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Protein

Olfactory receptor 1P1

Gene

OR1P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1P1
Alternative name(s):
Olfactory receptor 17-208
Short name:
OR17-208
Olfactory receptor OR17-9
Gene namesi
Name:OR1P1
Synonyms:OR1P1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:8222 OR1P1
neXtProtiNX_Q8NH06

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 71CytoplasmicSequence analysisAdd BLAST11
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 111ExtracellularSequence analysisAdd BLAST19
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 137CytoplasmicSequence analysis5
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 209ExtracellularSequence analysisAdd BLAST51
Transmembranei210 – 230Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini231 – 257CytoplasmicSequence analysisAdd BLAST27
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 286ExtracellularSequence analysis8
Transmembranei287 – 307Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini308 – 330CytoplasmicSequence analysisAdd BLAST23

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166215841

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141211 – 330Olfactory receptor 1P1Add BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NH06
ProteomicsDBi73642

Structurei

3D structure databases

ProteinModelPortaliQ8NH06
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625
InParanoidiQ8NH06
PhylomeDBiQ8NH06

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8NH06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTQDFFPP TSELLEGGNQ TSTFEFLLWG LSDQPQQQHI FFLLFLWMYV
60 70 80 90 100
VTVAGNLLIV LAIGTDTHLH TPMYFFLASL SCADIFSTST TVPKALVNIQ
110 120 130 140 150
TQSRSISYAG CLAQLYFFLT FGDMDIFLPA TMAYDRYVAI CHLLHYMMIM
160 170 180 190 200
SLHRCAFLVT ACWTLTSLLA MTRTFLIFRL SLCSAILPGF FCDLGPLMKV
210 220 230 240 250
SCSDAQVNEL VLLFLGGAVI LIPFMLILVS YIRIVSAILR APSAQGRRKA
260 270 280 290 300
FSTCDSHLVV VALFFGTVIR AYLCPSSSSS NSVKEDTAAA VMYTVVTPLL
310 320 330
NPFIYSMRNK DMKAAVVRLL KGRVSFSQGQ
Length:330
Mass (Da):36,638
Last modified:January 15, 2008 - v2
Checksum:i99E8373A75520998
GO

Polymorphismi

A stop codon in the gene coding for this protein at position Ala-185 is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087927 mRNA No translation available.
AB065608 Genomic DNA Translation: BAC05835.1 Sequence problems.
AF399436 mRNA No translation available.
BK004548 mRNA No translation available.

Similar proteinsi

Entry informationi

Entry nameiOR1P1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: June 20, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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