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Protein

Olfactory receptor 8U1

Gene

OR8U1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172199-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8U1
Gene namesi
Name:OR8U1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19611. OR8U1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 309CytoplasmicSequence analysisAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172199.
PharmGKBiPA134970669.

Polymorphism and mutation databases

BioMutaiOR8U1.
DMDMi74762588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506751 – 309Olfactory receptor 8U1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH10.
PeptideAtlasiQ8NH10.
PRIDEiQ8NH10.

Expressioni

Gene expression databases

CleanExiHS_OR8U1.

Organism-specific databases

HPAiCAB011677.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304188.

Structurei

3D structure databases

ProteinModelPortaliQ8NH10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJV. Eukaryota.
ENOG410YAZQ. LUCA.
GeneTreeiENSGT00810000125371.
HOVERGENiHBG017625.
InParanoidiQ8NH10.
KOiK04257.
OMAiCAQINCT.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH10.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHINCTQAT EFILVGLTDH QELKMPLFVL FLSIYLFTVV GNLGLILLIR
60 70 80 90 100
ADTSLNTPMY FFLSNLAFVD FCYSSVITPK MLGNFLYKQN VISFDACATQ
110 120 130 140 150
LGCFLTFMIS ESLLLASMAY DRYVAICNPL LYMVVMTPGI CIQLVAVPYS
160 170 180 190 200
YSFLMALFHT ILTFRLSYCH SNIVNHFYCD DMPLLRLTCS DTRFKQLWIF
210 220 230 240 250
ACAGIMFISS LLIVFVSYMF IISAILRMHS AEGRQKAFST CGSHMLAVTI
260 270 280 290 300
FYGTLIFMYL QPSSSHALDT DKMASVFYTV IIPMLNPLIY SLQNKEVKEA

LKKIIINKN
Length:309
Mass (Da):35,088
Last modified:October 1, 2002 - v1
Checksum:i5EDA2E45FB2A1548
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05324720H → R.Corresponds to variant rs11228166dbSNPEnsembl.1
Natural variantiVAR_053248109I → V.Corresponds to variant rs12788990dbSNPEnsembl.1
Natural variantiVAR_053249112S → C.Corresponds to variant rs10791961dbSNPEnsembl.1
Natural variantiVAR_060014137T → S.Corresponds to variant rs10791962dbSNPEnsembl.1
Natural variantiVAR_053250165R → C.Corresponds to variant rs17150411dbSNPEnsembl.1
Natural variantiVAR_060015206M → I.Corresponds to variant rs10896310dbSNPEnsembl.1
Natural variantiVAR_060016206M → T.Corresponds to variant rs10896309dbSNPEnsembl.1
Natural variantiVAR_053251288L → V.Corresponds to variant rs1573509dbSNPEnsembl.1
Natural variantiVAR_053252293Q → R.Corresponds to variant rs12272403dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065603 Genomic DNA. Translation: BAC05831.1.
CCDSiCCDS41647.1.
RefSeqiNP_001005204.1. NM_001005204.1.
UniGeneiHs.553618.

Genome annotation databases

EnsembliENST00000302270; ENSP00000304188; ENSG00000172199.
GeneIDi219417.
KEGGihsa:219417.
UCSCiuc031xpd.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065603 Genomic DNA. Translation: BAC05831.1.
CCDSiCCDS41647.1.
RefSeqiNP_001005204.1. NM_001005204.1.
UniGeneiHs.553618.

3D structure databases

ProteinModelPortaliQ8NH10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000304188.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR8U1.
DMDMi74762588.

Proteomic databases

PaxDbiQ8NH10.
PeptideAtlasiQ8NH10.
PRIDEiQ8NH10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302270; ENSP00000304188; ENSG00000172199.
GeneIDi219417.
KEGGihsa:219417.
UCSCiuc031xpd.1. human.

Organism-specific databases

CTDi219417.
GeneCardsiOR8U1.
HGNCiHGNC:19611. OR8U1.
HPAiCAB011677.
neXtProtiNX_Q8NH10.
OpenTargetsiENSG00000172199.
PharmGKBiPA134970669.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHJV. Eukaryota.
ENOG410YAZQ. LUCA.
GeneTreeiENSGT00810000125371.
HOVERGENiHBG017625.
InParanoidiQ8NH10.
KOiK04257.
OMAiCAQINCT.
OrthoDBiEOG091G0AZH.
PhylomeDBiQ8NH10.
TreeFamiTF352753.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172199-MONOMER.
ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii219417.
PROiQ8NH10.

Gene expression databases

CleanExiHS_OR8U1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR8U1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.