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Q8NH18

- OR5J2_HUMAN

UniProt

Q8NH18 - OR5J2_HUMAN

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Protein

Olfactory receptor 5J2

Gene

OR5J2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 5J2
Alternative name(s):
Olfactory receptor OR11-266
Gene namesi
Name:OR5J2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:19612. OR5J2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence AnalysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence Analysis
Transmembranei55 – 7521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini161 – 19636ExtracellularSequence AnalysisAdd
BLAST
Transmembranei197 – 21721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini293 – 31220CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134982020.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 5J2PRO_0000150599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH18.
PRIDEiQ8NH18.

Expressioni

Gene expression databases

CleanExiHS_OR5J2.
GenevestigatoriQ8NH18.

Organism-specific databases

HPAiHPA059466.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000310788.

Structurei

3D structure databases

ProteinModelPortaliQ8NH18.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG42357.
GeneTreeiENSGT00760000118942.
HOGENOMiHOG000041364.
HOVERGENiHBG017625.
InParanoidiQ8NH18.
KOiK04257.
OMAiCIVQHLF.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH18.
TreeFamiTF352748.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH18-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADDNFTVVT EFILLGLTDH AELKAVLFVV FLVIYAITLL RNLGMILLIQ
60 70 80 90 100
ITSKLHTPMY FLLSCLSFVD ACYSSAIAPK MLVNLLVVKA TISFSACMVQ
110 120 130 140 150
HLCFGVFITT EGFLLSVMAY DRYVAIVSPL LYTVAMSDRK CVELVTGSWI
160 170 180 190 200
GGIVNTLIHT ISLRRLSFCR LNAVSHFFCD IPSLLKLSCS DTSMNELLLL
210 220 230 240 250
TFSGVIAMAT FLTVIISYIF IAFASLRIHS ASGRQQAFST CASHLTAVTI
260 270 280 290 300
FYGTLIFSYI QPSSQYFVEQ EKVVSMFYTL GIPMLNLLIH SLRNKDVKEA
310
VKRAIEMKHF LC
Length:312
Mass (Da):34,808
Last modified:October 1, 2002 - v1
Checksum:iF21D7E3DB3D02B70
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti136 – 1361M → I.
Corresponds to variant rs12279899 [ dbSNP | Ensembl ].
VAR_034226

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065595 Genomic DNA. Translation: BAC05823.1.
BK004517 Genomic DNA. Translation: DAA04915.1.
CCDSiCCDS31522.1.
RefSeqiNP_001005492.1. NM_001005492.1.
UniGeneiHs.537145.

Genome annotation databases

EnsembliENST00000312298; ENSP00000310788; ENSG00000174957.
GeneIDi282775.
KEGGihsa:282775.
UCSCiuc010rjb.2. human.

Polymorphism databases

DMDMi38372500.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065595 Genomic DNA. Translation: BAC05823.1 .
BK004517 Genomic DNA. Translation: DAA04915.1 .
CCDSi CCDS31522.1.
RefSeqi NP_001005492.1. NM_001005492.1.
UniGenei Hs.537145.

3D structure databases

ProteinModelPortali Q8NH18.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000310788.

Protein family/group databases

GPCRDBi Search...

Polymorphism databases

DMDMi 38372500.

Proteomic databases

PaxDbi Q8NH18.
PRIDEi Q8NH18.

Protocols and materials databases

DNASUi 282775.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000312298 ; ENSP00000310788 ; ENSG00000174957 .
GeneIDi 282775.
KEGGi hsa:282775.
UCSCi uc010rjb.2. human.

Organism-specific databases

CTDi 282775.
GeneCardsi GC11P055944.
H-InvDB HIX0171361.
HGNCi HGNC:19612. OR5J2.
HPAi HPA059466.
neXtProti NX_Q8NH18.
PharmGKBi PA134982020.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG42357.
GeneTreei ENSGT00760000118942.
HOGENOMi HOG000041364.
HOVERGENi HBG017625.
InParanoidi Q8NH18.
KOi K04257.
OMAi CIVQHLF.
OrthoDBi EOG71K63J.
PhylomeDBi Q8NH18.
TreeFami TF352748.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR5J2.
GenomeRNAii 282775.
NextBioi 93504.
PROi Q8NH18.

Gene expression databases

CleanExi HS_OR5J2.
Genevestigatori Q8NH18.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: IDENTIFICATION.
  3. Erratum
    Malnic B., Godfrey P.A., Buck L.B.
    Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004)

Entry informationi

Entry nameiOR5J2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH18
Secondary accession number(s): Q6IEU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 14, 2003
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3