Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Olfactory receptor 1P1

Gene

OR1P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Olfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 1P1
Alternative name(s):
Olfactory receptor 17-208
Short name:
OR17-208
Olfactory receptor OR17-9
Gene namesi
Name:OR1P1
Synonyms:OR1P1P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:8222. OR1P1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3939ExtracellularSequence analysisAdd
BLAST
Transmembranei40 – 6021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini61 – 7111CytoplasmicSequence analysisAdd
BLAST
Transmembranei72 – 9221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini93 – 11119ExtracellularSequence analysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini133 – 1375CytoplasmicSequence analysis
Transmembranei138 – 15821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini159 – 20951ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 23021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini231 – 25727CytoplasmicSequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini279 – 2868ExtracellularSequence analysis
Transmembranei287 – 30721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini308 – 33023CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi166215841.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 330330Olfactory receptor 1P1PRO_0000314121Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi111 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8NH06.

Structurei

3D structure databases

ProteinModelPortaliQ8NH06.
SMRiQ8NH06. Positions 40-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ8NH06.
PhylomeDBiQ8NH06.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8NH06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLTQDFFPP TSELLEGGNQ TSTFEFLLWG LSDQPQQQHI FFLLFLWMYV
60 70 80 90 100
VTVAGNLLIV LAIGTDTHLH TPMYFFLASL SCADIFSTST TVPKALVNIQ
110 120 130 140 150
TQSRSISYAG CLAQLYFFLT FGDMDIFLPA TMAYDRYVAI CHLLHYMMIM
160 170 180 190 200
SLHRCAFLVT ACWTLTSLLA MTRTFLIFRL SLCSAILPGF FCDLGPLMKV
210 220 230 240 250
SCSDAQVNEL VLLFLGGAVI LIPFMLILVS YIRIVSAILR APSAQGRRKA
260 270 280 290 300
FSTCDSHLVV VALFFGTVIR AYLCPSSSSS NSVKEDTAAA VMYTVVTPLL
310 320 330
NPFIYSMRNK DMKAAVVRLL KGRVSFSQGQ
Length:330
Mass (Da):36,638
Last modified:January 15, 2008 - v2
Checksum:i99E8373A75520998
GO

Polymorphismi

A stop codon in the gene coding for this protein at position Ala-185 is responsible for functional diversity thus producing a pseudogene. The stop codon is more frequent in non-Africans than in African-Americans.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087927 mRNA. No translation available.
AB065608 Genomic DNA. Translation: BAC05835.1. Sequence problems.
AF399436 mRNA. No translation available.
BK004548 mRNA. No translation available.

Cross-referencesi

Web resourcesi

Human Olfactory Receptor Data Exploratorium (HORDE)

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087927 mRNA. No translation available.
AB065608 Genomic DNA. Translation: BAC05835.1. Sequence problems.
AF399436 mRNA. No translation available.
BK004548 mRNA. No translation available.

3D structure databases

ProteinModelPortaliQ8NH06.
SMRiQ8NH06. Positions 40-324.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

DMDMi166215841.

Proteomic databases

PRIDEiQ8NH06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiOR1P1.
HGNCiHGNC:8222. OR1P1.
neXtProtiNX_Q8NH06.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG017625.
InParanoidiQ8NH06.
PhylomeDBiQ8NH06.

Enzyme and pathway databases

ReactomeiR-HSA-381753. Olfactory Signaling Pathway.

Miscellaneous databases

PROiQ8NH06.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000725. Olfact_rcpt.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00245. OLFACTORYR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOR1P1_HUMAN
AccessioniPrimary (citable) accession number: Q8NH06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 17, 2016
This is version 86 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.