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Q8NH18 (OR5J2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Olfactory receptor 5J2
Alternative name(s):
Olfactory receptor OR11-266
Gene names
Name:OR5J2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Odorant receptor Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Olfactory receptor 5J2
PRO_0000150599

Regions

Topological domain1 – 2525Extracellular Potential
Transmembrane26 – 4621Helical; Name=1; Potential
Topological domain47 – 548Cytoplasmic Potential
Transmembrane55 – 7521Helical; Name=2; Potential
Topological domain76 – 9924Extracellular Potential
Transmembrane100 – 12021Helical; Name=3; Potential
Topological domain121 – 13919Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 19636Extracellular Potential
Transmembrane197 – 21721Helical; Name=5; Potential
Topological domain218 – 23720Cytoplasmic Potential
Transmembrane238 – 25821Helical; Name=6; Potential
Topological domain259 – 27113Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31220Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Disulfide bond97 ↔ 189 By similarity

Natural variations

Natural variant1361M → I.
Corresponds to variant rs12279899 [ dbSNP | Ensembl ].
VAR_034226

Sequences

Sequence LengthMass (Da)Tools
Q8NH18 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: F21D7E3DB3D02B70

FASTA31234,808
        10         20         30         40         50         60 
MADDNFTVVT EFILLGLTDH AELKAVLFVV FLVIYAITLL RNLGMILLIQ ITSKLHTPMY 

        70         80         90        100        110        120 
FLLSCLSFVD ACYSSAIAPK MLVNLLVVKA TISFSACMVQ HLCFGVFITT EGFLLSVMAY 

       130        140        150        160        170        180 
DRYVAIVSPL LYTVAMSDRK CVELVTGSWI GGIVNTLIHT ISLRRLSFCR LNAVSHFFCD 

       190        200        210        220        230        240 
IPSLLKLSCS DTSMNELLLL TFSGVIAMAT FLTVIISYIF IAFASLRIHS ASGRQQAFST 

       250        260        270        280        290        300 
CASHLTAVTI FYGTLIFSYI QPSSQYFVEQ EKVVSMFYTL GIPMLNLLIH SLRNKDVKEA 

       310 
VKRAIEMKHF LC 

« Hide

References

[1]"Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The human olfactory receptor gene family."
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[3]Erratum
Malnic B., Godfrey P.A., Buck L.B.
Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB065595 Genomic DNA. Translation: BAC05823.1.
BK004517 Genomic DNA. Translation: DAA04915.1.
CCDSCCDS31522.1.
RefSeqNP_001005492.1. NM_001005492.1.
UniGeneHs.537145.

3D structure databases

ProteinModelPortalQ8NH18.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000310788.

Protein family/group databases

GPCRDBSearch...

Polymorphism databases

DMDM38372500.

Proteomic databases

PaxDbQ8NH18.
PRIDEQ8NH18.

Protocols and materials databases

DNASU282775.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000312298; ENSP00000310788; ENSG00000174957.
GeneID282775.
KEGGhsa:282775.
UCSCuc010rjb.2. human.

Organism-specific databases

CTD282775.
GeneCardsGC11P055944.
H-InvDBHIX0171361.
HGNCHGNC:19612. OR5J2.
HPAHPA059466.
neXtProtNX_Q8NH18.
PharmGKBPA134982020.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG42357.
HOGENOMHOG000041364.
HOVERGENHBG017625.
InParanoidQ8NH18.
KOK04257.
OMACIVQHLF.
OrthoDBEOG71K63J.
PhylomeDBQ8NH18.
TreeFamTF352748.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

CleanExHS_OR5J2.
GenevestigatorQ8NH18.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSPR00245. OLFACTORYR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiOR5J2.
GenomeRNAi282775.
NextBio93504.
PROQ8NH18.

Entry information

Entry nameOR5J2_HUMAN
AccessionPrimary (citable) accession number: Q8NH18
Secondary accession number(s): Q6IEU5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries