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Protein

Olfactory receptor 2L2

Gene

OR2L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:G66-30819-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2L2
Alternative name(s):
HTPCRH07
Olfactory receptor 2L12
Olfactory receptor 2L4
Gene namesi
Name:OR2L2
Synonyms:OR2L12, OR2L4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8266. OR2L2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24ExtracellularSequence analysisAdd BLAST24
Transmembranei25 – 48Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini49 – 56CytoplasmicSequence analysis8
Transmembranei57 – 78Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini79 – 99ExtracellularSequence analysisAdd BLAST21
Transmembranei100 – 119Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini120 – 138CytoplasmicSequence analysisAdd BLAST19
Transmembranei139 – 157Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini158 – 194ExtracellularSequence analysisAdd BLAST37
Transmembranei195 – 218Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini219 – 235CytoplasmicSequence analysisAdd BLAST17
Transmembranei236 – 258Helical; Name=6Sequence analysisAdd BLAST23
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 291Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini292 – 312CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26246.
OpenTargetsiENSG00000203663.
PharmGKBiPA32183.

Polymorphism and mutation databases

BioMutaiOR2L2.
DMDMi38258181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001504861 – 312Olfactory receptor 2L2Add BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi88N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH16.
PRIDEiQ8NH16.

PTM databases

iPTMnetiQ8NH16.
PhosphoSitePlusiQ8NH16.

Expressioni

Gene expression databases

BgeeiENSG00000203663.
CleanExiHS_OR2L2.
ExpressionAtlasiQ8NH16. baseline and differential.
GenevisibleiQ8NH16. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355435.

Structurei

3D structure databases

ProteinModelPortaliQ8NH16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIYV. Eukaryota.
ENOG41116WC. LUCA.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH16.
KOiK04257.
OMAiSWMISSI.
OrthoDBiEOG091G0F82.
PhylomeDBiQ8NH16.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYNQTSTD FILLGLFPQS RIGLFVFTLI FLIFLMALIG NLSMILLIFL
60 70 80 90 100
DIHLHTPMYF LLSQLSLIDL NYISTIVPKM VYDFLYGNKS ISFTGCGIQS
110 120 130 140 150
FFFLTLAVAE GLLLTSMAYD RYVAICFPLH YPIRISKRVC VMMITGSWMI
160 170 180 190 200
SSINSCAHTV YALCIPYCKS RAINHFFCDV PAMLTLACTD TWVYESTVFL
210 220 230 240 250
SSTIFLVLPF TGIACSYGRV LLAVYRMHSA EGRKKAYSTC STHLTVVSFY
260 270 280 290 300
YAPFAYTYVR PRSLRSPTED KILAVFYTIL TPMLNPIIYS LRNKEVMGAL
310
TQVIQKIFSV KM
Length:312
Mass (Da):35,495
Last modified:October 1, 2002 - v1
Checksum:iC85F0368D685C1DE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053144249F → L.Corresponds to variant rs12134979dbSNPEnsembl.1
Natural variantiVAR_053145259V → L.Corresponds to variant rs6658141dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065597 Genomic DNA. Translation: BAC05825.1.
BC104792 mRNA. Translation: AAI04793.1.
BC104794 mRNA. Translation: AAI04795.1.
X64978 mRNA. No translation available.
CCDSiCCDS31103.1.
RefSeqiNP_001004686.1. NM_001004686.2.
XP_011542460.1. XM_011544158.2.
UniGeneiHs.684888.

Genome annotation databases

EnsembliENST00000366479; ENSP00000355435; ENSG00000203663.
GeneIDi26246.
KEGGihsa:26246.
UCSCiuc001idw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065597 Genomic DNA. Translation: BAC05825.1.
BC104792 mRNA. Translation: AAI04793.1.
BC104794 mRNA. Translation: AAI04795.1.
X64978 mRNA. No translation available.
CCDSiCCDS31103.1.
RefSeqiNP_001004686.1. NM_001004686.2.
XP_011542460.1. XM_011544158.2.
UniGeneiHs.684888.

3D structure databases

ProteinModelPortaliQ8NH16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355435.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ8NH16.
PhosphoSitePlusiQ8NH16.

Polymorphism and mutation databases

BioMutaiOR2L2.
DMDMi38258181.

Proteomic databases

PaxDbiQ8NH16.
PRIDEiQ8NH16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366479; ENSP00000355435; ENSG00000203663.
GeneIDi26246.
KEGGihsa:26246.
UCSCiuc001idw.4. human.

Organism-specific databases

CTDi26246.
DisGeNETi26246.
GeneCardsiOR2L2.
HGNCiHGNC:8266. OR2L2.
neXtProtiNX_Q8NH16.
OpenTargetsiENSG00000203663.
PharmGKBiPA32183.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIYV. Eukaryota.
ENOG41116WC. LUCA.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH16.
KOiK04257.
OMAiSWMISSI.
OrthoDBiEOG091G0F82.
PhylomeDBiQ8NH16.
TreeFamiTF337295.

Enzyme and pathway databases

BioCyciZFISH:G66-30819-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2L2.
GenomeRNAii26246.
PROiQ8NH16.

Gene expression databases

BgeeiENSG00000203663.
CleanExiHS_OR2L2.
ExpressionAtlasiQ8NH16. baseline and differential.
GenevisibleiQ8NH16. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR2L2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH16
Secondary accession number(s): Q2M3T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.