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Protein

Olfactory receptor 2L2

Gene

OR2L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 2L2
Alternative name(s):
HTPCRH07
Olfactory receptor 2L12
Olfactory receptor 2L4
Gene namesi
Name:OR2L2
Synonyms:OR2L12, OR2L4P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:8266. OR2L2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei25 – 4824Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini49 – 568CytoplasmicSequence Analysis
Transmembranei57 – 7822Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini79 – 9921ExtracellularSequence AnalysisAdd
BLAST
Transmembranei100 – 11920Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini120 – 13819CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei139 – 15719Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini158 – 19437ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21824Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini219 – 23517CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei236 – 25823Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei272 – 29120Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini292 – 31221CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA32183.

Polymorphism and mutation databases

BioMutaiOR2L2.
DMDMi38258181.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Olfactory receptor 2L2PRO_0000150486Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi96 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH16.
PRIDEiQ8NH16.

PTM databases

PhosphoSiteiQ8NH16.

Expressioni

Gene expression databases

BgeeiQ8NH16.
CleanExiHS_OR2L2.
GenevisibleiQ8NH16. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355435.

Structurei

3D structure databases

ProteinModelPortaliQ8NH16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272740.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH16.
KOiK04257.
OMAiFLDIHLH.
OrthoDBiEOG7M0NRV.
PhylomeDBiQ8NH16.
TreeFamiTF337295.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENYNQTSTD FILLGLFPQS RIGLFVFTLI FLIFLMALIG NLSMILLIFL
60 70 80 90 100
DIHLHTPMYF LLSQLSLIDL NYISTIVPKM VYDFLYGNKS ISFTGCGIQS
110 120 130 140 150
FFFLTLAVAE GLLLTSMAYD RYVAICFPLH YPIRISKRVC VMMITGSWMI
160 170 180 190 200
SSINSCAHTV YALCIPYCKS RAINHFFCDV PAMLTLACTD TWVYESTVFL
210 220 230 240 250
SSTIFLVLPF TGIACSYGRV LLAVYRMHSA EGRKKAYSTC STHLTVVSFY
260 270 280 290 300
YAPFAYTYVR PRSLRSPTED KILAVFYTIL TPMLNPIIYS LRNKEVMGAL
310
TQVIQKIFSV KM
Length:312
Mass (Da):35,495
Last modified:October 1, 2002 - v1
Checksum:iC85F0368D685C1DE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491F → L.
Corresponds to variant rs12134979 [ dbSNP | Ensembl ].
VAR_053144
Natural varianti259 – 2591V → L.
Corresponds to variant rs6658141 [ dbSNP | Ensembl ].
VAR_053145

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065597 Genomic DNA. Translation: BAC05825.1.
BC104792 mRNA. Translation: AAI04793.1.
BC104794 mRNA. Translation: AAI04795.1.
X64978 mRNA. No translation available.
CCDSiCCDS31103.1.
RefSeqiNP_001004686.1. NM_001004686.2.
UniGeneiHs.684888.

Genome annotation databases

EnsembliENST00000366479; ENSP00000355435; ENSG00000203663.
GeneIDi26246.
KEGGihsa:26246.
UCSCiuc001idw.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065597 Genomic DNA. Translation: BAC05825.1.
BC104792 mRNA. Translation: AAI04793.1.
BC104794 mRNA. Translation: AAI04795.1.
X64978 mRNA. No translation available.
CCDSiCCDS31103.1.
RefSeqiNP_001004686.1. NM_001004686.2.
UniGeneiHs.684888.

3D structure databases

ProteinModelPortaliQ8NH16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355435.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ8NH16.

Polymorphism and mutation databases

BioMutaiOR2L2.
DMDMi38258181.

Proteomic databases

PaxDbiQ8NH16.
PRIDEiQ8NH16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366479; ENSP00000355435; ENSG00000203663.
GeneIDi26246.
KEGGihsa:26246.
UCSCiuc001idw.3. human.

Organism-specific databases

CTDi26246.
GeneCardsiGC01P248201.
HGNCiHGNC:8266. OR2L2.
neXtProtiNX_Q8NH16.
PharmGKBiPA32183.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG272740.
GeneTreeiENSGT00760000119248.
HOGENOMiHOG000041362.
HOVERGENiHBG017625.
InParanoidiQ8NH16.
KOiK04257.
OMAiFLDIHLH.
OrthoDBiEOG7M0NRV.
PhylomeDBiQ8NH16.
TreeFamiTF337295.

Enzyme and pathway databases

ReactomeiREACT_15488. Olfactory Signaling Pathway.

Miscellaneous databases

GeneWikiiOR2L2.
GenomeRNAii26246.
NextBioi48449.
PROiQ8NH16.

Gene expression databases

BgeeiQ8NH16.
CleanExiHS_OR2L2.
GenevisibleiQ8NH16. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Expression of members of the putative olfactory receptor gene family in mammalian germ cells."
    Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A., Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A., Vassart G.
    Nature 355:453-455(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 125-238.
    Tissue: Testis.

Entry informationi

Entry nameiOR2L2_HUMAN
AccessioniPrimary (citable) accession number: Q8NH16
Secondary accession number(s): Q2M3T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.