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Protein

Olfactory receptor 8U1

Gene

OR8U1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 8U1
Gene namesi
Name:OR8U1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:19611. OR8U1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525ExtracellularSequence analysisAdd
BLAST
Transmembranei26 – 4621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini47 – 548CytoplasmicSequence analysis
Transmembranei55 – 7521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini76 – 9924ExtracellularSequence analysisAdd
BLAST
Transmembranei100 – 12021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini121 – 13919CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 19737ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21720Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini218 – 23720CytoplasmicSequence analysisAdd
BLAST
Transmembranei238 – 25821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini259 – 27113ExtracellularSequence analysisAdd
BLAST
Transmembranei272 – 29221Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini293 – 30917CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134970669.

Polymorphism and mutation databases

BioMutaiOR8U1.
DMDMi74762588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Olfactory receptor 8U1PRO_0000150675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Disulfide bondi97 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8NH10.
PRIDEiQ8NH10.

Expressioni

Gene expression databases

CleanExiHS_OR8U1.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000304188.

Structurei

3D structure databases

ProteinModelPortaliQ8NH10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHJV. Eukaryota.
ENOG410YAZQ. LUCA.
GeneTreeiENSGT00810000125371.
HOVERGENiHBG017625.
InParanoidiQ8NH10.
KOiK04257.
OMAiWIFICAG.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH10.
TreeFamiTF352753.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHINCTQAT EFILVGLTDH QELKMPLFVL FLSIYLFTVV GNLGLILLIR
60 70 80 90 100
ADTSLNTPMY FFLSNLAFVD FCYSSVITPK MLGNFLYKQN VISFDACATQ
110 120 130 140 150
LGCFLTFMIS ESLLLASMAY DRYVAICNPL LYMVVMTPGI CIQLVAVPYS
160 170 180 190 200
YSFLMALFHT ILTFRLSYCH SNIVNHFYCD DMPLLRLTCS DTRFKQLWIF
210 220 230 240 250
ACAGIMFISS LLIVFVSYMF IISAILRMHS AEGRQKAFST CGSHMLAVTI
260 270 280 290 300
FYGTLIFMYL QPSSSHALDT DKMASVFYTV IIPMLNPLIY SLQNKEVKEA

LKKIIINKN
Length:309
Mass (Da):35,088
Last modified:October 1, 2002 - v1
Checksum:i5EDA2E45FB2A1548
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti20 – 201H → R.
Corresponds to variant rs11228166 [ dbSNP | Ensembl ].
VAR_053247
Natural varianti109 – 1091I → V.
Corresponds to variant rs12788990 [ dbSNP | Ensembl ].
VAR_053248
Natural varianti112 – 1121S → C.
Corresponds to variant rs10791961 [ dbSNP | Ensembl ].
VAR_053249
Natural varianti137 – 1371T → S.
Corresponds to variant rs10791962 [ dbSNP | Ensembl ].
VAR_060014
Natural varianti165 – 1651R → C.
Corresponds to variant rs17150411 [ dbSNP | Ensembl ].
VAR_053250
Natural varianti206 – 2061M → I.
Corresponds to variant rs10896310 [ dbSNP | Ensembl ].
VAR_060015
Natural varianti206 – 2061M → T.
Corresponds to variant rs10896309 [ dbSNP | Ensembl ].
VAR_060016
Natural varianti288 – 2881L → V.
Corresponds to variant rs1573509 [ dbSNP | Ensembl ].
VAR_053251
Natural varianti293 – 2931Q → R.
Corresponds to variant rs12272403 [ dbSNP | Ensembl ].
VAR_053252

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065603 Genomic DNA. Translation: BAC05831.1.
CCDSiCCDS41647.1.
RefSeqiNP_001005204.1. NM_001005204.1.
UniGeneiHs.553618.

Genome annotation databases

EnsembliENST00000302270; ENSP00000304188; ENSG00000172199.
GeneIDi219417.
KEGGihsa:219417.
UCSCiuc031xpd.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065603 Genomic DNA. Translation: BAC05831.1.
CCDSiCCDS41647.1.
RefSeqiNP_001005204.1. NM_001005204.1.
UniGeneiHs.553618.

3D structure databases

ProteinModelPortaliQ8NH10.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000304188.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiOR8U1.
DMDMi74762588.

Proteomic databases

PaxDbiQ8NH10.
PRIDEiQ8NH10.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302270; ENSP00000304188; ENSG00000172199.
GeneIDi219417.
KEGGihsa:219417.
UCSCiuc031xpd.1. human.

Organism-specific databases

CTDi219417.
GeneCardsiOR8U1.
HGNCiHGNC:19611. OR8U1.
neXtProtiNX_Q8NH10.
PharmGKBiPA134970669.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHJV. Eukaryota.
ENOG410YAZQ. LUCA.
GeneTreeiENSGT00810000125371.
HOVERGENiHBG017625.
InParanoidiQ8NH10.
KOiK04257.
OMAiWIFICAG.
OrthoDBiEOG71K63J.
PhylomeDBiQ8NH10.
TreeFamiTF352753.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

GenomeRNAii219417.
PROiQ8NH10.

Gene expression databases

CleanExiHS_OR8U1.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome-wide discovery and analysis of human seven transmembrane helix receptor genes."
    Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S., Tsutsumi S., Aburatani H., Asai K., Akiyama Y.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiOR8U1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH10
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.