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Q8NH16

- OR2L2_HUMAN

UniProt

Q8NH16 - OR2L2_HUMAN

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Protein
Olfactory receptor 2L2
Gene
OR2L2, OR2L12, OR2L4P
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Odorant receptor Reviewed prediction.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. olfactory receptor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2L2
Alternative name(s):
HTPCRH07
Olfactory receptor 2L12
Olfactory receptor 2L4
Gene namesi
Name:OR2L2
Synonyms:OR2L12, OR2L4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:8266. OR2L2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424Extracellular Reviewed prediction
Add
BLAST
Transmembranei25 – 4824Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini49 – 568Cytoplasmic Reviewed prediction
Transmembranei57 – 7822Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini79 – 9921Extracellular Reviewed prediction
Add
BLAST
Transmembranei100 – 11920Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini120 – 13819Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei139 – 15719Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini158 – 19437Extracellular Reviewed prediction
Add
BLAST
Transmembranei195 – 21824Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini219 – 23517Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei236 – 25823Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini259 – 27113Extracellular Reviewed prediction
Add
BLAST
Transmembranei272 – 29120Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini292 – 31221Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32183.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2L2
PRO_0000150486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Glycosylationi88 – 881N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi96 ↔ 188 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH16.
PRIDEiQ8NH16.

PTM databases

PhosphoSiteiQ8NH16.

Expressioni

Gene expression databases

BgeeiQ8NH16.
CleanExiHS_OR2L2.
GenevestigatoriQ8NH16.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355435.

Structurei

3D structure databases

ProteinModelPortaliQ8NH16.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272740.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH16.
KOiK04257.
OMAiVPKMVYD.
OrthoDBiEOG7M0NRV.
PhylomeDBiQ8NH16.
TreeFamiTF337295.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH16-1 [UniParc]FASTAAdd to Basket

« Hide

MENYNQTSTD FILLGLFPQS RIGLFVFTLI FLIFLMALIG NLSMILLIFL    50
DIHLHTPMYF LLSQLSLIDL NYISTIVPKM VYDFLYGNKS ISFTGCGIQS 100
FFFLTLAVAE GLLLTSMAYD RYVAICFPLH YPIRISKRVC VMMITGSWMI 150
SSINSCAHTV YALCIPYCKS RAINHFFCDV PAMLTLACTD TWVYESTVFL 200
SSTIFLVLPF TGIACSYGRV LLAVYRMHSA EGRKKAYSTC STHLTVVSFY 250
YAPFAYTYVR PRSLRSPTED KILAVFYTIL TPMLNPIIYS LRNKEVMGAL 300
TQVIQKIFSV KM 312
Length:312
Mass (Da):35,495
Last modified:October 1, 2002 - v1
Checksum:iC85F0368D685C1DE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491F → L.
Corresponds to variant rs12134979 [ dbSNP | Ensembl ].
VAR_053144
Natural varianti259 – 2591V → L.
Corresponds to variant rs6658141 [ dbSNP | Ensembl ].
VAR_053145

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065597 Genomic DNA. Translation: BAC05825.1.
BC104792 mRNA. Translation: AAI04793.1.
BC104794 mRNA. Translation: AAI04795.1.
X64978 mRNA. No translation available.
CCDSiCCDS31103.1.
RefSeqiNP_001004686.1. NM_001004686.2.
UniGeneiHs.684888.

Genome annotation databases

EnsembliENST00000366479; ENSP00000355435; ENSG00000203663.
GeneIDi26246.
KEGGihsa:26246.
UCSCiuc001idw.3. human.

Polymorphism databases

DMDMi38258181.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB065597 Genomic DNA. Translation: BAC05825.1 .
BC104792 mRNA. Translation: AAI04793.1 .
BC104794 mRNA. Translation: AAI04795.1 .
X64978 mRNA. No translation available.
CCDSi CCDS31103.1.
RefSeqi NP_001004686.1. NM_001004686.2.
UniGenei Hs.684888.

3D structure databases

ProteinModelPortali Q8NH16.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000355435.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8NH16.

Polymorphism databases

DMDMi 38258181.

Proteomic databases

PaxDbi Q8NH16.
PRIDEi Q8NH16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000366479 ; ENSP00000355435 ; ENSG00000203663 .
GeneIDi 26246.
KEGGi hsa:26246.
UCSCi uc001idw.3. human.

Organism-specific databases

CTDi 26246.
GeneCardsi GC01P248201.
HGNCi HGNC:8266. OR2L2.
neXtProti NX_Q8NH16.
PharmGKBi PA32183.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272740.
HOGENOMi HOG000041362.
HOVERGENi HBG017625.
InParanoidi Q8NH16.
KOi K04257.
OMAi VPKMVYD.
OrthoDBi EOG7M0NRV.
PhylomeDBi Q8NH16.
TreeFami TF337295.

Enzyme and pathway databases

Reactomei REACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikii OR2L2.
GenomeRNAii 26246.
NextBioi 48449.
PROi Q8NH16.

Gene expression databases

Bgeei Q8NH16.
CleanExi HS_OR2L2.
Genevestigatori Q8NH16.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-238.
    Tissue: Testis.

Entry informationi

Entry nameiOR2L2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH16
Secondary accession number(s): Q2M3T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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