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Protein

Olfactory receptor 8U1

Gene

OR8U1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8U1
Gene namesi
Name:OR8U1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000172199.1
HGNCiHGNC:19611 OR8U1
neXtProtiNX_Q8NH10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25ExtracellularSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 54CytoplasmicSequence analysis8
Transmembranei55 – 75Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini76 – 99ExtracellularSequence analysisAdd BLAST24
Transmembranei100 – 120Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini121 – 139CytoplasmicSequence analysisAdd BLAST19
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 197ExtracellularSequence analysisAdd BLAST37
Transmembranei198 – 217Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini218 – 237CytoplasmicSequence analysisAdd BLAST20
Transmembranei238 – 258Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini259 – 271ExtracellularSequence analysisAdd BLAST13
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 309CytoplasmicSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172199
PharmGKBiPA134970669

Polymorphism and mutation databases

BioMutaiOR8U1
DMDMi74762588

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001506751 – 309Olfactory receptor 8U1Add BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH10
PRIDEiQ8NH10

Expressioni

Gene expression databases

BgeeiENSG00000172199
CleanExiHS_OR8U1

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304188

Structurei

3D structure databases

ProteinModelPortaliQ8NH10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJV Eukaryota
ENOG410YAZQ LUCA
GeneTreeiENSGT00910000144078
HOVERGENiHBG017625
InParanoidiQ8NH10
KOiK04257
OMAiNQAFMFM
OrthoDBiEOG091G0AZH
PhylomeDBiQ8NH10
TreeFamiTF352753

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHINCTQAT EFILVGLTDH QELKMPLFVL FLSIYLFTVV GNLGLILLIR
60 70 80 90 100
ADTSLNTPMY FFLSNLAFVD FCYSSVITPK MLGNFLYKQN VISFDACATQ
110 120 130 140 150
LGCFLTFMIS ESLLLASMAY DRYVAICNPL LYMVVMTPGI CIQLVAVPYS
160 170 180 190 200
YSFLMALFHT ILTFRLSYCH SNIVNHFYCD DMPLLRLTCS DTRFKQLWIF
210 220 230 240 250
ACAGIMFISS LLIVFVSYMF IISAILRMHS AEGRQKAFST CGSHMLAVTI
260 270 280 290 300
FYGTLIFMYL QPSSSHALDT DKMASVFYTV IIPMLNPLIY SLQNKEVKEA

LKKIIINKN
Length:309
Mass (Da):35,088
Last modified:October 1, 2002 - v1
Checksum:i5EDA2E45FB2A1548
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05324720H → R. Corresponds to variant dbSNP:rs11228166Ensembl.1
Natural variantiVAR_053248109I → V. Corresponds to variant dbSNP:rs12788990Ensembl.1
Natural variantiVAR_053249112S → C. Corresponds to variant dbSNP:rs10791961Ensembl.1
Natural variantiVAR_060014137T → S. Corresponds to variant dbSNP:rs10791962Ensembl.1
Natural variantiVAR_053250165R → C. Corresponds to variant dbSNP:rs17150411Ensembl.1
Natural variantiVAR_060015206M → I. Corresponds to variant dbSNP:rs10896310Ensembl.1
Natural variantiVAR_060016206M → T. Corresponds to variant dbSNP:rs10896309Ensembl.1
Natural variantiVAR_053251288L → V. Corresponds to variant dbSNP:rs1573509Ensembl.1
Natural variantiVAR_053252293Q → R. Corresponds to variant dbSNP:rs12272403Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065603 Genomic DNA Translation: BAC05831.1
CCDSiCCDS41647.1
RefSeqiNP_001005204.1, NM_001005204.1
UniGeneiHs.553618

Genome annotation databases

EnsembliENST00000302270; ENSP00000304188; ENSG00000172199
GeneIDi219417
KEGGihsa:219417
UCSCiuc031xpd.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR8U1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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