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Q8NH16

- OR2L2_HUMAN

UniProt

Q8NH16 - OR2L2_HUMAN

Protein

Olfactory receptor 2L2

Gene

OR2L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Odorant receptor.Curated

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. olfactory receptor activity Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Olfaction, Sensory transduction

    Enzyme and pathway databases

    ReactomeiREACT_15488. Olfactory Signaling Pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Olfactory receptor 2L2
    Alternative name(s):
    HTPCRH07
    Olfactory receptor 2L12
    Olfactory receptor 2L4
    Gene namesi
    Name:OR2L2
    Synonyms:OR2L12, OR2L4P
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:8266. OR2L2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA32183.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312Olfactory receptor 2L2PRO_0000150486Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ8NH16.
    PRIDEiQ8NH16.

    PTM databases

    PhosphoSiteiQ8NH16.

    Expressioni

    Gene expression databases

    BgeeiQ8NH16.
    CleanExiHS_OR2L2.
    GenevestigatoriQ8NH16.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000355435.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8NH16.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini49 – 568CytoplasmicSequence Analysis
    Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272740.
    HOGENOMiHOG000041362.
    HOVERGENiHBG017625.
    InParanoidiQ8NH16.
    KOiK04257.
    OMAiVPKMVYD.
    OrthoDBiEOG7M0NRV.
    PhylomeDBiQ8NH16.
    TreeFamiTF337295.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8NH16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENYNQTSTD FILLGLFPQS RIGLFVFTLI FLIFLMALIG NLSMILLIFL    50
    DIHLHTPMYF LLSQLSLIDL NYISTIVPKM VYDFLYGNKS ISFTGCGIQS 100
    FFFLTLAVAE GLLLTSMAYD RYVAICFPLH YPIRISKRVC VMMITGSWMI 150
    SSINSCAHTV YALCIPYCKS RAINHFFCDV PAMLTLACTD TWVYESTVFL 200
    SSTIFLVLPF TGIACSYGRV LLAVYRMHSA EGRKKAYSTC STHLTVVSFY 250
    YAPFAYTYVR PRSLRSPTED KILAVFYTIL TPMLNPIIYS LRNKEVMGAL 300
    TQVIQKIFSV KM 312
    Length:312
    Mass (Da):35,495
    Last modified:October 1, 2002 - v1
    Checksum:iC85F0368D685C1DE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti249 – 2491F → L.
    Corresponds to variant rs12134979 [ dbSNP | Ensembl ].
    VAR_053144
    Natural varianti259 – 2591V → L.
    Corresponds to variant rs6658141 [ dbSNP | Ensembl ].
    VAR_053145

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065597 Genomic DNA. Translation: BAC05825.1.
    BC104792 mRNA. Translation: AAI04793.1.
    BC104794 mRNA. Translation: AAI04795.1.
    X64978 mRNA. No translation available.
    CCDSiCCDS31103.1.
    RefSeqiNP_001004686.1. NM_001004686.2.
    UniGeneiHs.684888.

    Genome annotation databases

    EnsembliENST00000366479; ENSP00000355435; ENSG00000203663.
    GeneIDi26246.
    KEGGihsa:26246.
    UCSCiuc001idw.3. human.

    Polymorphism databases

    DMDMi38258181.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Human Olfactory Receptor Data Exploratorium (HORDE)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB065597 Genomic DNA. Translation: BAC05825.1 .
    BC104792 mRNA. Translation: AAI04793.1 .
    BC104794 mRNA. Translation: AAI04795.1 .
    X64978 mRNA. No translation available.
    CCDSi CCDS31103.1.
    RefSeqi NP_001004686.1. NM_001004686.2.
    UniGenei Hs.684888.

    3D structure databases

    ProteinModelPortali Q8NH16.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000355435.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8NH16.

    Polymorphism databases

    DMDMi 38258181.

    Proteomic databases

    PaxDbi Q8NH16.
    PRIDEi Q8NH16.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000366479 ; ENSP00000355435 ; ENSG00000203663 .
    GeneIDi 26246.
    KEGGi hsa:26246.
    UCSCi uc001idw.3. human.

    Organism-specific databases

    CTDi 26246.
    GeneCardsi GC01P248201.
    HGNCi HGNC:8266. OR2L2.
    neXtProti NX_Q8NH16.
    PharmGKBi PA32183.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272740.
    HOGENOMi HOG000041362.
    HOVERGENi HBG017625.
    InParanoidi Q8NH16.
    KOi K04257.
    OMAi VPKMVYD.
    OrthoDBi EOG7M0NRV.
    PhylomeDBi Q8NH16.
    TreeFami TF337295.

    Enzyme and pathway databases

    Reactomei REACT_15488. Olfactory Signaling Pathway.

    Miscellaneous databases

    GeneWikii OR2L2.
    GenomeRNAii 26246.
    NextBioi 48449.
    PROi Q8NH16.

    Gene expression databases

    Bgeei Q8NH16.
    CleanExi HS_OR2L2.
    Genevestigatori Q8NH16.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000725. Olfact_rcpt.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00245. OLFACTORYR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
      Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
      Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
      Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-238.
      Tissue: Testis.

    Entry informationi

    Entry nameiOR2L2_HUMAN
    AccessioniPrimary (citable) accession number: Q8NH16
    Secondary accession number(s): Q2M3T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3