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Q8NH18

- OR5J2_HUMAN

UniProt

Q8NH18 - OR5J2_HUMAN

Protein

Olfactory receptor 5J2

Gene

OR5J2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 5J2
    Alternative name(s):
    Olfactory receptor OR11-266
    Gene namesi
    Name:OR5J2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:19612. OR5J2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134982020.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 5J2PRO_0000150599Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH18.
    PRIDEiQ8NH18.

    Expressioni

    Gene expression databases

    CleanExiHS_OR5J2.
    GenevestigatoriQ8NH18.

    Organism-specific databases

    HPAiHPA059466.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000310788.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH18.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini47 – 548CytoplasmicSequence Analysis
    Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG42357.
    HOGENOMiHOG000041364.
    HOVERGENiHBG017625.
    InParanoidiQ8NH18.
    KOiK04257.
    OMAiCIVQHLF.
    OrthoDBiEOG71K63J.
    PhylomeDBiQ8NH18.
    TreeFamiTF352748.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH18-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADDNFTVVT EFILLGLTDH AELKAVLFVV FLVIYAITLL RNLGMILLIQ    50
    ITSKLHTPMY FLLSCLSFVD ACYSSAIAPK MLVNLLVVKA TISFSACMVQ 100
    HLCFGVFITT EGFLLSVMAY DRYVAIVSPL LYTVAMSDRK CVELVTGSWI 150
    GGIVNTLIHT ISLRRLSFCR LNAVSHFFCD IPSLLKLSCS DTSMNELLLL 200
    TFSGVIAMAT FLTVIISYIF IAFASLRIHS ASGRQQAFST CASHLTAVTI 250
    FYGTLIFSYI QPSSQYFVEQ EKVVSMFYTL GIPMLNLLIH SLRNKDVKEA 300
    VKRAIEMKHF LC 312
    Length:312
    Mass (Da):34,808
    Last modified:October 1, 2002 - v1
    Checksum:iF21D7E3DB3D02B70
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti136 – 1361M → I.
    Corresponds to variant rs12279899 [ dbSNP | Ensembl ].
    VAR_034226

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065595 Genomic DNA. Translation: BAC05823.1.
    BK004517 Genomic DNA. Translation: DAA04915.1.
    CCDSiCCDS31522.1.
    RefSeqiNP_001005492.1. NM_001005492.1.
    UniGeneiHs.537145.

    Genome annotation databases

    EnsembliENST00000312298; ENSP00000310788; ENSG00000174957.
    GeneIDi282775.
    KEGGihsa:282775.
    UCSCiuc010rjb.2. human.

    Polymorphism databases

    DMDMi38372500.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065595 Genomic DNA. Translation: BAC05823.1 .
    BK004517 Genomic DNA. Translation: DAA04915.1 .
    CCDSi CCDS31522.1.
    RefSeqi NP_001005492.1. NM_001005492.1.
    UniGenei Hs.537145.

    3D structure databases

    ProteinModelPortali Q8NH18.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000310788.

    Protein family/group databases

    GPCRDBi Search...

    Polymorphism databases

    DMDMi 38372500.

    Proteomic databases

    PaxDbi Q8NH18.
    PRIDEi Q8NH18.

    Protocols and materials databases

    DNASUi 282775.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000312298 ; ENSP00000310788 ; ENSG00000174957 .
    GeneIDi 282775.
    KEGGi hsa:282775.
    UCSCi uc010rjb.2. human.

    Organism-specific databases

    CTDi 282775.
    GeneCardsi GC11P055944.
    H-InvDB HIX0171361.
    HGNCi HGNC:19612. OR5J2.
    HPAi HPA059466.
    neXtProti NX_Q8NH18.
    PharmGKBi PA134982020.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG42357.
    HOGENOMi HOG000041364.
    HOVERGENi HBG017625.
    InParanoidi Q8NH18.
    KOi K04257.
    OMAi CIVQHLF.
    OrthoDBi EOG71K63J.
    PhylomeDBi Q8NH18.
    TreeFami TF352748.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR5J2.
    GenomeRNAii 282775.
    NextBioi 93504.
    PROi Q8NH18.

    Gene expression databases

    CleanExi HS_OR5J2.
    Genevestigatori Q8NH18.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: IDENTIFICATION.
    3. Erratum
      Malnic B., Godfrey P.A., Buck L.B.
      Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

    Entry informationi

    Entry nameiOR5J2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH18
    Secondary accession number(s): Q6IEU5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 14, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3