – 188ExtracellularSequence analysisAdd BLAST37
Transmembranei189 – 208Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini209 – 228CytoplasmicSequence analysisAdd BLAST20
Transmembranei229 – 249Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini250 – 262ExtracellularSequence analysisAdd BLAST13
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 301CytoplasmicSequence analysisAdd BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000174970.
PharmGKBiPA134929321.

Polymorphism and mutation databases

BioMutaiOR10AG1.
DMDMi38503050.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506921 – 301Olfactory receptor 10AG1Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi88 ↔ 180PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH19.
PeptideAtlasiQ8NH19.
PRIDEiQ8NH19.

PTM databases

iPTMnetiQ8NH19.
PhosphoSitePlusiQ8NH19.

Expressioni

Gene expression databases

CleanExiHS_OR10AG1.
ExpressionAtlasiQ8NH19. baseline.

Organism-specific databases

HPAiCAB002145.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000311477.

Structurei

3D structure databases

ProteinModelPortaliQ8NH19.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJMK. Eukaryota.
ENOG410YADW. LUCA.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH19.
KOiK04257.
OMAiPENSHIT.
OrthoDBiEOG091G0D7T.
PhylomeDBiQ8NH19.
TreeFamiTF337350.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVLLGFSD IPNLHWMLFS IFLLMYLMIL MCNGIIILLI KIHPALQTPM
60 70 80 90 100
YFFLSNFSLL EICYVTIIIP RMLMDIWTQK GNISLFACAT QMCFFLMLGG
110 120 130 140 150
TECLLLTVMA YDRYVAICKP LQYPLVMNHK VCIQLIIASW TITIPVVIGE
160 170 180 190 200
TCQIFLLPFC GTNTINHFFC DIPPILKLAC GNIFVNEITV HVVAVVFITV
210 220 230 240 250
PFLLIVVSYG KIISNILKLS SARGKAKAFS TCSSHLIVVI LFFGAGTITY
260 270 280 290 300
LQPKPHQFQR MGKLISLFYT ILIPTLNPII YTLRNKDIMV ALRKLLAKLL

T
Length:301
Mass (Da):34,105
Last modified:October 1, 2002 - v1
Checksum:iBDDC23BD2F3D6822
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065594 Genomic DNA. Translation: BAC05822.1.
CH471076 Genomic DNA. Translation: EAW73692.1.
BC136890 mRNA. Translation: AAI36891.1.
BC136891 mRNA. Translation: AAI36892.1.
BK004519 Genomic DNA. Translation: DAA04917.1.
CCDSiCCDS31514.1.
RefSeqiNP_001005491.1. NM_001005491.1.
UniGeneiHs.554525.

Genome annotation databases

EnsembliENST00000312345; ENSP00000311477; ENSG00000174970.
GeneIDi282770.
KEGGihsa:282770.
UCSCiuc010rit.2. human.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065594 Genomic DNA. Translation: BAC05822.1.
CH471076 Genomic DNA. Translation: EAW73692.1.
BC136890 mRNA. Translation: AAI36891.1.
BC136891 mRNA. Translation: AAI36892.1.
BK004519 Genomic DNA. Translation: DAA04917.1.
CCDSiCCDS31514.1.
RefSeqiNP_001005491.1. NM_001005491.1.
UniGeneiHs.554525.

3D structure databases

ProteinModelPortaliQ8NH19.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000311477.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH19.
PhosphoSitePlusiQ8NH19.

Polymorphism and mutation databases

BioMutaiOR10AG1.
DMDMi38503050.

Proteomic databases

PaxDbiQ8NH19.
PeptideAtlasiQ8NH19.
PRIDEiQ8NH19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000312345; ENSP00000311477; ENSG00000174970.
GeneIDi282770.
KEGGihsa:282770.
UCSCiuc010rit.2. human.

Organism-specific databases

CTDi282770.
GeneCardsiOR10AG1.
HGNCiHGNC:19607. OR10AG1.
HPAiCAB002145.
neXtProtiNX_Q8NH19.
OpenTargetsiENSG00000174970.
PharmGKBiPA134929321.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJMK. Eukaryota.
ENOG410YADW. LUCA.
GeneTreeiENSGT00760000119002.
HOGENOMiHOG000041365.
HOVERGENiHBG017625.
InParanoidiQ8NH19.
KOiK04257.
OMAiPENSHIT.
OrthoDBiEOG091G0D7T.
PhylomeDBiQ8NH19.
TreeFamiTF337350.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174970-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR10AG1.
GenomeRNAii282770.
PROiQ8NH19.

Gene expression databases

CleanExiHS_OR10AG1.
ExpressionAtlasiQ8NH19. baseline.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiO10AG_HUMAN
AccessioniPrimary (citable) accession number: Q8NH19
Secondary accession number(s): B2RNH4, Q6IEU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.