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Protein

Olfactory receptor 5J2

Gene

OR5J2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5J2
Alternative name(s):
Olfactory receptor OR11-266
Gene namesi
Name:OR5J2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19612. OR5J2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 196ExtracellularSequence analysisAdd BLAST36
Transmembranei197 – 217Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 312CytoplasmicSequence analysisAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982020.

Polymorphism and mutation databases

BioMutaiOR5J2.
DMDMi38372500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505991 – 312Olfactory receptor 5J2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH18.
PeptideAtlasiQ8NH18.
PRIDEiQ8NH18.

PTM databases

PhosphoSitePlusiQ8NH18.

Expressioni

Gene expression databases

CleanExiHS_OR5J2.
ExpressionAtlasiQ8NH18. baseline and differential.
GenevisibleiQ8NH18. HS.

Organism-specific databases

HPAiHPA059466.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310788.

Structurei

3D structure databases

ProteinModelPortaliQ8NH18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIU6. Eukaryota.
ENOG4111BJM. LUCA.
GeneTreeiENSGT00860000133742.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH18.
KOiK04257.
OMAiCIVQHLF.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH18.
TreeFamiTF352748.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
PRINTSiPR00245. OLFACTORYR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8NH18-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDNFTVVT EFILLGLTDH AELKAVLFVV FLVIYAITLL RNLGMILLIQ
60 70 80 90 100
ITSKLHTPMY FLLSCLSFVD ACYSSAIAPK MLVNLLVVKA TISFSACMVQ
110 120 130 140 150
HLCFGVFITT EGFLLSVMAY DRYVAIVSPL LYTVAMSDRK CVELVTGSWI
160 170 180 190 200
GGIVNTLIHT ISLRRLSFCR LNAVSHFFCD IPSLLKLSCS DTSMNELLLL
210 220 230 240 250
TFSGVIAMAT FLTVIISYIF IAFASLRIHS ASGRQQAFST CASHLTAVTI
260 270 280 290 300
FYGTLIFSYI QPSSQYFVEQ EKVVSMFYTL GIPMLNLLIH SLRNKDVKEA
310
VKRAIEMKHF LC
Length:312
Mass (Da):34,808
Last modified:October 1, 2002 - v1
Checksum:iF21D7E3DB3D02B70
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034226136M → I. Corresponds to variant dbSNP:rs12279899Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065595 Genomic DNA. Translation: BAC05823.1.
BK004517 Genomic DNA. Translation: DAA04915.1.
CCDSiCCDS31522.1.
RefSeqiNP_001005492.1. NM_001005492.1.
UniGeneiHs.537145.

Genome annotation databases

EnsembliENST00000312298; ENSP00000310788; ENSG00000174957.
GeneIDi282775.
KEGGihsa:282775.
UCSCiuc010rjb.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiOR5J2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH18
Secondary accession number(s): Q6IEU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: May 10, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families